SitesBLAST
Comparing WP_017750791.1 NCBI__GCF_000816635.1:WP_017750791.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9KNV2 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
35% identity, 89% coverage: 33:352/358 of query aligns to 32:355/361 of Q9KNV2
3okfA 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase (arob) from vibrio cholerae
35% identity, 89% coverage: 33:352/358 of query aligns to 33:354/360 of 3okfA
- active site: R120 (= R118), K142 (= K140), E184 (= E182), K226 (= K224), R238 (= R238), N242 (= N242), H245 (= H245), H249 (= H249), H262 (= H261)
- binding nicotinamide-adenine-dinucleotide: N42 (≠ E42), L48 (= L48), D71 (≠ H69), E73 (= E71), K76 (= K74), G104 (= G102), G105 (= G103), V106 (≠ L104), D109 (= D107), T129 (= T127), T130 (= T128), L132 (= L130), D136 (= D134), T172 (= T170), L173 (= L171), E177 (≠ Q175)
Q5NFS1 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
39% identity, 84% coverage: 31:331/358 of query aligns to 30:336/359 of Q5NFS1
5hvnA 3.0 angstrom crystal structure of 3-dehydroquinate synthase (arob) from francisella tularensis in complex with NAD.
37% identity, 91% coverage: 8:331/358 of query aligns to 13:331/354 of 5hvnA
- active site: R123 (= R118), K145 (= K140), E187 (= E182), K228 (= K224), R239 (= R238), N243 (= N242), H246 (= H245), H250 (= H249), H263 (= H261)
- binding nicotinamide-adenine-dinucleotide: N45 (≠ E42), L51 (= L48), D73 (≠ H69), E75 (= E71), K78 (= K74), G107 (= G102), G108 (= G103), V109 (≠ L104), D112 (= D107), T132 (= T127), T133 (= T128), L135 (= L130), D139 (= D134), K145 (= K140), F172 (= F167), T175 (= T170), L176 (= L171), E180 (≠ Q175)
U3KRF2 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Actinidia chinensis var. chinensis (Chinese soft-hair kiwi) (see paper)
31% identity, 91% coverage: 10:336/358 of query aligns to 90:423/445 of U3KRF2
3zokA Structure of 3-dehydroquinate synthase from actinidia chinensis in complex with NAD (see paper)
32% identity, 91% coverage: 10:336/358 of query aligns to 10:343/365 of 3zokA
- active site: R122 (= R118), K144 (= K140), E186 (= E182), K228 (= K224), E238 (≠ D234), R242 (= R238), N246 (= N242), H249 (= H245), H253 (= H249), H266 (= H261)
- binding glycine: K144 (= K140), K228 (= K224), R242 (= R238)
- binding nicotinamide-adenine-dinucleotide: T44 (≠ I44), V45 (= V45), D73 (≠ H69), E75 (= E71), K78 (= K74), G106 (= G102), G107 (= G103), V108 (≠ L104), D111 (= D107), T131 (= T127), T132 (= T128), M134 (≠ L130), D138 (= D134), S139 (= S135), K144 (= K140), K153 (= K149), T174 (= T170), L175 (= L171), E179 (≠ Q175), H266 (= H261)
6llaB Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+ and NAD (see paper)
33% identity, 100% coverage: 1:357/358 of query aligns to 2:363/363 of 6llaB
- active site: R121 (= R118), K143 (= K140), E185 (= E182), K227 (= K224), E237 (≠ D234), R242 (= R238), N246 (= N242), H249 (= H245), H253 (= H249), H266 (= H261)
- binding magnesium ion: E185 (= E182), H249 (= H245), H266 (= H261)
- binding nicotinamide-adenine-dinucleotide: L46 (≠ V45), D72 (≠ H69), E74 (= E71), K77 (= K74), G105 (= G102), G106 (= G103), V107 (≠ L104), D110 (= D107), T130 (= T127), T131 (= T128), L133 (= L130), D137 (= D134), K143 (= K140), T173 (= T170), L174 (= L171), E178 (≠ Q175)
P56081 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
33% identity, 98% coverage: 1:352/358 of query aligns to 1:339/343 of P56081
6lk2A Crystal structure of providencia alcalifaciens 3-dehydroquinate synthase (dhqs) in complex with mg2+, NAD and chlorogenic acid (see paper)
33% identity, 98% coverage: 1:352/358 of query aligns to 2:354/357 of 6lk2A
- active site: R121 (= R118), K143 (= K140), E185 (= E182), K227 (= K224), R238 (= R238), N242 (= N242), H245 (= H245), H249 (= H249), H262 (= H261)
- binding (1R,3R,4S,5R)-3-[3-[3,4-bis(oxidanyl)phenyl]propanoyloxy]-1,4,5-tris(oxidanyl)cyclohexane-1-carboxylic acid: D137 (= D134), E185 (= E182), K227 (= K224), R238 (= R238), N242 (= N242), H245 (= H245), T246 (= T246), H249 (= H249), H262 (= H261)
- binding magnesium ion: E185 (= E182), H245 (= H245), H262 (= H261)
- binding nicotinamide-adenine-dinucleotide: L46 (≠ V45), D72 (≠ H69), E74 (= E71), K77 (= K74), G105 (= G102), G106 (= G103), V107 (≠ L104), D110 (= D107), T130 (= T127), T131 (= T128), L133 (= L130), D137 (= D134), S138 (= S135), C170 (≠ F167), T173 (= T170), L174 (= L171), P175 (≠ E172), E178 (≠ Q175)
6c5cA Crystal structure of the 3-dehydroquinate synthase (dhqs) domain of aro1 from candida albicans sc5314 in complex with nadh (see paper)
34% identity, 80% coverage: 55:341/358 of query aligns to 64:372/385 of 6c5cA
- active site: R130 (= R118), K152 (= K140), E194 (= E182), K246 (= K224), E254 (≠ D234), R258 (= R238), N262 (= N242), H265 (= H245), H269 (= H249), H281 (= H261)
- binding nicotinamide-adenine-dinucleotide: E83 (= E71), K86 (= K74), G114 (= G102), G115 (= G103), V116 (≠ L104), D119 (= D107), T139 (= T127), T140 (= T128), D146 (= D134), S147 (= S135), F179 (= F167), T182 (= T170), L183 (= L171), Q187 (= Q175)
Sites not aligning to the query:
1dqsA Crystal structure of dehydroquinate synthase (dhqs) complexed with carbaphosphonate, NAD+ and zn2+ (see paper)
34% identity, 79% coverage: 64:347/358 of query aligns to 71:375/381 of 1dqsA
- active site: R127 (= R118), K149 (= K140), E191 (= E182), K240 (= K224), E250 (≠ D234), R254 (= R238), N258 (= N242), H261 (= H245), H265 (= H249), H277 (= H261)
- binding [1r-(1alpha,3beta,4alpha,5beta)]-5-(phosphonomethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid: D143 (= D134), K149 (= K140), N159 (= N150), E191 (= E182), K240 (= K224), R254 (= R238), L257 (= L241), N258 (= N242), H261 (= H245), H265 (= H249), H277 (= H261), K346 (= K319)
- binding nicotinamide-adenine-dinucleotide: E78 (= E71), K81 (= K74), G111 (= G102), G112 (= G103), V113 (≠ L104), D116 (= D107), T136 (= T127), T137 (= T128), L139 (= L130), D143 (= D134), S144 (= S135), K158 (= K149), T179 (= T170), P181 (≠ E172), E184 (≠ Q175), H277 (= H261)
- binding zinc ion: E191 (= E182), H261 (= H245), H277 (= H261)
Sites not aligning to the query:
1nvbB Crystal structure of 3-dehydroquinate synthase (dhqs) in complex with zn2+ and carbaphosphonate (see paper)
34% identity, 79% coverage: 64:347/358 of query aligns to 72:383/391 of 1nvbB
- active site: R128 (= R118), K150 (= K140), E192 (= E182), K248 (= K224), E258 (≠ D234), R262 (= R238), N266 (= N242), H269 (= H245), H273 (= H249), H285 (= H261)
- binding [1r-(1alpha,3beta,4alpha,5beta)]-5-(phosphonomethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid: D144 (= D134), K150 (= K140), N160 (= N150), E192 (= E182), K248 (= K224), R262 (= R238), L265 (= L241), N266 (= N242), H269 (= H245), H273 (= H249), K354 (= K319)
- binding zinc ion: E192 (= E182), H269 (= H245), H285 (= H261)
P9WPX9 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
33% identity, 73% coverage: 71:331/358 of query aligns to 75:336/362 of P9WPX9