SitesBLAST
Comparing WP_017601060.1 NCBI__GCF_000341125.1:WP_017601060.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8e9hF Mycobacterial respiratory complex i, fully-inserted quinone (see paper)
71% identity, 96% coverage: 2:427/443 of query aligns to 1:434/436 of 8e9hF
- binding flavin mononucleotide: G53 (= G54), R54 (= R55), G55 (= G56), A57 (= A58), K64 (= K65), N90 (= N82), D92 (= D84), Y178 (= Y170), G181 (= G173), E182 (= E174), E183 (= E175), N217 (= N209), N218 (= N210), S221 (= S213), L398 (= L390)
- binding iron/sulfur cluster: P197 (= P189), S349 (= S341), C350 (= C342), G351 (= G343), K352 (= K344), C353 (= C345), C356 (= C348), S394 (= S386), F395 (= F387), C396 (= C388), L398 (= L390), G399 (= G391)
- binding zinc ion: C333 (= C325), E371 (= E363), H420 (= H412), C425 (= C418)
7p61F Complex i from e. Coli, ddm-purified, with nadh, resting state (see paper)
51% identity, 91% coverage: 20:423/443 of query aligns to 26:430/442 of 7p61F
- binding flavin mononucleotide: G61 (= G54), G63 (= G56), K72 (= K65), N90 (= N82), D92 (= D84), G181 (= G173), E182 (= E174), N217 (= N209), N218 (= N210), A399 (= A389), H400 (≠ L390)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G63 (= G56), G64 (= G57), A65 (= A58), F67 (= F60), K72 (= K65), L75 (≠ F68), E95 (= E87), Y178 (= Y170), E183 (= E175), F203 (= F195), R320 (≠ M311), T323 (= T314)
- binding iron/sulfur cluster: S350 (= S341), C351 (= C342), W353 (≠ K344), C354 (= C345), C357 (= C348), F397 (= F387), C398 (= C388), H400 (≠ L390)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
49% identity, 95% coverage: 8:428/443 of query aligns to 17:437/438 of Q56222
- K75 (= K65) binding FMN
- NADES 92:96 (= NADES 82:86) binding FMN
- YICGEE 180:185 (= YICGEE 170:175) binding FMN
- INN 218:220 (≠ VNN 208:210) binding FMN
- C353 (= C342) binding [4Fe-4S] cluster
- C356 (= C345) binding [4Fe-4S] cluster
- C359 (= C348) binding [4Fe-4S] cluster
- C400 (= C388) binding [4Fe-4S] cluster
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
49% identity, 95% coverage: 8:428/443 of query aligns to 16:436/437 of 4hea1
- binding flavin mononucleotide: G63 (= G54), K74 (= K65), N91 (= N82), D93 (= D84), Y179 (= Y170), G182 (= G173), E183 (= E174), N218 (= N209), N219 (= N210), L401 (= L390)
- binding iron/sulfur cluster: I180 (= I171), P198 (= P189), S351 (= S341), C352 (= C342), G353 (= G343), K354 (= K344), C355 (= C345), C358 (= C348), F398 (= F387), C399 (= C388), L401 (= L390)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
49% identity, 95% coverage: 8:428/443 of query aligns to 16:436/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G54), G65 (= G56), N91 (= N82), D93 (= D84), G182 (= G173), E183 (= E174), E184 (= E175), N218 (= N209), N219 (= N210), T222 (≠ S213), P400 (≠ A389)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G56), G66 (= G57), F69 (= F60), K74 (= K65), F77 (= F68), E96 (= E87), Y179 (= Y170), E184 (= E175), K201 (= K192), F204 (= F195), T324 (= T314)
- binding iron/sulfur cluster: S351 (= S341), C352 (= C342), K354 (= K344), C355 (= C345), C358 (= C348), F398 (= F387), C399 (= C388), L401 (= L390), A402 (≠ G391)
7arcF Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
47% identity, 92% coverage: 7:414/443 of query aligns to 15:425/430 of 7arcF
- binding flavin mononucleotide: G61 (= G54), R62 (= R55), K72 (= K65), N90 (= N82), D92 (= D84), E93 (= E85), S94 (= S86), Y178 (= Y170), G181 (= G173), E182 (= E174), T217 (≠ N209), N218 (= N210), L401 (= L390)
- binding iron/sulfur cluster: S352 (= S341), C353 (= C342), G354 (= G343), Q355 (≠ K344), C356 (= C345), C359 (= C348), T397 (≠ S386), C399 (= C388), L401 (= L390)
8b9zF Drosophila melanogaster complex i in the active state (dm1) (see paper)
48% identity, 91% coverage: 7:408/443 of query aligns to 23:427/441 of 8b9zF
- binding flavin mononucleotide: G69 (= G54), G71 (= G56), K80 (= K65), N98 (= N82), D100 (= D84), G189 (= G173), E191 (= E175), N226 (= N210), A408 (= A389), L409 (= L390)
- binding iron/sulfur cluster: P205 (= P189), C361 (= C342), G362 (= G343), Q363 (≠ K344), C364 (= C345), C367 (= C348), T405 (≠ S386), C407 (= C388), L409 (= L390)
8eswV1 NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A (see paper)
48% identity, 91% coverage: 7:408/443 of query aligns to 21:425/439 of 8eswV1
- binding flavin mononucleotide: G67 (= G54), G69 (= G56), K78 (= K65), N96 (= N82), D98 (= D84), E99 (= E85), G187 (= G173), E188 (= E174), N224 (= N210), A406 (= A389)
- binding iron/sulfur cluster: I185 (= I171), P203 (= P189), C359 (= C342), Q361 (≠ K344), C362 (= C345), C365 (= C348), T403 (≠ S386), I404 (≠ F387), C405 (= C388), L407 (= L390)
- binding : Y143 (≠ V129), N144 (≠ H130), Q150 (≠ R136), D174 (= D160)
8j9iV1 ndufv1 (see paper)
47% identity, 89% coverage: 20:414/443 of query aligns to 35:435/504 of 8j9iV1
- binding flavin mononucleotide: G69 (= G54), G71 (= G56), K80 (= K65), N100 (= N82), D102 (= D84), E103 (= E85), G191 (= G173), E192 (= E174), V226 (= V208), N228 (= N210), T231 (≠ S213), A410 (= A389), L411 (= L390)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G71 (= G56), G72 (= G57), F75 (= F60), K80 (= K65), F83 (= F68), E105 (= E87), Y188 (= Y170), E193 (= E175), F213 (= F195), T335 (= T314), A410 (= A389)
- binding iron/sulfur cluster: P207 (= P189), S362 (= S341), C363 (= C342), N364 (≠ G343), Q365 (≠ K344), C366 (= C345), C369 (= C348), C409 (= C388), L411 (= L390)
8iufV1 ndufv2 (see paper)
47% identity, 89% coverage: 20:414/443 of query aligns to 35:435/504 of 8iufV1
- binding flavin mononucleotide: G69 (= G54), G71 (= G56), K80 (= K65), N100 (= N82), D102 (= D84), Y188 (= Y170), G191 (= G173), E192 (= E174), N228 (= N210), L411 (= L390)
- binding iron/sulfur cluster: S362 (= S341), C363 (= C342), N364 (≠ G343), Q365 (≠ K344), C366 (= C345), C369 (= C348), C409 (= C388), L411 (= L390)
6zk91 Peripheral domain of open complex i during turnover (see paper)
47% identity, 92% coverage: 7:415/443 of query aligns to 13:424/430 of 6zk91
- binding flavin mononucleotide: G59 (= G54), G61 (= G56), K70 (= K65), N88 (= N82), D90 (= D84), E91 (= E85), G179 (= G173), E180 (= E174), A215 (≠ N209), N216 (= N210), A398 (= A389), L399 (= L390)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G61 (= G56), G62 (= G57), A63 (= A58), F65 (= F60), K70 (= K65), E93 (= E87), Y176 (= Y170), E181 (= E175), F201 (= F195), T323 (= T314)
- binding iron/sulfur cluster: I177 (= I171), P195 (= P189), C351 (= C342), G352 (= G343), Q353 (≠ K344), C354 (= C345), C357 (= C348), T395 (≠ S386), C397 (= C388), L399 (= L390)
5lnk1 Entire ovine respiratory complex i (see paper)
47% identity, 92% coverage: 7:415/443 of query aligns to 15:426/432 of 5lnk1
- binding fe2/s2 (inorganic) cluster: P96 (= P88), G97 (= G89)
- binding flavin mononucleotide: G61 (= G54), R62 (= R55), K72 (= K65), N90 (= N82), D92 (= D84), E93 (= E85), G94 (≠ S86), Y178 (= Y170), G181 (= G173), E182 (= E174), V216 (= V208), A217 (≠ N209), N218 (= N210), T221 (≠ S213), L401 (= L390)
- binding iron/sulfur cluster: P197 (= P189), S352 (= S341), C353 (= C342), Q355 (≠ K344), C356 (= C345), C359 (= C348), T397 (≠ S386), I398 (≠ F387), C399 (= C388)
7dgq8 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (see paper)
47% identity, 92% coverage: 7:415/443 of query aligns to 10:421/427 of 7dgq8
- binding flavin mononucleotide: G58 (= G56), K67 (= K65), N85 (= N82), D87 (= D84), E88 (= E85), G89 (≠ S86), C175 (= C172), G176 (= G173), A212 (≠ N209), N213 (= N210)
- binding iron/sulfur cluster: S347 (= S341), C348 (= C342), G349 (= G343), C351 (= C345), C354 (= C348), C394 (= C388), L396 (= L390)
- binding : R121 (≠ S118), Y132 (≠ V129), Q139 (≠ R136), R143 (≠ A140), Y146 (= Y143), E147 (≠ D144), F165 (≠ V162), R168 (≠ A165)
P25708 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Bos taurus (Bovine) (see paper)
48% identity, 91% coverage: 7:408/443 of query aligns to 41:445/464 of P25708
- C379 (= C342) binding [4Fe-4S] cluster
- C382 (= C345) binding [4Fe-4S] cluster
- C385 (= C348) binding [4Fe-4S] cluster
- C425 (= C388) binding [4Fe-4S] cluster
7aqrF Cryo-em structure of arabidopsis thaliana complex-i (peripheral arm) (see paper)
49% identity, 87% coverage: 20:405/443 of query aligns to 26:415/434 of 7aqrF
- binding flavin mononucleotide: G60 (= G54), R61 (= R55), G62 (= G56), K71 (= K65), N89 (= N82), D91 (= D84), Y177 (= Y170), G180 (= G173), E181 (= E174), E182 (= E175), T216 (≠ N209), N217 (= N210)
- binding iron/sulfur cluster: S351 (= S341), C352 (= C342), G353 (= G343), Q354 (≠ K344), C355 (= C345), C358 (= C348), T396 (≠ S386), C398 (= C388), L400 (= L390)
7v2cA Active state complex i from q10 dataset (see paper)
47% identity, 92% coverage: 7:415/443 of query aligns to 16:427/433 of 7v2cA
- binding flavin mononucleotide: G62 (= G54), K73 (= K65), N91 (= N82), Y179 (= Y170), G182 (= G173), E183 (= E174), N219 (= N210), A401 (= A389), L402 (= L390)
- binding iron/sulfur cluster: P198 (= P189), C354 (= C342), G355 (= G343), Q356 (≠ K344), C357 (= C345), C360 (= C348), T398 (≠ S386), C400 (= C388), L402 (= L390)
8a6tB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
44% identity, 95% coverage: 5:425/443 of query aligns to 150:571/630 of 8a6tB
- binding flavin mononucleotide: G201 (= G56), N227 (= N82), E230 (= E85), N355 (= N210), G535 (≠ A389), L536 (= L390)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: S320 (≠ E175), R337 (≠ K192), R340 (≠ F195), T341 (≠ P196), N342 (≠ A197), S433 (= S287)
- binding iron/sulfur cluster: S487 (= S341), C488 (= C342), G489 (= G343), C491 (= C345), C494 (= C348), C534 (= C388), L536 (= L390), G537 (= G391)
- binding zinc ion: C471 (= C325), H558 (= H412), C564 (= C418)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 31, 33, 36, 82, 85, 86
- binding iron/sulfur cluster: 575, 577, 582, 583, 585, 588, 592, 596, 597, 607, 612, 618, 622, 624, 626, 627
7t30B Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
46% identity, 91% coverage: 16:419/443 of query aligns to 15:420/425 of 7t30B
- binding fe2/s2 (inorganic) cluster: C326 (= C325), C364 (≠ E363), H413 (= H412), C419 (= C418)
- binding flavin mononucleotide: G54 (= G54), G56 (= G56), K65 (= K65), N82 (= N82), D84 (= D84), E85 (= E85), G173 (= G173), E175 (= E175), N210 (= N210), G390 (≠ A389), L391 (= L390)
- binding nicotinamide-adenine-dinucleotide: G56 (= G56), G57 (= G57), A58 (= A58), F60 (= F60), K65 (= K65), F68 (= F68), E85 (= E85), E175 (= E175), R192 (≠ K192), F195 (= F195), I312 (≠ M311), M313 (≠ L312), S315 (≠ T314)
- binding iron/sulfur cluster: S342 (= S341), C343 (= C342), G344 (= G343), C346 (= C345), C349 (= C348), S387 (= S386), C389 (= C388), L391 (= L390), G392 (= G391)
Sites not aligning to the query:
7t2rB Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn-free apo state (see paper)
46% identity, 91% coverage: 16:419/443 of query aligns to 15:420/425 of 7t2rB
- binding fe2/s2 (inorganic) cluster: C326 (= C325), D329 (≠ R328), C364 (≠ E363), H413 (= H412), C419 (= C418)
- binding iron/sulfur cluster: P189 (= P189), C343 (= C342), G344 (= G343), C346 (= C345), C349 (= C348), C389 (= C388), G392 (= G391)
Sites not aligning to the query:
Q91YT0 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Mus musculus (Mouse) (see 2 papers)
46% identity, 92% coverage: 7:415/443 of query aligns to 41:452/464 of Q91YT0
- C379 (= C342) binding [4Fe-4S] cluster
- C382 (= C345) binding [4Fe-4S] cluster
- C385 (= C348) binding [4Fe-4S] cluster
- C425 (= C388) binding [4Fe-4S] cluster
Sites not aligning to the query:
- 1:20 modified: transit peptide, Mitochondrion
Query Sequence
>WP_017601060.1 NCBI__GCF_000341125.1:WP_017601060.1
MTTLTPILSEHWDRPDSFTLDGYRATGGYAALRKALAMEPDAIVDAVKQSGLRGRGGAGF
PTGMKWGFLPPDNPNPRYLVVNADESEPGTCKDIPLMLANPHALVEGVAIASYAIKSSQA
FIYVRGEVVHVIRRLRRAVAEAYDAGLLGTNILGTGFDLDVVVHAGAGAYICGEETALLD
SLEGYRGQPRLKPPFPAVAGLYASPTVVNNVESIASVPSIVANGAEWFTSMGTEKSAGFG
FFSLSGHVSNPGQYEAPLGVTLRELLDMAGGVRPGHRLKFWTPGGSSTPIFTDEHLDTPL
DFESVGAAGSMLGTRALQIFDETTCVVRAVGRWIAFYAHESCGKCTPCREGNFWMVQVLD
RLENGQGTEEDLDKLLDICDNLLGRSFCALGDGATSPVTSSIKYFRQEYIDHVEKGGCPF
DHSRATLWGDRPTSTTTERGGNQ
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory