SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_018123680.1 NCBI__GCF_000375485.1:WP_018123680.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

2pv7B Crystal structure of chorismate mutase / prephenate dehydrogenase (tyra) (1574749) from haemophilus influenzae rd at 2.00 a resolution (see paper)
30% identity, 78% coverage: 7:211/262 of query aligns to 11:218/280 of 2pv7B

query
sites
2pv7B
R
 
K
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I
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V
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I
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G
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Y
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I

5t9fB Prephenate dehydrogenase n222d mutant from soybean (see paper)
26% identity, 47% coverage: 45:166/262 of query aligns to 53:181/253 of 5t9fB

query
sites
5t9fB
A
 
A
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F
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H

Sites not aligning to the query:

4wjiA Crystal structure of cyclohexadienyl dehydrogenase from sinorhizobium meliloti in complex with NADP and tyrosine
27% identity, 52% coverage: 45:179/262 of query aligns to 59:205/293 of 4wjiA

query
sites
4wjiA
A
 
A
E
 
E
I
 
A
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E
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D
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x
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V
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G
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D
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L

Sites not aligning to the query:

2f1kA Crystal structure of synechocystis arogenate dehydrogenase (see paper)
26% identity, 64% coverage: 7:173/262 of query aligns to 2:189/279 of 2f1kA

query
sites
2f1kA
R
 
K
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I
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G
V
 
V
A
 
V
G
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G
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L
D
 
-
G
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G
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M
x
I
G
 
G
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A
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S
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L
M
 
A
E
 
G
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D
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L
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R
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R
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R
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G
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I
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G
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x
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S
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T
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C
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E
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A
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D
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L
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K
L
 
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H
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P
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A
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A
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H
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Q
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A
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A
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H
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P
Y
 
V
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M
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V
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S
A
 
A
A
 
A
Y
 
L
L
 
I

Query Sequence

>WP_018123680.1 NCBI__GCF_000375485.1:WP_018123680.1
MQPAFARIAVAGSDGQMGALLMERFRATGAHVQGYDCETKPAEVAEIVAGCDLLLLCIPV
TAFPSVLGTLKENLQPDTVLADVCSVKVKPMKEMMDAHGGPVVGTHPLFGPVIPEGFEPR
VAVAEGRDTDAANRVAALFEACGYDTFMTTAEEHDRAMAAIQGLNYITTAAYLGMASRLP
NADKFVTPSFNRRLDAARKMLTQDSELFADISEANPYLQETARGFMSFLSLAAGGDFDLL
TSLAQWWWREDNTGEGCIREPD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory