SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_017548275.1 NCBI__GCF_000330705.1:WP_017548275.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
34% identity, 77% coverage: 1:236/307 of query aligns to 1:256/285 of 4yerA

query
sites
4yerA

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binding adenosine-5'-diphosphate: F14 (= F15), F17 (≠ H18), N39 (= N40), G40 (= G41), G42 (= G43), K43 (= K44), T44 (≠ S45), T45 (= T46), T135 (≠ N133), F136 (= F134), S137 (= S135)

8k1pB Mycobacterial efflux pump, adp+vanadate bound state
38% identity, 69% coverage: 6:218/307 of query aligns to 4:213/213 of 8k1pB

query
sites
8k1pB

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binding adenosine-5'-diphosphate: F13 (= F15), N38 (= N40), G39 (= G41), A40 (= A42), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)
binding adenosine-5'-triphosphate: T129 (≠ N133), S131 (= S135)

8k1oB Mycobacterial efflux pump, amppnp bound state (see paper)
38% identity, 69% coverage: 6:218/307 of query aligns to 6:215/215 of 8k1oB

query
sites
8k1oB

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binding phosphoaminophosphonic acid-adenylate ester: N40 (= N40), G43 (= G43), K44 (= K44), S45 (= S45), T46 (= T46), T131 (≠ N133), S133 (= S135)

Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see paper)
33% identity, 69% coverage: 1:212/307 of query aligns to 1376:1592/1704 of Q8R420

query
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Q8R420

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Sites not aligning to the query:

292 E→V: Knockin new born mice are healthy and survive into adulthood without overt signs of respiratory distress. Knockin mice show a severe lung phenotype that begins with alveolar inflammatory cell infiltration at the early stage of the mouse life followed by aberrant lung remodeling with characteristics of diffuse parenchymal lung disease (DPLD)- and emphysema-like alveolar disruption in older mice.

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
34% identity, 71% coverage: 5:221/307 of query aligns to 1:228/343 of P30750

query
sites
P30750

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40:46 (vs. 40:46, 86% identical) binding ATP
E166 (= E159) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
33% identity, 71% coverage: 4:221/307 of query aligns to 1:229/344 of 3tuzC

query
sites
3tuzC

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E

E

G

G

S

S

L

V

E

L

I

V

F

D

G

G

-

Q

-

E

-

L

-

T

T

T

D

L

A

S

R

E

T

S

G

E

L

L

N

T

D

K

A

A

Q

R

K

R

R

Q

M

I

G

G

A

M

I

I

I

F

E

Q

S

H

P

F

A

N

L

L

F

L

S

S

E

S

M

R

T

T

S

V

R

F

E

G

N

N

L

V

E

A

V

L

H

P

R

L

R

E

Q

L

K

D

G

N

I

T

P

P

G

K

R

D

E

E

C

V

-

K

-

R

I

V

D

T

E

E

T

L

L

L

R

S

L

L

V

V

G

G

L

L

S

G

G

D

T

K

G

H

E

D

K

S

K

Y

A

P

K

S

N

N

F

L

S

S

L

G

G

G

M

Q

K

K

Q

Q

R

R

L

V

G

A

L

I

A

A

M

R

A

A

L

L

L

A

S

S

D

N

P

P

E

K

F

V

L

L

I

L

L

C

D

D

E

Q

P

A

T

T

N

S

G

A

L

L

D

D

P

P

I

A

G

T

I

T

V

R

E

S

F

I

R

L

D

E

L

L

I

L

R

K

K

D

L

I

N

N

R

R

E

R

K

L

G

G

L

L

T

T

V

I

L

L

I

L

S

I

S

T

H

H

I

E

L

M

G

D

E

V

L

V

Y

K

Q

R

L

I

A

C

T

D

T

C

Y

V

G

A

I

V

I

I

H

S

E

N

G

G

K

E

L

L

I

I

E

E

E

Q

L

D

S

T

L

V

K

S

E

E

L

V

binding adenosine-5'-diphosphate: F12 (= F15), Q14 (vs. gap), G42 (= G41), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
33% identity, 71% coverage: 4:221/307 of query aligns to 1:229/344 of 3tuiC

query
sites
3tuiC

Y

H

I

M

L

I

K

K

T

L

N

S

G

N

L

I

T

T

K

K

K

V

F
|
F

-

H

-

Q

-

G

-

T

K

R

N

T

H

I

H

Q

A

A

V

L

D

N

K

N

V

V

D

S

L

L

S

H

I

V

R

P

K

A

G

G

D

Q

I

I

Y

Y

G

G

F

V

I

I

G

G

Q

A

N

S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

M

L

L

I

R

R

L

C

V

V

T

N

G

L

L

L

S

E

F

R

P

P

T

T

E

E

G

G

S

S

L

V

E

L

I

V

F

D

G

G

-

Q

-

E

-

L

-

T

T

T

D

L

A

S

R

E

T

S

G

E

L

L

N

T

D

K

A

A

Q

R

K

R

R

Q

M

I

G

G

A

M

I

I

I

F

E

Q

S

H

P

F

A

N

L

L

F

L

S

S

E

S

M

R

T

T

S

V

R

F

E

G

N

N

L

V

E

A

V

L

H

P

R

L

R

E

Q

L

K

D

G

N

I

T

P

P

G

K

R

D

E

E

C

V

-

K

-

R

I

V

D

T

E

E

T

L

L

L

R

S

L

L

V

V

G

G

L

L

S

G

G

D

T

K

G

H

E

D

K

S

K

Y

A

P

K

S

N

N

F

L

S

S

L

G

G

G

M

Q

K

K

Q

Q

R

R

L

V

G

A

L

I

A

A

M

R

A

A

L

L

L

A

S

S

D

N

P

P

E

K

F

V

L

L

I

L

L

C

D

D

E

Q

P

A

T

T

N

S

G

A

L

L

D

D

P

P

I

A

G

T

I

T

V

R

E

S

F

I

R

L

D

E

L

L

I

L

R

K

K

D

L

I

N

N

R

R

E

R

K

L

G

G

L

L

T

T

V

I

L

L

I

L

S

I

S

T

H

H

I

E

L

M

G

D

E

V

L

V

Y

K

Q

R

L

I

A

C

T

D

T

C

Y

V

G

A

I

V

I

I

H

S

E

N

G

G

K

E

L

L

I

I

E

E

E

Q

L

D

S

T

L

V

K

S

E

E

L

V

binding adenosine-5'-diphosphate: F12 (= F15), G42 (= G41), A43 (= A42), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
33% identity, 71% coverage: 4:221/307 of query aligns to 1:229/344 of 6cvlD

query
sites
6cvlD

Y

H

I

M

L

I

K

K

T

L

N

S

G

N

L

I

T

T

K

K

K

V

F
|
F

-

H

-
x
Q

-

G

-

T

K

R

N

T

H
x
I

H

Q

A

A

V

L

D

N

K

N

V

V

D

S

L

L

S

H

I

V

R

P

K

A

G

G

D

Q

I

I

Y

Y

G

G

F

V

I

I

G

G

Q

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

M

L

L

I

R

R

L

C

V

V

T

N

G

L

L

L

S

E

F

R

P

P

T

T

E

E

G

G

S

S

L

V

E

L

I

V

F

D

G

G

-

Q

-

E

-

L

-

T

T

T

D

L

A

S

R

E

T

S

G

E

L

L

N

T

D

K

A

A

Q

R

K

R

R

Q

M

I

G

G

A

M

I

I

I

F

E

Q

S

H

P

F

A

N

L

L

F

L

S

S

E

S

M

R

T

T

S

V

R

F

E

G

N

N

L

V

E

A

V

L

H

P

R

L

R

E

Q

L

K

D

G

N

I

T

P

P

G

K

R

D

E

E

C

V

-

K

-

R

I

V

D

T

E

E

T

L

L

L

R

S

L

L

V

V

G

G

L

L

S

G

G

D

T

K

G

H

E

D

K

S

K

Y

A

P

K

S

N
|
N

F

L

S
|
S

L

G

G

G

M
x
Q

K

K

Q

Q

R

R

L

V

G

A

L

I

A

A

M

R

A

A

L

L

L

A

S

S

D

N

P

P

E

K

F

V

L

L

I

L

L

C

D

D

E

Q

P

A

T

T

N

S

G

A

L

L

D

D

P

P

I

A

G

T

I

T

V

R

E

S

F

I

R

L

D

E

L

L

I

L

R

K

K

D

L

I

N

N

R

R

E

R

K

L

G

G

L

L

T

T

V

I

L

L

I

L

S

I

S

T

H
|
H

I

E

L

M

G

D

E

V

L

V

Y

K

Q

R

L

I

A

C

T

D

T

C

Y

V

G

A

I

V

I

I

H

S

E

N

G

G

K

E

L

L

I

I

E

E

E

Q

L

D

S

T

L

V

K

S

E

E

L

V

binding phosphothiophosphoric acid-adenylate ester: F12 (= F15), Q14 (vs. gap), I19 (≠ H18), S41 (≠ N40), G42 (= G41), A43 (= A42), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46), N141 (= N133), S143 (= S135), Q146 (≠ M138), H200 (= H192)

Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 15 papers)
33% identity, 63% coverage: 20:212/307 of query aligns to 1398:1592/1704 of Q99758

query
sites
Q99758

A

A

V

V

D

D

K

R

V

L

D

S

L

L

S

A

I

V

R

Q

K

K

G

G

D

E

I

C

Y

F

G

G

F

L

I

L

G

G

Q

F

N

N

G

G

A

A

G

G

K

K

S

T

T

T

M

T

L

F

R

K

L

M

V

L

T

T

G

G

L

E

S

E

F

S

P

L

T

T

E

S

G

G

S

D

L

A

E

F

I

V

F

G

G

G

T

H

D

R

A

I

R

S

T

S

G

D

L

V

N

G

D

K

A

V

Q

R

K

Q

R

R

M

I

G

G

A

Y

I

C

I

P

E

Q

S

F

P

D

A

A

L

L

F

L

S

D

E

H

M

M

T

T

S

G

R

R

E

E

N

M

L

L

E

V

V

M

H

Y

R

A

R

R

Q

L

K

R

G

G

I

I

P

P

G

E

R

R

E

H

-

I

-

G

-

A

C

C

I

V

D

E

E

N

T

T

L

L

R

R

L

G

V

L

G

L

L

L

S

E

G

P

T

H

G

A

E

N

K

K

K

L

A

V

K

R

N

T

F

Y

S

S

L

G

G

G

M

N

K

K

Q

R

R

K

L

L

G

S

L

T

A

G

M

I

A

A

L

L

L

I

S

G

D

E

P

P

E

A

F

V

L

I

I

F

L

L

D

D

E

E

P

P

T

S

N

T

G

G

L

M

D

D

P

P

I

V

G

A

I

R

V

R

E

L

F
x
L

R

W

D

D

L

T

I

V

R

A

K

R

L

-

N

A

R

R

E

E

K

S

G

G

L

K

T

A

V

I

L

I

I

I

S

T

S

S

H

H

I

S

L

M

G

E

E

E

L

C

Y

E

Q

A

L
|
L

A

C

T

T

T

R

Y

L

G

A

I

I

I

M

H

V

E

Q

G

G

K
x
Q

L

F

L1553 (≠ F172) to P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs121909183
L1580 (= L200) to P: in SMDP3; does not affect location in intracellular vesicle membrane; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; affects the intracellular vesicles development; decreases phosphatidylcholine transport; mutation to A: Decreases ATP hydrolysis activity of 13% compared to the wild-type.; mutation to F: Decreases ATP hydrolysis activity of 13% compared to the wild-type.; mutation to V: Decreases ATP hydrolysis activity of 56% compared to the wild-type.
Q1591 (≠ K211) to P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs28936691

Sites not aligning to the query:

43 R → L: in SMDP3; uncertain significance
53 N→Q: Does not affect N-glycosylation. Does not affect protein expression. Does not affect lamellar body membrane location.
101 L → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; dbSNP:rs121909182
124 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→Q: Loss of N-glycosylation. Reduces protein expression by 50%. Affects anterograde trafficking; when associated with Q-140. Reduces protein expression by 85%; when associated with Q-140. Does not affect lamellar body membrane location.
140 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N → H: in dbSNP:rs45447801; N→Q: Loss of N-glycosylation. Reduces protein expression by 50%. Affects anterograde trafficking; when associated with Q-124. Reduces protein expression by 85%; when associated with Q-140. Does not affect lamellar body membrane location.
173:174 LK→AA: Loss of proteolytic processing.
174:175 Cleavage; by CTSL
215 Q → K: in SMDP3; loss of lamellar bodies membrane location; loss of proteolytic cleavage; increases cellular free cholesterol and phosphatidylcholine transport; loss of vesicles formation; increases free cholesterol induced cell death; loss of protein oligomerization; dbSNP:rs879159551
280 R → C: in SMDP3; uncertain significance; does not affect protein oligomerization; dbSNP:rs201299260
288 R → K: in SMDP3; uncertain significance; does not affect protein oligomerization; dbSNP:rs117603931
290 L → M: in a breast cancer sample; somatic mutation
292 E → V: in SMDP3; uncertain significance; does not affect lamellar bodies membrane location; does not affect proteolytic cleavage; affects lamellar bodies formation; does not affect cholesterol and phosphatidylcholine transport; decreases vesicles formation; does not affect free cholesterol induced cell death; dbSNP:rs149989682
568 N → D: in SMDP3; does not affect location in intracellular vesicle membrane; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; does not affect protein expression; does not affect multivesicular bodies and lamellar bodies location; affects multivesicular bodies and lamellar bodies development; loss of phosphatidylcholine transport; does not affect cholesterol transport; dbSNP:rs121909184
579 L → P: in SMDP3; uncertain significance
605 R → Q: in SMDP3; uncertain significance; dbSNP:rs760006956
693 S→L: Does not affect protein oligomerization.
766 P → S: in dbSNP:rs45592239
801 E → D: in a breast cancer sample; somatic mutation
945 N→Q: Does not affect lamellar body membrane location. Does not affect protein expression. Does not affect proteolytic processing.
982 L → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs1402761450
1069 H → Q: in a breast cancer sample; somatic mutation
1076 N → K: in SMDP3; uncertain significance; dbSNP:rs2093663770
1221 G → S: in SMDP3; does not affect intracellular vesicle membrane location; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; G→A: Decreases ATP hydrolysis activity of 15% compared to the wild-type.; G→T: Decreases ATP hydrolysis activity of 36% compared to the wild-type.; G→V: Decreases ATP hydrolysis activity of 18% compared to the wild-type.
1302 G → E: in SMDP3; uncertain significance; dbSNP:rs2093657978
1388 K → N: in SMDP3; decreases phosphatidylcholine transport; increases protein abundance; does not affect folding in the endoplasmic reticulum; decreases proteolytic processing; affects lamellar bodies development; reduces free cholesterol transport

7chaI Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
33% identity, 74% coverage: 4:230/307 of query aligns to 2:240/262 of 7chaI

query
sites
7chaI

Y

Y

I

A

L

V

K

E

T

L

N

K

G

G

L

L

T

T

K

F

K

K

F
x
R

K

G

N

S

H

R

H

A

A

I

V

F

D

D

K

N

V

I

D

D

L

V

S

R

I

I

R

P

K

R

G

G

D

K

I

V

Y

T

G

G

F

I

I

M

G

G

Q

P

N
x
S

G
|
G

A
x
C

G
|
G

K
|
K

S
x
T

T
|
T

M

L

L

L

R

R

L

L

V

I

T

A

G

S

L

Q

S

L

F

R

P

P

T

S

E

K

G

G

S

E

L

V

E

W

I

V

F

N

G

G

T

Q

D

N

-

L

-

P

-

Q

-

L

A

S

R

R

T

G

G

D

L

L

N

F

D

D

A

M

Q

R

K

K

R

Q

M

F

G

G

A

V

I

L

I

F

E

Q

S

S

P

G

A

A

L

L

F

F

S

T

E

D

M

L

T

D

S

V

R

F

E

E

N

N

-

V

-

A

-

F

-

P

L

L

E

R

V

V

H

H

R

T

R

Q

Q

L

K

P

G

E

I

E

P

M

G

I

R

R

E

D

C

I

I

V

D

L

E

M

T

K

L

L

R

Q

L

A

V

V

G

G

L

L

S

R

G

G

T

A

G

V

E

E

K

L

K

M

A

P

K

D

N

E

F

L

S

S

L

G

G

G

M

M

K

K

Q

R

R

R

L

V

G

A

L

L

A

A

M

R

A

A

L

I

L

A

S

L

D

D

P

P

E

Q

F

I

L

L

I

L

L

Y

D

D

E

E

P

P

T

F

N

V

G

G

L

Q

D

D

P

P

I

I

G

A

I

M

V

G

E

V

F

L

R

V

D

R

L

L

I

I

R

R

K

L

L

L

N

N

R

D

E

A

K

L

G

G

L

I

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T

V

S

L

I

I

V

S

V

S

S

H

H

I

D

L

L

G

A

E

E

L

T

Y

A

Q

S

L

I

A

A

T

D

T

Y

Y

I

G

Y

I

I

I

V

H

G

E

D

G

G

K

R

L

V

I

L

E

G

E

H

L

G

S

T

-

P

-

D

-

V

L

L

K

K

E

E

L

T

D

D

E

D

-

P

K

R

C

I

R

R

R

Q

H

F

L

V

K

K

binding phosphoaminophosphonic acid-adenylate ester: R13 (≠ F15), S38 (≠ N40), G39 (= G41), C40 (≠ A42), G41 (= G43), K42 (= K44), T43 (≠ S45), T44 (= T46)

7o12B Abc transporter nosdfy, amppnp-bound in gdn (see paper)
32% identity, 78% coverage: 6:244/307 of query aligns to 3:237/298 of 7o12B

query
sites
7o12B

L

V

K

E

T

I

N

Q

G

G

L

V

T

S

K

Q

K

R

F
x
Y

K

G

N

S

H

M

H

T

A
x
V

V

L

D

H

K

D

V

L

D

N

L

L

S

N

I

L

R

G

K

E

G

G

D

E

I

V

Y

L

G

G

F

L

I

F

G

G

Q

H

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

M

S

L

M

R

K

L

L

V

I

T

L

G

G

L

L

S

L

F

S

P

P

T

S

E

E

G

G

S

Q

L

V

E

K

I

V

F

L

G

G

T

R

D

A

A

P

R

-

T

-

G

-

L

-

N

N

D

D

A

P

Q

Q

K

V

R

R

-

R

-

Q

M

L

G

G

A

Y

I

L

I

P

E
|
E

S

N

P

V

A

T

L

F

F

Y

S

P

E

Q

M

L

T

S

S

G

R

R

E

E

N

T

L

L

E

R

V

H

H

F

R

A

R

R

Q

L

K

K

G

G

I

A

P

A

G

L

R

T

E

Q

C

-

I

V

D

D

E

E

T

L

L

L

R

E

L

Q

V

V

G

G

L

L

S

A

G

H

T

A

G

A

E

D

K

R

A

V

K

K

N

T

F

Y

S

S

L

K

G

G

M

M

K

R

Q

Q

R

R

L

L

G

G

L

L

A

A

M

Q

A

A

L

L

S

G

D

E

P

P

E

R

F

L

L

L

I

L

L

L

D

D

E

E

P

P

T

T

N

V

G

G

L

L

D

D

P

P

I

I

G

A

I

T

V

Q

E

D

F

L

R

Y

D

L

L

L

I

I

R

D

K

R

L

L

N

-

R

R

E

Q

K

R

G

G

L

T

T

S

V

I

L

I

I

L

S

C

S

S

H

H

I

V

L

L

G

P

E

G

L

V

Y

E

Q

A

L

H

A

I

T

N

T

R

Y

A

G

A

I

I

I

L

H

A

E

K

G

G

K

C

L

L

I

Q

E

A

E

V

L

G

S

S

L

L

K

S

E

Q

L

L

D

R

E

A

K

E

C

A

R

G

R

L

H

P

L

V

K

R

I

I

E

R

V

A

D

S

D

G

V

I

T

S

K

E

G

R

A

D

T

S

V

W

L

L

E

Q

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F15), V17 (≠ A20), N37 (= N40), G38 (= G41), G40 (= G43), K41 (= K44), T42 (≠ S45), T43 (= T46), E80 (= E85)
binding magnesium ion: T42 (≠ S45), E80 (= E85)

6xjiC Pmtcd abc exporter at c1 symmetry (see paper)
30% identity, 70% coverage: 6:220/307 of query aligns to 1:206/290 of 6xjiC

query
sites
6xjiC

L

M

K

K

T

L

N

E

G

H

L

I

T

T

K

K

F
x
Y

K

G

N

S

H

N

H

V

A
x
V

V

L

D

N

K

D

V

I

D

D

L

F

S

D

I

F

R

G

K

D

G

S

D

R

I

I

Y

V

G

G

F

L

I

I

G

G

Q

K

N
|
N

G
|
G

A

V

G
|
G

K
|
K

S
x
T

T
|
T

M

V

L

M

R

K

L

V

V

M

T

N

G

G

L

N

S

I

F

I

P

K

T

F

E

D

G

G

S

K

L

V

E

D

I

I

F

-

G

-

T

-

D

-

A

-

R

-

T

-

G

-

L

-

N

-

D

D

A

N

Q

A

K

D

R

N

M

I

G

G

A

F

I

L

I

I

E
|
E

S

H

P

P

A

K

L

L

F

Y

S

D

E

N

M

K

T

S

S

G

R

L

E

Y

N

N

L

L

E

K

V

L

H

F

R

A

R

Q

Q

V

-

L

-

G

K

K

G

G

I

F

P

D

G

-

R

K

E

A

C

Y

I

T

D

D

E

K

T

I

L

I

R

D

L

A

V

F

G

G

L

M

S

R

G

P

T

Y

G

I

E

K

K
|
K

K

K

A

V

K

K

N
x
K

F

Y

S
|
S

L

M

G

G

M

M

K

K

Q

Q

R

K

L

L

G

A

L

I

A

A

M

V

A

S

L

L

L

M

S

N

D

K

P

P

E

K

F

F

L

L

I

I

L

L

D

D

E

E

P

P

T

T

N

N

G

G

L

M

D

D

P

P

I

D

G

G

I

S

V

I

E

D

F

V

R

L

D

T

L

T

I

I

R

K

K

S

L

L

N

V

R

N

E

E

K

L

G

D

L

M

T

R

V

I

L

L

I

I

S

S

H

H

I

K

L

L

G

E

E

D

L

I

Y

E

Q

L

L

I

A

C

T

D

T

R

Y

A

G

V

I

F

I

L

H

R

E

D

G

G

K

H

L

F

I

V

E

Q

E

D

L

V

S

N

L

M

K

E

E

E

binding phosphothiophosphoric acid-adenylate ester: Y10 (≠ F15), V15 (≠ A20), N35 (= N40), G36 (= G41), G38 (= G43), K39 (= K44), T40 (≠ S45), T41 (= T46), K115 (= K129), K119 (≠ N133), S121 (= S135)
binding magnesium ion: T40 (≠ S45), E70 (= E85)

7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc (see paper)
32% identity, 78% coverage: 6:244/307 of query aligns to 3:237/298 of 7o17B

query
sites
7o17B

L

V

K

E

T

I

N

Q

G

G

L

V

T

S

K

Q

K

R

F
x
Y

K

G

N

S

H

M

H

T

A
x
V

V

L

D

H

K

D

V

L

D

N

L

L

S

N

I

L

R

G

K

E

G

G

D

E

I

V

Y

L

G

G

F

L

I

F

G

G

Q

H

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

M

S

L

M

R

K

L

L

V

I

T

L

G

G

L

L

S

L

F

S

P

P

T

S

E

E

G

G

S

Q

L

V

E

K

I

V

F

L

G

G

T

R

D

A

A

P

R

-

T

-

G

-

L

-

N

N

D

D

A

P

Q

Q

K

V

R

R

-

R

-

Q

M

L

G

G

A

Y

I

L

I

P

E
|
E

S

N

P

V

A

T

L

F

F

Y

S

P

E

Q

M

L

T

S

S

G

R

R

E

E

N

T

L

L

E

R

V

H

H

F

R

A

R

R

Q

L

K

K

G

G

I

A

P

A

G

L

R

T

E

Q

C

-

I

V

D

D

E

E

T

L

L

L

R

E

L

Q

V

V

G

G

L

L

S

A

G

H

T

A

G

A

E

D

K
x
R

K

R

A

V

K

K

N
x
T

F

Y

S
|
S

L
x
K

G
|
G

M
|
M

K

R

Q

Q

R

R

L

L

G

G

L

L

A

A

M

Q

A

A

L

L

S

G

D

E

P

P

E

R

F

L

L

L

I

L

L

L

D

D

E

Q

P

P

T

T

N

V

G

G

L

L

D

D

P

P

I

I

G

A

I

T

V

Q

E

D

F

L

R

Y

D

L

L

L

I

I

R

D

K

R

L

L

N

-

R

R

E

Q

K

R

G

G

L

T

T

S

V

I

L

I

I

L

S

C

S

S

H

H

I

V

L

L

G

P

E

G

L

V

Y

E

Q

A

L

H

A

I

T

N

T

R

Y

A

G

A

I

I

I

L

H

A

E

K

G

G

K

C

L

L

I

Q

E

A

E

V

L

G

S

S

L

L

K

S

E

Q

L

L

D

R

E

A

K

E

C

A

R

G

R

L

H

P

L

V

K

R

I

I

E

R

V

A

D

S

D

G

V

I

T

S

K

E

G

R

A

D

T

S

V

W

L

L

E

Q

binding adenosine-5'-triphosphate: Y12 (≠ F15), V17 (≠ A20), N37 (= N40), G38 (= G41), A39 (= A42), G40 (= G43), K41 (= K44), T42 (≠ S45), T43 (= T46), E80 (= E85), R123 (≠ K129), T127 (≠ N133), S129 (= S135), K130 (≠ L136), G131 (= G137), M132 (= M138)
binding magnesium ion: K41 (= K44), T42 (≠ S45)

Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see paper)
33% identity, 69% coverage: 2:212/307 of query aligns to 2047:2263/2435 of Q9BZC7

query
sites
Q9BZC7

N

N

D

D

Y

-

I

M

L

V

K

K

T

I

N

E

G

N

L

L

T

T

K

K

K

V

F

Y

K

K

N

S

H

R

H

K

-

I

-

G

-

R

-

I

-

L

A

A

V

V

D

D

K

R

V

L

D

C

L

L

S

G

I

V

R

R

K

P

G

G

D

E

I

C

Y

F

G

G

F

L

I

L

G

G

Q

V

N

N

G

G

A

A

G

G

K

K

S

T

T

S

M

T

L

F

R

K

L

M

V

L

T

T

G

G

L

D

S

E

F

S

P

T

T

T

E

G

G

G

S

E

L

A

E

F

I

V

F

N

G

G

T

H

D

S

A

V

R

L

T

K

G

E

L

L

N

L

D

Q

A

V

Q

Q

K

Q

R

S

M

L

G

G

A

Y

I

C

I

P

E

Q

S

C

P

D

A

A

L

L

F

F

S

D

E

E

M

L

T

T

S

A

R

R

E

E

N

H

L

L

E

Q

V

L

H

Y

R

T

R

R

Q

L

K

R

G

G

I

I

P

S

G

W

R

K

E

D

-

E

-

A

-

R

C

V

I

V

D

K

E

W

T

A

L

L

R

E

L

K

V

L

G

E

L

L

S

T

G

K

T

Y

G

A

E

D

K

K

K

P

A

A

K

G

N

T

F

Y

S

S

L

G

G

G

M

N

K

K

Q

R

R

K

L

L

G

S

L

T

A

A

M

I

A

A

L

L

L

I

S

G

D

Y

P

P

E

A

F

F

L

I

I

F

L

L

D

D

E

E

P

P

T

T

N

T

G

G

L

M

D

D

P

P

I

K

G

A

I

R

V

R

E

F

F

L

R

W

D

N

L

L

I

I

R

L

K

D

L

L

N

I

R

K

E

-

K

T

G

G

L

R

T

S

V

V

L

V

I

L

S

T

S

S

H

H

I

S

L

M

G

E

E

E

L

C

Y

E

Q

A

L

L

A

C

T

T

T

R

Y

L

G

A

I

I

I

M

H

V

E

N

G

G

K

R

L

L

Sites not aligning to the query:

271 modified: N5-methylglutamine; Q→R: Abolishes methylation by N6AMT1.

F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 2 papers)
32% identity, 68% coverage: 5:212/307 of query aligns to 1935:2146/2281 of F1MWM0

query
sites
F1MWM0

I

I

L

L

K

R

T

L

N

N

G

E

L

L

T

T

K

K

K

V

F

Y

K

S

-

G

-

T

N

S

H

S

H

P

A

A

V

V

D

D

K

R

V

L

D

C

L

V

S

G

I

V

R

R

K

P

G

G

D

E

I

C

Y

F

G

G

F

L

I

L

G

G

Q

V

N

N

G

G

A

A

G

G

K

K

S

T

T

T

M

T

L

F

R

K

L

M

V

L

T

T

G

G

L

D

S

T

F

A

P

V

T

T

E

S

G

G

S

D

L

A

E

T

I

V

F

A

G

G

T

K

D

S

A

I

R

L

T

T

G

N

L

I

N

S

D

D

A

V

Q

H

K

Q

R

S

M

M

G

G

A

Y

I

C

I

P

E

Q

S

F

P

D

A

A

L

I

F

D

S

D

E

L

M

L

T

T

S

G

R

R

E

E

N

H

L

L

E

Y

V

L

H

Y

R

A

R

R

Q

L

K

R

G

G

I

V

P

P

G

A

R

E

E

E

-

I

-

E

-

R

C

V

I

T

D

N

E

W

T

S

L

I

R

Q

L

S

V

L

G

G

L

L

S

S

G

L

T

Y

G

A

E

D

K

R

K

L

A

A

K

G

N

T

F

Y

S

S

L

G

G

G

M

N

K

K

Q

R

R

K

L

L

G

S

L

T

A

A

M

I

A

A

L

L

L

I

S

G

D

C

P

P

E

P

F

L

L

V

I

L

L

L

D

D

E

E

P

P

T

T

N

T

G

G

L

M

D

D

P

P

I

Q

G

A

I

R

V

R

E

M

F

L

R

W

D

N

L

T

I

I

R

M

K

G

L

I

N

I

R

R

E

E

K

-

G

G

L

R

T

A

V

V

L

V

I

L

S

T

S

S

H

H

I

S

L

M

G

E

E

E

L

C

Y

E

Q

A

L

L

A

C

T

T

T

R

Y

L

G

A

I

I

I

M

H

V

E

K

G

G

K

A

L

F

Sites not aligning to the query:

415 modified: carbohydrate, N-linked (Hex...) asparagine
504 modified: carbohydrate, N-linked (Hex...) asparagine
901 modified: Phosphothreonine; T→A: Decreases expression level. Affects subcellular location.
1185 modified: Phosphoserine; S→A: Does not affect subcellular location. Does not affect expression level. Does not affect ATPase activity. Reduces the stimulating effect of all-trans-retinal on ATP hydrolysis.
1309 Cleavage; by trypsin
1313 modified: Phosphothreonine; T→A: Does not affect subcellular location. Does not affect expression level. Does not affect ATPase activity. Reduces the stimulating effect of all-trans-retinal on ATP hydrolysis.
1317 modified: Phosphoserine; S→A: Does not affect subcellular location. Does not affect expression level. Affects both the basal and stimulated ATPase activity.
1319 modified: Phosphoserine
1455 modified: carbohydrate, N-linked (Hex...) asparagine
1527 modified: carbohydrate, N-linked (Hex...) asparagine
1660 modified: carbohydrate, N-linked (Hex...) asparagine

6xjhC Pmtcd abc exporter without the basket domain at c2 symmetry (see paper)
30% identity, 69% coverage: 6:218/307 of query aligns to 1:204/219 of 6xjhC

query
sites
6xjhC

L

M

K

K

T

L

N

E

G

H

L

I

T

T

K

K

F
x
Y

K

G

N

S

H

N

H

V

A
x
V

V

L

D

N

K

D

V

I

D

D

L

F

S

D

I

F

R

G

K

D

G

S

D

R

I

I

Y

V

G

G

F

L

I

I

G

G

Q

K

N
|
N

G
|
G

A

V

G
|
G

K
|
K

S
x
T

T
|
T

M

V

L

M

R

K

L

V

V

M

T

N

G

G

L

N

S

I

F

I

P

K

T

F

E

D

G

G

S

K

L

V

E

D

I

I

F

-

G

-

T

-

D

-

A

-

R

-

T

-

G

-

L

-

N

-

D

D

A

N

Q

A

K

D

R

N

M

I

G

G

A

F

I

L

I

I

E
|
E

S

H

P

P

A

K

L

L

F

Y

S

D

E

N

M

K

T

S

S

G

R

L

E

Y

N

N

L

L

E

K

V

L

H

F

R

A

R

Q

Q

V

-

L

-

G

K

K

G

G

I

F

P

D

G

-

R

K

E

A

C

Y

I

T

D

D

E

K

T

I

L

I

R

D

L

A

V

F

G

G

L

M

S

R

G

P

T

Y

G

I

E

K

K
|
K

K

K

A

V

K

K

N
x
K

F

Y

S
|
S

L

M

G

G

M

M

K

K

Q

Q

R

K

L

L

G

A

L

I

A

A

M

V

A

S

L

L

L

M

S

N

D

K

P

P

E

K

F

F

L

L

I

I

L

L

D

D

E

E

P

P

T

T

N

N

G

G

L

M

D

D

P

P

I

D

G

G

I

S

V

I

E

D

F

V

R

L

D

T

L

T

I

I

R

K

K

S

L

L

N

V

R

N

E

E

K

L

G

D

L

M

T

R

V

I

L

L

I

I

S

S

H

H

I

K

L

L

G

E

E

D

L

I

Y

E

Q

L

L

I

A

C

T

D

T

R

Y

A

G

V

I

F

I

L

H

R

E

D

G

G

K

H

L

F

I

V

E

Q

E

D

L

V

S

N

L

M

binding phosphothiophosphoric acid-adenylate ester: Y10 (≠ F15), V15 (≠ A20), N35 (= N40), G36 (= G41), G38 (= G43), K39 (= K44), T40 (≠ S45), T41 (= T46), K115 (= K129), K119 (≠ N133), S121 (= S135)
binding magnesium ion: T40 (≠ S45), E70 (= E85)

8ee6A Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
32% identity, 68% coverage: 5:212/307 of query aligns to 1497:1708/1808 of 8ee6A

query
sites
8ee6A

I

V

L

L

K

V

T

L

N

R

G

N

L

L

T

T

K

K

K

V

F
x
Y

K

R

N

G

H

Q

H

R

-

M

-

P

A
|
A

V

V

D

D

K

R

V

L

D

C

L

L

S

G

I

I

R

P

K

P

G

G

D

E

I

C

Y

F

G

G

F

L

I

L

G

G

Q

V

N

N

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T

S

M

T

L

F

R

R

L

M

V

V

T

T

G

G

L

D

S

T

F

L

P

A

T

S

E

R

G

G

S

E

L

A

E

V

I

L

F

A

G

G

T

H

D

S

A

V

R

A

T

R

G

E

L

P

N

S

D

A

A

A

Q

H

K

L

R

S

M

M

G

G

A

Y

I

C

I

P

E

Q

S

S

P

D

A

A

L

I

F

F

S

E

E

L

M

L

T

T

S

G

R

R

E

E

N

H

L

L

E

E

V

L

H

L

R

A

R

R

Q

L

K

R

G

G

I

V

P

P

G

E

R

A

E

Q

C

V

I

A

D

Q

E

T

T

A

-

G

-

S

-

G

L

L

R

A

L

R

V

L

G

G

L

L

S

S

G

W

T

Y

G

A

E

D

K

R

K

P

A

A

K

G

N

T

F

Y

S

S

L

G

G

G

M

N

K

K

Q

R

R

K

L

L

G

A

L

T

A

A

M

L

A

A

L

L

L

V

S

G

D

D

P

P

E

A

F

V

L

V

I

F

L

L

D

D

E

E

P

P

T

T

N

T

G

G

L

M

D

D

P

P

I

S

G

A

I

R

V

R

E

F

F

L

R

W

D

N

L

S

I

L

R

L

K

A

L

V

N

V

R

R

E

E

K

-

G

G

L

R

T

S

V

V

L

M

I

L

S

T

S

S

H

H

I

S

L

M

G

E

E

E

L

C

Y

E

Q

A

L

L

A

C

T

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T

R

Y

L

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A

I

I

I

M

H

V

E

N

G

G

K

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F

binding phosphothiophosphoric acid-adenylate ester: Y1507 (≠ F15), A1514 (= A20), G1535 (= G41), A1536 (= A42), G1537 (= G43), K1538 (= K44), T1539 (≠ S45)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 607, 608, 633, 640, 660, 661, 663, 664, 665, 666

E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
32% identity, 66% coverage: 9:212/307 of query aligns to 1349:1555/2595 of E9Q876

query
sites
E9Q876

N

H

G

G

L

V

T

T

K

K

K

I

F

Y

K

G

N

S

H

K

H

T

A

A

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E

K

N

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D

N

L

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N

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F

R

Y

K

E

G

G

D

H

I

I

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F

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G

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N

N

G

G

A

A

G

G

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K

S

T

T

T

M

T

L
x
I

R
x
S

L
x
M

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x
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|
T

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G

L
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L

S
x
F

F
x
G

P
x
A

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T

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x
A

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G

S
x
T

L
x
I

E
x
F

I
x
V

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x
Y

G
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G

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x
K

D
|
D

A
x
I

R
x
K

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T

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x
D

L
|
L

N
|
N

D
x
T

A
x
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x
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K

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x
N

M
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M

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G

A
x
V

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x
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x
M

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x
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D

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x
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L

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S

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x
Y

M
x
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x
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x
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E
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E

N
x
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L

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x
L

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x
Y

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-

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x
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P

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x
H

-
x
W

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K

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x
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x
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x
R

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G

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Y

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M

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M

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A

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I

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D

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E

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T

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G

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V

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F

I

R

W

D

D

L

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I

I

R

S

K

K

L

-

N

-

R

N

E

K

K

T

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A

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V

I

L

I

I

L

S

S

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H

I

H

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D

E

E

L

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E

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G

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G

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L

1388:1461 (vs. 48:116, 29% identical) mutation to M: In a mouse model for harlequin ichthyosis (HI), smooth skin (smsk) mutant mice show a pronounced perinatal lethal skin phenotype in 25% of the offspring and newborn mutant pups die within a few hours after birth, and appear severely dehydrated with dry cracking skin. Smsk homozygous mutants embryos show a normal appearance at 14.5 dpc, but at 16.5 dpc develop a partial absence of normal skin folds around the trunk and limbs, and by 18.5 dpc develop a taut, thick skin and limb contractures.

Sites not aligning to the query:

1996 G→D: In a mouse model for harlequin ichthyosis (HI), homozygous mice are embryonic lethal but occasionally pups are found in the first few hours after birth but die and are severely dehydrated and fail to suckle normally. Homozygous pups show hallmarks of HI desease including hyperkeratosis, abnormal extracellular lipid lamellae and defects in cornified envelope processing. At 14.5 dpc and 15.5 dpc homozygous embryos appear normal; however from 16.5 dpc onwards they are characterized by an absence of normal skin folds around the trunk and limbs. As development progressed, embryos develop a taut, thick epidermis and multiple contractures affecting the limbs. Late stage embryos are smaller.

8eopA Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
32% identity, 68% coverage: 5:212/307 of query aligns to 1451:1662/1687 of 8eopA

query
sites
8eopA

I

V

L

L

K

V

T

L

N

R

G

N

L

L

T

T

K

K

K

V

F
x
Y

K

R

N

G

H

Q

H

R

-

M

-

P

A

A

V

V

D

D

K

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V

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D

C

L

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G

I

I

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K

P

G

G

D

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I

C

Y

F

G

G

F

L

I

L

G

G

Q

V

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
x
S

M

T

L

F

R

R

L

M

V

V

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T

G

G

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D

S

T

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P

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G

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L

A

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I

L

F

A

G

G

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A

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P

N

S

D

A

A

A

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H

K

L

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M

M

G

G

A

Y

I

C

I

P

E
x
Q

S

S

P

D

A

A

L

I

F

F

S

E

E

L

M

L

T

T

S

G

R

R

E

E

N

H

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L

E

E

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L

H

L

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A

R

R

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L

K

R

G

G

I

V

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P

G

E

R

A

E

Q

C

V

I

A

D

Q

E

T

T

A

-

G

-

S

-

G

L

L

R

A

L

R

V

L

G

G

L

L

S

S

G

W

T

Y

G

A

E

D

K

R

K

P

A

A

K

G

N
x
T

F

Y

S
|
S

L

G

G

G

M

N

K

K

Q

R

R

K

L

L

G

A

L

T

A

A

M

L

A

A

L

L

L

V

S

G

D

D

P

P

E

A

F

V

L

V

I

F

L

L

D

D

E

Q

P

P

T

T

N

T

G

G

L

M

D

D

P

P

I

S

G

A

I

R

V

R

E

F

F

L

R

W

D

N

L

S

I

L

R

L

K

A

L

V

N

V

R

R

E

E

K

-

G

G

L

R

T

S

V

V

L

M

I

L

S

T

S

S

H

H

I

S

L

M

G

E

E

E

L

C

Y

E

Q

A

L

L

A

C

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R

Y

L

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A

I

I

I

M

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V

E

N

G

G

K

R

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F

binding adenosine-5'-triphosphate: Y1461 (≠ F15), N1488 (= N40), G1489 (= G41), G1491 (= G43), K1492 (= K44), S1494 (≠ T46), Q1533 (≠ E85), T1584 (≠ N133), S1586 (= S135)
binding magnesium ion: T1493 (≠ S45), Q1533 (≠ E85)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 659, 662, 666, 686, 687, 689, 690, 691, 692, 782, 784

7w02A Cryo-em structure of atp-bound abca3 (see paper)
34% identity, 63% coverage: 20:212/307 of query aligns to 1285:1473/1566 of 7w02A

query
sites
7w02A

A

A

V

V

D

D

K

R

V

L

D

S

L

L

S

A

I

V

R

Q

K

K

G

G

D

E

I

C

Y

F

G

G

F

L

I

L

G

G

Q

F

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T

T

M

T

L

F

R

K

L

M

V

L

T

T

G

G

L

E

S

E

F

S

P

L

T

T

E

S

G

G

S

-

L

-

E

-

I

-

F

-

G

-

T

-

D

D

A

A

R

F

T

V

G

G

L

G

N

H

D

R

-

I

A

S

Q

S

K

D

R

R

M

I

G

G

A

Y

I

C

I

P

E
x
Q

S

F

P

D

A

A

L

L

F

L

S

D

E

H

M

M

T

T

S

G

R

R

E

E

N

M

L

L

E

V

V

M

H

Y

R

A

R

R

Q

L

K

R

G

G

I

I

P

P

G

E

R

R

E

H

-

I

-

G

-

A

C

C

I

V

D

E

E

N

T

T

L

L

R

R

L

G

V

L

G

L

L

L

S

E

G

P

T

H

G

A

E

N

K

K

K

L

A

V

K

R

N
x
T

F

Y

S

S

L
x
G

G

G

M

N

K

K

Q

R

R

K

L

L

G

S

L

T

A

G

M

I

A

A

L

L

L

I

S

G

D

E

P

P

E

A

F

V

L

I

I

F

L

L

D

D

E

Q

P

P

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S

N

T

G

G

L

M

D

D

P

P

I

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G

A

I

R

V

R

E

L

F

L

R

W

D

D

L

T

I

V

R

A

K

R

L

-

N

A

R

R

E

E

K

S

G

G

L

K

T

A

V

I

L

I

I

I

S

T

S

S

H

H

I

S

L

M

G

E

E

E

L

C

Y

E

Q

A

L

L

A

C

T

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Y

L

G

A

I

I

I

M

H

V

E

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G

G

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Q

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F

binding adenosine-5'-triphosphate: N1305 (= N40), G1306 (= G41), A1307 (= A42), G1308 (= G43), K1309 (= K44), T1310 (≠ S45), Q1344 (≠ E85), T1395 (≠ N133), G1398 (≠ L136)
binding magnesium ion: T1310 (≠ S45), Q1344 (≠ E85)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 504, 533, 534, 536, 537, 538, 539, 578, 630, 631, 1277
binding magnesium ion: 538, 578

Query Sequence

>WP_017548275.1 NCBI__GCF_000330705.1:WP_017548275.1
MNDYILKTNGLTKKFKNHHAVDKVDLSIRKGDIYGFIGQNGAGKSTMLRLVTGLSFPTEG
SLEIFGTDARTGLNDAQKRMGAIIESPALFSEMTSRENLEVHRRQKGIPGRECIDETLRL
VGLSGTGEKKAKNFSLGMKQRLGLAMALLSDPEFLILDEPTNGLDPIGIVEFRDLIRKLN
REKGLTVLISSHILGELYQLATTYGIIHEGKLIEELSLKELDEKCRRHLKIEVDDVTKGA
TVLESVLGITDFEVMPDKTINLYQHLDDVRMVSRALTDNGLIIEHFARAGDSLESYFSKL
VGGGRHD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory