Comparing WP_018123824.1 NCBI__GCF_000375485.1:WP_018123824.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P16703 Cysteine synthase B; CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B; EC 2.5.1.47 from Escherichia coli (strain K12) (see paper)
49% identity, 38% coverage: 9:295/759 of query aligns to 8:293/303 of P16703
2bhtA Crystal structure of o-acetylserine sulfhydrylase b (see paper)
48% identity, 38% coverage: 9:295/759 of query aligns to 8:293/294 of 2bhtA
4jbnA Crystal structure of o-acetyl serine sulfhydrylase from entamoeba histolytica in complex with serine acetyl transferase derived tetrapeptide, spsi (see paper)
42% identity, 38% coverage: 5:294/759 of query aligns to 16:318/336 of 4jbnA
4il5A Crystal structure of o-acetyl serine sulfhydrylase from entamoeba histolytica in complex with isoleucine (see paper)
42% identity, 38% coverage: 5:294/759 of query aligns to 16:318/336 of 4il5A
4jblB Crystal structure of o-acetyl serine sulfhydrylase from entamoeba histolytica in complex with methionine (see paper)
42% identity, 38% coverage: 5:294/759 of query aligns to 16:318/335 of 4jblB
3bm5B Crystal structure of o-acetyl-serine sulfhydrylase from entamoeba histolytica in complex with cysteine (see paper)
42% identity, 38% coverage: 5:294/759 of query aligns to 16:318/335 of 3bm5B
3bm5A Crystal structure of o-acetyl-serine sulfhydrylase from entamoeba histolytica in complex with cysteine (see paper)
42% identity, 38% coverage: 3:294/759 of query aligns to 14:318/338 of 3bm5A
P0A1E3 Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; EC 2.5.1.47 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
44% identity, 38% coverage: 9:295/759 of query aligns to 12:313/323 of P0A1E3
Sites not aligning to the query:
P9WP55 O-acetylserine sulfhydrylase; OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase; EC 2.5.1.47 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
44% identity, 38% coverage: 5:295/759 of query aligns to 7:306/310 of P9WP55
6z4nAAA structure of oass complexed with upar inhibitor (see paper)
44% identity, 38% coverage: 9:295/759 of query aligns to 13:314/321 of 6z4nAAA
2q3dA 2.2 a resolution crystal structure of o-acetylserine sulfhydrylase (oass) from mycobacterium tuberculosis in complex with the reaction intermediate alpha-aminoacrylate (see paper)
44% identity, 38% coverage: 5:295/759 of query aligns to 7:306/306 of 2q3dA
P0ABK5 Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; S-carboxymethylcysteine synthase; Sulfate starvation-induced protein 5; SSI5; EC 2.5.1.47; EC 4.5.1.5 from Escherichia coli (strain K12) (see 5 papers)
44% identity, 38% coverage: 9:295/759 of query aligns to 12:313/323 of P0ABK5
Sites not aligning to the query:
5xoqA Crystal structure of o-acetylserine sulfhydrylase with bound transcription factor peptide inhibitor from planctomyces limnophilus
45% identity, 38% coverage: 9:294/759 of query aligns to 12:306/310 of 5xoqA
1d6sA Crystal structure of the k41a mutant of o-acetylserine sulfhydrylase complexed in external aldimine linkage with methionine (see paper)
44% identity, 38% coverage: 9:295/759 of query aligns to 11:312/322 of 1d6sA
6kr5B Crystal structure of o-acetyl serine sulfhydrylase isoform 3 from entamoeba histolytica (see paper)
41% identity, 38% coverage: 5:294/759 of query aligns to 15:317/336 of 6kr5B
8b9wA Cysteine synthase from trypanosoma theileri with plp bound (see paper)
42% identity, 38% coverage: 8:295/759 of query aligns to 16:312/329 of 8b9wA
2efyA Crystal structure of t.Th. Hb8 o-acetylserine sulfhydrylase complexed with 4-acetylbutyric acid
45% identity, 38% coverage: 7:295/759 of query aligns to 5:302/302 of 2efyA
2ecqA Crystal structure of t.Th. Hb8 o-acetylserine sulfhydrylase complexed with 3-hydroxylactate
45% identity, 38% coverage: 7:295/759 of query aligns to 5:302/302 of 2ecqA
2ecoA Crystal structure of t.Th. Hb8 o-acetylserine sulfhydrylase complexed with 4-methylvalerate
45% identity, 38% coverage: 7:295/759 of query aligns to 5:302/302 of 2ecoA
8b9yC Cysteine synthase from trypanosoma cruzi with plp and oas (see paper)
42% identity, 38% coverage: 8:295/759 of query aligns to 17:313/330 of 8b9yC
>WP_018123824.1 NCBI__GCF_000375485.1:WP_018123824.1
MENGILGLIGNTPLVELKRLNPNPRVRILAKLETANPGGSVKDRVAWAMIRRAEENGELQ
PGKILIEATSGNTGIGLAMVAAVKGYPIRLIMPETASEERKMIMRAYGAEIELTPGHLAT
DGAIELAYRMAREEPDKYVLLDQYNNPACVEAHYNGTGLEIWEQTGGEVTHAVATLGTTG
TAMGMARRLHEMGGVFVAAVEPYEGHRIQGLKNMHESYPPGIYDKSELDAVLRVDDETAF
DLCRRLAAEEGIFAGMSSGAALGGAIRLAEDMEQGTIVVLFPDGGERYLSTPLFAPRTRQ
GVRLYDVARAGKELVRTEQGTGIYTMGPSLDNPAGLDSWRRVLVADVLFRHLTLRGVDVT
PVAGLSDMDDRTLAAARARDASRADFASRTRQTILDTAKELGVSEAMLFPLTGPSEGTAL
DLCRKMLGKGLAYEKLRSVYFDIFRDPRYGAFGLQDPEHLSAGKTVDLDAYVKDNPFDFT
LLKRATLLDLKLGDVLETEWGNVRPSWFLQHAACATEVTGRTDIFIGSESHRFPHLENLR
AIWSSAGREVQAWMVANRTGSGNLDGITQLVEILGSAHAARMWLLSAHYRKPLAATEENL
RMWARNWQRVQDAAATLATMQDAPGTETDDRAEQMVFDLNAALREAMDDDLALHHFWPAL
FTFAKSVNTLSAERKLSGKTAQMLLEALHSADQVLAIIDNDALPHPLSSLPEEVRGLVAD
RQKARAEKNYTESDRIRDTLATKGFKVEDSNQGPRVYRI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory