SitesBLAST

4gnrA 1.0 angstrom resolution crystal structure of the branched-chain amino acid transporter substrate binding protein livj from streptococcus pneumoniae str. Canada mdr_19a in complex with isoleucine
25% identity, 86% coverage: 39:393/411 of query aligns to 3:333/348 of 4gnrA

query
sites
4gnrA

L

I

Q

K

F

I

G

G

F

F

V

N

F

F

P

E

Q

E

T

S

G

G

D

S

L

L

A

A

H

A

L
x
Y

G

G

P

T

P

A

Q

E

E

Q

S

K

A

G

A

A

K

Q

Y

L

A

A

L

V

Q

D

E

E

I

I

N

N

A

A

G

G

V

I

N

D

G

G

A

K

E

Q

L

I

P

-

D

E

F

V

L

V

E

D

G

K

D

D

E

N

A

K

N

S

D

E

A

T

A

A

Q

E

A

A

N

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D

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A

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A

T

Q

T

R

N

H

L

V

V

D

T

Q

Q

G

S

-

K

A

V

D

S

I

A

I

V

L

V

G

G

A

P

A
|
A

A
x
T

S
|
S

G

G

M

A

T

T

Q

A

A

A

I

A

M

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D

A

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N

V

A

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K

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E

G

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S

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x
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T

A

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D

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G

L

L

A

T

E

K

E

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Q

E

D

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-

G

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Y

Y

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D

D

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Y

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A

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K

A

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Y

-

T

-

D

R

N

A

A

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D

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Y
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Y

G

A

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K

G

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I

A

A

N

K

A

S

A

F

A

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D

E

A

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L

Y

E

K

E

G

N

-

G

-

I

-

E

E

V

I

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Y

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D

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E

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T

Y

F

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D

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D

D

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A

A

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-

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x
Y

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Y

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Y

D

D

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N

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D

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P

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T

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E

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-

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K

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M

binding isoleucine: Y18 (≠ L54), A78 (= A114), T79 (≠ A115), S80 (= S116), S101 (= S137), A102 (≠ N138), T103 (= T139), Y151 (= Y187), Y200 (≠ S238), D224 (= D263), F277 (= F313)

3ip9A Structure of atu2422-gaba receptor in complex with gaba (see paper)
27% identity, 50% coverage: 46:250/411 of query aligns to 10:209/348 of 3ip9A

query
sites
3ip9A

P

P

Q

L

T

T

G

G

D

P

L

N

A

A

H

A

L

F

G

G

P

A

P

Q

Q

I

E

Q

S

K

A

G

A

A

K

E

Y

Q

A

A

L

A

Q

K

E

D

I

I

N

N

A

A

G

G

V

I

N

N

G

G

A

E

E

Q

L

I

P

K

D

I

F

V

L

L

E

-

G

G

D

D

E

D

A

V

N

S

D

D

A

P

A

K

Q

Q

A

G

N

I

D

S

A

V

A

A

Q

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R

K

H

F

V

V

D

A

Q

D

G

G

A

V

D

K

I

F

I

V

L

V

G

G

A

H

A

F

A
x
N

S
|
S

G

G

M

V

T

S

Q

I

A

P

I

A

M

S

D

E

T

V

V

Y

T

A

S

E

N

N

E

G

V

I

V

L

Q

E

C

I

S

T

G

P

S
x
A

N
x
A

T
|
T

A

N

P

P

G

V

L

F

A

T

E

E

E

R

D

G

E

L

T

W

G

N

Y

T

Y

F

W

-

R

R

T

T

A

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G

S

R

D

D

L

D

L

Q

Q

Q

G

G

P

G

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I

L

A

A

G

E

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K

Y

I

L

A

A

S

D

D

H

G

F

H

K

Q

D

S

A

-

K

V

V

A

A

V

I

T

I

Y

H

R

D

A

K

D

T

D

P

Y
|
Y

G

G

E

Q

G

G

L

L

A

A

N

D

A

E

A

T

A

K

D

K

A

A

L

A

E

N

E

A

N

A

G

G

I

V

E

T

V

E

V

V

Y

M

N

Y

E

E

G

G

Y

V

D

N

P

V

N

G

A

D

P

K

N

D

F

F

D

S

A

A

V

L

V

I

N

S

E

K

L

M

A

-

G

-

A

-

E

-

A

K

D

E

A

A

A

G

L

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M

S

V

I

S

I

F

Y

E

W

E

G

G

G

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L

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T

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E

T

A

G

G

L

L

I

I

binding gamma-amino-butanoic acid: N78 (≠ A115), S79 (= S116), A100 (≠ S137), A101 (≠ N138), T102 (= T139), Y150 (= Y187)

Sites not aligning to the query:

binding gamma-amino-butanoic acid: 226, 275

3ip7A Structure of atu2422-gaba receptor in complex with valine (see paper)
27% identity, 50% coverage: 46:250/411 of query aligns to 10:209/348 of 3ip7A

query
sites
3ip7A

P

P

Q

L

T

T

G

G

D

P

L

N

A

A

H

A

L

F

G

G

P

A

P

Q

Q

I

E

Q

S

K

A

G

A

A

K

E

Y

Q

A

A

L

A

Q

K

E

D

I

I

N

N

A

A

G

G

V

I

N

N

G

G

A

E

E

Q

L

I

P

K

D

I

F

V

L

L

E

-

G

G

D

D

E

D

A

V

N

S

D

D

A

P

A

K

Q

Q

A

G

N

I

D

S

A

V

A

A

Q

N

R

K

H

F

V

V

D

A

Q

D

G

G

A

V

D

K

I

F

I

V

L

V

G

G

A

H

A
x
F

A
x
N

S
|
S

G
|
G

M

V

T

S

Q

I

A

P

I

A

M

S

D

E

T

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V

Y

T

A

S

E

N

N

E

G

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V

L

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E

C

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S

T

G

P

S
x
A

N
x
A

T
|
T

A

N

P

P

G

V

L

F

A

T

E

E

E

R

D

G

E

L

T

W

G

N

Y

T

Y

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-

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R

T

T

A

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S

R

D

D

L

D

L

Q

Q

Q

G

G

P

G

V

I

L

A

A

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E

K

K

Y

I

L

A

A

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D

D

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G

F

H

K

Q

D

S

A

-

K

V

V

A

A

V

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T

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Y

H

R

D

A

K

D
x
T

D
x
P

Y
|
Y

G

G

E

Q

G

G

L

L

A

A

N

D

A

E

A

T

A

K

D

K

A

A

L

A

E

N

E

A

N

A

G

G

I

V

E

T

V

E

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Y

M

N

Y

E

E

G

G

Y

V

D

N

P

V

N

G

A

D

P

K

N

D

F

F

D

S

A

A

V

L

V

I

N

S

E

K

L

M

A

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G

-

A

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E

-

A

K

D

E

A

A

A

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M

S

V

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S

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F

Y

E

W

E

G

G

G

V

L

Q

H

I

T

I

E

T

A

G

G

L

L

I

I

binding calcium ion: S79 (= S116), G80 (= G117), T148 (≠ D185), P149 (≠ D186), Y150 (= Y187)
binding valine: F77 (≠ A114), N78 (≠ A115), S79 (= S116), A100 (≠ S137), A101 (≠ N138), T102 (= T139), Y150 (= Y187)

Sites not aligning to the query:

3ip6A Structure of atu2422-gaba receptor in complex with proline (see paper)
27% identity, 50% coverage: 46:250/411 of query aligns to 10:209/348 of 3ip6A

query
sites
3ip6A

P

P

Q

L

T

T

G

G

D

P

L

N

A

A

H

A

L

F

G

G

P

A

P

Q

Q

I

E

Q

S

K

A

G

A

A

K

E

Y

Q

A

A

L

A

Q

K

E

D

I

I

N

N

A

A

G

G

V

I

N

N

G

G

A

E

E

Q

L

I

P

K

D

I

F

V

L

L

E

-

G

G

D

D

E

D

A

V

N

S

D

D

A

P

A

K

Q

Q

A

G

N

I

D

S

A

V

A

A

Q

N

R

K

H

F

V

V

D

A

Q

D

G

G

A

V

D

K

I

F

I

V

L

V

G

G

A

H

A
x
F

A
x
N

S
|
S

G

G

M

V

T

S

Q

I

A

P

I

A

M

S

D

E

T

V

V

Y

T

A

S

E

N

N

E

G

V

I

V

L

Q

E

C

I

S

T

G

P

S
x
A

N
x
A

T
|
T

A

N

P

P

G

V

L

F

A

T

E

E

E

R

D

G

E

L

T

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G

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Y

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W

-

R

R

T

T

A

C

P

G

S

R

D

D

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D

L

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Q

Q

G

G

P

G

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I

L

A

A

G

E

K

K

Y

I

L

A

A

S

D

D

H

G

F

H

K

Q

D

S

A

-

K

V

V

A

A

V

I

T

I

Y

H

R

D

A

K

D

T

D

P

Y
|
Y

G

G

E

Q

G

G

L

L

A

A

N

D

A

E

A

T

A

K

D

K

A

A

L

A

E

N

E

A

N

A

G

G

I

V

E

T

V

E

V

V

Y

M

N

Y

E

E

G

G

Y

V

D

N

P

V

N

G

A

D

P

K

N

D

F

F

D

S

A

A

V

L

V

I

N

S

E

K

L

M

A

-

G

-

A

-

E

-

A

K

D

E

A

A

A

G

L

V

M

S

V

I

S

I

F

Y

E

W

E

G

G

G

V

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Q

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T

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I

binding proline: F77 (≠ A114), N78 (≠ A115), S79 (= S116), A100 (≠ S137), A101 (≠ N138), T102 (= T139), Y150 (= Y187)

Sites not aligning to the query:

binding proline: 226, 275

3ip5A Structure of atu2422-gaba receptor in complex with alanine (see paper)
27% identity, 50% coverage: 46:250/411 of query aligns to 10:209/348 of 3ip5A

query
sites
3ip5A

P

P

Q

L

T

T

G

G

D

P

L

N

A

A

H

A

L

F

G

G

P

A

P

Q

Q

I

E

Q

S

K

A

G

A

A

K

E

Y

Q

A

A

L

A

Q

K

E

D

I

I

N

N

A

A

G

G

V

I

N

N

G

G

A

E

E

Q

L

I

P

K

D

I

F

V

L

L

E

-

G

G

D

D

E

D

A

V

N

S

D

D

A

P

A

K

Q

Q

A

G

N

I

D

S

A

V

A

A

Q

N

R

K

H

F

V

V

D

A

Q

D

G

G

A

V

D

K

I

F

I

V

L

V

G

G

A

H

A
x
F

A
x
N

S
|
S

G

G

M

V

T

S

Q

I

A

P

I

A

M

S

D

E

T

V

V

Y

T

A

S

E

N

N

E

G

V

I

V

L

Q

E

C

I

S

T

G

P

S
x
A

N
x
A

T
|
T

A

N

P

P

G

V

L

F

A

T

E

E

E

R

D

G

E

L

T

W

G

N

Y

T

Y

F

W

-

R

R

T

T

A

C

P

G

S

R

D

D

L

D

L

Q

Q

Q

G

G

P

G

V

I

L

A

A

G

E

K

K

Y

I

L

A

A

S

D

D

H

G

F

H

K

Q

D

S

A

-

K

V

V

A

A

V

I

T

I

Y

H

R

D

A

K

D

T

D

P

Y
|
Y

G

G

E

Q

G

G

L

L

A

A

N

D

A

E

A

T

A

K

D

K

A

A

L

A

E

N

E

A

N

A

G

G

I

V

E

T

V

E

V

V

Y

M

N

Y

E

E

G

G

Y

V

D

N

P

V

N

G

A

D

P

K

N

D

F

F

D

S

A

A

V

L

V

I

N

S

E

K

L

M

A

-

G

-

A

-

E

-

A

K

D

E

A

A

A

G

L

V

M

S

V

I

S

I

F

Y

E

W

E

G

G

G

V

L

Q

H

I

T

I

E

T

A

G

G

L

L

I

I

binding alanine: F77 (≠ A114), N78 (≠ A115), S79 (= S116), A100 (≠ S137), A101 (≠ N138), T102 (= T139), Y150 (= Y187)

Sites not aligning to the query:

binding alanine: 226

4mlcA Abc transporter substrate-binding protein fromdesulfitobacterium hafniense
28% identity, 39% coverage: 65:225/411 of query aligns to 25:184/336 of 4mlcA

query
sites
4mlcA

A

A

L

V

Q

Q

E

E

I

I

N

N

A

E

A

Q

G

G

V

V

N

Q

G

G

A

R

E

K

L

L

P

-

D

S

F

L

L

V

E

K

G

A

D

D

E

D

A

E

N

A

D

E

A

L

A

E

Q

K

A

G

N

L

D

A

A

I

A

A

Q

Q

R

A

H

F

V

A

D

D

Q

N

-

A

G

G

A

I

D

Q

I

A

I

V

L

I

G

G

A

H

A

R

A

N

S

S

G

F

M

I

T

S

Q

I

A

P

I

A

M

A

D

S

T

I

V

Y

T

D

S

Q

N

A

E

G

V

L

V

V

Q

M

C

L

S

S

G

P

S

A

N

S

T

T

A

S

P

P

G

D

L

L

A

T

E

D

E

H

D

G

E

Y

T

I

G

-

Y

H

Y

V

W

F

R

R

T

N

A

I

P

P

S

S

D

D

L

Q

L

E

Q

I

G

A

P

R

V

Q

L

L

A

A

E

I

K

Y

I

L

A

A

S

E

D

Q

G

G

H

H

Q
x
E

S

R

V

M

A

V

V

I

T

Y

Y

Y

R

T

A

D

D

D

D

S

Y

Y

G

G

E

N

G

G

L

L

A

A

N

N

A

A

A

F

A

E

D

D

A

Y

L

A

E

R

E

A

N

Q

G
|
G

I

I

E

T

V

I

V

V

Y

D

N

R

E

F

G

N

Y

Y

D

Y

P

G

N

N

A

L

P

K

N

D

F

L

D

E

A

R

V

L

V

Y

N

D

E

K

binding calcium ion: E135 (≠ Q176), G162 (= G203)

4q6bA Crystal structure of abc transporter substrate-binding protein fromdesulfitobacterium hafniense complex with leu
28% identity, 39% coverage: 65:225/411 of query aligns to 25:184/335 of 4q6bA

query
sites
4q6bA

A

A

L

V

Q

Q

E

E

I

I

N

N

A

E

A

Q

G

G

V

V

N

Q

G

G

A

R

E

K

L

L

P

-

D

S

F

L

L

V

E

K

G

A

D

D

E

D

A

E

N

A

D

E

A

L

A

E

Q

K

A

G

N

L

D

A

A

I

A

A

Q

Q

R

A

H

F

V

A

D

D

Q

N

-

A

G

G

A

I

D

Q

I

A

I

V

L

I

G

G

A

H

A
x
R

A
x
N

S
|
S

G

F

M

I

T

S

Q

I

A

P

I

A

M

A

D

S

T

I

V

Y

T

D

S

Q

N

A

E

G

V

L

V

V

Q

M

C

L

S

S

G

P

S
x
A

N
x
S

T
|
T

A

S

P

P

G

D

L

L

A

T

E

D

E

H

D

G

E

Y

T

I

G

-

Y

H

Y

V

W

F

R

R

T

N

A

I

P

P

S

S

D

D

L

Q

L

E

Q

I

G

A

P

R

V

Q

L

L

A

A

E

I

K

Y

I

L

A

A

S

E

D

Q

G

G

H

H

Q

E

S

R

V

M

A

V

V

I

T

Y

Y

Y

R

T

A

D

D

D

D

S

Y

Y

G

G

E

N

G

G

L

L

A

A

N

N

A

A

A

F

A

E

D

D

A

Y

L

A

E

R

E

A

N

Q

G

G

I

I

E

T

V

I

V

V

Y
x
D

N
x
R

E

F

G

N

Y

Y

D

Y

P

G

N

N

A

L

P

K

N

D

F

L

D

E

A

R

V

L

V

Y

N

D

E

K

binding calcium ion: D167 (≠ Y208), R168 (≠ N209)
binding leucine: R74 (≠ A114), N75 (≠ A115), S76 (= S116), A97 (≠ S137), S98 (≠ N138), T99 (= T139)

Sites not aligning to the query:

binding leucine: 266

Q9Z0U4 Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1 from Rattus norvegicus (Rat) (see 6 papers)
21% identity, 46% coverage: 29:217/411 of query aligns to 159:349/960 of Q9Z0U4

query
sites
Q9Z0U4

N
|
N

G
x
R

G
x
T

G
x
P

G
x
H

G

S

E

E

G

R

D

R

A

A

L

V

Q

Y

F

I

G

G

F

A

V

L

F

F

P

P

Q

M

T

S

G

G

D

G

L

W

A

P

H

G

L

-

G

G

P

Q

P

A

Q

C

E

Q

S

P

A

A

A

V

K

E

Y

M

A

A

L

L

Q

E

E

D

I

V

N

N

A

S

A

R

G

R

G

D

V

I

N

-

G

-

A

-

E

-

L

L

P

P

D

D

F

Y

-

E

-

L

-

K

-

L

L

I

E

H

G

H

D

D

E

S

A

K

N

C

D

D

A

P

A

G

Q

Q

A

A

N

T

D

K

A

Y

A

L

Q

Y

R

E

H

L

V

L

-

Y

D

N

Q

D

G

P

A

I

D

K

I

I

L

L

G

M

A

P

A

G

A

C

S

S

G
x
S

M

V

T

S

Q

T

A

L

I

V

M

A

D

E

T

A

V

A

T

R

S

M

N

W

E

N

V

L

V

I

Q

V

C

L

S

S

G

Y

S

G

N
x
S

T
x
S

A

S

P

P

G

A

L

L

A

S

E

N

E

R

D

Q

E

R

T

F

G

P

Y

T

Y

F

W

F

R

R

T

T

A

H

P

P

S

S

D

A

L

T

L

L

Q

H

G

N

P

P

V

T

L

R

A

V

E

K

K

L

I

F

A

E

S

K

D

W

G

G

H

W

Q

K

S

K

V

I

A

A

V

T

T

I

Y

Q

R

Q

A

T

D

T

D

E

Y

V

G

F

E

T

G

S

L

T

A

L

N

D

A

D

A

L

A

E

D

E

A

R

L

V

E

K

E

E

N

A

G

G

I

I

E

E

V

I

V

T

Y

F

N

R

E

Q

G

S

Y

F

-

F

-

S

D

D

P

P

N

A

A

V

P

P

S247 (≠ G117) mutation to A: No change in the affinity for GABA.
S268 (≠ N138) mutation to A: No change in the affinity for GABA.
S269 (≠ T139) mutation to A: Decrease in the affinity for GABA.

Sites not aligning to the query:

1:163 modified: Variant sequence, MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPH -> MGPGGPCTPVGWPLPLLLVMAAGVAPVWASHSPHLPRPHPRVPPHPS (in isoform 1B, isoform 1C and isoform 1D)
99 modified: Disulfide link with 144
130 modified: Disulfide link with 156
144 modified: Disulfide link with 99
156 modified: Disulfide link with 130
770 modified: Variant sequence, G -> GELWSFAVSSDVQRRATVGGDSPICVWPAPES (in isoform 1C and isoform 1E)
887:915 Interaction with ATF4
904:928 modified: Variant sequence, KEERVSELRHQLQSRQQLRSRRHPP -> VCGDKQPGPPVSEGGLPVVGPSIEV (in isoform 1D)
929:960 modified: Variant sequence, Missing (in isoform 1D)

6wivA Structure of human gaba(b) receptor in an inactive state (see paper)
21% identity, 45% coverage: 34:217/411 of query aligns to 1:186/681 of 6wivA

query
sites
6wivA

G

S

E

E

G

R

D

R

A

A

L

V

Q

Y

F

I

G

G

F

A

V

L

F

F

P

P

Q

M

T

S

G

G

D

G

L

W

A

P

H

G

L

-

G

G

P

Q

P

A

Q

C

E

Q

S

P

A

A

A

V

K

E

Y

M

A

A

L

L

Q

E

E

D

I

V

N

N

A

S

A

R

G

R

G

D

V

I

N

-

G

-

A

-

E

-

L

L

P

P

D

D

F

Y

-

E

-

L

-

K

-

L

L

I

E

H

G

H

D

D

E

S

A

K

N

C

D

D

A

P

A

G

Q

Q

A

A

N

T

D

K

A

Y

A

L

Q

Y

R

E

H

L

V

L

-

Y

D

N

Q

D

G

P

A

I

D

K

I

I

L

L

G

M

A

P

A

G

A

C

S

S

G

S

M

V

T

S

Q

T

A

L

I

V

M

A

D

E

T

A

V

A

T

R

S

M

N

W

E

N

V

L

V

I

Q

V

C

L

S

S

G

Y

S

G

N

S

T

S

A

S

P

P

G

A

L

L

A

S

E

N

E

R

D

Q

E

R

T

F

G

P

Y

T

Y

F

W

F

R

R

T

T

A

H

P

P

S

S

D

A

L

T

L

L

Q

H

G

N

P

P

V

T

L

R

A

V

E

K

K

L

I

F

A

E

S

K

D

W

G

G

H

W

Q

K

S

K

V

I

A

A

V

T

T

I

Y

Q

R

Q

A

T

D

T

D

E

Y

V

G

F

E

T

G

S

L

T

A

L

N

D

A

D

A

L

A

E

D

E

A

R

L

V

E

K

E

E

N

A

G

G

I

I

E

E

V

I

V

T

Y

F

N

R

E

Q

G

S

Y

F

-

F

-

S

D

D

P

P

N

A

A

V

P

P

Sites not aligning to the query:

binding cholesterol: 530, 533, 534, 585, 588, 589, 593, 599, 603, 606, 606, 631
binding (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate: 465, 494, 498, 502, 505, 577, 591, 594, 633, 637, 658, 665

4mqfA Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist 2-hydroxysaclofen (see paper)
21% identity, 45% coverage: 34:217/411 of query aligns to 1:186/406 of 4mqfA

query
sites
4mqfA

G

S

E

E

G

R

D

R

A

A

L

V

Q

Y

F

I

G

G

F

A

V

L

F

F

P

P

Q

M

T

S

G

G

D

G

L
x
W

A

P

H

G

L

-

G

G

P

Q

P

A

Q

C

E

Q

S

P

A

A

A

V

K

E

Y

M

A

A

L

L

Q

E

E

D

I

V

N

N

A

S

A

R

G

R

G

D

V

I

N

-

G

-

A

-

E

-

L

L

P

P

D

D

F

Y

-

E

-

L

-

K

-

L

L

I

E

H

G

H

D

D

E

S

A

K

N

C

D

D

A

P

A

G

Q

Q

A

A

N

T

D

K

A

Y

A

L

Q

Y

R

E

H

L

V

L

-

Y

D

N

Q

D

G

P

A

I

D

K

I

I

L

L

G

M

A

P

A

G

A
x
C

S
|
S

G

S

M

V

T

S

Q

T

A

L

I

V

M

A

D

E

T

A

V

A

T

R

S

M

N

W

E

N

V

L

V

I

Q

V

C

L

S

S

G

Y

S
x
G

N

S

T
x
S

A

S

P

P

G

A

L

L

A

S

E

N

E

R

D

Q

E

R

T

F

G

P

Y

T

Y

F

W

F

R

R

T

T

A
x
H

P

P

S

S

D

A

L

T

L

L

Q

H

G

N

P

P

V

T

L

R

A

V

E

K

K

L

I

F

A

E

S

K

D

W

G

G

H

W

Q

K

S

K

V

I

A

A

V

T

T

I

Y

Q

R

Q

A

T

D

T

D

E

Y

V

G

F

E

T

G

S

L

T

A

L

N

D

A

D

A

L

A

E

D

E

A

R

L

V

E

K

E

E

N

A

G

G

I

I

E

E

V

I

V

T

Y

F

N

R

E

Q

G

S

Y

F

-

F

-

S

D

D

P

P

N

A

A

V

P

P

binding 2-hydroxysaclofen: W18 (≠ L51), C82 (≠ A115), S83 (= S116), G104 (≠ S137), S106 (≠ T139), H123 (≠ A156)

Sites not aligning to the query:

binding 2-hydroxysaclofen: 231, 302

6w2xA Cryoem structure of inactive gabab heterodimer (see paper)
21% identity, 45% coverage: 35:217/411 of query aligns to 1:185/676 of 6w2xA

query
sites
6w2xA

E

E

G

R

D

R

A

A

L

V

Q

Y

F

I

G

G

F

A

V

L

F

F

P

P

Q

M

T

S

G

G

D
x
G

L

W

A

P

H

G

L

-

G

G

P

Q

P

A

Q

C

E

Q

S

P

A

A

A

V

K

E

Y

M

A

A

L

L

Q

E

E

D

I

V

N

N

A

S

A

R

G

R

G

D

V

I

N

-

G

-

A

-

E

-

L

L

P

P

D

D

F

Y

-

E

-

L

-

K

-

L

L

I

E

H

G

H

D

D

E

S

A

K

N

C

D

D

A

P

A

G

Q

Q

A

A

N

T

D

K

A

Y

A

L

Q

Y

R

E

H

L

V

L

-

Y

D

N

Q

D

G

P

A

I

D

K

I

I

L

L

G

M

A

P

A

G

A

C

S
|
S

G

S

M

V

T

S

Q

T

A

L

I

V

M

A

D

E

T

A

V

A

T

R

S

M

N

W

E

N

V

L

V

I

Q

V

C

L

S

S

G

Y

S
x
G

N

S

T
x
S

A

S

P

P

G

A

L

L

A

S

E

N

E

R

D

Q

E

R

T

F

G

P

Y

T

Y

F

W

F

R

R

T

T

A
x
H

P

P

S

S

D

A

L

T

L

L

Q

H

G

N

P

P

V

T

L

R

A

V

E

K

K

L

I

F

A

E

S

K

D

W

G

G

H

W

Q

K

S

K

V

I

A

A

V

T

T

I

Y

Q

R

Q

A

T

D

T

D

E

Y

V

G

F

E

T

G

S

L

T

A

L

N

D

A

D

A

L

A

E

D

E

A

R

L

V

E

K

E

E

N

A

G

G

I

I

E

E

V

I

V

T

Y

F

N

R

E

Q

G

S

Y

F

-

F

-

S

D

D

P

P

N

A

A

V

P

P

binding [(2~{S})-3-[[(1~{S})-1-(3,4-dichlorophenyl)ethyl]amino]-2-oxidanyl-propyl]-(phenylmethyl)phosphinic acid: G16 (≠ D50), S82 (= S116), G103 (≠ S137), S105 (≠ T139), H122 (≠ A156)

Sites not aligning to the query:

4ms1A Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist cgp46381 (see paper)
21% identity, 45% coverage: 34:217/411 of query aligns to 1:186/407 of 4ms1A

query
sites
4ms1A

G

S

E

E

G

R

D

R

A

A

L

V

Q

Y

F

I

G

G

F

A

V

L

F

F

P

P

Q

M

T

S

G

G

D
x
G

L
x
W

A

P

H

G

L

-

G

G

P

Q

P

A

Q

C

E

Q

S

P

A

A

A

V

K

E

Y

M

A

A

L

L

Q

E

E

D

I

V

N

N

A

S

A

R

G

R

G

D

V

I

N

-

G

-

A

-

E

-

L

L

P

P

D

D

F

Y

-

E

-

L

-

K

-

L

L

I

E

H

G

H

D

D

E

S

A

K

N

C

D

D

A

P

A

G

Q

Q

A

A

N

T

D

K

A

Y

A

L

Q

Y

R

E

H

L

V

L

-

Y

D

N

Q

D

G

P

A

I

D

K

I

I

L

L

G

M

A

P

A

G

A
x
C

S
|
S

G

S

M

V

T

S

Q

T

A

L

I

V

M

A

D

E

T

A

V

A

T

R

S

M

N

W

E

N

V

L

V

I

Q

V

C

L

S

S

G

Y

S
x
G

N

S

T
x
S

A

S

P

P

G

A

L

L

A

S

E

N

E

R

D

Q

E

R

T

F

G

P

Y

T

Y

F

W

F

R

R

T

T

A
x
H

P

P

S

S

D

A

L

T

L

L

Q

H

G

N

P

P

V

T

L

R

A

V

E

K

K

L

I

F

A

E

S

K

D

W

G

G

H

W

Q

K

S

K

V

I

A

A

V

T

T

I

Y

Q

R

Q

A

T

D

T

D

E

Y

V

G

F

E

T

G

S

L

T

A

L

N

D

A

D

A

L

A

E

D

E

A

R

L

V

E

K

E

E

N

A

G

G

I

I

E

E

V

I

V

T

Y

F

N

R

E

Q

G

S

Y

F

-

F

-

S

D

D

P

P

N

A

A

V

P

P

binding (S)-(3-aminopropyl)(cyclohexylmethyl)phosphinic acid: G17 (≠ D50), W18 (≠ L51), C82 (≠ A115), S83 (= S116), G104 (≠ S137), S106 (≠ T139), H123 (≠ A156)

Sites not aligning to the query:

binding (S)-(3-aminopropyl)(cyclohexylmethyl)phosphinic acid: 302

4mrmA Crystal structure of the extracellular domain of human gaba(b) receptor bound to the antagonist phaclofen (see paper)
21% identity, 45% coverage: 34:217/411 of query aligns to 1:186/407 of 4mrmA

query
sites
4mrmA

G

S