SitesBLAST
Comparing WP_017540510.1 NCBI__GCF_000341205.1:WP_017540510.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
40% identity, 83% coverage: 41:263/268 of query aligns to 15:239/240 of 1ji0A
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
36% identity, 81% coverage: 47:262/268 of query aligns to 17:235/238 of 6s8nB
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
36% identity, 81% coverage: 47:262/268 of query aligns to 17:235/238 of 6s8gA
Sites not aligning to the query:
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
36% identity, 81% coverage: 47:262/268 of query aligns to 17:235/235 of 6mhzA
- binding adp orthovanadate: N37 (= N67), G38 (= G68), G40 (= G70), K41 (= K71), T42 (≠ S72), T43 (= T73), Q84 (= Q114), S136 (≠ A163), S138 (= S165), G139 (= G166), G140 (= G167), E162 (= E189), G166 (= G193), H194 (≠ Q221)
Sites not aligning to the query:
6mbnA Lptb e163q in complex with atp (see paper)
36% identity, 81% coverage: 47:262/268 of query aligns to 18:236/241 of 6mbnA
Sites not aligning to the query:
6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
36% identity, 80% coverage: 47:261/268 of query aligns to 17:234/234 of 6b89A
- binding adenosine-5'-diphosphate: V17 (≠ I47), N37 (= N67), G38 (= G68), G40 (= G70), K41 (= K71), T42 (≠ S72), T43 (= T73)
- binding magnesium ion: T42 (≠ S72), Q84 (= Q114)
- binding novobiocin: L71 (≠ A101), H72 (= H102), P83 (= P113), A86 (≠ Q116), S87 (≠ N117), F89 (= F119), R90 (≠ P120), R91 (≠ S121), L92 (= L122), V101 (= V132), Q135 (vs. gap), R149 (= R176)
Sites not aligning to the query:
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
36% identity, 80% coverage: 47:261/268 of query aligns to 17:234/234 of 4p31A
Sites not aligning to the query:
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
35% identity, 80% coverage: 47:260/268 of query aligns to 17:233/233 of 6b8bA
- binding adenosine-5'-diphosphate: V17 (≠ I47), G38 (= G68), G40 (= G70), K41 (= K71), T42 (≠ S72), T43 (= T73)
- binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F119), R90 (≠ P120), R91 (≠ S121)
Sites not aligning to the query:
6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 81% coverage: 46:262/268 of query aligns to 16:235/240 of 6mjpA
1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
33% identity, 83% coverage: 41:262/268 of query aligns to 13:253/254 of 1g6hA
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
33% identity, 83% coverage: 41:262/268 of query aligns to 13:253/253 of 1g9xB
4u00A Crystal structure of ttha1159 in complex with adp (see paper)
35% identity, 80% coverage: 41:255/268 of query aligns to 11:228/241 of 4u00A
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state (see paper)
36% identity, 79% coverage: 44:254/268 of query aligns to 14:224/371 of 3puyA
- binding phosphoaminophosphonic acid-adenylate ester: S37 (≠ N67), G38 (= G68), C39 (≠ A69), G40 (= G70), K41 (= K71), S42 (= S72), T43 (= T73), Q81 (= Q114), R128 (≠ Q159), A132 (= A163), S134 (= S165), G136 (= G167), Q137 (≠ E168), E158 (= E189), H191 (≠ Q221)
- binding magnesium ion: S42 (= S72), Q81 (= Q114)
Sites not aligning to the query:
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3 (see paper)
36% identity, 79% coverage: 44:254/268 of query aligns to 14:224/371 of 3puxA
- binding adenosine-5'-diphosphate: G38 (= G68), C39 (≠ A69), G40 (= G70), K41 (= K71), S42 (= S72), T43 (= T73), R128 (≠ Q159), S134 (= S165), Q137 (≠ E168)
- binding beryllium trifluoride ion: S37 (≠ N67), G38 (= G68), K41 (= K71), Q81 (= Q114), S134 (= S165), G136 (= G167), H191 (≠ Q221)
- binding magnesium ion: S42 (= S72), Q81 (= Q114)
Sites not aligning to the query:
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4 (see paper)
36% identity, 79% coverage: 44:254/268 of query aligns to 14:224/371 of 3puwA
- binding adenosine-5'-diphosphate: V17 (≠ I47), G38 (= G68), C39 (≠ A69), G40 (= G70), K41 (= K71), S42 (= S72), T43 (= T73), R128 (≠ Q159), A132 (= A163), S134 (= S165), Q137 (≠ E168)
- binding tetrafluoroaluminate ion: S37 (≠ N67), G38 (= G68), K41 (= K71), Q81 (= Q114), S134 (= S165), G135 (= G166), G136 (= G167), E158 (= E189), H191 (≠ Q221)
- binding magnesium ion: S42 (= S72), Q81 (= Q114)
Sites not aligning to the query:
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4 (see paper)
36% identity, 79% coverage: 44:254/268 of query aligns to 14:224/371 of 3puvA
- binding adenosine-5'-diphosphate: V17 (≠ I47), G38 (= G68), C39 (≠ A69), G40 (= G70), K41 (= K71), S42 (= S72), T43 (= T73), R128 (≠ Q159), A132 (= A163), S134 (= S165), Q137 (≠ E168)
- binding magnesium ion: S42 (= S72), Q81 (= Q114)
Sites not aligning to the query:
1q12A Crystal structure of the atp-bound e. Coli malk (see paper)
36% identity, 79% coverage: 44:254/268 of query aligns to 12:222/367 of 1q12A
- binding adenosine-5'-triphosphate: S35 (≠ N67), G36 (= G68), C37 (≠ A69), G38 (= G70), K39 (= K71), S40 (= S72), T41 (= T73), R126 (≠ Q159), A130 (= A163), S132 (= S165), G134 (= G167), Q135 (≠ E168)
Sites not aligning to the query:
2awnB Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
36% identity, 79% coverage: 44:254/268 of query aligns to 14:224/374 of 2awnB
Sites not aligning to the query:
P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 5 papers)
36% identity, 79% coverage: 44:254/268 of query aligns to 15:225/371 of P68187
- A85 (≠ N117) mutation to M: Suppressor of EAA loop mutations in MalFG.
- K106 (≠ R135) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V114 (≠ F143) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V117 (= V146) mutation to M: Suppressor of EAA loop mutations in MalFG.
- E119 (= E148) mutation to K: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- A124 (= A154) mutation to T: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- G137 (= G167) mutation to A: Loss of maltose transport. Has greater ability to decrease mal gene expression than wild-type MalK.
- D158 (= D188) mutation to N: Loss of maltose transport but retains ability to repress mal genes.
Sites not aligning to the query:
- 228 R→C: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 241 F→I: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 267 W→G: Normal maltose transport but constitutive mal gene expression.
- 278 G→P: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 282 S→L: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 284 G→S: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 302 G→D: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 308 E→Q: Maltose transport is affected but retains ability to interact with MalT.
- 322 S→F: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 340 G→A: Maltose transport is affected but retains ability to interact with MalT.
- 346 G→S: Normal maltose transport but constitutive mal gene expression.
- 355 F→Y: Maltose transport is affected but retains ability to interact with MalT.
P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
35% identity, 79% coverage: 44:254/268 of query aligns to 15:225/369 of P19566