SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_017220912.1 NCBI__GCF_000276805.1:WP_017220912.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 11 hits to proteins with known functional sites (download)

5z16B A novel dimeric isocitrate dehydrogenase from acinetobacter baumannii
75% identity, 99% coverage: 6:742/745 of query aligns to 1:737/739 of 5z16B

query
sites
5z16B

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binding magnesium ion: D347 (= D352), D546 (= D551), D550 (= D555)

4zdaA Crystal structure of isocitrate dehydrogenase in complex with isocitrate and mn from m. Smegmatis
76% identity, 98% coverage: 8:740/745 of query aligns to 3:735/735 of 4zdaA

query
sites
4zdaA

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G

G

S

S

A

A

P

P

K

K

H

H

V

V

Q

H

Q

Q

L

L

V

V

E

E

E

E

N

N

H

H

L

L

R

R

W

W

D

D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

I

L

T

G

V

A

S

S

L

L

E

E

S

D

V

M

A

G

K

N

K

K

S

T

G

G

S

N

I

E

K

K

A

A

K

K

V

V

L

L

A

A

T

K

T

A

L

L

D

D

Q

T

A

A

T

T

E

G

M

K

L

L

L

L

D

E

N

E

G

N

K

K

S

S

P

P

S

S

R

R

R

R

T

T

G

G

E

E

L

L

D

D

N

N

R

R

G

G

S

S

H

Q

F

F

Y

Y

L

L

S

S

L

L

F

F

W

W

A

A

K

Q

C

A

I

L

A

A

E

E

Q

Q

T

T

E

E

D

D

T

A

E

E

L

L

A

A

A

E

K

R

F

F

A

K

P

P

L

L

A

A

A

K

S

A

L

L

A

A

E

E

N

Q

E

E

L

E

K

A

I

I

V

V

E

S

E

E

L

L

N

N

S

S

A

V

Q

Q

G

G

K

K

A

T

V

V

D

D

I

I

G

G

G

G

Y

Y

F

Y

N

Y

A

P

D

D

P

P

A

E

K

K

M

T

E

S

A

E

I

V

M

M

R

R

P

P

S

S

K

K

T

T

F

F

N

N

A

T

V

T

L

L

binding manganese (ii) ion: D347 (= D352), D546 (= D551), D550 (= D555)

5kvuA Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from mycobacterium tuberculosis
74% identity, 98% coverage: 8:740/745 of query aligns to 4:735/738 of 5kvuA

query
sites
5kvuA

I

I

I

I

Y

Y

T

T

L

L

T

T

D

D

E

E

A

A

P

P

L

L

L

L

A

A

T

T

Y

Y

S

A

L

F

L

L

P

P

I

I

V

V

E

R

K

A

F

F

T

A

S

E

A

P

A

A

G

G

I

I

D

K

V

I

V

E

K

A

S

S

D

D

I

I

S

S

V

V

A

A

A

A

R

R

I

I

L

L

A

A

E

E

F

F

P

P

E

D

Y

Y

L

L

S

T

E

E

E

E

Q

Q

Q

R

L

V

P

P

D

D

N

N

L

L

S

A

E

E

L

L

G

G

R

R

L

L

T

T

Q

Q

D

L

S

P

N

D

T

T

N

N

I

I

I

I

K

K

L

L

P
|
P

N
|
N

I

I

S
|
S

A

A

S

S

V

V

P

P

Q

Q

L

L

Q

V

A

A

A

A

I

I

S

K

E

E

L

L

Q

Q

S

D

Q

K

G

G

F

Y

N

A

I

V

P

P

N

D

L

Y

P

P

E

A

N

D

P

P

Q

-

T

T

D

D

E

Q

G

E

K

K

A

A

L

I

L

K

Q

E

R

R

Y

Y

S

A

K

R

A

C

L

L

G

G

S

S

A

A

V

V

N
|
N

P

P

V

V

L

L

R

R

E

Q

G

G

N

N

S

S

D

D

R

R

R

R

A

A

P

P

K

K

A

A

V

V

K

K

N

E

F

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

S

M

M

G

G

K

E

W

W

S

S

Q

M

A

A

S

S

Q

R

T

T

H

H

V

V

A

A

H

H

M

M

R

R

E

H

G

G

D

D

F

F

Y

Y

H

A

G

G

E

E

K

K

S

S

I

M

T

T

L

L

D

D

R

R

A

A

R

R

T

N

V

V

R

R

M

M

E

E

L

L

V

L

A

A

E

K

N

S

G

G

E

K

T

T

I

I

I

V

L

L

K

K

N

P

N

E

L

V

A

P

L

L

L

D

D

D

G

G

E

D

I

V

I

I

D

D

S

S

M

M

Y

F

M

M

S

S

K

K

T

K

A

A

L

L

C

C

D

D

F

F

Y

Y

E

E

Q

E

E

Q

M

M

Q

Q

D

D

A

A

Y

F

E

E

T

T

G

G

M

V

M

M

F

F

S

S

L

L

H

H

V

V

K

K

A

A

T

T

M

M

M

M

K

K

V

V

S

S

H

H

P

P

I

I

V

V

F

F

G

G

H

H

A

A

V

V

R

R

I

I

F

F

Y

Y

K

K

D

D

A

A

F

F

A

A

K

K

H

H

D

Q

E

E

L

L

F

F

K

D

K

D

L

L

G

G

V

V

N

N

V

V

N

N

N

N

G

G

L

L

S

S

N

D

L

L

Y

Y

E

S

K

K

I

I

A

E

D

S

L

L

P

P

S

A

S

S

Q

Q

R

R

E

D

E

E

I

I

R

I

R

E

D

D

L

L

H

H

A

R

C

C

H

H

A

E

H

H

R

R

P

P

E

E

L

L

A

A

M

M

V

V

D

D

S

S

D

A

K

R

G

G

I

I

S

S

N

N

L

F

H

H

A

S

P

P

N

S

D

D

V

V

I
|
I

V

V

D

D

A
|
A

S

S

M

M

P

P

A

A

M

M

I

I

R

R

S

A

G

G

G

G

K

K

M

M

W

Y

G

G

A

A

D

D

G

G

R

K

P

L

K

K

D

D

T

T

K

K

A

A

V

V

I

N

P

P

E

E

S

S

T

T

F

F

A

S

R

R

I

I

Y

Y

Q

Q

E

E

I

I

I

I

A

N

F

F

C

C

K

K

T

T

N

N

G

G

A

Q

F

F

D

D

P

P

V

T

T

T

M

M

G

G

S

T

V

V

P

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

Q

A

A

E

E

E

E

Y

Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

E

A

I

P

P

A

E

T

D

G

G

E

V

A

A

R

N

I

I

V

V

D

D

I

V

D

A

T

T

G

G

E

E

V

V

L

L

M

L

I

T

Q

E

N

N

V

V

E

E

K

A

D

G

D

D

I

I

W

W

R

R

M

M

C

C

Q

I

V

V

K

K

D

D

A

A

P

P

I

I

R

R

D

D

W

W

V

V

K

K

L

L

S

A

V

V

E

T

R

R

A

A

R

R

D

I

S

S

D

G

T

M

P

P

V

V

V

L

F

F

W

W

L

L

D

D

R

P

Y

Y

R

R

P

P

H

H

E

E

N

N

E

E

L

L

I

I

T

K

K

K

V

V

N

K

E

T

Y

Y

L

L

K

K

D

D

H

H

N

D

T

T

D

E

G

G

L

L

D

D

I

I

Q

Q

I

I

M

M

S

S

Q

Q

V

V

R

R

A

S

M

M

R

R

Y

Y

T

T

L

C

E

E

R

R

V

L

V

V

R

R

G

G

L

L

D

D

T

T

I

I

S

A

S

A

T

T

G

G

N

N

I

I

L

L

R

R

D

D

Y

Y

L

L

T

T

D

D

L

L

F

F

P

P

I

I

M

L

E

E

L

L

G

G

T
|
T

S

S

A
|
A

K

K

M

M

L

L

S

S

I

V

V

V

P

P

L

L

M

M

A

A

G

G

G

G

G

G

L

M

F

Y

E

E

T

T

G

G

A

A

G

G

G
|
G

S
|
S

A
|
A

P

P

K

K

H
|
H

V

V

Q

K

Q

Q

L

L

V

V

E

E

E

E

N

N

H

H

L

L

R
|
R

W
|
W

D
|
D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

I

L

T

G

V

A

S

G

L

F

E

E

S

D

V

I

A

G

K

I

K

K

S

T

G

G

S

N

I

E

K

R

A

A

K

K

V

L

L

L

A

G

T

K

T

T

L

L

D

D

Q

A

A

A

T

I

E

G

M

K

L

L

L

L

D

D

N

N

G

D

K

K

S

S

P

P

S

S

R
|
R

R

K

T

T

G

G

E

E

L

L

D

D

N

N

R

R

G

G

S

S

H

Q

F

F

Y

Y

L

L

S

A

L

M

F

Y

W

W

A

A

K

Q

C

E

I

L

A

A

E

A

Q

Q

T

T

E

D

D

D

T

Q

E

Q

L

L

A

A

A

E

K

H

F

F

A

A

P

S

L

L

A

A

A

D

S

V

L

L

A

T

E

K

N

N

E

E

L

D

K

V

I

I

V

V

E

R

E

E

L

L

N

T

S

E

A

V

Q

Q

G

G

K

E

A

P

V

V

D

D

I

I

G

G

G

G

Y

Y

F

Y

N

A

A

P

D

D

P

S

A

D

K

M

M

T

E

T

A

A

I

V

M

M

R

R

P

P

S

S

K

K

T

T

F

F

N

N

A

A

V

A

L

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: P82 (= P86), N83 (= N87), S85 (= S89), N132 (= N137), I345 (= I350), A348 (= A353), T559 (= T564), A561 (= A566), G582 (= G587), S583 (= S588), A584 (= A589), H587 (= H592), R598 (= R603), W599 (= W604), D600 (= D605), R647 (= R652)

6g3uA Structure of pseudomonas aeruginosa isocitrate dehydrogenase, idh (see paper)
66% identity, 99% coverage: 6:741/745 of query aligns to 1:734/737 of 6g3uA

query
sites
6g3uA

S

S

K

K

I

I

I

T

Y

Y

T

T

L

F

T

T

D

D

E

E

A

A

P

P

L

A

L

L

A

A

T

T

Y

Y

S

S

L

L

L

L

P

P

I

I

V

V

E

K

K

A

F

F

T

A

S

A

A

S

A

A

G

G

I

I

D

D

V

V

V

E

K

T

S

S

D

D

I

I

S

S

V

L

A

A

A

G

R

R

I

I

L

L

A

A

E

N

F

F

P

A

E

D

Y

R

L

L

S

E

E

A

E

D

Q

Q

Q

R

L

I

P

E

D

D

N

D

L

L

S

A

E

R

L

L

G

A

R

V

L

L

T

A

Q

T

D

S

S

P

N

D

T

A

N

N

I

I

I

I

K

K

L

L

P
|
P

N
|
N

I

I

S
|
S

A

A

S

S

V

V

P

P

Q

Q

L

L

Q

K

A

G

A

A

I

I

S

A

E

E

L

L

Q

Q

S

G

Q

L

G

G

F

Y

N

K

I

V

P

P

N

D

L

F

P

P

E

E

N

D

P

P

Q

Q

T

T

D

D

E

E

G

E

K

K

A

E

L

V

L

R

Q

A

R

R

Y

Y

S

A

K

K

A

I

L

L

G

G

S
|
S

A

A

V

V

N
|
N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R
|
R

R

R

A

A

P

P

K

A

A

A

V

V

K

K

N

A

F

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

S

M

M

G

G

K

K

W

W

S

S

Q

M

A

A

S

S

Q

R

T

S

H

H

V

A

A

D

H

Y

M

M

R

R

E

G

G

G

D

D

F

F

Y

F

H

S

G

S

E

E

K

Q

S

S

I

I

T

T

L

M

D

A

R

K

A

A

R

G

T

D

V

V

R

R

M

I

E

E

L

F

V

V

A

G

E

K

N

D

G

G

E

K

T

-

I

V

I

E

L

V

K

K

N

K

N

Q

L

L

A

S

L

L

L

Q

D

E

G

G

E

E

I

V

I

L

D

D

S

S

M

M

Y

F

M

M

S

S

K

C

T

G

A

K

L

L

C

R

D

D

F

F

Y

F

E

E

Q

K

E

T

M

L

Q

Q

D

D

A

C

Y

K

E

E

T

T

G

G

M

V

M

M

F

W

S

S

L

L

H

H

V

V

K
|
K

A

A

T

T

M

M

M

M

K

K

V

I

S

S

H

H

P

P

I

I

V

V

F

F

G

G

H

H

A

A

V

V

R

S

I

V

F

Y

Y

Y

K

K

D

D

A

V

F

F

A

D

K

K

H

W

D

G

E

Q

L

L

F

F

K

E

K

E

L

L

G

G

V

V

N

N

V

P

N

N

N

N

G

G

L

I

S

S

N

S

L

V

Y

Y

E

D

K

K

I

I

A

K

D

S

L

L

P

P

S

A

S

S

Q

Q

R

Q

E

E

E

E

I

I

R

L

R

H

D

D

L

I

H

H

A

E

C

V

H

Y

A

S

H

H

R

R

P

P

E

E

L

M

A

A

M

M

V

V

D

D

S

S

D

V

K

K

G

G

I

I

S

T

N

N

L

L

H

H

A

I

P

P

N

S

D

D

V

V

I
|
I

V

V

D

D

A
|
A

S

S

M

M

P

P

A

A

M

M

I

I

R

R

S

N

G

S

G

G

K

Q

M

M

W

W

G

G

A

K

D

D

G

G

R

K

P

Q

K

K

D

D

T

T

K

K

A

A

V

V

I

M

P

P

E

E

S

S

T

T

F

Y

A

A

R

R

I

I

Y

Y

Q

Q

E

E

I

M

I

I

A

N

F

F

C

C

K

K

T

T

N

N

G

G

A

A

F

F

D

D

P

P

V

T

T

T

M

M

G

G

S

S

V

V

P

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

K

A

A

E

E

E

E

Y
|
Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

E

A

M

P

T

A

A

T

D

G

G

E

T

A

M

R

R

I

V

V

V

D

L

I

A

D

D

T

-

G

G

E

S

V

V

L

L

M

M

I

Q

Q

H

N

K

V

V

E

E

K

T

D

G

D

D

I

I

W

W

R

R

M

A

C

C

Q

Q

V

T

K

K

D

D

A

A

P

P

I

I

R

R

D

D

W

W

V

V

K

K

L

L

S

A

V

V

E

T

R

R

A

A

R

R

D

Q

S

S

D

D

T

T

P

P

V

A

V

I

F

F

W

W

L

L

D

D

R

P

Y

E

R

R

P

A

H

H

E

D

N

R

E

E

L

L

I

R

T

K

K

K

V

V

N

E

E

L

Y

Y

L

L

K

K

D

D

H

H

N

D

T

L

D

T

G

G

L

L

D

D

I

I

Q

S

I

I

M

M

S

G

Q

Y

V

N

R

E

A

A

M

I

R

R

Y

V

T

S

L

M

E

E

R

R

V

L

V

I

R

R

G

G

L

K

D

D

T

T

I

I

S

S

S

V

T

T

G

G

N

N

I

V

L

L

R
|
R

D
|
D

Y

Y

L

L

T

T

D

D

L

L

F

F

P

P

I

I

M

M

E

E

L

L

G

G

T
|
T

S

S

A
|
A

K

K

M

M

L

L

S

S

I

I

V

V

P

P

L

L

M

M

A

A

G

G

G

G

G

G

L

M

F

Y

E

E

T

T

G

G

A

A

G
|
G

G
|
G

S
|
S

A
|
A

P
|
P

K

K

H
|
H

V

V

Q

Q

Q

Q

L

L

V

V

E

E

E

E

N

N

H

Y

L

L

R
|
R

W
|
W

D
|
D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

I

L

T

A

V

V

S

S

L

L

E

E

S

E

V

T

A

G

K

I

K

K

S

T

G

G

S

N

I

A

K

K

A

A

K

K

V

L

L

L

A

G

T

K

T

A

L

L

D

D

Q

E

A

A

T

T

E

G

M

K

L

L

L

L

D

D

N

N

G

N

K

K

S

S

P

P

S

S

R
|
R

R

K

T

V

G

G

E

D

L

I

D

D

N

N

R

R

G

G

S

S

H

H

F

F

Y

Y

L

L

S

A

L

M

F

Y

W

W

A

A

K

Q

C

A

I

L

A

A

E

A

Q

Q

T

N

E

E

D

D

T

A

E

E

L

L

A

K

A

A

K

H

F

F

A

A

P

P

L

L

A

A

A

K

S

A

L

L

A

T

E

E

N

Q

E

E

L

A

K

T

I

I

V

V

E

A

E

E

L

L

N

N

S

A

A

V

Q

Q

G

G

K

K

A

P

V

A

D

E

I

I

G

G

G

G

Y

Y

F

Y

N

R

A

S

D

N

P

P

A

E

K

L

M

T

E

S

A

K

I

V

M

M

R

R

P

P

S

S

K

A

T

T

F

F

N

N

A

A

V

A

L

I

N

D

binding 2-oxoglutaric acid: S84 (= S89), S129 (= S134), R142 (= R147), K251 (= K257), Y416 (= Y422), R543 (= R550), D544 (= D551)
binding nadp nicotinamide-adenine-dinucleotide phosphate: P81 (= P86), N82 (= N87), S84 (= S89), N132 (= N137), I344 (= I350), A347 (= A353), T557 (= T564), A559 (= A566), G579 (= G586), G580 (= G587), S581 (= S588), A582 (= A589), P583 (= P590), H585 (= H592), R596 (= R603), W597 (= W604), D598 (= D605), R645 (= R652)

1j1wA Crystal structure of the monomeric isocitrate dehydrogenase in complex with NADP+ (see paper)
62% identity, 99% coverage: 7:740/745 of query aligns to 3:735/738 of 1j1wA

query
sites
1j1wA

K

K

I

I

I

I

Y

Y

T

T

L

L

T

T

D

D

E

E

A

A

P

P

L

A

L

L

A

A

T

T

Y

Y

S

S

L

L

L

L

P

P

I

I

V

I

E

K

K

A

F

F

T

T

S

G

A

S

A

S

G

G

I

I

D

A

V

V

V

E

K

T

S

R

D

D

I

I

S

S

V

L

A

A

A

G

R

R

I

L

L

I

A

A

E

T

F

F

P

P

E

E

Y

Y

L

L

S

T

E

D

E

T

Q

Q

Q

K

L

I

P

S

D

D

N

D

L

L

S

A

E

E

L

L

G

G

R

K

L

L

T

A

Q

T

D

T

S

P

N

D

T

A

N

N

I

I

I

I

K

K

L

L

P
|
P

N
|
N

I

I

S
|
S

A

A

S

S

V

V

P

P

Q

Q

L

L

Q

K

A

A

A

A

I

I

S

K

E

E

L

L

Q

Q

S

Q

Q

Q

G

G

F

Y

N

K

I

L

P

P

N

D

L

Y

P

P

E

E

N

E

P

P

Q

K

T

T

D

D

E

T

G

E

K

K

A

D

L

V

L

K

Q

A

R

R

Y

Y

S

D

K

K

A

I

L

K

G

G

S

S

A

A

V

V

N
|
N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R

R

R

R

A

A

P

P

K

L

A

S

V

V

K

K

N

N

F

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

K

M

M

G

G

K

A

W

W

S

S

Q

A

A

D

S

S

Q

K

T

S

H

H

V

V

A

A

H

H

M

M

R

D

E

N

G

G

D

D

F

F

Y

Y

H

G

G

S

E

E

K

K

S

A

I

A

T

L

L

I

D

G

R

A

A

P

R

G

T

S

V

V

R

K

M

I

E

E

L

L

V

I

A

A

E

K

N

D

G

G

E

S

T

S

I

T

I

V

L

L

K

K

N

A

N

K

L

T

A

S

L

V

L

Q

D

A

G

G

E

E

I

I

I

I

D

D

S

S

M

S

Y

V

M

M

S

S

K

K

T

N

A

A

L

L

C

R

D

N

F

F

Y

I

E

A

Q

A

E

E

M

I

Q

E

D

D

A

A

Y

K

E

K

T

Q

G

G

M

V

M

L

F

L

S

S

L

V

H

H

V

L

K

K

A

A

T

T

M

M

M

M

K

K

V

V

S

S

H

D

P

P

I

I

V

M

F

F

G

G

H

Q

A

I

V

V

R

S

I

E

F

F

Y

Y

K

K

D

D

A

A

F

L

A

T

K

K

H

H

D

A

E

E

L

V

F

L

K

K

K

Q

L

I

G

G

V

F

N

D

V

V

N

N

N

N

G

G

L

I

S

G

N

D

L

L

Y

Y

E

A

K

R

I

I

A

K

D

T

L

L

P

P

S

E

S

A

Q

K

R

Q

E

K

E

E

I

I

R

E

R

A

D

D

L

I

H

Q

A

A

C

V

H

Y

A

A

H

Q

R

R

P

P

E

Q

L

L

A

A

M

M

V

V

D

N

S

S

D

D

K

K

G

G

I

I

S

T

N

N

L

L

H

H

A

V

P

P

N

S

D

D

V

V

I

I

V

V

D

D

A

A

S

S

M

M

P

P

A

A

M

M

I

I

R

R

S

D

G

S

G

G

K

K

M

M

W

W

G

G

A

P

D

D

G

G

R

K

P

L

K

H

D

D

T

T

K

K

A

A

V

V

I

I

P

P

E

D

S

R

T

C

F

Y

A

A

R

G

I

V

Y

Y

Q

Q

E

V

I

V

I

I

A

E

F

D

C

C

K

K

T

Q

N

H

G

G

A

A

F

F

D

D

P

P

V

T

T

T

M

M

G

G

S

S

V

V

P

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

K

A

A

E

E

E

E

Y

Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

Q

A

I

P

P

A

A

T

D

G

G

E

V

A

V

R

R

I

V

V

T

D

D

I

-

D

E

T

S

G

G

E

K

V

L

L

L

M

L

I

E

Q

Q

N

S

V

V

E

E

K

A

D

G

D

D

I

I

W

W

R

R

M

M

C

C

Q

Q

V

A

K

K

D

D

A

A

P

P

I

I

R

Q

D

D

W

W

V

V

K

K

L

L

S

A

V

V

E

N

R

R

A

A

R

R

D

A

S

T

D

N

T

T

P

P

V

A

V

V

F

F

W

W

L

L

D

D

R

P

Y

A

R

R

P

A

H

H

E

D

N

A

E

Q

L

V

I

I

T

A

K

K

V

V

N

E

E

R

Y

Y

L

L

K

K

D

D

H

Y

N

D

T

T

D

S

G

G

L

L

D

D

I

I

Q

R

I

I

M

L

S

S

Q

P

V

V

R

E

A

A

M

T

R

R

Y

F

T

S

L

L

E

A

R

R

V

I

V

R

R

E

G

G

L

K

D

D

T

T

I

I

S

S

S

V

T

T

G

G

N

N

I

V

L

L

R

R

D

D

Y

Y

L

L

T

T

D

D

L

L

F

F

P

P

I

I

M

M

E

E

L

L

G

G

T
|
T

S

S

A
|
A

K

K

M

M

L

L

S

S

I

I

V

V

P

P

L

L

M

M

A

S

G

G

G

G

G

G

L

L

F

F

E

E

T

T

G

G

A

A

G
|
G

G
|
G

S
|
S

A

A

P

P

K

K

H
|
H

V

V

Q

Q

Q

Q

L

F

V

L

E

E

E

E

N

G

H

Y

L

L

R
|
R

W
|
W

D
|
D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

I

L

T

A

V

A

S

S

L

L

E

E

S

H

V

L

A

G

K

N

K

A

S

Y

G

K

S

N

I

P

K

K

A

A

K

L

V

V

L

L

A

A

T

S

T

T

L

L

D

D

Q

Q

A

A

T

T

E

G

M

K

L

I

L

L

D

D

N

N

G

N

K

K

S

S

P

P

S

A

R
|
R

R

K

T

V

G

G

E

E

L

I

D

D

N

N

R

R

G

G

S

S

H

H

F

F

Y

Y

L

L

S

A

L

L

F

Y

W

W

A

A

K

Q

C

A

I

L

A

A

E

A

Q

Q

T

T

E

E

D

D

T

K

E

E

L

L

A

Q

A

A

K

Q

F

F

A

T

P

G

L

I

A

A

A

K

S

A

L

L

A

T

E

D

N

N

E

E

L

T

K

K

I

I

V

V

E

G

E

E

L

L

N

A

S

A

A

A

Q

Q

G

G

K

K

A

P

V

V

D

D

I

I

G

A

G

G

Y

Y

F

Y

N

H

A

P

D

N

P

T

A

D

K

L

M

T

E

S

A

K

I

A

M

M

R

R

P

P

S

S

K

A

T

T

F

F

N

N

A

A

V

A

L

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: P82 (= P86), N83 (= N87), S85 (= S89), N133 (= N137), T559 (= T564), A561 (= A566), G581 (= G586), G582 (= G587), S583 (= S588), H587 (= H592), R598 (= R603), W599 (= W604), D600 (= D605), R647 (= R652)

1itwA Crystal structure of the monomeric isocitrate dehydrogenase in complex with isocitrate and mn (see paper)
62% identity, 99% coverage: 7:740/745 of query aligns to 4:736/740 of 1itwA

query
sites
1itwA

K

K

I

I

I

I

Y

Y

T

T

L

L

T

T

D

D

E

E

A

A

P

P

L

A

L

L

A

A

T

T

Y

Y

S

S

L

L

L

L

P

P

I

I

V

I

E

K

K

A

F

F

T

T

S

G

A

S

A

S

G

G

I

I

D

A

V

V

V

E

K

T

S

R

D

D

I

I

S

S

V

L

A

A

A

G

R

R

I

L

L

I

A

A

E

T

F

F

P

P

E

E

Y

Y

L

L

S

T

E

D

E

T

Q

Q

Q

K

L

I

P

S

D

D

N

D

L

L

S

A

E

E

L

L

G

G

R

K

L

L

T

A

Q

T

D

T

S

P

N

D

T

A

N

N

I

I

I

I

K

K

L

L

P

P

N

N

I

I

S

S

A

A

S

S

V

V

P

P

Q

Q

L

L

Q

K

A

A

A

A

I

I

S

K

E

E

L

L

Q

Q

S

Q

Q

Q

G

G

F

Y

N

K

I

L

P

P

N

D

L

Y

P

P

E

E

N

E

P

P

Q

K

T

T

D

D

E

T

G

E

K

K

A

D

L

V

L

K

Q

A

R

R

Y

Y

S

D

K

K

A

I

L

K

G

G

S

S

A

A

V

V

N

N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R

R

R

R

A

A

P

P

K

L

A

S

V

V

K

K

N

N

F

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

K

M

M

G

G

K

A

W

W

S

S

Q

A

A

D

S

S

Q

K

T

S

H

H

V

V

A

A

H

H

M

M

R

D

E

N

G

G

D

D

F

F

Y

Y

H

G

G

S

E

E

K

K

S

A

I

A

T

L

L

I

D

G

R

A

A

P

R

G

T

S

V

V

R

K

M

I

E

E

L

L

V

I

A

A

E

K

N

D

G

G

E

S

T

S

I

T

I

V

L

L

K

K

N

A

N

K

L

T

A

S

L

V

L

Q

D

A

G

G

E

E

I

I

I

I

D

D

S

S

M

S

Y

V

M

M

S

S

K

K

T

N

A

A

L

L

C

R

D

N

F

F

Y

I

E

A

Q

A

E

E

M

I

Q

E

D

D

A

A

Y

K

E

K

T

Q

G

G

M

V

M

L

F

L

S

S

L

V

H

H

V

L

K

K

A

A

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T

M

M

M

M

K

K

V

V

S

S

H

D

P

P

I

I

V

M

F

F

G

G

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A

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V

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F

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K

D

D

A

A

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L

A

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K

K

H

H

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A

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E

L

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F

L

K

K

K

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L

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G

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N

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N

N

N

N

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G

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Y

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L

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M

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D

K

K

G

G

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N

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L

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D

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|
D

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M

M

G

G

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S

V

V

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P

N

N

V

V

G

G

L

L

M

M

A

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Q

K

K

A

A

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E

E

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Y

Y

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G

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H

H

D

D

K

K

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D

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A

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W

W

A

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C

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D

D

T

K

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E

L

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A

A

K

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F

F

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G

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A

A

A

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S

A

L

L

A

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D

N

N

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E

L

T

K

K

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I

V

V

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G

E

E

L

L

N

A

S

A

A

A

Q

Q

G

G

K

K

A

P

V

V

D

D

I

I

G

A

G

G

Y

Y

F

Y

N

H

A

P

D

N

P

T

A

D

K

L

M

T

E

S

A

K

I

A

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M

R

R

P

P

S

S

K

A

T

T

F

F

N

N

A

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A

L

L

binding manganese (ii) ion: D349 (= D352), D547 (= D551)

P16100 Isocitrate dehydrogenase [NADP]; IDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Azotobacter vinelandii (see 2 papers)
62% identity, 99% coverage: 7:740/745 of query aligns to 5:737/741 of P16100

query
sites
P16100

K

K

I

I

I

I

Y

Y

T

T

L

L

T

T

D

D

E

E

A

A

P

P

L

A

L

L

A

A

T

T

Y

Y

S

S

L

L

L

L

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P

I

I

V

I

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K

K

A

F

F

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T

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G

A

S

A

S

G

G

I

I

D

A

V

V

V

E

K

T

S

R

D

D

I

I

S

S

V

L

A

A

A

G

R

R

I

L

L

I

A

A

E

T

F

F

P

P

E

E

Y

Y

L

L

S

T

E

D

E

T

Q

Q

Q

K

L

I

P

S

D

D

N

D

L

L

S

A

E

E

L

L

G

G

R

K

L

L

T

A

Q

T

D

T

S

P

N

D

T

A

N

N

I

I

I

I

K

K

L

L

P

P

N

N

I

I

S

S

A

A

S

S

V

V

P

P

Q

Q

L

L

Q

K

A

A

A

A

I

I

S

K

E

E

L

L

Q

Q

S

Q

Q

Q

G

G

F

Y

N

K

I

L

P

P

N

D

L

Y

P

P

E

E

N

E

P

P

Q

K

T

T

D

D

E

T

G

E

K

K

A

D

L

V

L

K

Q

A

R

R

Y

Y

S

D

K

K

A

I

L

K

G

G

S

S

A

A

V

V

N

N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R

R

R

R

A

A

P

P

K

L

A

S

V

V

K

K

N

N

F

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

K

M

M

G

G

K

A

W

W

S

S

Q

A

A

D

S

S

Q

K

T

S

H

H

V

V

A

A

H

H

M

M

R

D

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N

G

G

D

D

F

F

Y

Y

H

G

G

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E

K

K

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A

I

A

T

L

L

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D

G

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A

A

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R

G

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V

V

R

K

M

I

E

E

L

L

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I

A

A

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K

N

D

G

G

E

S

T

S

I

T

I

V

L

L

K

K

N

A

N

K

L

T

A

S

L

V

L

Q

D

A

G

G

E

E

I

I

I

I

D

D

S

S

M

S

Y

V

M

M

S

S

K

K

T

N

A

A

L

L

C

R

D

N

F

F

Y

I

E

A

Q

A

E

E

M

I

Q

E

D

D

A

A

Y

K

E

K

T

Q

G

G

M

V

M

L

F

L

S

S

L

V

H

H

V

L

K

K

A

A

T

T

M

M

M

M

K

K

V

V

S

S

H

D

P

P

I

I

V

M

F

F

G

G

H

Q

A

I

V

V

R

S

I

E

F

F