SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_017548567.1 NCBI__GCF_000330705.1:WP_017548567.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 10 hits to proteins with known functional sites (download)

6n2oC 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
36% identity, 97% coverage: 2:565/579 of query aligns to 2:563/572 of 6n2oC

query
sites
6n2oC

K

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M

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E

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-

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I

binding succinyl-coenzyme a: G14 (= G14), G16 (= G16), I17 (= I17), I18 (≠ E18), S19 (= S19), F41 (= F41), A43 (≠ S43), E44 (≠ R44), I45 (= I45), R128 (≠ L126), N131 (= N129), F157 (= F155), N168 (= N166), T226 (= T225), R302 (= R301)
binding thiamine diphosphate: P224 (= P223), I225 (= I224), E252 (= E251)

6n2oA 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
36% identity, 97% coverage: 2:565/579 of query aligns to 2:563/572 of 6n2oA

query
sites
6n2oA

K

K

E

K

Q

D

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L

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V

G

A

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G

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G

I

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S

T

S

G

G

E

D

I

F

F

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K

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K

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D

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F

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C

A

A

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F

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G

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D

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Y

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K

D

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E

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K

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D

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G

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A

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K

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K

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N

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M

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A

A

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G

A

A

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L

A

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R

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L

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F

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N

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Y

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A

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K

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I

binding 2-oxoglutaric acid: T226 (= T225), R302 (= R301)
binding coenzyme a: G14 (= G14), G16 (= G16), S19 (= S19), N131 (= N129), K156 (≠ M154)
binding thiamine diphosphate: Y223 (= Y222), P224 (= P223), I225 (= I224), E252 (= E251)

6n2nA Crystal structure of 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus (see paper)
36% identity, 97% coverage: 2:565/579 of query aligns to 2:563/572 of 6n2nA

query
sites
6n2nA

K

K

E

K

Q

D

L

L

S

I

W

I

K

R

V

V

G

A

G

G

Q

E

Q

G

G

G

E

E

G

G

I

I

E

I

S

S

T

S

G

G

E

D

I

F

F

I

S

A

T

A

T

A

L

C

N

A

R

R

M

A

G

G

Y

L

H

E

L

V

Y

Y

S

T

Y

F

R

K

H

T

F

F

S

P

S

A

R

E

I

I

K

K

G

G

G

G

H

Y

T

A

N

M

N

Y

N

Q

V

V

R

R

I

A

S

S

A

S

K

E

E

K

V

L

R

Y

A

C

V

Q

S

G

D

D

N

T

I

F

N

D

I

V

L

F

V

C

A

A

F

F

D

N

Q

G

Q

E

T

A

I

Y

D

E

L

Q

N

N

A

K

H

D

E

K

L

I

V

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binding thiamine diphosphate: Y223 (= Y222), P224 (= P223), I225 (= I224), E252 (= E251)

P72578 2-oxoacid:ferredoxin oxidoreductase subunit alpha; OFOR; EC 1.2.7.11 from Sulfolobus sp. (see 2 papers)
33% identity, 99% coverage: 4:574/579 of query aligns to 2:615/632 of P72578

query
sites
P72578

Q

R

L

L

S

S

W

W

K

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V

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G

G

G

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G

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Y253 (= Y222) mutation Y->A,W: Loss of oxidoreductase activity.; mutation to F: Significant decrease in the catalytic efficiency, while the affinity for 2-oxoacid is only slightly affected.
YPITP 253:257 (= YPITP 222:226) YPITP motif
P254 (= P223) mutation to G: Significant decrease in the catalytic efficiency, while the affinity for 2-oxoacid is only slightly affected.
I255 (= I224) mutation I->L,M,S,V: Significant decrease in the catalytic efficiency, while the affinity for 2-oxoacid is only slightly affected.
T256 (= T225) mutation T->A,S,V: Significant decrease in the catalytic efficiency, while the affinity for 2-oxoacid is only slightly affected.
P257 (= P226) mutation P->A,G,V: Loss of oxidoreductase activity.
R344 (= R301) mutation R->A,K: Loss of oxidoreductase activity.
T353 (= T310) Plays a key role in the broad substrate specificity; mutation T->I,V: Strong decrease of the oxidoreductase activity with pyruvate, 2-oxobutyrate and 2-oxoglutarate.

Q96Y66 2-oxoacid:ferredoxin oxidoreductase 1, subunit alpha; OFOR1; EC 1.2.7.11 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
33% identity, 99% coverage: 4:574/579 of query aligns to 2:615/627 of Q96Y66

query
sites
Q96Y66

Q

R

L

L

S

S

W

W

K

V

V

I

G

G

G

G

Q

A

Q

Q

G

G

E

T

G

G

I

I

E

D

S

T

T

A

G

A

E

N

I

I

F

F

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G

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N

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A

L

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N

A

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M

A

G

G

Y

Y

H

Y

L

I

Y

Y

S

G

Y

N

R

R

H

E

F

Y

S

Y

S
|
S

R

N

I

I

K

K

G

G

G

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H

H

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|
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S41 (= S43) mutation to A: Same oxidoreductase activity as the wild-type.
T349 (= T306) mutation to L: Same oxidoreductase activity as the wild-type.
D468 (≠ V430) mutation to A: Loss of oxidoreductase activity toward 2-oxoglutarate but retains its activity toward pyruvate.

5b48A 2-oxoacid:ferredoxin oxidoreductase 1 from sulfolobus tokodai (see paper)
32% identity, 99% coverage: 4:574/579 of query aligns to 2:567/576 of 5b48A

query
sites
5b48A

Q

R

L

L

S

S

W

W

K

V

V

I

G

G

G

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Q

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Q

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|
Y

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|
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|
I

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|
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L

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K

M

M

N

-

Y

Y

H

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G

G

H

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D

D

R

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S

H

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V

L

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K

Y

W

D

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G

G

T

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P

F

F

K

L

P

R

N

D

E

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L

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S

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binding 2-[(2E)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-(1-oxidanylpropylidene)-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: Y221 (= Y222), P222 (= P223), I223 (= I224), E262 (= E251), R312 (= R301)

Q96XT2 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha; OFOR2; EC 1.2.7.11 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
31% identity, 99% coverage: 4:574/579 of query aligns to 3:616/628 of Q96XT2

query
sites
Q96XT2

Q

R

L

I

S

V

W

W

K

M

V

I

G

G

G

G

Q

A

Q

Q

G

G

E

L

G

G

I

V

E

D

S

T

T

S

G

A

E

N

I

I

F

F

S

G

T

N

T

A

L

V

N

A

R

K

M

A

G

G

Y

Y

H

Y

L

L

Y

F

S

G

Y

N

R

R

H

E

F

Y

S

Y

S

S

R

N

I

I

K

K

G

G

G

R

H

H

T

S

N

Y

N

F

N

E

V

V

R

V

I

I

S

S

A

E

K

K

E

P

V

I

R

R

A

S

V

L

S

S

D

S

N

Y

I

V

N

N

I

I

L

L

V

A

A

S

F

F

D

D

Q

A

Q

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T

T

I

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D

F

L

Q

N

H

A

F

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E

L

T

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K

D

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G

-

G

-

V

Y

I

L

I

I

A

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N

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K

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Y

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N

N

P

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T

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D

D

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K

M

F

Q

D

P

Y

F

L

R

K

D

D

M

A

I

I

Y

S

T

S

M

T

F

F

I

-

R

-

K

K

G

N

E

E

Q

L

I

F

V

I

D

K

S

F

N

N

N

T

E

M

A

A

L

A

K

E

E

L

G

G

Y

Y

E

N

L

S

M

V

D

P

S

N

A

V

M

Y

A

K

D

L

I

Q

S

E

G

Y

D

K

F

I

E

E

M

-

V

-

P

-

S

-

E

-

Q

-

E

K

E

Q

R

R

L

I

F

Q

L

V

I

D

G

G

N

N

D

T

A

I

I

S

S

A

F

M

G

G

A

K

L

L

N

A

A

G

G

G

V

L

R

R

F

F

M

Q

A

S

A

Y

Y

Y

P

P

I

I

T
|
T

P

P

A

A

S

S

E

D

I

E

M

S

E

V

Y

Y

M

I

I

E

E

A

N

N

-

Q

-

N

-

L

-

D

-

M

-

I

-

V

-

E

-

G

-

N

-

E

L

L

P

R

K

K

V

G

G

G

G

V

T

V

V

V

I

V

Q

Q

T

A

E

E

D

D

E

E

I

L

S

A

A

A

V

I

T

N

M

M

A

A

I

V

G

G

S

A

N

A

Y

L

A

T

G

G

A

V

R

R

S

S

F

A

T

T

S

A

S

T

A

S

G

G

P

P

G

G

L

F

S

S

L

L

M

M

M

S

E

E

S

G

I

I

G

S

L

W

S

A

G

G

M

M

T

N

E

E

T

V

P

P

L

V

V

V

I

I

I

T

D

Y

T

Y

M

M

R
|
R

G

G

G

A

P

P

S

A

T

T

G

G

L

L

P

P

T

T

K

R

Q

S

E

G

Q

Q

S

A

D

D

L

L

M

K

Q

F

M

A

I

L

Y

N

G

V

T

G

H

H

G

G

D

E

I

F

P

P

K

R

V

I

V

V

L

I

A

A

P

S

S

G

D

D

V

H

E

V

D

E

A

I

F

F

Y

W

T

D

T

A

I

I

D

W

A

A

F

L

N

N

I

L

A

A

E

E

Y

K

Y

Y

Q

Q

V

T

P

P

V

V

I

I

L

H

L

I

S

I

D

E

L

K

Q

T

M

L

S

A

L

N

G

A

K

Y

Q

S

-

V

-

F

-

E

-

E

-

E

-

L

-

I

S

T

S

N

R

R

P

P

F

Y

D

-

L

-

S

-

S

-

V

-

E

V

I

I

S

E

R

R

G

G

K

K

T

I

I

V

T

-

E

-

D

-

L

-

E

-

R

K

D

P

E

T

T

S

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Y

Y

F

F

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N

R

R

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V

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T

K

E

D

D

G

G

I

I

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S

S

P

R

R

P

V

I

F

P

L

G

G

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-

K

Q

G

A

G

S

I

I

H

F

H

Y

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-

T

T

G

G

V

D

E

E

H

H

S

N

T

E

T

E

G

G

T

H

P

I

N

T

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S

N

A

S

D

I

N

N

R

R

Q

M

V

K

Q

M

M

Y

D

E

K

K

R

R

M

N

R

K

K

K

L

L

K

E

-

T

-

A

D

D

F

K

T

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M

I

D

P

E

E

P

E

F

Q

K

R

V

V

K

N

G

I

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V

V

G

G

D

S

A

E

D

L

I

L

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V

L

I

L

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T

F

W

L

G

S

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N

K

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A

V

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L

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A

A

A

M

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R

E

L

L

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S

A

K

D

D

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G

I

I

T

K

T

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-

M

-

M

I

V

S

Q

L

V

K

K

Q

M

I

F

H

N

P

P

F

Y

P

P

I

K

D

N

A

L

L

M

R

K

P

K

Y

I

L

L

D

S

G

G

A

K

E

S

E

K

I

I

L

I

V

A

I

V

E

E

Q

N

N

N

Y

Y

S

N

G

A

Q

Q

L

G

N

A

S

E

V

V

L

L

-

A

-

E

K

K

M

T

N

G

Y

I

H

F

G

A

H

T

D

N

R

Y

I

I

K

-

S

-

H

-

V

L

K

K

Y

W

D

T

G

G

T

R

P

P

F

I

K

T

P

R

N

E

E

E

I

V

E

I

T

E

H

G

M

I

S

K

S

K

I

I

L

L

K

E

T257 (= T225) binding substrate
R344 (= R301) binding substrate

5b47A 2-oxoacid:ferredoxin oxidoreductase 2 from sulfolobus tokodai - pyruvate complex (see paper)
31% identity, 99% coverage: 4:574/579 of query aligns to 2:615/627 of 5b47A

query
sites
5b47A

Q

R

L

I

S

V

W

W

K

M

V

I

G

G

G

G

Q

A

Q

Q

G

G

E

L

G

G

I

V

E

D

S

T

T

S

G

A

E

N

I

I

F

F

S

G

T

N

T

A

L

V

N

A

R

K

M

A

G

G

Y

Y

H

Y

L

L

Y

F

S

G

Y

N

R

R

H

E

F

Y

S

Y

S

S

R

N

I

I

K

K

G

G

G

R

H

H

T

S

N

Y

N

F

N

E

V

V

R

V

I

I

S

S

A

E

K

K

E

P

V

I

R

R

A

S

V

L

S

S

D

S

N

Y

I

V

N

N

I

I

L

L

V

A

A

S

F

F

D

D

Q

A

Q

E

T

T

I

V

D

F

L

Q

N

H

A

F

H

T

E

E

L

T

V

K

D

E

G

-

G

-

V

Y

I

L

I

I

A

Y

D

N

S

V

K

E

F

Y

-

E

N

N

P

T

T

T

K

V

D

D

-

L

-

V

-

K

-

S

-

M

-

E

-

P

-

E

-

M

-

A

-

E

-

Q

-

V

-

K

E

E

S

A

L

L

D

S

-

K

-

E

-

R

-

L

-

G

-

F

-

T

-

I

-

K

-

D

-

V

-

L

-

E

-

Y

-

L

-

K

-

R

-

R

-

G

V

V

Q

K

L

V

I

I

P

G

I

F

P

N

F

Y

T

T

E

E

T

L

A

I

K

K

E

K

L

I

G

A

S

D

Q

T

L

F

-

K

-

V

-

P

-

M

-

S

-

V

-

V

-

E

-

R

M

A

K

K

N

N

M

M

V

I

A

A

I

V

G

G

A

A

S

S

A

Y

R

G

L

L

M

L

N

G

L

L

E

K

M

F

Q

D

P

Y

F

L

R

K

D

D

M

A

I

I

Y

S

T

S

M

T

F

F

I

-

R

-

K

K

G

N

E

E

Q

L

I

F

V

I

D

K

S

F

N

N

N

T

E

M

A

A

L

A

K

E

E

L

G

G

Y

Y

E

N

L

S

M

V

D

P

S

N

A

V

M

Y

A

K

D

L

I

Q

S

E

G

Y

D

K

F

I

E

E

M

-

V

-

P

-

S

-

E

-

Q

-

E

K

E

Q

R

R

L

I

F

Q

L

V

I

D

G

G

N

N

D

T

A

I

I

S

S

A

F

M

G

G

A

K

L

L

N

A

A

G

G

G

V

L

R

R

F

F

M

Q

A

S

A

Y

Y
|
Y

P
|
P

I
|
I

T
|
T

P

P

A

A

S

S

E

D

I

E

M

S

E

V

Y

Y

M

I

I

E

E

A

N

N

-

Q

-

N

-

L

-

D

-

M

-

I

-

V

-

E

-

G

-

N

-

E

L

L

P

R

K

K

V

G

G

G

G

V

T

V

V

V

I

V

Q

Q

T

A

E

E

D

D

E
|
E

I

L

S

A

A

A

V

I

T

N

M

M

A

A

I

V

G

G

S

A

N

A

Y

L

A

T

G

G

A

V

R

R

S

S

F

A

T

T

S

A

S

T

A

S

G

G

P
|
P

G

G

L

F

S

S

L

L

M

M

M

S

E

E

S

G

I

I

G

S

L

W

S

A

G

G

M

M

T

N

E

E

T

V

P

P

L

V

V

V

I

I

I

T

D

Y

T

Y

M

M

R
|
R

G

G

G

A

P

P

S

A

T

T

G

G

L

L

P
|
P

T

T

K

R

Q

S

E

G

Q

Q

S

A

D

D

L

L

M

K

Q

F

M

A

I

L

Y

N

G

V

T

G

H

H

G

G

D

E

I

F

P

P

K

R

V

I

V

V

L

I

A

A

P

S

S

G

D

D

V

H

E

V

D

E

A

I

F

F

Y

W

T

D

T

A

I

I

D

W

A

A

F

L

N

N

I

L

A

A

E

E

Y

K

Y

Y

Q

Q

V

T

P

P

V

V

I

I

L

H

L

I

S

I

D

E

L

K

Q

T

M

L

S

A

L

N

G

A

K

Y

Q

S

-

V

-

F

-

E

-

E

-

E

-

L

-

I

S

T

S

N

R

R

P

P

F

Y

D

-

L

-

S

-

S

-

V

-

E

V

I

I

S

E

R

R

G

G

K

K

T

I

I

V

T

-

E

-

D

-

L

-

E

-

R

K

D

P

E

T

T

S

E

D

Y

Y

F

F

E

N

R

R

Y

F

S

E

D

V

E

T

K

E

D

D

G

G

I

I

S

S

S

P

R

R

P

V

I

F

P

L

G

G

V

-

K

Q

G

A

G

S

I

I

H

F

H

Y

V

-

T

T

G

G

V

D

E

E

H

H

S

N

T

E

T

E

G

G

T

H

P

I

N

T

E

E

S

N

A

S

D

I

N

N

R

R

Q

M

V

K

Q

M

M

Y

D

E

K

K

R

R

M

N

R

K

K

K

L

L

K

E

-

T

-

A

D

D

F

K

T

E

M

I

D

P

E

E

P

E

F

Q

K

R

V

V

K

N

G

I

T

V

V

G

G

D

S

A

E

D

L

I

L

V

V

L

I

L

S

T

F

W

L

G

S

S

V

P

N

K

G

G

V

A

V

I

Q

L

E

D

A

A

A

M

E

E

R

E

L

L

D

S

A

K

D

D

-

G

I

I

T

K

T

T

-

M

-

M

I

V

S

Q

L

V

K

K

Q

M

I

F

H

N

P

P

F

Y

P

P

I

K

D

N

A

L

L

M

R

K

P

K

Y

I

L

L

D

S

G

G

A

K

E

S

E

K

I

I

L

I

V

A

I

V

E

E

Q

N

N

N

Y

Y

S

N

G

A

Q

Q

L

G

N

A

S

E

V

V

L

L

-

A

-

E

K

K

M

T

N

G

Y

I

H

F

G

A

H

T

D

N

R

Y

I

I

K

-

S

-

H

-

V

L

K

K

Y

W

D

T

G

G

T

R

P

P

F

I

K

T

P

R

N

E

E

E

I

V

E

I

T

E

H

G

M

I

S

K

S

K

I

I

L

L

K

E

binding pyruvic acid: T256 (= T225), R343 (= R301), P351 (= P309)
binding thiamine diphosphate: Y253 (= Y222), P254 (= P223), I255 (= I224), E293 (= E251), P317 (= P275)

5b46A 2-oxoacid:ferredoxin oxidoreductase 2 from sulfolobus tokodai - ligand free form (see paper)
31% identity, 99% coverage: 4:574/579 of query aligns to 2:615/627 of 5b46A

query
sites
5b46A

Q

R

L

I

S

V

W

W

K

M

V

I

G

G

G

G

Q

A

Q

Q

G

G

E

L

G

G

I

V

E

D

S

T

T

S

G

A

E

N

I

I

F

F

S

G

T

N

T

A

L

V

N

A

R

K

M

A

G

G

Y

Y

H

Y

L

L

Y

F

S

G

Y

N

R

R

H

E

F

Y

S

Y

S

S

R

N

I

I

K

K

G

G

G

R

H

H

T

S

N

Y

N

F

N

E

V

V

R

V

I

I

S

S

A

E

K

K

E

P

V

I

R

R

A

S

V

L

S

S

D

S

N

Y

I

V

N

N

I

I

L

L

V

A

A

S

F

F

D

D

Q

A

Q

E

T

T

I

V

D

F

L

Q

N

H

A

F

H

T

E

E

L

T

V

K

D

E

G

-

G

-

V

Y

I

L

I

I

A

Y

D

N

S

V

K

E

F

Y

-

E

N

N

P

T

T

T

K

V

D

D

-

L

-

V

-

K

-

S

-

M

-

E

-

P

-

E

-

M

-

A

-

E

-

Q

-

V

-

K

E

E

S

A

L

L

D

S

-

K

-

E

-

R

-

L

-

G

-

F

-

T

-

I

-

K

-

D

-

V

-

L

-

E

-

Y

-

L

-

K

-

R

-

R

-

G

V

V

Q

K

L

V

I

I

P

G

I

F

P

N

F

Y

T

T

E

E

T

L

A

I

K

K

E

K

L

I

G

A

S

D

Q

T

L

F

-

K

-

V

-

P

-

M

-

S

-

V

-

V

-

E

-

R

M

A

K

K

N

N

M

M

V

I

A

A

I

V

G

G

A

A

S

S

A

Y

R

G

L

L

M

L

N

G

L

L

E

K

M

F

Q

D

P

Y

F

L

R

K

D

D

M

A

I

I

Y

S

T

S

M

T

F

F

I

-

R

-

K

K

G

N

E

E

Q

L

I

F

V

I

D

K

S

F

N

N

N

T

E

M

A

A

L

A

K

E

E

L

G

G

Y

Y

E

N

L

S

M

V

D

P

S

N

A

V

M

Y

A

K

D

L

I

Q

S

E

G

Y

D

K

F

I

E

E

M

-

V

-

P

-

S

-

E

-

Q

-

E

K

E

Q

R

R

L

I

F

Q

L

V

I

D

G

G

N

N

D

T

A

I

I

S

S

A

F

M

G

G

A

K

L

L

N

A

A

G

G

G

V

L

R

R

F

F

M

Q

A

S

A

Y

Y
|
Y

P
|
P

I
|
I

T

T

P

P

A

A

S

S

E

D

I

E

M

S

E

V

Y

Y

M

I

I

E

E

A

N

N

-

Q

-

N

-

L

-

D

-

M

-

I

-

V

-

E

-

G

-

N

-

E

L

L

P

R

K

K

V

G

G

G

G

V

T

V

V

V

I

V

Q

Q

T

A

E

E

D

D

E
|
E

I

L

S

A

A

A

V

I

T

N

M

M

A

A

I

V

G

G

S

A

N

A

Y

L

A

T

G

G

A

V

R

R

S

S

F

A

T

T

S

A

S

T

A

S

G

G

P

P

G

G

L

F

S

S

L

L

M

M

M

S

E

E

S

G

I

I

G

S

L

W

S

A

G

G

M

M

T

N

E

E

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P

P

L

V

V

V

I

I

I

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D

Y

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M

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R

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G

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L

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-

T

-

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I

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-

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N

A

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L

M

R

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P

K

Y

I

L

L

D

S

G

G

A

K

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S

E

K

I

I

L

I

V

A

I

V

E

E

Q

N

N

N

Y

Y

S

N

G

A

Q

Q

L

G

N

A

S

E

V

V

L

L

-

A

-

E

K

K

M

T

N

G

Y

I

H

F

G

A

H

T

D

N

R

Y

I

I

K

-

S

-

H

-

V

L

K

K

Y

W

D

T

G

G

T

R

P

P

F

I

K

T

P

R

N

E

E

E

I

V

E

I

T

E

H

G

M

I

S

K

S

K

I

I

L

L

K

E

binding thiamine diphosphate: Y253 (= Y222), P254 (= P223), I255 (= I224), E293 (= E251)

9bt4A Pyruvate:ferredoxin oxidoreductase from methanosarcina acetivorans (see paper)
22% identity, 57% coverage: 203:532/579 of query aligns to 15:331/402 of 9bt4A

query
sites
9bt4A

G

G

N

S

D

Y

A

A

I

V

S

A

F

H

G

A

A

A

L

K

N

V

A

S

G

R

V

P

R

N

F

V

M

I

A

S

A

A

Y

Y

P
|
P

I
|
I

T

T

P

P

A

Q

S

T

E

H

I

I

M

V

E

E

-

D

-

L

-

S

-

Q

Y

F

M

M

I

A

E

D

-

G

N

E

L

I

P

P

K

N

V

C

G

-

G

-

T

E

V

Y

I

I

Q

N

T

V

E

E

D

S

E
|
E

I

F

S

S

A

A

V

I

T

S

M

A

A

L

I

V

G

G

S

A

N

S

Y

A

A

V

G

G

A

A

R

R

S

T

F

Y

T

S

S

A

S

T

A

T

G

S

P

Q

G

G

L

L

S

L

L

L

M

M

M

H

E

E

S

V

I

L

G

F

L

N

S

A

G

A

M

G

T

M

E

R

T

L

P

P

L

I

V

V

I

M

I

T

D

V

T

A

M

N

R

R

G

A

G

V

P

S

S

A

-

P

-

I

-

N

-

I

-

W

-

N

-

D

-

H

-

Q

-

D

-

S

-

I

-

A

-

Q

-

R

-

D

T

T

G

G

L

W

-

L

-

Q

-

L

-

Y

-

A

P

E

T

D

K

V

Q

Q

E

E

Q

A

S

A

D

D

L

M

M

V

Q

P

M

Q

I

I

Y

F

G

K

T

I

H

A

G

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D

D

I

-

P

-

K

K

V

D

V

V

L

L

A

L

P

P

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G

D

-

V

-

E

-

D

-

A

-

F

-

Y

M

T

A

T

C

I

M

D

D

A

G

F

F

N

I

I

L

A

S

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H

Y

V

Y

Y

Q

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P

P

V

V

V

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L

L

L

L

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S

Q

D

D

L

L

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T

M

D

S

E

L

F

G

L

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P

Q

K

S

Y

S

E

R

P

P

E

F

Y

D

V

L

L

S

D

S

P

V

-

E

-

I

-

S

-

R

-

G

K

K

N

T

P

I

L

T

T

E

F

D

G

L

A

E

F

R

A

D

D

E

P

T

S

E

T

Y

Y

F

T

E

E

-

F

R

R

Y

Y

S

L

D

Q

E

E

K

K

D

A

G

M

I

Q

S

A

S

A

R

L

P

P

-

K

I

I

P

E

G

A

V

V

K

S

G

K

G

E

I

F

H

A

H

E

V

I

T

Y

G

G

V

R

E

D

H

H

S

G

T

G

T

L

G

-

T

-

P

-

N

-

E

-

S

-

A

I

D

D

N

G

R

Y

Q

Q

V

L

Q

E

M

-

D

-

K

-

R

-

M

-

R

-

K

-

L

-

K

-

D

-

F

-

T

-

M

-

D

-

E

-

P

-

F

-

K

-

V

-

K

-

G

-

T

-

V

-

G

D

S

A

E

E

L

V

L

V

V

I

I

M

S

A

F

M

L

G

S

S

V

L

N

V

G

G

V

T

V

L

Q

K

E

D

A

V

A

V

E

D

R

R

L

Y

D

R

A

A

-

K

-

G

-

E

D

K

I

I

T

G

T

I

I

L

S

K

L

V

K

R

Q

S

I

F

H

R

P

P

F

F

P

P

I

K

D

M

A

Q

L

I

R

R

P

K

Y

A

L

L

D

A

G

N

A

A

E

N

E

A

I

V

L

V

V

V

I

L

E

D

Q

K

N

N

Y

I

S

S

binding thiamine diphosphate: P35 (= P223), I36 (= I224), E66 (= E251)

Query Sequence

>WP_017548567.1 NCBI__GCF_000330705.1:WP_017548567.1
MKEQLSWKVGGQQGEGIESTGEIFSTTLNRMGYHLYSYRHFSSRIKGGHTNNNVRISAKE
VRAVSDNINILVAFDQQTIDLNAHELVDGGVIIADSKFNPTKDESLDVQLIPIPFTETAK
ELGSQLMKNMVAIGASARLMNLEMQPFRDMIYTMFIRKGEQIVDSNNEALKEGYELMDSA
MADISGDFEMVPSEQEERLFLIGNDAISFGALNAGVRFMAAYPITPASEIMEYMIENLPK
VGGTVIQTEDEISAVTMAIGSNYAGARSFTSSAGPGLSLMMESIGLSGMTETPLVIIDTM
RGGPSTGLPTKQEQSDLMQMIYGTHGDIPKVVLAPSDVEDAFYTTIDAFNIAEYYQVPVI
LLSDLQMSLGKQSSRPFDLSSVEISRGKTITEDLERDETEYFERYSDEKDGISSRPIPGV
KGGIHHVTGVEHSTTGTPNESADNRQVQMDKRMRKLKDFTMDEPFKVKGTVGSELLVISF
LSVNGVVQEAAERLDADITTISLKQIHPFPIDALRPYLDGAEEILVIEQNYSGQLNSVLK
MNYHGHDRIKSHVKYDGTPFKPNEIETHMSSILKIKEVL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory