SitesBLAST
Comparing WP_015887690.1 NCBI__GCF_000018545.1:WP_015887690.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
33% identity, 92% coverage: 13:564/600 of query aligns to 13:556/592 of 8beoB
- binding methyl hydrogen (s)-acetylphosphonate: C490 (≠ H503), Q492 (≠ A505)
- binding flavin-adenine dinucleotide: R153 (= R159), P154 (= P160), G210 (= G217), G211 (= G218), G212 (= G219), N215 (≠ T222), T236 (= T243), L237 (≠ W244), M238 (≠ N245), V254 (= V261), G255 (= G262), Q257 (= Q263), T258 (= T264), G277 (= G283), N278 (≠ C284), R279 (= R285), A281 (≠ T287), R283 (≠ W289), H284 (≠ S290), D301 (= D311), I302 (≠ L312), Q306 (≠ E316), D320 (= D330), A321 (= A331), G415 (= G429)
- binding magnesium ion: D445 (= D459), F450 (≠ M464), L451 (≠ S465), E453 (≠ P467), N472 (= N486), Y474 (≠ G488)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (≠ W289), G393 (= G407), L394 (≠ N408), S395 (≠ T409), L420 (≠ M434), G444 (= G458), D445 (= D459), F446 (≠ G460), D447 (= D461), N472 (= N486), Y474 (≠ G488), L475 (≠ Y489), G476 (≠ M490), L477 (≠ S491), I478 (= I492)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q352 (= Q362), R356 (= R369)
Sites not aligning to the query:
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
33% identity, 92% coverage: 13:564/600 of query aligns to 13:556/592 of 8beoA
- binding flavin-adenine dinucleotide: R153 (= R159), P154 (= P160), G210 (= G217), G211 (= G218), G212 (= G219), N215 (≠ T222), T236 (= T243), L237 (≠ W244), M238 (≠ N245), V254 (= V261), G255 (= G262), Q257 (= Q263), T258 (= T264), G277 (= G283), N278 (≠ C284), R279 (= R285), A281 (≠ T287), R283 (≠ W289), H284 (≠ S290), D301 (= D311), I302 (≠ L312), Q306 (≠ E316), D320 (= D330), A321 (= A331), I397 (≠ G411), G415 (= G429)
- binding magnesium ion: R384 (= R398), V405 (= V419), F406 (≠ Y420), H410 (≠ T424), D445 (= D459), F450 (≠ M464), L451 (≠ S465), E453 (≠ P467), N472 (= N486), Y474 (≠ G488)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (≠ W289), G393 (= G407), L394 (≠ N408), S395 (≠ T409), L420 (≠ M434), G444 (= G458), D445 (= D459), F446 (≠ G460), D447 (= D461), N472 (= N486), Y474 (≠ G488), L475 (≠ Y489), G476 (≠ M490), L477 (≠ S491), I478 (= I492)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: E248 (≠ A255), Q352 (= Q362)
Sites not aligning to the query:
8i01A Crystal structure of escherichia coli glyoxylate carboligase (see paper)
33% identity, 92% coverage: 13:564/600 of query aligns to 15:558/594 of 8i01A
- binding flavin-adenine dinucleotide: R155 (= R159), G212 (= G217), G213 (= G218), G214 (= G219), N217 (≠ T222), T238 (= T243), L239 (≠ W244), M240 (≠ N245), V256 (= V261), G257 (= G262), Q259 (= Q263), T260 (= T264), G279 (= G283), N280 (≠ C284), R281 (= R285), A283 (≠ T287), R285 (≠ W289), H286 (≠ S290), D303 (= D311), I304 (≠ L312), Q308 (≠ E316), D322 (= D330), A323 (= A331), G417 (= G429)
- binding magnesium ion: D447 (= D459), F452 (≠ M464), E455 (≠ P467), N474 (= N486), Y476 (≠ G488)
- binding thiamine diphosphate: G395 (= G407), L396 (≠ N408), S397 (≠ T409), L422 (≠ M434), G446 (= G458), D447 (= D459), F448 (≠ G460), D449 (= D461), N474 (= N486), Y476 (≠ G488), L477 (≠ Y489), G478 (≠ M490), L479 (≠ S491), I480 (= I492)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q354 (= Q362), C492 (≠ H503), Q494 (≠ A505)
Sites not aligning to the query:
6lpiB Crystal structure of ahas holo-enzyme (see paper)
30% identity, 93% coverage: 2:560/600 of query aligns to 5:517/539 of 6lpiB
- active site: I27 (≠ V24), G29 (= G26), G30 (≠ H27), S31 (≠ G28), I32 (= I29), E53 (= E51), C76 (≠ S74), F115 (≠ M113), Q116 (= Q114), E117 (= E115), K165 (≠ M169), M256 (≠ Q263), A283 (≠ S293), V375 (≠ S406), G401 (≠ S432), M403 (= M434), D428 (= D459), N455 (= N486), A457 (≠ G488), L458 (≠ Y489), L460 (≠ S491), V461 (≠ I492), Q464 (≠ G495)
- binding flavin-adenine dinucleotide: R155 (= R159), G212 (= G217), G213 (= G218), G214 (= G219), T236 (= T243), L237 (≠ W244), M238 (≠ N245), L254 (≠ V261), M256 (≠ Q263), H257 (≠ T264), G276 (= G283), A277 (≠ C284), R278 (= R285), D280 (≠ T287), R282 (≠ S292), A283 (≠ S293), D300 (= D311), I301 (≠ L312), D319 (= D330), V320 (≠ A331), M380 (≠ G411), G398 (= G429)
- binding magnesium ion: D428 (= D459), N455 (= N486)
- binding thiamine diphosphate: E53 (= E51), C76 (≠ S74), P79 (= P77), G376 (= G407), Q377 (≠ N408), H378 (≠ T409), G401 (≠ S432), M403 (= M434), G427 (= G458), D428 (= D459), G429 (= G460), S430 (≠ D461), M433 (= M464), N455 (= N486), A457 (≠ G488), L458 (≠ Y489), G459 (≠ M490), L460 (≠ S491), V461 (≠ I492)
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde (see paper)
33% identity, 92% coverage: 13:564/600 of query aligns to 15:558/594 of 8i07D
- binding 2-oxidanylethanal: R285 (≠ W289), I480 (= I492)
- binding flavin-adenine dinucleotide: R155 (= R159), P156 (= P160), G212 (= G217), G213 (= G218), G214 (= G219), N217 (≠ T222), T238 (= T243), L239 (≠ W244), M240 (≠ N245), V256 (= V261), G257 (= G262), Q259 (= Q263), T260 (= T264), G279 (= G283), N280 (≠ C284), R281 (= R285), R285 (≠ W289), H286 (≠ S290), D303 (= D311), I304 (≠ L312), Q308 (≠ E316), D322 (= D330), A323 (= A331), I399 (≠ G411), G417 (= G429)
- binding magnesium ion: D447 (= D459), F452 (≠ M464), L453 (≠ S465), E455 (≠ P467), N474 (= N486), Y476 (≠ G488)
- binding thiamine diphosphate: V52 (≠ E51), T76 (≠ S74), G395 (= G407), L396 (≠ N408), S397 (≠ T409), L422 (≠ M434), G446 (= G458), D447 (= D459), F448 (≠ G460), D449 (= D461), N474 (= N486), Y476 (≠ G488), L477 (≠ Y489), G478 (≠ M490), L479 (≠ S491), I480 (= I492)
- binding ubiquinone-1: Q354 (= Q362), R358 (= R369), C492 (≠ H503), Q494 (≠ A505)
Sites not aligning to the query:
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde (see paper)
33% identity, 92% coverage: 13:564/600 of query aligns to 15:558/594 of 8i07A
- binding flavin-adenine dinucleotide: R155 (= R159), P156 (= P160), G212 (= G217), G213 (= G218), G214 (= G219), N217 (≠ T222), T238 (= T243), L239 (≠ W244), M240 (≠ N245), V256 (= V261), G257 (= G262), Q259 (= Q263), T260 (= T264), G279 (= G283), N280 (≠ C284), R281 (= R285), R285 (≠ W289), H286 (≠ S290), D303 (= D311), I304 (≠ L312), Q308 (≠ E316), D322 (= D330), A323 (= A331), I394 (≠ S406), I399 (≠ G411), G417 (= G429)
- binding magnesium ion: D447 (= D459), F452 (≠ M464), L453 (≠ S465), E455 (≠ P467), N474 (= N486), Y476 (≠ G488)
- binding thiamine diphosphate: I394 (≠ S406), G395 (= G407), L396 (≠ N408), S397 (≠ T409), L422 (≠ M434), G446 (= G458), D447 (= D459), F448 (≠ G460), D449 (= D461), N474 (= N486), Y476 (≠ G488), L477 (≠ Y489), G478 (≠ M490), L479 (≠ S491), I480 (= I492)
- binding ubiquinone-1: Q354 (= Q362), C492 (≠ H503), Q494 (≠ A505)
Sites not aligning to the query:
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 13:554/582 of 3ea4A
- active site: Y32 (≠ V24), G34 (= G26), G35 (≠ H27), A36 (≠ G28), S37 (≠ I29), E58 (= E51), T81 (≠ S74), F120 (≠ M113), Q121 (= Q114), E122 (= E115), K170 (≠ M169), M265 (≠ Q263), V292 (≠ S290), V399 (≠ S406), G425 (≠ S432), M427 (= M434), D452 (= D459), N479 (= N486), H481 (≠ G488), L482 (≠ Y489), M484 (≠ S491), V485 (≠ I492), W488 (≠ G495)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D288), R291 (≠ W289), W488 (≠ G495)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R159), G221 (= G217), G222 (= G218), G223 (= G219), T245 (= T243), L246 (≠ W244), M247 (≠ N245), L263 (≠ V261), G264 (= G262), M265 (≠ Q263), H266 (≠ T264), G285 (= G283), R287 (= R285), D289 (≠ T287), R291 (≠ W289), D309 (= D311), I310 (≠ L312), G327 (≠ S329), D328 (= D330), V329 (≠ A331), M404 (≠ G411), G422 (= G429)
- binding magnesium ion: D452 (= D459), N479 (= N486), H481 (≠ G488)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ S406), G400 (= G407), Q401 (≠ N408), H402 (≠ T409), M427 (= M434), G451 (= G458), D452 (= D459), G453 (= G460), S454 (≠ D461), N479 (= N486), H481 (≠ G488), L482 (≠ Y489), G483 (≠ M490), M484 (≠ S491), V485 (≠ I492)
Sites not aligning to the query:
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 13:554/582 of 3e9yA
- active site: Y32 (≠ V24), G34 (= G26), G35 (≠ H27), A36 (≠ G28), S37 (≠ I29), E58 (= E51), T81 (≠ S74), F120 (≠ M113), Q121 (= Q114), E122 (= E115), K170 (≠ M169), M265 (≠ Q263), V292 (≠ S290), V399 (≠ S406), G425 (≠ S432), M427 (= M434), D452 (= D459), N479 (= N486), H481 (≠ G488), L482 (≠ Y489), M484 (≠ S491), V485 (≠ I492), W488 (≠ G495)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D288), R291 (≠ W289), W488 (≠ G495)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R159), G221 (= G217), G222 (= G218), G223 (= G219), T245 (= T243), L246 (≠ W244), M247 (≠ N245), L263 (≠ V261), G285 (= G283), R287 (= R285), D289 (≠ T287), R291 (≠ W289), D309 (= D311), I310 (≠ L312), G327 (≠ S329), D328 (= D330), V329 (≠ A331), M404 (≠ G411), G422 (= G429)
- binding magnesium ion: D452 (= D459), N479 (= N486), H481 (≠ G488)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ S406), G400 (= G407), Q401 (≠ N408), H402 (≠ T409), M427 (= M434), G451 (= G458), G453 (= G460), S454 (≠ D461), N479 (= N486), H481 (≠ G488), L482 (≠ Y489), G483 (≠ M490), M484 (≠ S491), V485 (≠ I492)
Sites not aligning to the query:
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ Q263), R292 (≠ W289), W489 (≠ G495)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ S406), G401 (= G407), Q402 (≠ N408), H403 (≠ T409), G426 (≠ S432), M428 (= M434), G452 (= G458), D453 (= D459), G454 (= G460), S455 (≠ D461), L483 (≠ Y489), G484 (≠ M490), M485 (≠ S491), V486 (≠ I492)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), M263 (≠ A260), L264 (≠ V261), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), R288 (= R285), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429)
- binding magnesium ion: A37 (≠ G28), T82 (≠ S74), S83 (≠ V75), Q122 (= Q114), Y381 (≠ R387), D453 (= D459), M458 (= M464), Q461 (≠ P467), N480 (= N486), H482 (≠ G488), K533 (≠ D539)
Sites not aligning to the query:
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/583 of 5k3sA
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (≠ W289), M485 (≠ S491), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), M266 (≠ Q263), G286 (= G283), R288 (= R285), D290 (≠ T287), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ S406), G401 (= G407), Q402 (≠ N408), H403 (≠ T409), G426 (≠ S432), M428 (= M434), D453 (= D459), G454 (= G460), S455 (≠ D461), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), G484 (≠ M490), M485 (≠ S491), V486 (≠ I492)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ S406), G401 (= G407), Q402 (≠ N408), H403 (≠ T409), G426 (≠ S432), M428 (= M434), G452 (= G458), D453 (= D459), G454 (= G460), S455 (≠ D461), M458 (= M464), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), G484 (≠ M490), M485 (≠ S491), V486 (≠ I492)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), V287 (≠ C284), R288 (= R285), D290 (≠ T287), R292 (≠ W289), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429)
- binding magnesium ion: F370 (= F383), D453 (= D459), M458 (= M464), Q461 (≠ P467), N480 (= N486), H482 (≠ G488), K533 (≠ D539)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ Q263), R292 (≠ W289), M485 (≠ S491), W489 (≠ G495)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 5wj1A
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), M263 (≠ A260), L264 (≠ V261), G286 (= G283), R288 (= R285), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429), G424 (≠ S430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ Q263), D291 (= D288), R292 (≠ W289), M485 (≠ S491), W489 (≠ G495)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ S406), G401 (= G407), Q402 (≠ N408), H403 (≠ T409), M428 (= M434), D453 (= D459), G454 (= G460), S455 (≠ D461), M458 (= M464), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), G484 (≠ M490), M485 (≠ S491), V486 (≠ I492)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 5k6tA
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ T264), R292 (≠ W289), M485 (≠ S491), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), G286 (= G283), R288 (= R285), D290 (≠ T287), R292 (≠ W289), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), Q404 (= Q410), M405 (≠ G411), G423 (= G429)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ S406), G401 (= G407), Q402 (≠ N408), H403 (≠ T409), G426 (≠ S432), M428 (= M434), G452 (= G458), G454 (= G460), S455 (≠ D461), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), G484 (≠ M490)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 5k6rA
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (≠ W289), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), M266 (≠ Q263), G286 (= G283), R288 (= R285), R292 (≠ W289), V293 (≠ S290), D310 (= D311), I311 (≠ L312), G328 (≠ S329), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ S406), G401 (= G407), Q402 (≠ N408), H403 (≠ T409), G426 (≠ S432), M428 (= M434), D453 (= D459), G454 (= G460), S455 (≠ D461), M458 (= M464), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), G484 (≠ M490), M485 (≠ S491), V486 (≠ I492)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 1z8nA
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K133), R161 (= R159), Y191 (≠ G190), R194 (≠ Y193), D291 (= D288), R292 (≠ W289), D312 (= D313), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), G265 (= G262), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), V287 (≠ C284), R288 (= R285), D290 (≠ T287), R292 (≠ W289), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429), G424 (≠ S430)
- binding magnesium ion: D453 (= D459), N480 (= N486)
- binding thiamine diphosphate: V400 (≠ S406), G401 (= G407), Q402 (≠ N408), H403 (≠ T409), G426 (≠ S432), M428 (= M434), G452 (= G458), G454 (= G460), S455 (≠ D461), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), G484 (≠ M490), M485 (≠ S491), V486 (≠ I492)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 1yi1A
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D288), R292 (≠ W289), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), M263 (≠ A260), L264 (≠ V261), G265 (= G262), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), V287 (≠ C284), R288 (= R285), D290 (≠ T287), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429), G424 (≠ S430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 1yi0A
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D288), R292 (≠ W289), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), G265 (= G262), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), V287 (≠ C284), R288 (= R285), D290 (≠ T287), R292 (≠ W289), V293 (≠ S290), D310 (= D311), I311 (≠ L312), G328 (≠ S329), D329 (= D330), V330 (≠ A331), M405 (≠ G411), G423 (= G429), G424 (≠ S430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 1yhzA
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D288), R292 (≠ W289), M485 (≠ S491), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), V287 (≠ C284), R288 (= R285), D290 (≠ T287), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), Q404 (= Q410), M405 (≠ G411), G423 (= G429), G424 (≠ S430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 1yhyA
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D288), R292 (≠ W289), V486 (≠ I492), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G217), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), G265 (= G262), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), V287 (≠ C284), R288 (= R285), D290 (≠ T287), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), Q404 (= Q410), M405 (≠ G411), G423 (= G429), G424 (≠ S430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
Sites not aligning to the query:
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
31% identity, 93% coverage: 5:561/600 of query aligns to 14:555/582 of 1ybhA
- active site: Y33 (≠ V24), G35 (= G26), G36 (≠ H27), A37 (≠ G28), S38 (≠ I29), E59 (= E51), T82 (≠ S74), F121 (≠ M113), Q122 (= Q114), E123 (= E115), K171 (≠ M169), M266 (≠ Q263), V293 (≠ S290), V400 (≠ S406), G426 (≠ S432), M428 (= M434), D453 (= D459), N480 (= N486), H482 (≠ G488), L483 (≠ Y489), M485 (≠ S491), V486 (≠ I492), W489 (≠ G495)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ Q263), D291 (= D288), R292 (≠ W289), M485 (≠ S491), W489 (≠ G495)
- binding flavin-adenine dinucleotide: R161 (= R159), G223 (= G218), G224 (= G219), T246 (= T243), L247 (≠ W244), M248 (≠ N245), L264 (≠ V261), M266 (≠ Q263), H267 (≠ T264), G286 (= G283), V287 (≠ C284), R288 (= R285), D290 (≠ T287), V293 (≠ S290), D310 (= D311), I311 (≠ L312), D329 (= D330), V330 (≠ A331), Q404 (= Q410), M405 (≠ G411), G423 (= G429), G424 (≠ S430)
- binding magnesium ion: D453 (= D459), N480 (= N486), H482 (≠ G488)
Sites not aligning to the query:
Query Sequence
>WP_015887690.1 NCBI__GCF_000018545.1:WP_015887690.1
MKLTGGQVVAKALKEYGVEYVAGVPGHGIWSLFDAFLEEGSEIPFIQVMHEQSAVHMADG
YFRASGRPMACSTSVGPGAANTIIGLATAYCDSTSLFYVSGSPQTYMHGHGTMQELERQQ
DNAFPRITEQVTKRAWQANSVQVLPSIMHRAFNAMVTGRPGPVHVEVPMDVQVEAADVTI
HPLEKRLPIGVAYPDPKAIEAAIKVLLNAERPVIVAGGGAITANASTELTRLAEKLGAAV
SITWNGKGAISEDHALFIGAVGQTGTTCGNKITASADVVVSVGCRFTDWSASSYAKGVSF
SIPSAKLIHIDLDPREIGKNYETEVGIVSDAKVALEALLAMISDAESKKMLSRRETFLAD
VQKAKADWRAQVEPRENSRETPFTSQRPLMALRKVLDRNGIVVVGSGNTQGSVKQSFPVY
EPRTHLTSGSYSPMGWAVPAALGAKLACPDRQVVAIVGDGDFMMSLPEMGTAAMNGINVV
FLVLNNQGYMSIRGGQRKFMGRHIASEFNRHAGNGQPYSADIAASARAFGLEAWKVEKDE
DLEKSLKAALECGGPALVEVIVSRDAAGPFATGWWDFPSPAYYEKEQAAYAEMRAREQHL
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory