SitesBLAST

W22 (≠ R17) mutation to A: Decreased heat stability.
E26 (≠ D21) mutation to Q: Increased dissociation of dodecamers into trimers.
M30 (≠ A25) mutation to A: Increased dissociation of dodecamers into trimers.
W34 (≠ A29) mutation to A: Increased dissociation of dodecamers into trimers.
Y228 (≠ V221) mutation to C: Becomes active at low temperatures; when associated with G-278.
A241 (≠ Y233) mutation to D: Becomes active at low temperatures; when associated with G-278.
E278 (= E270) mutation to G: Becomes active at low temperatures; when associated with C-228 or D-241.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

8qeuA Crystal structure of ornithine transcarbamylase from arabidopsis thaliana (atotc) in complex with ornithine (see paper)
45% identity, 99% coverage: 2:303/304 of query aligns to 1:303/304 of 8qeuA

query
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8qeuA

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binding L-ornithine: L125 (= L130), N161 (= N166), D222 (= D223), S226 (= S227), M227 (= M228), L263 (= L263)

Q81M99 Ornithine carbamoyltransferase; OTCase; EC 2.1.3.3 from Bacillus anthracis
42% identity, 99% coverage: 3:302/304 of query aligns to 12:309/316 of Q81M99

query
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Q81M99

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STRT 57:60 (= STRT 57:60) binding carbamoyl phosphate
Q84 (= Q84) binding carbamoyl phosphate
R108 (= R108) binding carbamoyl phosphate
HPCQ 135:138 (= HPCQ 135:138) binding carbamoyl phosphate
N166 (= N166) binding L-ornithine
D230 (= D223) binding L-ornithine
SM 234:235 (= SM 227:228) binding L-ornithine
CL 269:270 (= CL 262:263) binding carbamoyl phosphate
R297 (= R290) binding carbamoyl phosphate

4nf2A Crystal structure of anabolic ornithine carbamoyltransferase from bacillus anthracis in complex with carbamoyl phosphate and l- norvaline
42% identity, 99% coverage: 3:302/304 of query aligns to 8:305/307 of 4nf2A

query
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4nf2A

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active site: R55 (= R59), T56 (= T60), R83 (= R87), R104 (= R108), H131 (= H135), Q134 (= Q138), D226 (= D223), C265 (= C262), R293 (= R290)
binding phosphoric acid mono(formamide)ester: S53 (= S57), T54 (= T58), R55 (= R59), T56 (= T60), R104 (= R108), H131 (= H135), Q134 (= Q138), C265 (= C262), L266 (= L263), R293 (= R290)
binding norvaline: L126 (= L130), N162 (= N166), D226 (= D223), S230 (= S227), M231 (= M228)

8qevA Crystal structure of ornithine transcarbamylase from arabidopsis thaliana (atotc) in complex with carbamoyl phosphate (see paper)
44% identity, 99% coverage: 2:303/304 of query aligns to 1:296/297 of 8qevA

query
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8qevA

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Y

S

S

L

I

V

V

W

F

D

P

E

Q

A

A

E

E

N

N

R
|
R

I

M

H

H

A

A

Q

Q

K

N

A

A

V

I

L

M

A

L

W

H

C

L

F

L

G

G

binding phosphoric acid mono(formamide)ester: S52 (= S57), M53 (≠ T58), R54 (= R59), T55 (= T60), R103 (= R108), C255 (= C262), L256 (= L263), R283 (= R290)

P9WIT9 Ornithine carbamoyltransferase; OTCase; EC 2.1.3.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
47% identity, 99% coverage: 1:302/304 of query aligns to 1:304/307 of P9WIT9

query
sites
P9WIT9

M

M

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S
|
S

T
|
T

R
|
R

T
|
T

R

R

F

F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q
|
Q

L

L

G

G

R

R

G

D

E

E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V

V

L

L

S

S

R

R

M

Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P
|
P

C
|
C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

N
|
N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S
|
S

M
|
M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L
|
L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

STRT 50:53 (= STRT 57:60) binding carbamoyl phosphate
Q77 (= Q84) binding carbamoyl phosphate
R101 (= R108) binding carbamoyl phosphate
HPCQ 128:131 (= HPCQ 135:138) binding carbamoyl phosphate
N160 (= N166) binding L-ornithine
D224 (= D223) binding L-ornithine
SM 228:229 (= SM 227:228) binding L-ornithine
CL 264:265 (= CL 262:263) binding carbamoyl phosphate
R292 (= R290) binding carbamoyl phosphate

7nouA Crystal structure of mycobacterium tuberculosis argf in complex with (3,5-dichlorophenyl)boronic acid.
47% identity, 99% coverage: 1:302/304 of query aligns to 2:305/308 of 7nouA

query
sites
7nouA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I
|
I

F

F

E

D

K

K

N

N

S

S

T
|
T

R
|
R

T

T

R

R

F
|
F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q

Q

L
|
L

G

G

R

R

G
x
D

E
|
E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V
|
V

L

L

S

S

R

R

M
x
Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L
|
L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R102 (= R108), H129 (= H135), Q132 (= Q138), D225 (= D223), C265 (= C262), R293 (= R290)
binding [3,5-bis(chloranyl)phenyl]-oxidanyl-oxidanylidene-boron: I46 (= I52), T52 (= T58), R53 (= R59), R53 (= R59), F56 (= F62), F56 (= F62), L79 (= L85), D82 (≠ G88), E83 (= E89), V91 (= V97), Y95 (≠ M101), L266 (= L263), R293 (= R290)

7nosA Crystal structure of mycobacterium tuberculosis argf in complex with 4-bromo-6-(trifluoromethyl)-1h-benzo[d]imidazole.
47% identity, 99% coverage: 1:302/304 of query aligns to 2:305/308 of 7nosA

query
sites
7nosA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I
|
I

F

F

E

D

K

K

N

N

S

S

T

T

R

R

T

T

R

R

F

F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q

Q

L

L

G

G

R

R

G
x
D

E
|
E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V
|
V

L
|
L

S

S

R

R

M

Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L

L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R102 (= R108), H129 (= H135), Q132 (= Q138), D225 (= D223), C265 (= C262), R293 (= R290)
binding 4-bromanyl-6-(trifluoromethyl)-1~{H}-benzimidazole: I46 (= I52), D82 (≠ G88), E83 (= E89), V91 (= V97), L92 (= L98)

7norA Crystal structure of mycobacterium tuberculosis argf in complex with 2-fluoro-4-hydroxybenzonitrile.
47% identity, 99% coverage: 1:302/304 of query aligns to 2:305/308 of 7norA

query
sites
7norA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S

S

T
|
T

R

R

T

T

R

R

F
|
F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M
x
T

Q

Q

L
|
L

G

G

R

R

G

D

E

E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V

V

L

L

S

S

R

R

M

Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L

L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R102 (= R108), H129 (= H135), Q132 (= Q138), D225 (= D223), C265 (= C262), R293 (= R290)
binding 2-fluoro-4-hydroxybenzonitrile: T52 (= T58), F56 (= F62), T77 (≠ M83), L79 (= L85)

7nnyA Crystal structure of mycobacterium tuberculosis argf in complex with naphthalen-1-ol.
47% identity, 99% coverage: 1:302/304 of query aligns to 2:305/308 of 7nnyA

query
sites
7nnyA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S

S

T
|
T

R
|
R

T

T

R

R

F
|
F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q

Q

L

L

G

G

R

R

G

D

E
|
E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V
|
V

L

L

S

S

R

R

M
x
Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L

L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R102 (= R108), H129 (= H135), Q132 (= Q138), D225 (= D223), C265 (= C262), R293 (= R290)
binding 1-naphthol: T52 (= T58), R53 (= R59), F56 (= F62), E83 (= E89), V91 (= V97), Y95 (≠ M101)

7nnwA Crystal structure of mycobacterium tuberculosis argf in complex with methyl 4-hydroxy-3-iodobenzoate.
47% identity, 99% coverage: 1:302/304 of query aligns to 2:305/308 of 7nnwA

query
sites
7nnwA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I
|
I

F

F

E

D

K

K

N

N

S

S

T
|
T

R
|
R

T

T

R

R

F
|
F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q

Q

L
|
L

G

G

R

R

G

D

E

E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V

V

L
|
L

S

S

R

R

M
x
Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L

L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R102 (= R108), H129 (= H135), Q132 (= Q138), D225 (= D223), C265 (= C262), R293 (= R290)
binding methyl 3-iodanyl-4-oxidanyl-benzoate: I46 (= I52), T52 (= T58), R53 (= R59), F56 (= F62), L79 (= L85), L92 (= L98), Y95 (≠ M101)

7nnvA Crystal structure of mycobacterium tuberculosis argf in complex with carbamoyl phosphate.
47% identity, 99% coverage: 1:302/304 of query aligns to 2:305/308 of 7nnvA

query
sites
7nnvA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S
|
S

T
|
T

R
|
R

T
|
T

R

R

F

F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q

Q

L

L

G

G

R

R

G

D

E

E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V

V

L

L

S

S

R

R

M

Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L
|
L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R102 (= R108), H129 (= H135), Q132 (= Q138), D225 (= D223), C265 (= C262), R293 (= R290)
binding phosphoric acid mono(formamide)ester: S51 (= S57), T52 (= T58), R53 (= R59), T54 (= T60), R102 (= R108), H129 (= H135), C265 (= C262), L266 (= L263), R293 (= R290)

2i6uA Crystal structure of ornithine carbamoyltransferase complexed with carbamoyl phosphate and l-norvaline from mycobacterium tuberculosis (rv1656) at 2.2 a (see paper)
47% identity, 99% coverage: 1:302/304 of query aligns to 1:304/307 of 2i6uA

query
sites
2i6uA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S
|
S

T
|
T

R
|
R

T
|
T

R

R

F

F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q

Q

L

L

G

G

R
|
R

G

D

E

E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V

V

L

L

S

S

R

R

M

Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L
|
L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

N
|
N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S
|
S

M
|
M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L
|
L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R52 (= R59), T53 (= T60), R80 (= R87), R101 (= R108), H128 (= H135), Q131 (= Q138), D224 (= D223), C264 (= C262), R292 (= R290)
binding phosphoric acid mono(formamide)ester: S50 (= S57), T51 (= T58), R52 (= R59), T53 (= T60), R101 (= R108), C264 (= C262), L265 (= L263), R292 (= R290)
binding norvaline: L123 (= L130), N160 (= N166), D224 (= D223), S228 (= S227), M229 (= M228)

7np0A Crystal structure of mycobacterium tuberculosis argf in complex with (4-nitrophenyl)boronic acid.
47% identity, 99% coverage: 1:302/304 of query aligns to 2:302/305 of 7np0A

query
sites
7np0A

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S

S

T

T

R

R

T

T

R

R

F

F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

-

A

-

S

-

D

D

M

S

Q

G

L

L

G

G

R

R

G

D

E
|
E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V
|
V

L

L

S

S

R

R

M
x
Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L

L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R99 (= R108), H126 (= H135), Q129 (= Q138), D222 (= D223), C262 (= C262), R290 (= R290)
binding p-nitrophenylboronic acid: E80 (= E89), V88 (= V97), Y92 (≠ M101)

7nnzB Crystal structure of mycobacterium tuberculosis argf in complex with 5-methyl-4-phenylthiazol-2-amine.
46% identity, 99% coverage: 1:302/304 of query aligns to 1:294/297 of 7nnzB

query
sites
7nnzB

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S

S

T
|
T

R
|
R

T

T

R

R

F
|
F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

G

D

S

M

T

Q

Q

L

L

G

G

R

R

G

D

E

E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V

V

L

L

S

S

R

R

M

Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

-

M

-

G

-

D

-

Q

-

D

-

Y

-

E

-

A

-

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L

L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A

A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R101 (= R108), H128 (= H135), Q131 (= Q138), D224 (= D223), C254 (= C262), R282 (= R290)
binding 5-methyl-4-phenyl-1,3-thiazol-2-amine: T51 (= T58), R52 (= R59), F55 (= F62)

7novA Crystal structure of mycobacterium tuberculosis argf in complex with (4-methyl-3-nitrophenyl)boronic acid.
46% identity, 99% coverage: 1:302/304 of query aligns to 2:299/302 of 7novA

query
sites
7novA

M

V

V

I

R

R

H

H

F

F

L

L

D

R

I

D

H

D

R

D

L

L

D

S

A

P

A

A

D

E

L

Q

R

A

A

E

I

V

L

L

D

E

D

L

A

A

H

-

A

-

R

-

K

-

A

A

A

E

R

L

K

K

G

K

W

D

P

P

Q

V

G

S

R

R

A

R

D

P

A

L

D

Q

A

G

P

P

G

-

K

-

D

-

R

R

V

G

L

V

A

A

M

V

I

I

F

F

E

D

K

K

N

N

S

S

T

T

R
|
R

T

T

R

R

F
|
F

S

S

F

F

D

E

A

L

A

G

I

I

R

A

Q

Q

L

L

G

G

S

H

S

A

I

V

A

V

T

D

A

S

S

R

D

D

M

-

Q

-

L

-

G

-

R

-

G

-

E
|
E

P

T

V

L

E

Q

D

D

T

T

A

A

R

K

V
|
V

L

L

S

S

R

R

M
x
Y

V

V

D

D

A

A

V

I

M

V

I

W

R
|
R

A

T

N

F

D

G

H

Q

E

E

D

R

V

L

E

D

R

A

F

M

A

A

R

S

V

V

S

A

T

T

V

V

P

P

V

V

V

I

N

N

G

A

L

L

T

S

D

D

R

E

S

F

H
|
H

P

P

C

C

Q
|
Q

I

V

L

L

A

A

D

D

L

L

Q

Q

T

T

I

I

E

A

E

E

H

R

R

K

G

G

P

A

I

L

A

R

G

G

K

L

T

R

I

L

A

S

W

Y

I

F

G

G

D

D

G

G

-

A

N

N

V

M

C

A

H

H

S

S

F

L

M

L

H

L

A

G

P

V

K

T

F

A

G

G

F

I

H

H

L

V

N

T

V

V

A

A

C

A

P

P

A

E

E

G

Y

F

H

L

P

P

D

D

L

P

-

S

-

V

-

R

-

A

-

E

R

R

D

R

L

A

A

Q

K

D

G

T

G

G

D

A

A

S

V

V

T

T

L

V

T

T

S

A

D

D

P

A

R

H

E

A

A

A

V

A

K

A

G

G

A

A

D

D

V

V

V

L

V

V

T

T

D
|
D

T

T

W

W

V

T

S

S

M

M

G

G

-

Q

D

E

Q

N

D

D

Y

G

E

L

A

D

R

R

L

V

A

K

A

P

F

F

E

R

H

P

Y

F

G

Q

V

L

D

N

E

S

A

R

L

L

M

L

D

A

L

L

A

A

D

D

P

S

E

D

A

A

V

I

F

V

L

L

H

H

C
|
C

L
|
L

P

P

A

A

H

H

R

R

G

G

E

D

E

E

V

I

T

T

D

D

A

A

V

V

I

M

D

D

G

G

P

P

R

A

S

S

L

A

V

V

W

W

D

D

E

E

A
|
A

E

E

N

N

R
|
R

I

L

H

H

A

A

Q

Q

K

K

A

A

V

L

L

L

A

V

W

W

C

L

F

L

active site: R96 (= R108), H123 (= H135), Q126 (= Q138), D219 (= D223), C259 (= C262), R287 (= R290)
binding (4-methyl-3-nitro-phenyl)-oxidanyl-oxidanylidene-boron: R53 (= R59), F56 (= F62), E77 (= E89), V85 (= V97), Y89 (≠ M101), L260 (= L263), A284 (= A287), R287 (= R290)

P00481 Ornithine transcarbamylase, mitochondrial; OTCase; Ornithine carbamoyltransferase, mitochondrial; EC 2.1.3.3 from Rattus norvegicus (Rat) (see 2 papers)
47% identity, 83% coverage: 47:298/304 of query aligns to 80:338/354 of P00481

query
sites
P00481

R

K

V

S

L

L

A

G

M

M

I

I

F

F

E

E

K

K

N

R

S

S

T

T

R
|
R

T

T

R

R

F

L

S

S

F

T

D

E

A

T

A

G

I

F

R

A

Q

L

L

L

G

G

S

H

S

P

I

S

I

F

A

L

T

T

A

T

S

Q

D

D

M

I

Q

H

L

L

G

G

R

V

G

N

E

E

P

S

V

L

E

T

D

D

T

T

A

A

R

R

V

V

L

L

S

S

R

S

M

M

V

T

D

D

A

A

V

V

M

L

I

A

R

R

A

V

N

Y

D

K

H

Q

E

S

D

D

V

L

E

D

R

I

F

L

A

A

R

K

V

E

S

A

T

T

V

I

P

P

V

I

V

V

N

N

G

G

L

L

T

S

D

D

R

L

S

Y

H

H

P

P

C

I

Q

Q

I

I

L

L

A

A

D

D

L

Y

Q

L

T

T

I

L

E

Q

E

E

H

H

R

Y

G

G

P

S

I

L

A

K

G

G

K

L

T

T

I

L

A

S

W

W

I

I

G

G

D

D

G

G

N

N

V

I

C

L

H

H

S

S

F

I

M

M

H

M

A

S

A

A

P

A

K

K

F

F

G

G

F

M

H

H

L

L

N

Q

V

A

A

A

C

T

P

P

A

K

E

G

Y

Y

H

E

P

P

D

D

-

P

-

N

L

I

R

V

D

K

L

L

A

A

-

E

-

Q

-

Y

-

A

-

K

K

E

G

N

G

G

D

T

A

R

V

L

T

S

L

M

T

T

S

N

D

D

P

P

R

L

E

E

A

A

V

A

K

R

G

G

A

G

D

N

V

V

V

L

V

I

T

T

D

D

T

T

W

W

V

I

S

S

M

M

G

G

D

Q

Q

E

D

D

-

E

Y

K

E

K

A

K

R

R

L

L

A

Q

A

A

F

F

E

Q

H

G

Y

Y

G

Q

V

V

D

T

E

M

A

K

L

T

M

A

D

K

L

V

A

A

D

A

P

S

E

D

A

W

V

T

F

F

L

L

H

H

C
|
C

L

L

P

P

A

-

H

R

R

K

G

P

E

E

V

V

T

D

D

D

A

E

V

V

I

F

D

Y

G

S

P

P

R

R

S

S

L

L

V

V

W

F

D

P

E

E

A

A

E

E

N

N

R

R

I

K

H

W

A

T

Q

I

K

M

A

A

V

V

L

M

R92 (= R59) mutation to L: Strong decrease in ornithine carbamoyltransferase activity.
C303 (= C262) mutation to S: Increases KM for ornithine 5-fold and decreases kcat 20-fold.

Sites not aligning to the query:

1:32 modified: transit peptide, Mitochondrion

1othA Crystal structure of human ornithine transcarbamoylase complexed with n-phosphonacetyl-l-ornithine (see paper)
46% identity, 83% coverage: 47:298/304 of query aligns to 47:305/321 of 1othA

query
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active site: R59 (= R59), T60 (= T60), V87 (≠ R87), R108 (= R108), H135 (= H135), Q138 (= Q138), D230 (= D223), C270 (= C262), R297 (= R290)
binding n-(phosphonoacetyl)-l-ornithine: S57 (= S57), T58 (= T58), R59 (= R59), T60 (= T60), R108 (= R108), L130 (= L130), H135 (= H135), N166 (= N166), D230 (= D223), S234 (= S227), M235 (= M228), C270 (= C262), L271 (= L263), R297 (= R290)

1c9yA Human ornithine transcarbamylase: crystallographic insights into substrate recognition and catalytic mechanism (see paper)
46% identity, 83% coverage: 47:298/304 of query aligns to 47:305/321 of 1c9yA

query
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1c9yA

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active site: R59 (= R59), T60 (= T60), V87 (≠ R87), R108 (= R108), H135 (= H135), Q138 (= Q138), D230 (= D223), C270 (= C262), R297 (= R290)
binding phosphoric acid mono(formamide)ester: S57 (= S57), T58 (= T58), R59 (= R59), T60 (= T60), R108 (= R108), C270 (= C262), L271 (= L263), R297 (= R290)
binding norvaline: L130 (= L130), N166 (= N166), D230 (= D223), S234 (= S227), M235 (= M228)

P00480 Ornithine transcarbamylase, mitochondrial; OTCase; Ornithine carbamoyltransferase, mitochondrial; EC 2.1.3.3 from Homo sapiens (Human) (see 31 papers)
46% identity, 83% coverage: 47:298/304 of query aligns to 80:338/354 of P00480

query
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P00480

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K88 (= K55) modified: N6-acetyllysine; alternate; to N: in OTCD; late onset; dbSNP:rs72554339
STRT 90:93 (= STRT 57:60) binding carbamoyl phosphate
G100 (≠ A67) to D: in OTCD; late onset; dbSNP:rs72554349
F101 (≠ I68) to L: in dbSNP:rs1133135
L111 (≠ A78) to P: in dbSNP:rs1800324
T125 (≠ E92) to M: in OTCD; neonatal; dbSNP:rs72554356
D126 (= D93) to G: in OTCD; early onset; loss of ornithine carbamoyltransferase activity; 0.9% of wild-type activity; dbSNP:rs72554358
R129 (= R96) to H: in OTCD; early onset; decreased ornithine carbamoyltransferase activity; 2.1% of wild-type activity; dbSNP:rs66656800
A140 (≠ I107) to P: in OTCD; late onset; dbSNP:rs72556260
R141 (= R108) binding carbamoyl phosphate; to Q: in OTCD; most common variant; loss of ornithine carbamoyltransferase activity; activity is 100-fold lower; dbSNP:rs68026851
H168 (= H135) binding carbamoyl phosphate
Q171 (= Q138) binding carbamoyl phosphate
I172 (= I139) to M: in OTCD; early onset; loss of ornithine carbamoyltransferase activity; dbSNP:rs72556280
Y176 (≠ L143) to C: in OTCD; late onset; dbSNP:rs72556283
TL 178:179 (≠ TI 145:146) natural variant: Missing (in OTCD; neonatal)
Y183 (≠ R150) to D: in OTCD; late onset; dbSNP:rs72556292
G188 (= G155) to R: in OTCD; neonatal; dbSNP:rs72556294
G195 (= G162) to R: in OTCD; loss of ornithine carbamoyltransferase activity; dbSNP:rs67294955
D196 (= D163) to V: in OTCD; neonatal; decreased ornithine carbamoyltransferase activity; 3.7% activity; dbSNP:rs72556300
L201 (≠ C168) to P: in OTCD; neonatal; dbSNP:rs72558407
S207 (≠ A174) to R: in OTCD; neonatal; dbSNP:rs72558415
A209 (≠ P176) to V: in OTCD; neonatal; dbSNP:rs72558417
M213 (≠ F180) to K: in OTCD; late onset
H214 (= H181) to Y: in OTCD; neonatal; dbSNP:rs72558420
P220 (= P187) to A: in OTCD; late onset; dbSNP:rs72558425
P225 (= P192) to T: in OTCD; late onset; dbSNP:rs72558428
L244 (≠ V204) to Q: in OTCD; late onset; dbSNP:rs72558436
T262 (= T222) to K: in OTCD; mild; dbSNP:rs67333670
T264 (= T224) to A: in OTCD; late onset; decreased ornithine carbamoyltransferase activity; 8.9% activity; dbSNP:rs72558444; to I: in OTCD; late onset; dbSNP:rs67156896
W265 (= W225) to L: in OTCD; mild; dbSNP:rs72558446
G269 (= G229) to E: in OTCD; neonatal; dbSNP:rs72558450
Q270 (vs. gap) to R: in dbSNP:rs1800328
E272 (≠ Q231) natural variant: Missing (in OTCD; late onset; dbSNP:rs72558452)
R277 (= R236) to Q: in OTCD; late onset; dbSNP:rs66724222; to W: in OTCD; late onset; dbSNP:rs72558454
H302 (= H261) to L: in OTCD; female; late onset; dbSNP:rs67993095; to Y: in OTCD; neonatal; dbSNP:rs72558463
C303 (= C262) to R: in OTCD; neonatal; dbSNP:rs67468335
CL 303:304 (= CL 262:263) binding carbamoyl phosphate
E309 (= E269) natural variant: Missing (in OTCD; late onset)
R330 (= R290) binding carbamoyl phosphate
T333 (≠ A293) natural variant: T -> A

Sites not aligning to the query:

1:32 modified: transit peptide, Mitochondrion
15 R→G: Loss of cleavage of the transit peptide and loss of localization to mitochondrial matrix; when associated with G-23 and G-26.
23 R→G: Loss of cleavage of the transit peptide and loss of localization to mitochondrial matrix; when associated with G-15 and G-26.
26 R→G: Loss of cleavage of the transit peptide and loss of localization to mitochondrial matrix; when associated with G-15 and G-23.
39 G → C: in OTCD; late onset; dbSNP:rs72554306
40 R → H: in OTCD; late onset; dbSNP:rs72554308
43 L → F: in dbSNP:rs72554309
46 K → R: in dbSNP:rs1800321
55 Y → D: in OTCD; late onset; dbSNP:rs72554319
63 L → P: in OTCD; late onset; dbSNP:rs72554324
340 S → P: in OTCD; late onset; dbSNP:rs72558489
343 T → K: in OTCD; late onset; dbSNP:rs72558491

Query Sequence

>WP_017506612.1 NCBI__GCF_001636925.1:WP_017506612.1
MVRHFLDIHRLDAADLRAILDDAHARKAARKGWPQGRADADAPGKDRVLAMIFEKNSTRT
RFSFDAAIRQLGGSSIIATASDMQLGRGEPVEDTARVLSRMVDAVMIRANDHEDVERFAR
VSTVPVVNGLTDRSHPCQILADLQTIEEHRGPIAGKTIAWIGDGNNVCHSFMHAAPKFGF
HLNVACPAEYHPDLRDLAKGGDAVTLTSDPREAVKGADVVVTDTWVSMGDQDYEARLAAF
EHYGVDEALMDLADPEAVFLHCLPAHRGEEVTDAVIDGPRSLVWDEAENRIHAQKAVLAW
CFGG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory