SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_017367571.1 NCBI__GCF_000691145.1:WP_017367571.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
41% identity, 100% coverage: 1:474/474 of query aligns to 6:467/470 of P11959

query
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P11959

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39:47 (vs. 34:42, 67% identical) binding FAD
K56 (= K51) binding FAD
D314 (= D320) binding FAD
A322 (= A328) binding FAD

2yquB Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
42% identity, 99% coverage: 5:474/474 of query aligns to 2:455/455 of 2yquB

query
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2yquB

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active site: P11 (≠ T14), L36 (= L38), C40 (= C42), C45 (= C47), S48 (= S50), G72 (= G75), V73 (≠ I76), V177 (= V191), E181 (= E195), S314 (= S332), H432 (= H451), H434 (= H453), E439 (= E458)
binding carbonate ion: A310 (= A328), S314 (= S332), S423 (≠ T442), D426 (≠ E445)
binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), P11 (≠ T14), G12 (= G15), E31 (= E34), K32 (= K35), G38 (= G40), T39 (= T41), C40 (= C42), R42 (≠ H44), G44 (= G46), C45 (= C47), K49 (= K51), T110 (≠ I113), A111 (≠ G114), T137 (= T151), G138 (= G152), I178 (= I192), Y265 (≠ N284), G301 (= G319), D302 (= D320), M308 (≠ Q326), L309 (= L327), A310 (= A328), H311 (= H329)

2yquA Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
42% identity, 99% coverage: 5:474/474 of query aligns to 2:455/455 of 2yquA

query
sites
2yquA

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S

L

L

E

E

N

N

T

A

D

G

I

L

Q

S

T

T

E

D

N

E

H

R

G

G

-

R

I

I

V

P

V

V

N

D

E

E

H

H

Y

L

Q

R

T

T

K

R

E

V

S

P

H

H

I

I

Y

Y

A

A

I

I

G
|
G

D
|
D

V

V

I

V

G

R

G

G

L

P

Q
x
M

L
|
L

A
|
A

H

H

V

K

A

A

S
|
S

H

E

E

E

G

G

M

I

I

A

A

A

V

V

E

E

H

H

M

M

A

V

G

-

Q

R

D

G

P

F

K

G

P

H

L

V

D

D

E

Y

T

Q

L

A

V

I

S

P

K

S

C

V

V

V

Y

Y

S

T

H

H

P

P

E

E

T

I

A

A

S

A

V

V

G

G

L

Y

T

T

E

E

Q

E

A

E

A

L

K

K

E

A

Q

Q

G

G

Y

I

E

P

V

Y

K

K

I

V

G

G

K

K

F

F

P

P

F

Y

M

S

A

A

I

S

G

G

K

R

A

A

L

R

V

A

F

M

G

G

E

E

S

T

D

E

G

G

F

F

V

I

K

K

I

V

I

L

A

A

D

H

Q

A

K

K

T

T

D

D

D

R

I

I

L

L

G

G

I

V

H

H

M

G

I

I

G

G

P

A

H

R

V

V

T

G

D

D

M

V

I

L

S

A

E

E

A

A

G

A

L

L

A

A

K

L

V

F

L

F

D

K

A

A

T

S

P

A

W

E

E

D

V

L

G

G

Q

R

T

A

I

P

H
|
H

P

A

H
|
H

P

P

T

S

L

L

S

S

E
|
E

A

I

I

L

G

K

E

E

A

A

L

L

A

A

V

A

D

W

G

E

K

R

A

P

I

I

H

H

F

L

active site: P11 (≠ T14), L36 (= L38), C40 (= C42), C45 (= C47), S48 (= S50), G72 (= G75), V73 (≠ I76), V177 (= V191), E181 (= E195), S314 (= S332), H432 (= H451), H434 (= H453), E439 (= E458)
binding flavin-adenine dinucleotide: G8 (= G11), G10 (= G13), P11 (≠ T14), G12 (= G15), E31 (= E34), K32 (= K35), G38 (= G40), T39 (= T41), C40 (= C42), R42 (≠ H44), G44 (= G46), C45 (= C47), K49 (= K51), T110 (≠ I113), A111 (≠ G114), T137 (= T151), G138 (= G152), S157 (= S171), I178 (= I192), Y265 (≠ N284), G301 (= G319), D302 (= D320), M308 (≠ Q326), L309 (= L327), A310 (= A328)

1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
42% identity, 98% coverage: 2:464/474 of query aligns to 1:451/455 of 1ebdA

query
sites
1ebdA

A

A

T

I

E

E

Y

T

D

E

L

T

V

L

I

V

L

V

G
|
G

G

A

G
|
G

T
x
P

G

G

Y

Y

V

V

A

A

I

I

R

R

A

A

S

A

Q

Q

L

L

G

G

L

Q

K

K

T

V

A

T

V

I

V
|
V

E
|
E

K
|
K

S

G

K

N

L
|
L

G

G

G
|
G

T
x
V

C
|
C

L

L

H

N

K

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

I

R

S

S

A

A

S

E

H

V

R

Y

Y

Q

E

T

Q

V

A

K

K

R

H

A

S

A

E

D

E

F

M

G

G

V

I

E

K

A

A

S

E

G
x
N

I
x
V

A

T

L

I

Q

D

F

F

A

A

S

K

V

V

Q

Q

K

E

R

W

K

K

T

A

E

S

I

V

V

V

D

K

K

K

L

L

A

T

G

G

V

V

K

E

H

G

L

L

M

L

K

K

Q

G

G

N

K

K

I

V

D

E

V

I

Y

V

E

K

G

G

I
x
E

G
x
A

R

Y

I

F

L

V

G

D

P

A

S

N

I

-

F

-

S

-

P

-

M

-

P

-

G

-

T

-

I

-

S

T

V

V

E

R

M

V

A

V

N

N

G

G

D

D

E

S

N

A

E

Q

M

T

L

Y

I

T

P

F

K

K

Q

N

V

A

I

I

A

A

T
|
T

G
|
G

S

S

R

R

P

P

R

I

V

E

L

L

P

P

G

N

L

F

E

K

A

F

D

S

G

-

T

N

H

R

I

I

L

L

T

D

S

S

D

T

E

G

A

A

L

L

E

N

L

L

Q

G

E

E

L

V

P

P

Q

K

S

S

M

L

L

V

I

V

V

I

G

G

V
x
Y

I
|
I

G

G

I

I

E
|
E

W

L

A

G

S

T

M

A

L

Y

N

A

D

N

F

F

G

G

V

T

K

K

V

V

T

T

V

I

I

L

E

E

F

G

A

A

D

G

R

E

I

I

L

L

P

S

T

G

E

F

D

E

Q

K

D

Q

I

M

S

A

K

A

E

I

M

I

E

K

K

K

L

R

L

L

T

K

K

K

G

G

I

V

T

E

L

V

V

V

T

T

N

N

A

A

K

-

V

-

L

L

P

A

D

K

T

G

A

A

E

E

K

E

H

R

E

E

N

D

L

G

V

V

K

T

I

V

Q

T

V

Y

E

E

Q

A

G

N

G

G

D

E

T

T

Q

K

S

T

F

I

E

D

A

A

E

D

K

Y

L

V

L

L

L

V

S

T

V

V

G

G

R
|
R

V

R

P

P

N

N

V

T

E

D

G

E

I

L

G

G

L

L

E

E

N

Q

T

I

D

G

I

I

Q

K

T

M

E

T

N

N

H

R

G

G

I

L

V

I

-

E

V

V

N

D

E

Q

H

Q

Y

C

Q

R

T

T

K

S

E

V

S

P

H

N

I

I

Y

F

A

A

I

I

G

G

D
|
D

V

I

I

V

G

P

G

G

L

P

Q
x
A

L
|
L

A
|
A

H

H

V

K

A

A

S
|
S

H

Y

E

E

G

G

M

K

I

V

A

A

V

A

E

E

H

A

M

I

A

A

G

G

Q

H

D

-

P

P

K

S

P

A

L

V

D

D

E

Y

T

V

L

A

V

I

S

P

K

A

C

V

V

V

Y

F

S

S

H

D

P

P

E

E

T

C

A

A

S

S

V

V

G

G

L

Y

T

F

E

E

Q

Q

A

Q

A

A

K

K

E

D

Q

E

G

G

Y

I

E

D

V

V

K

I

I

A

G

A

K

K

F

F

P

P

F

F

M

A

A

A

I

N

G

G

K

R

A

A

L

L

V

A

F

L

G

N

E

D

S

T

D

D

G

G

F

F

V

L

K

K

I

L

I

V

A

V

D

R

Q

K

K

E

T

D

D

G

D

V

I

I

L

I

G

G

I

A

H

Q

M

I

I

I

G

G

P

P

H

N

V

A

T

S

D

D

M

M

I

I

S

A

E

E

A

L

G

G

L

L

A

A

K

I

V

E

L

A

D

G

A

M

T

T

P

A

W

E

E

D

V

I

G

A

Q

L

T

T

I

I

H
|
H

P

A

H
|
H

P

P

T

T

L

L

S

G

E
|
E

A

I

I

A

G

M

E

E

A

A

active site: P13 (≠ T14), L37 (= L38), C41 (= C42), C46 (= C47), S49 (= S50), N74 (≠ G75), V75 (≠ I76), Y180 (≠ V191), E184 (= E195), S320 (= S332), H438 (= H451), H440 (= H453), E445 (= E458)
binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), P13 (≠ T14), V32 (= V33), E33 (= E34), K34 (= K35), G39 (= G40), V40 (≠ T41), C41 (= C42), G45 (= G46), C46 (= C47), K50 (= K51), E112 (≠ I113), A113 (≠ G114), T141 (= T151), G142 (= G152), Y180 (≠ V191), I181 (= I192), R268 (= R281), D308 (= D320), A314 (≠ Q326), L315 (= L327), A316 (= A328)

2eq7A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8 with psbdo
43% identity, 97% coverage: 5:466/474 of query aligns to 2:447/452 of 2eq7A

query
sites
2eq7A

Y

Y

D

D

L

L

V

L

I

V

L

I

G

G

G

A

G
|
G

T
x
P

G
|
G

G

G

Y

Y

V

V

A

A

I

I

R

R

A

A

S

A

Q

Q

L

L

G

G

L

M

K

K

T

V

A

G

V

V

E
|
E

K
|
K

S

E

K

K

-

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

H
x
R

K

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

R

E

S

T

A

T

E

E

V

R

Y

I

Q

Y

T

E

V

A

K

K

R

K

A

G

A

L

D

-

F

L

G

G

V

A

E

K

A

V

S

K

G
|
G

I
x
V

A

E

L

L

Q

D

F

L

A

P

S

A

V

L

Q

M

K

A

R

H

K

K

T

D

E

K

I

V

V

V

D

Q

K

A

L

N

A

T

G

Q

G

G

V

V

K

E

H

F

L

L

M

F

K

K

Q

K

G

N

K

G

I

I

D

A

V

R

Y

H

E

Q

G

G

I
x
T

G
x
A

R

R

I

F

L

L

G

S

P

E

S

R

I

-

F

-

S

-

P

-

M

-

P

-

G

-

T

K

I

V

S

L

V

V

E

E

M

-

A

-

N

-

G

-

D

E

E

T

N

G

E

E

M

E

L

L

I

E

P

A

K

R

Q

Y

V

I

I

L

I

I

A

A

T
|
T

G
|
G

S

S

R

A

P

P

R

L

V

I

L

P

P

P

G
x
W

L

A

E

Q

A

V

D

D

G

Y

T

E

H

R

I

V

L

V

T

T

S
|
S

D

T

E

E

A

A

L

L

E

S

L

F

Q

P

E

E

L

V

P

P

Q

K

S

R

M

L

L

I

I

V

V

V

G
|
G

G

G

G
|
G

V
|
V

I
|
I

G

G

I

L

E
|
E

W

L

A

G

S

V

M

V

L

W

N

H

D

R

F

L

G

G

V

A

K

E

V

V

T

I

V

V

I

L

E
|
E

F
x
Y

A

M

D

D

R

R

I

I

L

L

P

P

T

T

E

M

D

D

Q

L

D

E

I

V

S

S

K

R

E

A

M

A

E

E

K

R

L

V

L

F

T

K

K

K

K

Q

G

G

I

L

T

T

L

I

V

R

T

T

N

G

A

V

K

R

V
|
V

L

T

P

A

D

V

T

V

A

P

E

E

K

A

H

K

E

G

N

A

L

R

V

V

K

E

I

L

Q

E

V

-

E

-

Q

-

G

G

D

E

T

V

Q

-

S

-

F

L

E

E

A

A

E

D

K

R

L

V

L

L

L

V

S

A

V
|
V

G
|
G

R
|
R

V

R

P

P

N
x
Y

V

T

E

E

G

G

I

L

G

S

L

L

E

E

N

N

T

A

D

G

I

L

Q

S

T

T

E

D

N

E

H

R

G

G

-

R

I

I

V

P

V

V

N

D

E

E

H

H

Y

L

Q

R

T

T

K

R

E

V

S

P

H

H

I

I

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

V

G

R

G

G

L

P

Q
x
M

L
|
L

A
|
A

H
|
H

V

K

A

A

S
|
S

H

E

E

E

G

G

M

I

I

A

A

A

V

V

E

E

H

H

M

M

A

V

G

-

Q

R

D

G

P

F

K

G

P

H

L

V

D

D

E

Y

T

Q

L

A

V

I

S

P

K

S

C
x
V

V

V

Y
|
Y

S

T

H

H

P

P

E

E

T

I

A

A

S

A

V

V

G

G

L

Y

T

T

E

E

Q

E

A

E

A

L

K

K

E

A

Q

Q

G

G

Y

I

E

P

V

Y

K

K

I

V

G

G

K

K

F

F

P

P

F

Y

M

S

A

A

I

S

G

G

K

R

A

A

L

R

V

A

F

M

G

G

E

E

S

T

D

E

G

G

F

F

V

I

K

K

I

V

I

L

A

A

D

H

Q

A

K

K

T

T

D

D

D

R

I

I

L

L

G

G

I

V

H

H

M

G

I

I

G

G

P

A

H

R

V

V

T

G

D

D

M

V

I

L

S

A

E

E

A

A

G

A

L

L

A

A

K

L

V

F

L

F

D

K

A

A

T

S

P

A

W

E

E

D

V

L

G

G

Q

R

T

A

I

P

H
|
H

P

A

H
|
H

P

P

T

S

L

L

S

S

E
|
E

A

I

I

L

G

K

E

E

A

A

L

L

A

A

active site: P11 (≠ T14), L36 (= L38), C40 (= C42), C45 (= C47), S48 (= S50), G72 (= G75), V73 (≠ I76), V177 (= V191), E181 (= E195), S314 (= S332), H432 (= H451), H434 (= H453), E439 (= E458)
binding flavin-adenine dinucleotide: G10 (= G13), P11 (≠ T14), G12 (= G15), E31 (= E34), K32 (= K35), G38 (= G40), T39 (= T41), C40 (= C42), R42 (≠ H44), G44 (= G46), C45 (= C47), K49 (= K51), T110 (≠ I113), A111 (≠ G114), T137 (= T151), G138 (= G152), S157 (= S171), I178 (= I192), R262 (= R281), Y265 (≠ N284), D302 (= D320), M308 (≠ Q326), L309 (= L327), A310 (= A328), H311 (= H329), Y341 (= Y360)
binding nicotinamide-adenine-dinucleotide: W146 (≠ G160), G174 (= G188), G176 (= G190), V177 (= V191), I178 (= I192), E197 (= E211), Y198 (≠ F212), V231 (= V245), V260 (= V279), G261 (= G280), R262 (= R281), M308 (≠ Q326), L309 (= L327), V339 (≠ C358)

6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
42% identity, 100% coverage: 3:474/474 of query aligns to 5:470/470 of 6uziC

query
sites
6uziC

T

N

E

Q

Y

F

D

D

L

V

V

A

I

V

L
x
I

G
|
G

G

S

G
|
G

T
x
P

G
|
G

G

G

Y

Y

V

V

A

A

I

I

R

R

A

C

S

A

Q

Q

L

L

G

G

L

F

K

K

T

T

A

V

V

I

E
|
E

K
|
K

-

Y

S

S

K

T

L

L

G

G

G
|
G

T
|
T

C
|
C

L

L

H

N

K

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

R

D

S

S

A

S

E

E

V

H

Y

F

Q

E

T

N

V

A

K

K

R

H

A

T

-

F

A

A

D

T

F

H

G

G

V

I

E

L

A

I

S

D

G

E

I

P

A

K

L

V

Q

D

F

I

A

A

S

Q

V

M

Q

I

K

S

R

R

K

K

T

N

E

D

I

V

V

V

D

D

K

Q

L

T

A

T

G

K

G

G

V

I

K

N

H

F

L

L

M

M

K

D

Q

K

G

N

K

K

I

I

D

T

V

V

Y

L

E

Q

G

G

I
x
V

G
|
G

R

S

I

F

L

E

G

S

P

A

S

T

I

-

F

-

S

-

P

-

M

-

P

-

G

-

T

Q

I

I

S

K

V

V

E

T

M

K

A

A

N

D

G

G

D

-

E

S

N

S

E

E

M

V

L

I

I

E

P

A

K

K

Q

N

V

T

I

I

A

A

T
|
T

G
|
G

S

S

R

K

P

P

R

S

V

S

L

L

P

P

G

F

L

I

E

T

A

L

D

D

G

K

T

E

H

R

I

V

L

I

T

T

S

S

D

T

E

E

A

A

L

L

E

N

L

L

Q

K

E

E

L

V

P

P

Q

K

S

H

M

L

L

I

I

V

V

I

G

G

V
|
V

I
|
I

G

G

I

L

E
|
E

W

L

A

G

S

S

M

V

L

Y

N

L

D

R

F

L

G

G

V

S

K

D

V

V

T

T

V

V

I

V

E

E

F

Y

A

L

D

D

R

K

I

I

L

I

P

P

T

G

E

M

D

D

Q

G

D

T

I

L

S

S

K

K

E

E

M

L

E

Q

K

K

L

T

L

L

T

K

K

K

K

Q

G

G

I

M

T

K

L

F

V

M

T

L

N

S

A

T

K

A

V

V

L

-

P

-

D

S

T

G

A

V

E

E

K

R

H

N

E

G

N

D

L

T

V

V

K

K

I

V

Q

T

V

A

-

K

E

D

Q

K

G

K

G

G

D

E

T

D

Q

V

S

V

F

V

E

E

A

G

E

D

K

Y

L

C

L

L

L

V

S

S

V

V

G

G

R
|
R

V

R

P

P

N

Y

V

T

E

D

G

G

I

L

G

G

L

L

E

E

N

K

T

A

D

G

I

V

Q

E

T

L

E

D

N

E

H

R

G

G

I

R

V

V

-

K

V

T

N

N

E

D

H

H

Y

L

Q

Q

T

T

K

N

E

V

S

P

H

N

I

I

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

V

G

K

G

G

L

A

Q
x
M

L
|
L

A
|
A

H

H

V

K

A

A

S

E

H

E

E

E

G

G

M

V

I

F

A

V

V

A

E

E

H

T

M

L

A

A

G

G

Q

E

D

K

P

P

K

H

P

-

L

V

D

N

E

Y

T

N

L

L

V

I

S

P

K

G

C

V

V

V

Y

Y

S

T

H

W

P

P

E

E

T

V

A

A

S

G

V

V

G

G

L

K

T

T

E

E

Q

E

A

Q

A

L

K

K

E

E

Q

A

G

G

Y

V

E

A

V

Y

K

K

I

T

G

G

K

S

F

F

P

P

F

M

M

R

A

A

I

L

G

G

K

R

A

S

L

R

V

A

F

S

G

M

E

D

S

T

D

D

G

G

F

V

V

I

K

K

I

I

I

L

A

A

D

D

Q

E

K

K

T

T

D

D

D

E

I

I

L

L

G

G

I

V

H

H

M

M

I

I

G

G

P

A

H

R

V

A

T

A

D

D

M

M

I

I

S

A

E

E

A

A

G

V

L

V

A

A

K

M

V

E

L

F

D

R

A

A

T

S

P

A

W

E

E

D

V

I

G

A

Q

R

T

I

I

S

H

H

P

A

H
|
H

P

P

T

T

L

Y

S

T

E
|
E

A

A

I

I

G

K

E

E

A

A

L

L

A

D

V

A

D

T

G

G

K

K

-

R

A

A

I

I

H

H

F

M

active site: C45 (= C42), C50 (= C47), S53 (= S50), V187 (= V191), E191 (= E195), H448 (= H453), E453 (= E458)
binding flavin-adenine dinucleotide: I12 (≠ L10), G13 (= G11), G15 (= G13), P16 (≠ T14), G17 (= G15), E36 (= E34), K37 (= K35), G43 (= G40), T44 (= T41), C45 (= C42), G49 (= G46), C50 (= C47), S53 (= S50), K54 (= K51), V117 (≠ I113), G118 (= G114), T147 (= T151), G148 (= G152), I188 (= I192), R276 (= R281), D316 (= D320), M322 (≠ Q326), L323 (= L327), A324 (= A328)
binding zinc ion: H448 (= H453), E453 (= E458)

P31023 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; Pyruvate dehydrogenase complex E3 subunit; E3; PDC-E3; EC 1.8.1.4 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
43% identity, 99% coverage: 4:474/474 of query aligns to 37:501/501 of P31023

query
sites
P31023

E

E

Y

N

D

D

L

V

V

V

I

I

L

I

G

G

T

P

G

G

Y

Y

V

V

A

A

I

I

R

K

A

A

S

A

Q

Q

L

L

G

G

L

F

K

K

T

T

A

T

V

C

V

I

E
|
E

K
|
K

S
x
R

-
x
G

K
x
A

L
|
L

G
|
G

T
|
T

C
|
C

L

L

H

N

K

V

G

G

C
|
C

I

I

P

P

S

S

K

K

A

A

L

L

R

H

S

S

A

S

E

H

V

M

Y

Y

Q

H

T

E

V

A

K

K

R

H

A

S

-

F

A

A

D

N

F

H

G

G

V

V

E

K

A

V

S

S

G

N

I

V

A

E

L

I

Q

D

F

L

A

A

S

A

V

M

Q

M

K

G

R

Q

K

K

T

D

E

K

I

A

V

V

D

S

K

N

L

L

A

T

G

R

G

G

V

I

K

E

H

G

L

L

M

F

K

K

Q

K

G

N

K

K

I

V

D

T

V

Y

Y

V

E

K

G

G

I

Y

G
|
G

R

K

I

F

L

V

G

S

P

P

S

S

I

-

F

-

S

-

P

-

M

-

P

-

G

-

T

E

I

I

S

S

V

V

E

D

M

T

A

I

N

E

G

G

D

-

E

E

N

N

E

T

M

V

L

V

I

K

P

G

K

K

Q

H

V

I

I

I

A

A

T

T

G

G

S

S

R

D

P

V

R

K

V

S

L

L

P

P

G

G

L

V

E

T

A

I

D

D

G

E

T

K

H

K

I

I

L

V

T

S

S

S

D

T

E

G

A

A

L

L

E

A

L

L

Q

S

E

E

L

I

P

P

Q

K

S

K

M

L

L

V

I

V

V

I

G

G

G

A

G

G

V

Y

I

I

G

G

I

L

E

E

W

M

A

G

S

S

M

V

L

W

N

G

D

R

F

I

G

G

V

S

K

E

V

V

T

T

V

V

I

V

E

E

F

F

A

A

D

S

R

E

I

I

L

V

P

P

T

T

E

M

D

D

Q

A

D

E

I

I

S

R

K

K

E

Q

M

F

E

Q

K

R

L

S

L

L

T

E

K

K

K

Q

G

G

I

M

T

K

L

F

V

K

T

L

N

K

A

T

K

K

V

V

L

V

-

G

P

V

D

D

T

T

A

S

E

G

K

-

H

-

E

-

N

D

L

G

V

V

K

K

I

L

Q

T

V

V

E

E

-

P

-

S

Q

A

G

G

D

E

T

Q

Q

T

S

I

F

I

E

E

A

A

E

D

K

V

L

V

L

L

L

V

S

S

V

A

G

G

R

R

V

T

P

P

N

F

V

T

E

S

G

G

I

L

G

N

L

L

E

D

N

K

T

I

D

G

I

V

Q

E

T

T

E

D

N

K

H

L

G

G

-

R

I

I

V

L

V

V

N

N

E

E

H

R

Y

F

Q

S

T

T

K

N

E

V

S

S

H

G

I

V

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

I

G

P

G

G

L

P

Q
x
M

L
|
L

A
|
A

H
|
H

V

K

A

A

S

E

H

E

E

D

G

G

M

V

I

A

A

C

V

V

E

E

H

Y

M

L

A

A

G

G

Q

K

D

-

P

V

K

G

P

H

L

V

D

D

E

Y

T

D

L

K

V

V

S

P

K

G

C

V

V

V

Y

Y

S

T

H

N

P

P

E

E

T

V

A

A

S

S

V

V

G

G

L

K

T

T

E

E

Q

E

A

Q

A

V

K

K

E

E

Q

T

G

G

Y

V

E

E

V

Y

K

R

I

V

G

G

K

K

F

F

P

P

F

F

M

M

A

A

I

N

G

S

K

R

A

A

L

K

V

A

F

I

G

D

E

N

S

A

D

E

G

G

F

L

V

V

K

K

I

I

A

A

D

E

Q

K

K

E

T

T

D

D

D

K

I

I

L

L

G

G

I

V

H

H

M

I

I

M

G

A

P

P

H

N

V

A

T

G

D

E

M

L

I

I

S

H

E

E

A

A

G

A

L

I

A

A

K

L

V

Q

L

Y

D

D

A

A

T

S

P

S

W

E

E

D

V

I

G

A

Q

R

T

V

I

C

H

H

P

A

H

H

P

P

T

T

L

M

S

S

E

E

A

A

I

I

G

K

E

E

A

A

L

M

A

A

V

T

D

Y

G

D

K

K

A

P

I

I

H

H

F

I

67:76 (vs. 34:42, 70% identical) binding FAD
C76 (= C42) modified: Disulfide link with 81, Redox-active
C81 (= C47) modified: Disulfide link with 76, Redox-active
G149 (= G114) binding FAD
D348 (= D320) binding FAD
MLAH 354:357 (≠ QLAH 326:329) binding FAD

Sites not aligning to the query:

1:31 modified: transit peptide, Mitochondrion

1dxlA Dihydrolipoamide dehydrogenase of glycine decarboxylase from pisum sativum (see paper)
43% identity, 99% coverage: 4:474/474 of query aligns to 3:467/467 of 1dxlA

query
sites
1dxlA

E

E

Y

N

D

D

L

V

V

V

I

I

L
x
I

G

G

T
x
P

G
|
G

G

G

Y

Y

V

V

A

A

I

I

R

K

A

A

S

A

Q

Q

L

L

G

G

L

F

K

K

T

T

A

T

V

C

V

I

E
|
E

K
|
K

S
x
R

-

G

K

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

H

N

K

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

R

H

S

S

A

S

E

H

V

M

Y

Y

Q

H

T

E

V

A

K

K

R

H

A

S

-

F

A

A

D

N

F

H

G

G

V

V

E

K

A

V

S

S

G

N

I

V

A

E

L

I

Q

D

F

L

A

A

S

A

V

M

Q

M

K

G

R

Q

K

K

T

D

E

K

I

A

V

V

D

S

K

N

L

L

A

T

G

R

G

G

V

I

K

E

H

G

L

L

M

F

K

K

Q

K

G

N

K

K

I

V

D

T

V

Y

Y

V

E

K

G

G

I
x
Y

G
|
G

R

K

I

F

L

V

G

S

P

P

S

S

I

-

F

-

S

-

P

-

M

-

P

-

G

-

T

E

I

I

S

S

V

V

E

D

M

T

A

I

N

E

G

G

D

-

E

E

N

N

E

T

M

V

L

V

I

K

P

G

K

K

Q

H

V

I

I

I

A

A

T
|
T

G
|
G

S

S

R

D

P

V

R

K

V

S

L

L

P

P

G

G

L

V

E

T

A

I

D

D

G

E

T

K

H

K

I

I

L

V

T

S

S

S

D

T

E

G

A

A

L

L

E

A

L

L

Q

S

E

E

L

I

P

P

Q

K

S

K

M

L

L

V

I

V

V

I

G

G

G

A

G

G

V
x
Y

I
|
I

G

G

I

L

E
|
E

W

M

A

G

S

S

M

V

L

W

N

G

D

R

F

I

G

G

V

S

K

E

V

V

T

T

V

V

I

V

E

E

F

F

A

A

D

S

R

E

I

I

L

V

P

P

T

T

E

M

D

D

Q

A

D

E

I

I

S

R

K

K

E

Q

M

F

E

Q

K

R

L

S

L

L

T

E

K

K

K

Q

G

G

I

M

T

K

L

F

V

K

T

L

N

K

A

T

K

K

V

V

L

V

-

G

P

V

D

D

T

T

A

S

E

G

K

-

H

-

E

-

N

D

L

G

V

V

K

K

I

L

Q

T

V

V

E

E

-

P

-

S

Q

A

G

G

D

E

T

Q

Q

T

S

I

F

I

E

E

A

A

E

D

K

V

L

V

L

L

L

V

S

S

V

A

G

G

R
|
R

V

T

P

P

N

F

V

T

E

S

G

G

I

L

G

N

L

L

E

D

N

K

T

I

D

G

I

V

Q

E

T

T

E

D

N

K

H

L

G

G

-

R

I

I

V

L

V

V

N

N

E

E

H

R

Y

F

Q

S

T

T

K

N

E

V

S

S

H

G

I

V

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

I

G

P

G

G

L

P

Q
x
M

L
|
L

A
|
A

H
|
H

V

K

A

A

S

E

H

E

E

D

G

G

M

V

I

A

A

C

V

V

E

E

H

Y

M

L

A

A

G

G

Q

K

D

-

P

V

K

G

P

H

L

V

D

D

E

Y

T

D

L

K

V

V

S

P

K

G

C

V

V

V

Y

Y

S

T

H

N

P

P

E

E

T

V

A

A

S

S

V

V

G

G

L

K

T

T

E

E

Q

E

A

Q

A

V

K

K

E

E

Q

T

G

G

Y

V

E

E

V

Y

K

R

I

V

G

G

K

K

F

F

P

P

F

F

M

M

A

A

I

N

G

S

K

R

A

A

L

K

V

A

F

I

G

D

E

N

S

A

D

E

G

G

F

L

V

V

K

K

I

I

A

A

D

E

Q

K

K

E

T

T

D

D

D

K

I

I

L

L

G

G

I

V

H

H

M

I

I

M

G

A

P

P

H

N

V

A

T

G

D

E

M

L

I

I

S

H

E

E

A

A

G

A

L

I

A

A

K

L

V

Q

L

Y

D

D

A

A

T

S

P

S

W

E

E

D

V

I

G

A

Q

R

T

V

I

C

H
|
H

P

A

H
|
H

P

P

T

T

L

M

S

S

E
|
E

A

A

I

I

G

K

E

E

A

A

L

M

A

A

V

T

D

Y

G

D

K

K

A

P

I

I

H

H

F

I

active site: L38 (= L38), C42 (= C42), C47 (= C47), S50 (= S50), Y184 (≠ V191), E188 (= E195), H444 (= H451), H446 (= H453), E451 (= E458)
binding flavin-adenine dinucleotide: I9 (≠ L10), P13 (≠ T14), G14 (= G15), E33 (= E34), K34 (= K35), R35 (≠ S36), G40 (= G40), T41 (= T41), C42 (= C42), G46 (= G46), C47 (= C47), K51 (= K51), Y114 (≠ I113), G115 (= G114), T144 (= T151), G145 (= G152), Y184 (≠ V191), I185 (= I192), R274 (= R281), D314 (= D320), M320 (≠ Q326), L321 (= L327), A322 (= A328), H323 (= H329)

3urhB Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
42% identity, 99% coverage: 5:473/474 of query aligns to 1:465/465 of 3urhB

query
sites
3urhB

Y

Y

D

D

L

L

V

I

I

V

L
x
I

G
|
G

G

S

G
|
G

T
x
P

G
|
G

G

G

Y

Y

V

V

A

C

A

A

I

I

R

K

A

A

S

A

Q

Q

L

L

G

G

L

M

K

K

T

V

A

A

V

V

E
|
E

K
|
K

-

R

S

S

K

T

L
x
Y

G

G

G
|
G

T
|
T

C
|
C

L

L

H

N

K

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

R

H

S

A

A

S

E

E

V

M

Y

F

Q

H

T

Q

V

A

K

Q

R

H

A

G

A

L

D

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-

A

F

L

G

G

V

V

E

E

A

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A

G

N

I

P

A

K

L

L

Q

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F

L

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K

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K

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A

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V

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K

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L

N

A

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G

G

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V

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H

F

L

L

M

F

K

K

Q

K

G

N

K

K

I

I

D

D

V

G

Y

F

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Q

G

G

I
x
T

G
|
G

R

K

I

V

L

L

G

G

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Q

S

-

I

-

F

-

S

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-

M

-

P

-

G

G

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K

I

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S

V

V

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M

N

A

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N

K

G

G

D

E

E

E

N

-

E

Q

M

V

L

L

I

E

P

A

K

K

Q

N

V

V

I

V

I

I

A
|
A

T
|
T

G
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G

S

S

R

D

P

V

R

A

V

G

L

I

P

P

G

G

L

V

E

E

A

V

-

A

-

F

D

D

G

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T

K

H

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I

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S

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A

A

L

L

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A

L

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S

M

M

L

I

I

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V

V

G

G

V
|
V

I
|
I

G

G

I

L

E
|
E

W

L

A

G

S

S

M

V

L

W

N

A

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F

L

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G

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A

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K

V

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F

F

A

L

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D

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I

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L

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G

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G

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M

D

D

Q

G

D

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I

V

S

A

K

K

E

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M

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L

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L

L

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T

K

K

K

Q

G

G

I

I

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K

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G

R
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R

V

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P

N

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D

G

G

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G

G

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Q

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A

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I

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Y

A

A

I

I

G
|
G

D
|
D

V

V

I

V

G

R

G

G

L

P

Q
x
M

L
|
L

A
|
A

H
|
H

V

K

A

A

S

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H

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E

G

G

M

V

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A

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G

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Q

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Y

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D

D

G

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F

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V

K

K

I

I

I

L

A

A

D

D

Q

K

K

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D

D

D

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L

G

G

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G

H

H

M

I

I

I

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M

M

I

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A

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A

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H
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H

P

A

H
|
H

P

P

T

T

L

M

S

S

E
|
E

A

A

I

V

G

K

E

E

A

A

A
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