SitesBLAST
Comparing WP_015942967.1 NCBI__GCF_000021925.1:WP_015942967.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
35% identity, 91% coverage: 41:457/460 of query aligns to 45:463/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P69), G75 (= G71), S76 (≠ A72), G77 (= G73), T78 (= T74), G79 (≠ N75), L80 (≠ V76), A83 (≠ G79), C84 (≠ T80), P137 (= P133), G138 (≠ S134), E139 (≠ S135), A142 (= A139), T143 (= T140), G146 (= G143), N147 (= N144), S149 (≠ A146), T150 (≠ E147), A152 (≠ S149), G153 (= G150), E203 (= E200), G204 (= G201), I209 (≠ V206), E422 (= E416), H423 (≠ Q417)
- binding fe (iii) ion: H377 (= H372), H384 (= H379), E422 (= E416)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
34% identity, 98% coverage: 9:458/460 of query aligns to 7:456/459 of P9WIT1
- K354 (≠ Q351) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
32% identity, 99% coverage: 2:458/460 of query aligns to 1:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), W322 (≠ F327), E413 (= E416), H414 (≠ Q417), N450 (= N453)
- binding lactic acid: R318 (= R323), H369 (= H372), H376 (= H379), H414 (≠ Q417)
- binding manganese (ii) ion: H369 (= H372), H376 (= H379), E413 (= E416)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
32% identity, 99% coverage: 2:458/460 of query aligns to 1:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R323), H369 (= H372), H376 (= H379), H414 (≠ Q417)
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), W322 (≠ F327), E413 (= E416), H414 (≠ Q417), N450 (= N453)
- binding manganese (ii) ion: H369 (= H372), H376 (= H379), E413 (= E416)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
32% identity, 99% coverage: 2:458/460 of query aligns to 1:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ F33), P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), W323 (≠ F327), E414 (= E416), H415 (≠ Q417), N451 (= N453)
- binding manganese (ii) ion: H370 (= H372), H377 (= H379), E414 (= E416)
- binding pyruvic acid: R319 (= R323), H370 (= H372), H377 (= H379), H415 (≠ Q417)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
32% identity, 99% coverage: 2:458/460 of query aligns to 1:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ F33), P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), W322 (≠ F327), E413 (= E416), H414 (≠ Q417), N450 (= N453)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R323), H369 (= H372), H376 (= H379), H414 (≠ Q417)
- binding manganese (ii) ion: H369 (= H372), H376 (= H379), E413 (= E416)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (= V76), R317 (= R323), W321 (≠ F327), H368 (= H372), H375 (= H379), H413 (≠ Q417)
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), W321 (≠ F327), Y322 (≠ G328), E412 (= E416), H413 (≠ Q417), N449 (= N453)
- binding manganese (ii) ion: H368 (= H372), H375 (= H379), E412 (= E416)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
32% identity, 99% coverage: 2:458/460 of query aligns to 1:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R323), W322 (≠ F327), H369 (= H372), H376 (= H379), H414 (≠ Q417)
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), W322 (≠ F327), E413 (= E416), N450 (= N453)
- binding manganese (ii) ion: H369 (= H372), H376 (= H379), E413 (= E416)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), H369 (= H372), E413 (= E416), N450 (= N453)
- binding deaminohydroxyvaline: R319 (= R323), H414 (≠ Q417)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), Y324 (≠ G328), H370 (= H372), E414 (= E416), N451 (= N453)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R323), W323 (≠ F327), H415 (≠ Q417)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R323), W323 (≠ F327), H370 (= H372), H415 (≠ Q417)
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), H370 (= H372), E414 (= E416), N451 (= N453)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R323), W323 (≠ F327), H415 (≠ Q417)
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), Y324 (≠ G328), H370 (= H372), E414 (= E416), N451 (= N453)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), H370 (= H372), E414 (= E416), N451 (= N453)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R323), W323 (≠ F327), H415 (≠ Q417)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), H370 (= H372), E414 (= E416), N451 (= N453)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R323), H415 (≠ Q417)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
31% identity, 99% coverage: 2:458/460 of query aligns to 1:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), Y324 (≠ G328), H370 (= H372), E414 (= E416), N451 (= N453)
- binding (2R)-2-oxidanyloctanoic acid: V75 (= V76), R319 (= R323), W323 (≠ F327), H415 (≠ Q417)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
32% identity, 99% coverage: 2:458/460 of query aligns to 1:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R323), W322 (≠ F327), H369 (= H372), H376 (= H379), H413 (≠ Q417)
- binding flavin-adenine dinucleotide: E32 (≠ F33), P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), W322 (≠ F327), E412 (= E416), H413 (≠ Q417), N449 (= N453)
- binding manganese (ii) ion: H369 (= H372), H376 (= H379), E412 (= E416)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
32% identity, 99% coverage: 2:458/460 of query aligns to 1:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R323), W322 (≠ F327), S336 (= S338), H369 (= H372), H376 (= H379), H413 (≠ Q417)
- binding flavin-adenine dinucleotide: P68 (= P69), G70 (= G71), T71 (≠ A72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (= G79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ S134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ E147), A146 (≠ S149), S147 (≠ G150), E200 (= E200), G201 (= G201), I206 (≠ V206), E412 (= E416), N449 (= N453)
- binding manganese (ii) ion: H369 (= H372), H376 (= H379), E412 (= E416)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
31% identity, 99% coverage: 2:457/460 of query aligns to 2:464/465 of 3pm9A
- active site: A149 (≠ S149), L159 (≠ V159)
- binding flavin-adenine dinucleotide: P69 (= P69), Q70 (≠ R70), G71 (= G71), G72 (≠ A72), N73 (≠ G73), T74 (= T74), G75 (≠ N75), L76 (≠ V76), G79 (= G79), Q80 (≠ T80), L91 (≠ F91), L133 (≠ P133), G134 (≠ S134), A135 (≠ S135), C139 (≠ A139), T140 (= T140), G142 (= G142), G143 (= G143), S146 (≠ A146), T147 (≠ E147), A149 (≠ S149), G150 (= G150), E200 (= E200), G201 (= G201), I205 (≠ L205), I206 (≠ V206), E423 (= E416)
6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
26% identity, 91% coverage: 44:460/460 of query aligns to 51:467/467 of 6lpnB
- binding flavin-adenine dinucleotide: P76 (= P69), G78 (= G71), G79 (≠ A72), N80 (≠ G73), T81 (= T74), G82 (≠ N75), M83 (≠ V76), G86 (= G79), S87 (≠ T80), L140 (≠ P133), A142 (≠ S135), C146 (≠ A139), H147 (≠ T140), G150 (= G143), N151 (= N144), A153 (= A146), T154 (≠ E147), G208 (= G201), I212 (≠ L205), I213 (≠ V206), E423 (= E416), N460 (= N453)
Sites not aligning to the query:
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
26% identity, 91% coverage: 44:460/460 of query aligns to 50:466/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R323), T337 (= T334), K348 (≠ R346), Y379 (vs. gap), H381 (= H372), H388 (= H379), H423 (≠ Q417)
- binding flavin-adenine dinucleotide: P75 (= P69), Q76 (≠ R70), G77 (= G71), G78 (≠ A72), N79 (≠ G73), T80 (= T74), G81 (≠ N75), M82 (≠ V76), G85 (= G79), S86 (≠ T80), L139 (≠ P133), G140 (≠ S134), A141 (≠ S135), C145 (≠ A139), G149 (= G143), N150 (= N144), A152 (= A146), T153 (≠ E147), G157 (= G151), G207 (= G201), I212 (≠ V206), E422 (= E416), N459 (= N453)
- binding zinc ion: H381 (= H372), H388 (= H379), E422 (= E416)
Sites not aligning to the query:
Query Sequence
>WP_015942967.1 NCBI__GCF_000021925.1:WP_015942967.1
MLSQTVIKRLKEIVGEKNFVTGKADLFPYTYGFCTLLSGDPLGVVSPQTTEQVVELVKYL
NEHNIKVIPRGAGTNVIGGTIPAEESVVISFTRMNKILEIDTENFVTVVQPGVVNFDLQL
ELEKRGFYYPPDPSSAKVATLGGNLAESSGGARCFKYGVTRDYILGVEVVLPNGKVINTG
GRNFKSEPGYDLTRILNGSEGTLGLVTKIILRVLPLPMARRMMLAVYDKVEDAAQTVDGI
FAAGIAPATLEMLDNFFINTTEDFCPTGIPRDAGAALIIEIDGYPEDMNEQVRIIGEITR
KAKARDFKIARSMGEVEQILTPRKVGFGSIASITPSYSINDIAVPRSNFSQAFAGIKKIA
KDLNVKIGVLAHAGDGNFHPFILYDQRNKEEVERVHAAEQALCEMALSFSGTITGEQGVG
IAKRKHLDKQFKPEAMEAFRKIKRSFDPQNRFNPGKIFDS
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory