SitesBLAST

40:46 (vs. 40:46, 100% identical) binding ATP
E166 (= E166) mutation to Q: Exhibits little ATPase activity.
VDAPLL 278:283 (≠ AARPFL 273:278) binding L-methionine
N295 (= N290) mutation to A: Reduces the binding of L-methionine to undetectable levels.
NI 295:296 (≠ NV 290:291) binding L-methionine

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
47% identity, 97% coverage: 1:330/340 of query aligns to 2:336/344 of 3tuzC

query
sites
3tuzC

M

M

I

I

E

K

F

L

K

S

G

N

L

I

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T

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K

T

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F
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F

E

H

G
x
Q

K

G

H

T

G

R

T

T

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I

H

Q

A

A

L

L

K

N

D

N

I

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N

S

M

L

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H

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V

G

P

K

A

G

G

E

Q

I

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Y

Y

G

G

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V

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I

G

G

F

A

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S

G
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G

A

A

G
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G

K
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K

S
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S

T
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T

L

L

I

I

R

R

C

C

V

V

N

N

Y

L

L

L

E

E

Q

R

P

P

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T

A

E

G

G

N

S

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V

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L

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D

D

G

G

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Q

D

E

L

L

T

T

R

T

I

L

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K

S

E

E

I

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N

K

A

A

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

H

H

F

F

N

N

L

L

N

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R

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T

V

V

Y

F

A

G

N

N

I

V

A

A

M

L

P

P

L

L

I

E

L

L

D

D

N

N

A

T

P

P

K

K

P

D

K

E

I

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K

E

R

R

R

V

V

M

T

E

E

L

L

D

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F

L

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V

G

G

L

L

A

G

D

D

K

K

A

H

K

D

M

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Y

Y

P

P

D

S

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N

L

L

S

S

G

G

Q

Q

K

K

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

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R

N

P

P

S

K

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L

L

C

C

D

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A

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A

A

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L

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D

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P

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A

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R

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S

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E

L

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K

K

D

I

I

N

N

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Y

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T

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I

L

L

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T

H

H

E

E

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K

E

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C

C

N

D

R

C

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A

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M

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N

G

G

N

E

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L

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E

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T

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E

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S

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L

G

A

R

Q

N

K

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F

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M

L

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H

T

L

E

D

I

I

P

P

K

E

Y

D

V

Y

T

Q

D

E

M

R

I

L

A

Q

A

A

D

E

D

P

-

F

-

T

-

D

-

C

-

V

N

P

V

M

Y

L

R

R

I

L

N

E

F
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F

V

T

D

G

H

Q

T

S

A
x
V

A

D

R
x
A

P
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P

F
x
L

L
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L

S

S

Q

E

I

T

S

A

K

R

F

F

D

N

V

V

E

N

V

N

N

N

V

I

L

I

F

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G

A

N

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E

Y

L

A

Q

G

G

G

V

V

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K

F

F

G
|
G

N

I

L
x
M

I

L

V

T

T

E

L

M

K

H

G

G

T

T

G

Q

Q

Q

E

D

I

T

S

Q

D

A

A

A

L

I

S

A

Y

W

L

L

E

Q

D

E

N

H

K

H

I

V

binding adenosine-5'-diphosphate: F12 (= F11), Q14 (≠ G13), G42 (= G41), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46)
binding selenomethionine: F274 (= F268), V279 (≠ A273), A281 (≠ R275), P282 (= P276), L283 (≠ F277), L284 (= L278), G311 (= G305), M313 (≠ L307)

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
47% identity, 97% coverage: 1:330/340 of query aligns to 2:336/344 of 3tuiC

query
sites
3tuiC

M

M

I

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E

K

F

L

K

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N

L

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K

T

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F
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F

E

H

G

Q

K

G

H

T

G

R

T

T

V

I

H

Q

A

A

L

L

K

N

D

N

I

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S

M

L

K

H

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V

G

P

K

A

G

G

E

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Y

Y

G

G

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V

V

I

G

G

F

A

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S

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G

A
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A

G
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G

K
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K

S
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S

T
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T

L

L

I

I

R

R

C

C

V

V

N

N

Y

L

L

L

E

E

Q

R

P

P

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T

A

E

G

G

N

S

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V

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V

D

D

G

G

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D

E

L

L

T

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T

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E

K

S

E

E

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N

K

A

A

K

R

K

Q

I

I

G

G

M

M

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I

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F

Q

Q

H

H

F

F

N

N

L

L

N

S

S

S

K

R

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T

V

V

Y

F

A

G

N

N

I

V

A

A

M

L

P

P

L

L

I

E

L

L

D

D

N

N

A

T

P

P

K

K

P

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K

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K

E

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R

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V

M

T

E

E

L

L

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S

F

L

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V

G

G

L

L

A

G

D

D

K

K

A

H

K

D

M

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Y

Y

P

P

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N

L

L

S

S

G

G

Q

Q

K

K

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

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R

N

P

P

S

K

I

V

L

L

C

C

D

D

E

Q

A

A

T

T

S

S

A

A

L

L

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D

P

P

Q

A

T

T

D

R

S

S

I

I

L

L

K

E

L

L

Q

K

K

D

I

I

N

N

E

R

Y

L

N

G

I

L

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T

I

I

L

L

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T

T

H

H

E

E

M

M

S

D

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K

E

R

I

I

C

C

N

D

R

C

V

V

A

A

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M

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S

H

N

G

G

N

E

V

L

I

I

E

E

E

Q

G

D

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T

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V

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S

E

E

I

V

F

F

S

S

N

H

P

P

Q

K

T

T

V

P

T

L

G

A

R

Q

N

K

F

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I

N

Q

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T

M

L

H

H

T

L

E

D

I

I

P

P

K

E

Y

D

V

Y

T

Q

D

E

M

R

I

L

A

Q

A

A

D

E

D

P

-

F

-

T

-

D

-

C

-

V

N

P

V

M

Y

L

R

R

I

L

N

E

F

F

V

T

D

G

H

Q

T

S

A

V

A

D

R

A

P

P

F

L

L

L

S

S

Q

E

I

T

S

A

K

R

F

F

D

N

V

V

E

N

V

N

N

N

V

I

L

I

F

S

G

A

N

Q

I

M

T

D

E

Y

L

A

Q

G

G

G

V

V

P

K

F

F

G

G

N

I

L

M

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E

L

M

K

H

G

G

T

T

G

Q

Q

Q

E

D

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T

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Q

D

A

A

A

L

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S

A

Y

W

L

L

E

Q

D

E

N

H

K

H

I

V

binding adenosine-5'-diphosphate: F12 (= F11), G42 (= G41), A43 (= A42), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
47% identity, 97% coverage: 1:330/340 of query aligns to 2:336/344 of 6cvlD

query
sites
6cvlD

M

M

I

I

E

K

F

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K

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L

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K

T

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F
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F

E

H

G
x
Q

K

G

H

T

G

R

T

T

V
x
I

H

Q

A

A

L

L

K

N

D

N

I

V

N

S

M

L

K

H

V

V

G

P

K

A

G

G

E

Q

I

I

Y

Y

G

G

V

V

V

I

G

G

F

A

S
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S

G
|
G

A
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A

G
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G

K
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K

S
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S

T
|
T

L

L

I

I

R

R

C

C

V

V

N

N

Y

L

L

L

E

E

Q

R

P

P

T

T

A

E

G

G

N

S

V

V

I

L

V

V

D

D

G

G

S

Q

D

E

L

L

T

T

R

T

I

L

S

S

T

E

K

S

E

E

I

L

R

T

N

K

A

A

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

H

H

F

F

N

N

L

L

N

S

S

S

K

R

T

T

V

V

Y

F

A

G

N

N

I

V

A

A

M

L

P

P

L

L

I

E

L

L

D

D

N

N

A

T

P

P

K

K

P

D

K

E

I

V

R

K

E

R

R

R

V

V

M

T

E

E

L

L

D

S

F

L

V

V

G

G

L

L

A

G

D

D

K

K

A

H

K

D

M

S

Y

Y

P

P

D

S

Q
x
N

L

L

S
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S

G

G

Q
|
Q

K

K

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

S

R

N

P

P

S

K

I

V

L

L

C

C

D

D

E

Q

A

A

T

T

S

S

A

A

L

L

D

D

P

P

Q

A

T

T

D

R

S

S

I

I

L

L

K

E

L

L

Q

K

K

D

I

I

N

N

E

R

Y

L

N

G

I

L

T

T

I

I

L

L

I

I

T

T

H
|
H

E

E

M

M

S

D

V

V

R

K

E

R

I

I

C

C

N

D

R

C

V

V

A

A

V

V

M

I

E

S

H

N

G

G

N

E

V

L

I

I

E

E

E

Q

G

D

T

T

V

V

F

S

E

E

I

V

F

F

S

S

N

H

P

P

Q

K

T

T

V

P

T

L

G

A

R

Q

N

K

F

F

V

I

N

Q

T

S

V

T

M

L

H

H

T

L

E

D

I

I

P

P

K

E

Y

D

V

Y

T

Q

D

E

M

R

I

L

A

Q

A

A

D

E

D

P

-

F

-

T

-

D

-

C

-

V

N

P

V

M

Y

L

R

R

I

L

N

E

F

F

V

T

D

G

H

Q

T

S

A

V

A

D

R

A

P

P

F

L

L

L

S

S

Q

E

I

T

S

A

K

R

F

F

D

N

V

V

E

N

V

N

N

A

V

I

L

I

F

S

G

A

N

Q

I

M

T

D

E

Y

L

A

Q

G

G

G

V

V

P

K

F

F

G

G

N

I

L

M

I

L

V

T

T

E

L

M

K

H

G

G

T

T

G

Q

Q

Q

E

D

I

T

S

Q

D

A

A

A

L

I

S

A

Y

W

L

L

E

Q

D

E

N

H

K

H

I

V

binding phosphothiophosphoric acid-adenylate ester: F12 (= F11), Q14 (≠ G13), I19 (≠ V18), S41 (= S40), G42 (= G41), A43 (= A42), G44 (= G43), K45 (= K44), S46 (= S45), T47 (= T46), N141 (≠ Q140), S143 (= S142), Q146 (= Q145), H200 (= H199)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
42% identity, 72% coverage: 1:246/340 of query aligns to 2:241/241 of 4u00A

query
sites
4u00A

M

I

I

I

E

R

F

I

K

R

G

N

L

L

E

H

K

K

T

W

F
|
F

E

-

G

-

K

-

H

-

G

G

T

P

V

L

H

H

A
x
V

L

L

K

K

D

G

I

I

N

H

M

L

K

E

V

V

G

A

K

P

G

G

E

E

I

K

Y

L

G

V

V

I

G

G

F

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

I

R

R

C

T

V

I

N

N

Y

R

L

L

E

E

Q

D

P

F

T

Q

A

E

G

G

N

E

V

V

I

V

V

V

D

D

G

G

S

-

D

-

L

L

T

S

R

V

I

K

S

D

T

D

K

R

E

A

I

L

R

R

N

E

A

I

K

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

H

Q

F

F

N

N

L

L

L

F

N

P

S

H

K

M

T

T

V

V

Y

L

A

E

N

N

I

V

A

T

M

L

-

A

P

P

L

M

I

R

L

V

D

R

N

R

A

W

P

P

K

R

P

E

K

K

I

A

R

E

E

K

R

K

V

A

M

L

E

E

L

L

D

E

F

R

V

V

G

G

L

I

A

L

D

D

K

Q

A

A

K

R

M

K

Y

Y

P

P

D

A

Q

Q

L

L

S

S

G

G

Q

Q

K

Q

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

R

E

P

P

S

K

I

I

L

M

L

L

C

F

D

D

E

E

A

P

T

T

S

S

A

A

L

L

D

D

P

P

Q

E

T

M

T

V

D

G

S

E

I

V

L

L

K

D

L

V

L

M

Q

R

K

D

I

L

N

A

E

-

E

Q

Y

G

N

G

I

M

T

T

I

M

L

V

I

V

T

T

H

H

E

E

M

M

S

G

V

F

V

A

R

R

E

E

I

V

C

A

N

D

R

R

V

V

A

V

V

F

M

M

E

D

H

G

G

G

N

Q

V

I

I

V

E

E

G

G

T

R

V

P

F

E

E

E

I

I

F

F

S

T

N

R

P

P

Q

K

T

E

V

E

T

R

G

T

R

R

N

S

F

F

V

L

N

Q

T

R

V

V

M

L

H

H

binding adenosine-5'-diphosphate: F12 (= F11), V17 (≠ A20), S37 (= S40), G38 (= G41), S39 (≠ A42), G40 (= G43), K41 (= K44), S42 (= S45), T43 (= T46)

3c4jA Abc protein artp in complex with atp-gamma-s
43% identity, 72% coverage: 1:244/340 of query aligns to 3:241/242 of 3c4jA

query
sites
3c4jA

M

M

I

I

E

D

F

V

K

H

G

Q

L

L

E

K

K

K

T

S

F
|
F

E

-

G

-

K

-

H

-

G

G

T

S

V

L

H

E

A
x
V

L

L

K

K

D

G

I

I

N

N

M

V

K

H

V

I

G

R

K

E

G

G

E

E

I

V

Y

V

G

V

V

V

V

I

G

G

F

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

I

L

R

R

C

C

V

L

N

N

Y

L

L

L

E

E

Q

D

P

F

T

D

A

E

G

G

N

E

V

I

I

I

V

I

D

D

G

G

S

I

D

N

L

L

T

K

R

A

I

K

S

D

T

T

K

N

E

-

I

L

R

N

N

K

A

V

K

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

H

R

F

F

N

N

L

L

L

F

N

P

S

H

K

M

T

T

V

V

Y

L

A

N

N

N

I

I

A

T

M

L

-

A

P

P

L

M

I

K

L

V

D

R

N

K

A

W

P

P

K

R

P

E

K

K

I

A

R

E

E

A

R

K

V

A

M

M

E

E

L

L

D

D

F

K

V

V

G

G

L

L

A

K

D

D

K

K

A

A

K

H

M

A

Y

Y

P

P

D

D

Q

S

L

L

S

S

G

G

Q

Q

K

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

R

E

P

P

S

K

I

I

L

M

L

L

C

F

D

D

E

E

A

P

T

T

S

S

A

A

L

L

D

D

P

P

Q

E

T

M

T

V

D

G

S

E

I

V

L

L

K

S

L

V

L

M

Q

K

K

Q

I

L

N

A

E

N

E

E

Y

-

N

G

I

M

T

T

I

M

L

V

I

V

T

T

H

H

E

E

M

M

S

G

V

F

V

A

R

R

E

E

I

V

C

G

N

D

R

R

V

V

A

L

V

F

M

M

E

D

H

G

G

G

N

Y

V

I

I

I

E

E

G

G

T

K

V

P

F

E

E

D

I

L

F

F

S

D

N

R

P

P

Q

Q

T

H

V

E

T

R

G

T

R

K

N

A

F

F

V

L

N

S

T

K

V

V

binding phosphothiophosphoric acid-adenylate ester: F13 (= F11), V18 (≠ A20), S38 (= S40), G39 (= G41), S40 (≠ A42), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)

3c41J Abc protein artp in complex with amp-pnp/mg2+
43% identity, 72% coverage: 1:244/340 of query aligns to 3:241/242 of 3c41J

query
sites
3c41J

M

M

I

I

E

D

F

V

K

H

G

Q

L

L

E

K

K

K

T

S

F
|
F

E

-

G

-

K

-

H

-

G

G

T

S

V

L

H

E

A
x
V

L

L

K

K

D

G

I

I

N

N

M

V

K

H

V

I

G

R

K

E

G

G

E

E

I

V

Y

V

G

V

V

V

V

I

G

G

F

P

S
|
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

I

L

R

R

C

C

V

L

N

N

Y

L

L

L

E

E

Q

D

P

F

T

D

A

E

G

G

N

E

V

I

I

I

V

I

D

D

G

G

S

I

D

N

L

L

T

K

R

A

I

K

S

D

T

T

K

N

E

-

I

L

R

N

N

K

A

V

K

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

H

R

F

F

N

N

L

L

L

F

N

P

S

H

K

M

T

T

V

V

Y

L

A

N

N

N

I

I

A

T

M

L

-

A

P

P

L

M

I

K

L

V

D

R

N

K

A

W

P

P

K

R

P

E

K

K

I

A

R

E

E

A

R

K

V

A

M

M

E

E

L

L

D

D

F

K

V

V

G

G

L

L

A

K

D

D

K

K

A

A

K

H

M

A

Y

Y

P

P

D

D

Q

S

L

L

S

S

G

G

Q

Q

K

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

R

E

P

P

S

K

I

I

L

M

L

L

C

F

D
|
D

E

E

A

P

T

T

S

S

A

A

L

L

D

D

P

P

Q

E

T

M

T

V

D

G

S

E

I

V

L

L

K

S

L

V

L

M

Q

K

K

Q

I

L

N

A

E

N

E

E

Y

-

N

G

I

M

T

T

I

M

L

V

I

V

T

T

H

H

E

E

M

M

S

G

V

F

V

A

R

R

E

E

I

V

C

G

N

D

R

R

V

V

A

L

V

F

M

M

E

D

H

G

G

G

N

Y

V

I

I

I

E

E

G

G

T

K

V

P

F

E

E

D

I

L

F

F

S

D

N

R

P

P

Q

Q

T

H

V

E

T

R

G

T

R

K

N

A

F

F

V

L

N

S

T

K

V

V

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F11), V18 (≠ A20), S38 (= S40), G39 (= G41), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)
binding magnesium ion: S43 (= S45), D163 (= D165)

2olkA Abc protein artp in complex with adp-beta-s
43% identity, 72% coverage: 1:244/340 of query aligns to 3:241/242 of 2olkA

query
sites
2olkA

M

M

I

I

E

D

F

V

K

H

G

Q

L

L

E

K

K

K

T

S

F
|
F

E

-

G

-

K

-

H

-

G

G

T

S

V

L

H

E

A
x
V

L

L

K

K

D

G

I

I

N

N

M

V

K

H

V

I

G

R

K

E

G

G

E

E

I

V

Y

V

G

V

V

V

V

I

G

G

F

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

I

L

R

R

C

C

V

L

N

N

Y

L

L

L

E

E

Q

D

P

F

T

D

A

E

G

G

N

E

V

I

I

I

V

I

D

D

G

G

S

I

D

N

L

L

T

K

R

A

I

K

S

D

T

T

K

N

E

-

I

L

R

N

N

K

A

V

K

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

H

R

F

F

N

N

L

L

L

F

N

P

S

H

K

M

T

T

V

V

Y

L

A

N

N

N

I

I

A

T

M

L

-

A

P

P

L

M

I

K

L

V

D

R

N

K

A

W

P

P

K

R

P

E

K

K

I

A

R

E

E

A

R

K

V

A

M

M

E

E

L

L

D

D

F

K

V

V

G

G

L

L

A

K

D

D

K

K

A

A

K

H

M

A

Y

Y

P

P

D

D

Q

S

L

L

S

S

G

G

Q

Q

K

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

R

E

P

P

S

K

I

I

L

M

L

L

C

F

D

D

E

E

A

P

T

T

S

S

A

A

L

L

D

D

P

P

Q

E

T

M

T

V

D

G

S

E

I

V

L

L

K

S

L

V

L

M

Q

K

K

Q

I

L

N

A

E

N

E

E

Y

-

N

G

I

M

T

T

I

M

L

V

I

V

T

T

H

H

E

E

M

M

S

G

V

F

V

A

R

R

E

E

I

V

C

G

N

D

R

R

V

V

A

L

V

F

M

M

E

D

H

G

G

G

N

Y

V

I

I

I

E

E

G

G

T

K

V

P

F

E

E

D

I

L

F

F

S

D

N

R

P

P

Q

Q

T

H

V

E

T

R

G

T

R

K

N

A

F

F

V

L

N

S

T

K

V

V

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F11), V18 (≠ A20), S38 (= S40), G39 (= G41), S40 (≠ A42), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)

2oljA Abc protein artp in complex with adp/mg2+
43% identity, 72% coverage: 1:244/340 of query aligns to 3:241/242 of 2oljA

query
sites
2oljA

M

M

I

I

E

D

F

V

K

H

G

Q

L

L

E

K

K

K

T

S

F
|
F

E

-

G

-

K

-

H

-

G

G

T

S

V

L

H

E

A
x
V

L

L

K

K

D

G

I

I

N

N

M

V

K

H

V

I

G

R

K

E

G

G

E

E

I

V

Y

V

G

V

V

V

V

I

G

G

F

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

I

L

R

R

C

C

V

L

N

N

Y

L

L

L

E

E

Q

D

P

F

T

D

A

E

G

G

N

E

V

I

I

I

V

I

D

D

G

G

S

I

D

N

L

L

T

K

R

A

I

K

S

D

T

T

K

N

E

-

I

L

R

N

N

K

A

V

K

R

K

E

I

V

G

G

M

M

V

V

F

F

Q

Q

H

R

F

F

N

N

L

L

L

F

N

P

S

H

K

M

T

T

V

V

Y

L

A

N

N

N

I

I

A

T

M

L

-

A

P

P

L

M

I

K

L

V

D

R

N

K

A

W

P

P

K

R

P

E

K

K

I

A

R

E

E

A

R

K

V

A

M

M

E

E

L

L

D

D

F

K

V

V

G

G

L

L

A

K

D

D

K

K

A

A

K

H

M

A

Y

Y

P

P

D

D

Q

S

L

L

S

S

G

G

Q

Q

K

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

R

E

P

P

S

K

I

I

L

M

L

L

C

F

D

D

E

E

A

P

T

T

S

S

A

A

L

L

D

D

P

P

Q

E

T

M

T

V

D

G

S

E

I

V

L

L

K

S

L

V

L

M

Q

K

K

Q

I

L

N

A

E

N

E

E

Y

-

N

G

I

M

T

T

I

M

L

V

I

V

T

T

H

H

E

E

M

M

S

G

V

F

V

A

R

R

E

E

I

V

C

G

N

D

R

R

V

V

A

L

V

F

M

M

E

D

H

G

G

G

N

Y

V

I

I

I

E

E

G

G

T

K

V

P

F

E

E

D

I

L

F

F

S

D

N

R

P

P

Q

Q

T

H

V

E

T

R

G

T

R

K

N

A

F

F

V

L

N

S

T

K

V

V

binding adenosine-5'-diphosphate: F13 (= F11), V18 (≠ A20), S38 (= S40), G39 (= G41), S40 (≠ A42), G41 (= G43), K42 (= K44), S43 (= S45), T44 (= T46)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
43% identity, 68% coverage: 16:245/340 of query aligns to 12:240/240 of 4ymuJ

query
sites
4ymuJ

G

G

T

S

V

L

H

E

A
x
V

L

L

K

K

D

G

I

V

N

T

M

L

K

K

V

V

G

N

K

K

G

G

E

E

I

V

Y

V

G

V

V

I

G

G

F

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

L

R

R

C

C

V

I

N

N

Y

L

L

L

E

E

Q

E

P

P

T

T

A

K

G

G

N

E

V

V

I

F

V

I

D

D

G

G

S

V

D

K

L

I

T

N

R

N

I

-

S

G

T

K

K

V

E

N

I

I

R

N

N

K

A

V

K

R

K

Q

K

K

I

V

G

G

M

M

V

V

F

F

Q

Q

H

H

F

F

N

N

L

L

L

F

N

P

S

H

K

L

T

T

V

A

Y

I

A

E

N

N

I

I

A

T

M

L

-

A

P

P

L

V

I

K

L

V

D

K

N

K

A

M

P

N

K

K

P

K

K

E

I

A

R

E

E

E

R

L

V

A

M

V

E

D

L

L

D

A

F

K

V

V

G

G

L

L

A

L

D

D

K

K

A

K

K

D

M

Q

Y

Y

P

P

D

I

Q

K

L

L

S

S

G

G

Q

Q

K

K

Q

Q

R

R

I

L

G

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

R

Q

P

P

S

E

I

V

L

M

L

L

C

F

D

D

E
|
E

A

P

T

T

S

S

A

A

L

L

D

D

P

P

Q

E

T

M

T

V

D

K

S

E

I

V

L

L

K

N

L

V

L

M

Q

K

K

Q

I

L

N

A

E

N

E

E

Y

-

N

G

I

M

T

T

I

M

L

V

I

V

T

T

H
|
H

E

E

M

M

S

G

V

F

V

A

R

R

E

E

I

V

C

G

N

D

R

R

V

V

A

I

V

F

M

M

E

D

H

D

G

G

N

V

V

I

I

V

E

E

G

G

T

T

V

P

F

E

E

E

I

I

F

F

S

Y

N

R

P

A

Q

K

T

N

V

E

T

R

G

T

R

R

N

E

F

F

V

L

N

S

T

K

V

I

M

L

binding adenosine-5'-triphosphate: V16 (≠ A20), S36 (= S40), G37 (= G41), S38 (≠ A42), G39 (= G43), K40 (= K44), S41 (= S45), T42 (= T46), E162 (= E166), H194 (= H199)
binding magnesium ion: S41 (= S45), E162 (= E166)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
40% identity, 64% coverage: 1:219/340 of query aligns to 1:215/222 of P0A9R7

query
sites
P0A9R7

M

M

I

I

E

R

F

F

K

E

G

H

L

V

E

S

K

K

T

A

F

Y

E

L

G

G

K

G

H

R

G

-

T

-

V

-

H

Q

A

A

L

L

K

Q

D

G

I

V

N

T

M

F

K

H

V

M

G

Q

K

P

G

G

E

E

I

M

Y

A

G

F

V

L

V

T

G

G

F

H

S

S

G

G

A

A

G

G

K
|
K

S

S

T

T

L

L

I

L

R

K

C

L

V

I

N
x
C

Y

G

L

I

E

E

Q

R

P

P

T

S

A

A

G

G

N

K

V

I

I

W

V

F

D

S

G

G

S

H

D

D

L

I

T

T

R

R

I

L

S

K

T

N

K

R

E

E

I

V

R

P

N

F

A

L

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

H

D

F

H

N

H

L

L

N

M

S

D

K

R

T

T

V

V

Y

Y

A

D

N

N

I

V

A

A

M

I

P

P

L

L

I

I

L

I

D

A

N

G

A

A

P

S

K

G

P

D

K

D

I

I

R

R

E

R

R

R

V

V

M

S

E

A

L

A

L

L

D

D

F

K

V

V

G

G

L

L

A

L

D

D

K

K

A

A

K

K

M

N

Y

F

P

P

D

I

Q

Q

L

L

S

S

G

G

Q

E

K

Q

Q

Q

R

R

I

V

G

G

I

I

A

A

R

R

A

A

L

V

A

V

T

N

R

K

P

P

S

A

I

V

L

L

C

A

D

D

E

E

A

P

T

T

S

G

A

N

L

L

D

D

P

D

Q

A

T

L

T

S

D

E

S

G

I

I

L

L

K

R

L

L

L

F

Q

E

K

E

I

F

N

N

E

-

E

R

Y

V

N

G

I

V

T

T

I

V

L

L

L

M

I

A

T

T

H

H

E

D

M

I

S

N

V

L

V

I

R

S

E

R

I

R

C

S

N

Y

R

R

V

M

A

L

V

T

M

L

E

S

H

D

G

G

N

H

V

L

K41 (= K44) mutation to R: Does not bind ATP.
C49 (≠ N52) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

8w6iD Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
40% identity, 64% coverage: 1:219/340 of query aligns to 1:215/219 of 8w6iD

query
sites
8w6iD

M

M

I

I

E

R

F

F

K

E

G

H

L

V

E

S

K

K

T

A

F
x
Y

E

L

G

G

K

G

H

R

G

-

T

-

V

-

H

Q

A

A

L

L

K

Q

D

G

I

V

N

T

M

F

K

H

V

M

G

Q

K

P

G

G

E

E

I

M

Y

A

G

F

V

L

V

T

G

G

F

H

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

L

R

K

C

L

V

I

N

C

Y

G

L

I

E

E

Q

R

P

P

T

S

A

A

G

G

N

K

V

I

I

W

V

F

D

S

G

G

S

H

D

D

L

I

T

T

R

R

I

L

S

K

T

N

K

R

E

E

I

V

R

P

N

F

A

L

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q
|
Q

H

D

F

H

N

H

L

L

N

M

S

D

K

R

T

T

V

V

Y

Y

A

D

N

N

I

V

A

A

M

I

P

P

L

L

I

I

L

I

D

A

N

G

A

A

P

S

K

G

P

D

K

D

I

I

R

R

E

R

R

R

V

V

M

S

E

A

L

A

L

L

D

D

F

K

V

V

G

G

L

L

A

L

D

D

K
|
K

A

A

K

K

M

N

Y

F

P

P

D

I

Q
|
Q

L

L

S
|
S

G
|
G

Q
x
E

K

Q

Q

Q

R

R

I

V

G

G

I

I

A

A

R

R

A

A

L

V

A

V

T

N

R

K

P

P

S

A

I

V

L

L

C

A

D

D

E

E

A

P

T

T

S

G

A

N

L

L

D

D

P

D

Q

A

T

L

T

S

D

E

S

G

I

I

L

L

K

R

L

L

L

F

Q

E

K

E

I

F

N

N

E

-

E

R

Y

V

N

G

I

V

T

T

I

V

L

L

L

M

I

A

T

T

H
|
H

E

D

M

I

S

N

V

L

V

I

R

S

E

R

I

R

C

S

N

Y

R

R

V

M

A

L

V

T

M

L

E

S

H

D

G

G

N

H

V

L

binding phosphothiophosphoric acid-adenylate ester: Y11 (≠ F11), S37 (= S40), G38 (= G41), A39 (= A42), G40 (= G43), K41 (= K44), S42 (= S45), T43 (= T46), Q86 (= Q89), K130 (= K133), Q137 (= Q140), S139 (= S142), G140 (= G143), G141 (= G144), E142 (≠ Q145), H195 (= H199)

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
39% identity, 64% coverage: 1:219/340 of query aligns to 1:215/218 of 8hd0A

query
sites
8hd0A

M

M

I

I

E

R

F

F

K

E

G

H

L

V

E

S

K

K

T

A

F
x
Y

E

L

G

G

K

G

H
x
R

G

-

T

-

V

-

H

Q

A
|
A

L

L

K

Q

D

G

I

V

N

T

M

F

K

H

V

M

G

Q

K

P

G

G

E

E

I

M

Y

A

G

F

V

L

V

T

G

G

F

H

S

S

G

G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

L

R

K

C

L

V

I

N

C

Y

G

L

I

E

E

Q

R

P

P

T

S

A

A

G

G

N

K

V

I

I

W

V

F

D

S

G

G

S

H

D

D

L

I

T

T

R

R

I

L

S

K

T

N

K

R

E

E

I

V

R

P

N

F

A

L

K

R

K

Q

I

I

G

G

M

M

V

I

F

F

Q

Q

H

D

F

H

N

H

L

L

N

M

S

D

K

R

T

T

V

V

Y

Y

A

D

N

N

I

V

A

A

M

I

P

P

L

L

I

I

L

I

D

A

N

G

A

A

P

S

K

G

P

D

K

D

I

I

R

R

E

R

R

R

V

V

M

S

E

A

L

A

L

L

D

D

F

K

V

V

G

G

L

L

A

L

D

D

K

K

A

A

K

K

M

N

Y

F

P

P

D

I

Q

Q

L

L

S
|
S

G

G

G
|
G

Q

E

K

Q

Q

Q

R

R

I

V

G

G

I

I

A

A

R

R

A

A

L

V

A

V

T

N

R

K

P

P

S

A

I

V

L

L

C

A

D

D

E

Q

A

P

T

T

S

G

A

N

L

L

D

D

P

D

Q

A

T

L

T

S

D

E

S

G

I

I

L

L

K

R

L

L

L

F

Q

E

K

E

I

F

N

N

E

-

E

R

Y

V

N

G

I

V

T

T

I

V

L

L

L

M

I

A

T

T

H

H

E

D

M

I

S

N

V

L

V

I

R

S

E

R

I

R

C

S

N

Y

R

R

V

M

A

L

V

T

M

L

E

S

H

D

G

G

N

H

V

L

binding adenosine-5'-triphosphate: Y11 (≠ F11), R15 (≠ H15), A17 (= A20), G40 (= G43), K41 (= K44), S42 (= S45), T43 (= T46), S139 (= S142), G141 (= G144)

7ahhC Opua inhibited inward-facing, sbd docked (see paper)
37% identity, 71% coverage: 14:256/340 of query aligns to 35:279/382 of 7ahhC

query
sites
7ahhC

K

K

H

T

G

G

T

A

V
x
T

H
x
V

A
x
G

L

V

K

Y

D

D

I

T

N

N

M

F

K

E

V

I

G

N

K

E

G

G

E

E

I

I

Y

F

G

V

V

I

V

M

G

G

F

L

S

S

G
|
G

A

S

G
|
G

K
|
K

S

S

T

T

L

L

I

L

R

R

C

L

V

L

N

N

Y

R

L

L

E

I

Q

E

P

P

T

T

A

S

G

G

N

K

V

I

I

F

V

I

D

D

G

N

S

Q

D

D

L

V

T

A

R

T

I

L

S

N

T

K

K

E

E

D

I

L

R

L

N

Q

A

V

K

R

K

K

-

T

I

M

G

S

M

M

V

V

F

F

Q

Q

H

N

F

F

N

G

L

L

L

F

N

P

S

H

K

R

T

T

V

I

Y

L

A

E

N

N

I

T

A

E

M

Y

P

G

L

L

I

E

L

V

D

Q

N

N

A

V

P

P

K

K

P

E

K

E

I

R

R

R

E

K

R

R

V

A

M

E

E

K

L

A

L

L

D

D

F

N

V

A

G

N

L

L

A

L

D

D

K

F

A

K

K

D

M

Q

Y

Y

P

P

D

K

Q

Q

L

L

S

S

G

G

Q

M

K

Q

Q

Q

R

R

I

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

T

N

R

D

P

P

S

E

I

I

L

L

C

M

D
|
D

E
|
E

A

A

T

F

S

S

A

A

L

L

D

D

P

P

Q

L

T

I

T

R

D

R

S

E

I

M

L

Q

K

D

L

E

L

L

Q

L

K

E

I

L

N

Q

E

A

E

K

Y

F

N

Q

I

K

T

T

I

I

L

I

L

F

I

V

T

S

H

H

E

D

M

L

S

N

V

E

V

A

R

L

E

R

I

I

C

G

N

D

R

R

V

I

A

A

V

I

M

M

E

K

H

D

G

G

N

K

V

I

I

M

E

Q

E

I

G

G

T

T

V

G

F

E

E

E

I

I

F

L

S

T

N

N

P

P

Q

A

T

N

V

D

T

Y

G

V

R

K

N

T

F

F

V

V

-

E

N

D

T

T

V

A

M

E

H

N

T

I

E

M

I

I

P

P

K

A

Y
x
L

V

T

T

T

D

N

M

I

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: L275 (≠ Y252)
binding phosphoaminophosphonic acid-adenylate ester: T39 (≠ V18), V40 (≠ H19), G41 (≠ A20), G62 (= G41), G64 (= G43), K65 (= K44), D187 (= D165), E188 (= E166)

Sites not aligning to the query:

7aheC Opua inhibited inward facing (see paper)
37% identity, 71% coverage: 14:256/340 of query aligns to 35:279/382 of 7aheC

query
sites
7aheC

K

K

H

T

G

G

T

A

V

T

H

V

A

G

L

V

K

Y

D

D

I

T

N

N

M

F

K

E

V

I

G

N

K

E

G

G

E

E

I

I

Y

F

G

V

V

I

V

M

G

G

F

L

S

S

G

G

A

S

G

G

K

K

S

S

T

T

L

L

I

L

R

R

C

L

V

L

N

N

Y

R

L

L

E

I

Q

E

P

P

T

T

A

S

G

G

N

K

V

I

I

F

V

I

D

D

G

N

S

Q

D

D

L

V

T

A

R

T

I

L

S

N

T

K

K

E

E

D

I

L

R

L

N

Q

A

V

K

R

K

K

-

T

I

M

G

S

M

M

V

V

F

F

Q

Q

H

N

F

F

N

G

L

L

L

F

N

P

S

H

K

R

T

T

V

I

Y

L

A

E

N

N

I

T

A

E

M

Y

P

G

L

L

I

E

L

V

D

Q

N

N

A

V

P

P

K

K

P

E

K

E

I

R

R

R

E

K

R

R

V

A

M

E

E

K

L

A

L

L

D

D

F

N

V

A

G

N

L

L

A

L

D

D

K

F

A

K

K

D

M

Q

Y

Y

P

P

D

K

Q

Q

L

L

S

S

G

G

Q

M

K

Q

Q

Q

R

R

I

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

T

N

R

D

P

P

S

E

I

I

L

L

C

M

D

D

E

E

A

A

T

F

S

S

A

A

L

L

D

D

P

P

Q

L

T

I

T

R

D

R

S

E

I

M

L

Q

K

D

L

E

L

L

Q

L

K

E

I

L

N

Q

E

A

E

K

Y

F

N

Q

I

K

T

T

I

I

L

I

L

F

I

V

T

S

H

H

E

D

M

L

S

N

V

E

V

A

R

L

E

R

I

I

C

G

N

D

R

R

V

I

A

A

V

I

M

M

E

K

H

D

G

G

N

K

V

I

I

M

E

Q

E

I

G

G

T

T

V

G

F

E

E

E

I

I

F

L

S

T

N

N

P

P

Q

A

T

N

V

D

T

Y

G

V

R

K

N

T

F

F

V

V

-

E

N

D

T

T

V

A

M

E

H

N

T

I

E

M

I

I

P

P

K

A

Y
x
L

V

T

T

T

D

N

M

I

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: L275 (≠ Y252)

Sites not aligning to the query:

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: 297, 298

8i6rB Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
38% identity, 65% coverage: 1:222/340 of query aligns to 1:218/222 of 8i6rB

query
sites
8i6rB

M

M

I

I

E

R

F

F

K

E

G

Q

L

V

E

G

K

K

T

R

F
x
Y

E

P

G

N

K

G

H
|
H

G

V

T

G

V

L

H

H

A

-

L

-

K

-

D

E

I

V

N

S

M

F

K

R

V

V

G

H

K

R

G

G

E

E

I

I

Y

L

G

F

V

V

V

T

G

G

F

H

S
|
S

G

G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

L

R

R

C

L

V

I

N

L

Y

A

L

M

E

E

Q

R

P

P

T

T

A

S

G

G

N

K

V

L

I

L

V

L

D

G

G

G

S

Q

D

D

L

L

T

G

R

R

I

I

S

T

T

T

K

A

E

Q

I

I

R

P

N

F

A

L

K

R

K

Q

I

I

G

G

M

V

V

V

F

F

Q

Q

H

N

F

H

N

Q

L

L

N

T

S

D

K

R

T

T

V

V

Y

A

A

D

N

N

I

I

A

A

M

L

P

P

L

L

I

Q

L

I

D

L

N

G

A

M

P

P

K

K

P

P

K

E

I

I

R

A

E

K

R

R

V

V

M

A

E

S

L

A

L

L

D

E

F

R

V

V

G

N

L

L

A

K

D

E

K

K

A

G

K

E

M

A

Y

L

P

P

D

S

Q
x
D

L

L

S
|
S

G
x
T

G
|
G

Q
|
Q

K

Q

Q

Q

R

R

I

V

G

G

I

I

A

A

R

R

A

A

L

I

A

V

T

H

R

Q

P

P

S

A

I

L

L

L

C

A

D

D

E

Q

A

P

T

T

S

G

A

N

L

L

D

D

P

P

Q

R

T

L

T

A

D

S

S

E

I

I

L

M

K

G

L

V

L

F

Q

E

K

D

I

I

N

N

E

-

E

R

Y

L

N

G

I

T

T

T

I

V

L

L

L

I

I

A

T

S

H

H

E

D

M

L

S

A

V

L

V

I

R

A

E

R

I

M

C

R

N

H

R

R

V

M

A

L

V

T

M

L

E

Q

H

R

G

G

N

R

V

I

I

I

E

A

E

D

binding adenosine-5'-triphosphate: Y11 (≠ F11), H15 (= H15), S37 (= S40), A39 (= A42), G40 (= G43), K41 (= K44), S42 (= S45), T43 (= T46), D137 (≠ Q140), S139 (= S142), T140 (≠ G143), G141 (= G144), Q142 (= Q145)
binding magnesium ion: K41 (= K44), S42 (= S45)

7ahdC Opua (e190q) occluded (see paper)
38% identity, 64% coverage: 14:232/340 of query aligns to 35:254/260 of 7ahdC

query
sites
7ahdC

K

K

H

T

G

G

T

A

V
x
T

H

V

A

G

L

V

K

Y

D

D

I

T

N

N

M

F

K

E

V

I

G

N

K

E

G

G

E

E

I

I

Y

F

G

V

V

I

V

M

G

G

F

L

S
|
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

L

R

R

C

L

V

L

N

N

Y

R

L

L

E

I

Q

E

P

P

T

T

A

S

G

G

N

K

V

I

I

F

V

I

D

D

G

N

S

Q

D

D

L

V

T

A

R

T

I

L

S

N

T

K

K

E

E

D

I

L

R

L

N

Q

A

V

K

R

K

K

-

T

I

M

G

S

M

M

V

V

F

F

Q
|
Q

H

N

F

F

N

G

L

L

L

F

N

P

S

H

K

R

T

T

V

I

Y

L

A

E

N

N

I

T

A

E

M

Y

P

G

L

L

I

E

L

V

D

Q

N

N

A

V

P

P

K

K

P

E

K

E

I

R

R

R

E

K

R

R

V

A

M

E

E

K

L

A

L

L

D

D

F

N

V

A

G

N

L

L

A

L

D

D

K

F

A

K

K

D

M

Q

Y

Y

P

P

D
x
K

Q
|
Q

L

L

S
|
S

G

G

G
|
G

Q
x
M

K

Q

Q

Q

R

R

I

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

T

N

R

D

P

P

S

E

I

I

L

L

C

M

D

D

E
x
Q

A

A

T

F

S

S

A

A

L

L

D

D

P

P

Q

L

T

I

T

R

D

R

S

E

I

M

L

Q

K

D

L

E

L

L

Q

L

K

E

I

L

N

Q

E

A

E

K

Y

F

N

Q

I

K

T

T

I

I

L

I

L

F

I

V

T

S

H
|
H

E

D

M

L

S

N

V

E

V

A

R

L

E

R

I

I

C

G

N

D

R

R

V

I

A

A

V

I

M

M

E

K

H

D

G

G

N

K

V

I

I

M

E

Q

E

I

G

G

T

T

V

G

F

E

E

E

I

I

F

L

S

T

N

N

P

P

binding adenosine-5'-triphosphate: T39 (≠ V18), S61 (= S40), G62 (= G41), G64 (= G43), K65 (= K44), S66 (= S45), T67 (= T46), Q111 (= Q89), K161 (≠ D139), Q162 (= Q140), S164 (= S142), G166 (= G144), M167 (≠ Q145), Q188 (≠ E166), H221 (= H199)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12

8tzjA Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
40% identity, 60% coverage: 1:204/340 of query aligns to 2:201/220 of 8tzjA

query
sites
8tzjA

M

V

I

I

E

R

F

F

K

Q

G

Q

L

V

E

S

K

K

T

A

F
x
Y

E

R

G

G

K

G

H
x
R

G

-

T

-

V

-

H

Q

A
|
A

L

L

K

Q

D

K

I

V

N

D

M

F

K

H