SitesBLAST
Comparing WP_018231145.1 NCBI__GCF_000378965.1:WP_018231145.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q7XSN8 Serine racemase; D-serine dehydratase; D-serine ammonia-lyase; L-serine dehydratase; L-serine ammonia-lyase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Oryza sativa subsp. japonica (Rice) (see paper)
49% identity, 94% coverage: 9:308/319 of query aligns to 24:328/339 of Q7XSN8
- E219 (= E204) mutation to A: Reduces catalytic activity and abolishes the regulatory effect of Mg(2+) addition; when associated with A-225.
- D225 (= D210) mutation to A: Reduces catalytic activity and abolishes the regulatory effect of Mg(2+) addition; when associated with A-219.
5cvcA Structure of maize serine racemase (see paper)
50% identity, 94% coverage: 9:308/319 of query aligns to 8:312/329 of 5cvcA
- active site: K52 (= K53), S77 (= S78), E203 (= E204), A207 (= A208), D209 (= D210), G231 (= G232), V306 (≠ L302), S307 (= S303)
- binding magnesium ion: E203 (= E204), A207 (= A208), D209 (= D210)
- binding pyridoxal-5'-phosphate: F51 (= F52), K52 (= K53), N79 (= N80), S178 (≠ G179), G179 (= G180), G180 (= G181), G181 (= G182), L232 (= L233), E275 (= E276), S307 (= S303), G308 (= G304)
Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 4 papers)
45% identity, 95% coverage: 6:308/319 of query aligns to 9:318/340 of Q9GZT4
- E13 (≠ R10) binding Mg(2+)
- S31 (≠ C28) binding ATP
- S32 (≠ T29) binding ATP
- I33 (≠ S30) binding ATP
- K51 (= K48) binding ATP
- T52 (≠ V49) binding ATP
- K56 (= K53) modified: N6-(pyridoxal phosphate)lysine
- P69 (vs. gap) binding Ca(2+)
- T81 (= T75) binding Ca(2+)
- N86 (= N80) binding pyridoxal 5'-phosphate
- Q89 (= Q83) binding ATP
- Y121 (= Y115) binding ATP
- D178 (= D172) binding Mg(2+)
- G185 (= G179) binding pyridoxal 5'-phosphate
- G186 (= G180) binding pyridoxal 5'-phosphate
- G187 (= G181) binding pyridoxal 5'-phosphate
- G188 (= G182) binding pyridoxal 5'-phosphate
- M189 (≠ L183) binding pyridoxal 5'-phosphate
- E210 (= E204) binding Ca(2+); binding Mg(2+); binding Mn(2+)
- A214 (= A208) binding Ca(2+); binding Mg(2+); binding Mn(2+)
- D216 (= D210) binding Ca(2+); binding Mg(2+); binding Mn(2+)
- N247 (≠ L240) binding Ca(2+); binding Mg(2+)
- K279 (= K272) binding ATP
- S313 (= S303) binding pyridoxal 5'-phosphate
- N316 (= N306) binding ATP
7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:315/322 of 7nbgAAA
- active site: K53 (= K53), S81 (= S78), E207 (= E204), A211 (= A208), D213 (= D210), G236 (= G232), L309 (= L302), S310 (= S303)
- binding calcium ion: E207 (= E204), A211 (= A208), D213 (= D210)
- binding pyridoxal-5'-phosphate: F52 (= F52), K53 (= K53), N83 (= N80), G182 (= G179), G183 (= G180), G184 (= G181), G185 (= G182), M186 (≠ L183), G236 (= G232), V237 (≠ L233), T282 (≠ S278), S310 (= S303), G311 (= G304)
- binding ~{N}-[2-(2-methylphenyl)ethyl]ethanamide: S81 (= S78), G85 (= G82), Q86 (= Q83), I101 (≠ V98), K111 (= K108), I115 (≠ V112), Y118 (= Y115)
7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:315/323 of 7nbfAAA
- active site: K53 (= K53), S81 (= S78), E207 (= E204), A211 (= A208), D213 (= D210), G236 (= G232), L309 (= L302), S310 (= S303)
- binding calcium ion: E207 (= E204), A211 (= A208), D213 (= D210)
- binding magnesium ion: N244 (≠ L240)
- binding pyridoxal-5'-phosphate: F52 (= F52), K53 (= K53), N83 (= N80), G182 (= G179), G183 (= G180), G184 (= G181), G185 (= G182), M186 (≠ L183), G236 (= G232), V237 (≠ L233), T282 (≠ S278), S310 (= S303), G311 (= G304)
- binding 2-[(methylsulfonyl)methyl]-1H-benzimidazole: H21 (= H21), L22 (≠ R22), T23 (= T23), P24 (= P24), L26 (≠ F26), T27 (= T27), F46 (≠ L46)
Sites not aligning to the query:
7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:315/323 of 7nbdAAA
- active site: K53 (= K53), S81 (= S78), E207 (= E204), A211 (= A208), D213 (= D210), G236 (= G232), L309 (= L302), S310 (= S303)
- binding calcium ion: E207 (= E204), A211 (= A208), D213 (= D210)
- binding [4-(1H-benzimidazol-1-yl)phenyl]methanol: W272 (= W268), L278 (≠ I274), V314 (= V307)
- binding magnesium ion: N244 (≠ L240)
- binding pyridoxal-5'-phosphate: F52 (= F52), K53 (= K53), N83 (= N80), G182 (= G179), G183 (= G180), G184 (= G181), G185 (= G182), M186 (≠ L183), G236 (= G232), V237 (≠ L233), E280 (= E276), T282 (≠ S278), S310 (= S303), G311 (= G304)
Sites not aligning to the query:
7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:315/323 of 7nbcCCC
- active site: K53 (= K53), S81 (= S78), E207 (= E204), A211 (= A208), D213 (= D210), G236 (= G232), L309 (= L302), S310 (= S303)
- binding biphenyl-4-ylacetic acid: T78 (= T75), H79 (= H76), H84 (= H81), V148 (≠ I145), H149 (= H146), P150 (= P147)
- binding calcium ion: E207 (= E204), A211 (= A208), D213 (= D210)
- binding pyridoxal-5'-phosphate: F52 (= F52), K53 (= K53), N83 (= N80), G182 (= G179), G183 (= G180), G184 (= G181), G185 (= G182), M186 (≠ L183), G236 (= G232), V237 (≠ L233), T282 (≠ S278), S310 (= S303), G311 (= G304)
7nbcAAA structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:315/323 of 7nbcAAA
- active site: K53 (= K53), S81 (= S78), E207 (= E204), A211 (= A208), D213 (= D210), G236 (= G232), L309 (= L302), S310 (= S303)
- binding calcium ion: E207 (= E204), A211 (= A208), D213 (= D210)
- binding magnesium ion: N244 (≠ L240)
- binding pyridoxal-5'-phosphate: F52 (= F52), K53 (= K53), N83 (= N80), G182 (= G179), G183 (= G180), G184 (= G181), G185 (= G182), M186 (≠ L183), G236 (= G232), V237 (≠ L233), T282 (≠ S278), S310 (= S303), G311 (= G304)
Sites not aligning to the query:
7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:315/320 of 7nbhAAA
- active site: K53 (= K53), S81 (= S78), E207 (= E204), A211 (= A208), D213 (= D210), G236 (= G232), L309 (= L302), S310 (= S303)
- binding calcium ion: E207 (= E204), A211 (= A208), D213 (= D210)
- binding N-[(1H-benzimidazol-2-yl)methyl]furan-2-carboxamide: S81 (= S78), G85 (= G82), Q86 (= Q83), K111 (= K108), I115 (≠ V112), Y118 (= Y115), D235 (= D231), P281 (= P277), N313 (= N306), V314 (= V307), D315 (= D308)
6zspAAA serine racemase bound to atp and malonate. (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:308/320 of 6zspAAA
- active site: K53 (= K53), S74 (= S78), E200 (= E204), A204 (= A208), D206 (= D210), G229 (= G232), L302 (= L302), S303 (= S303)
- binding adenosine-5'-triphosphate: S28 (≠ C28), S29 (≠ T29), I30 (≠ S30), K48 (= K48), T49 (≠ V49), Q79 (= Q83), Y111 (= Y115), E266 (= E269), R267 (= R270), K269 (= K272), N306 (= N306)
- binding magnesium ion: E200 (= E204), A204 (= A208), D206 (= D210)
- binding malonate ion: K53 (= K53), S73 (= S77), S74 (= S78), N76 (= N80), H77 (= H81), R125 (= R129), G229 (= G232), S232 (≠ G235)
3l6bA X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 7:311/322 of 3l6bA
- active site: K54 (= K53), S77 (= S78), E203 (= E204), A207 (= A208), D209 (= D210), G232 (= G232), T278 (≠ S278), L305 (= L302), S306 (= S303)
- binding malonate ion: K54 (= K53), S76 (= S77), S77 (= S78), N79 (= N80), H80 (= H81), R128 (= R129), G232 (= G232)
- binding manganese (ii) ion: E203 (= E204), A207 (= A208), D209 (= D210)
- binding pyridoxal-5'-phosphate: F53 (= F52), K54 (= K53), N79 (= N80), G178 (= G179), G179 (= G180), G180 (= G181), G181 (= G182), M182 (≠ L183), V233 (≠ L233), E276 (= E276), T278 (≠ S278), S306 (= S303), G307 (= G304)
7nbgDDD structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen (see paper)
45% identity, 95% coverage: 6:308/319 of query aligns to 6:310/310 of 7nbgDDD
- active site: K53 (= K53), S76 (= S78), E202 (= E204), A206 (= A208), D208 (= D210), G231 (= G232), L304 (= L302), S305 (= S303)
- binding calcium ion: E202 (= E204), A206 (= A208), D208 (= D210)
- binding magnesium ion: N239 (≠ L240)
- binding ortho-xylene: S76 (= S78), Q81 (= Q83), I96 (≠ V98), Y113 (= Y115)
- binding pyridoxal-5'-phosphate: F52 (= F52), K53 (= K53), N78 (= N80), G177 (= G179), G178 (= G180), G179 (= G181), G180 (= G182), M181 (≠ L183), G231 (= G232), V232 (≠ L233), E275 (= E276), T277 (≠ S278), S305 (= S303), G306 (= G304)
Sites not aligning to the query:
A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see paper)
45% identity, 94% coverage: 8:308/319 of query aligns to 8:309/319 of A4F2N8
- K53 (= K53) mutation to A: Loss of enzymatic activity.
Q9QZX7 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Mus musculus (Mouse) (see paper)
43% identity, 97% coverage: 6:314/319 of query aligns to 9:324/339 of Q9QZX7
- C113 (≠ V107) modified: S-nitrosocysteine; mutation to S: Abolishes S-nitrosylation.
Q76EQ0 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Rattus norvegicus (Rat) (see paper)
43% identity, 97% coverage: 6:314/319 of query aligns to 9:324/333 of Q76EQ0
- K56 (= K53) modified: N6-(pyridoxal phosphate)lysine
- N86 (= N80) binding pyridoxal 5'-phosphate
- N154 (≠ Y148) binding pyridoxal 5'-phosphate
- G185 (= G179) binding pyridoxal 5'-phosphate
- G186 (= G180) binding pyridoxal 5'-phosphate
- G187 (= G181) binding pyridoxal 5'-phosphate
- G188 (= G182) binding pyridoxal 5'-phosphate
- M189 (≠ L183) binding pyridoxal 5'-phosphate
- E210 (= E204) binding Mn(2+)
- A214 (= A208) binding Mn(2+)
- D216 (= D210) binding Mn(2+)
- S313 (= S303) binding pyridoxal 5'-phosphate
3hmkA Crystal structure of serine racemase (see paper)
43% identity, 95% coverage: 6:308/319 of query aligns to 7:316/321 of 3hmkA
- active site: K54 (= K53), S82 (= S78), E208 (= E204), A212 (= A208), D214 (= D210), G237 (= G232), T283 (≠ S278), L310 (= L302), S311 (= S303)
- binding manganese (ii) ion: E208 (= E204), A212 (= A208), D214 (= D210)
- binding pyridoxal-5'-phosphate: F53 (= F52), K54 (= K53), N84 (= N80), G183 (= G179), G184 (= G180), G185 (= G181), G186 (= G182), M187 (≠ L183), G237 (= G232), V238 (≠ L233), T283 (≠ S278), S311 (= S303), G312 (= G304)
O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
42% identity, 96% coverage: 4:308/319 of query aligns to 8:313/323 of O59791
- K57 (= K53) active site, Proton acceptor; modified: Lysino-D-alanine (Lys); alternate; modified: N6-(pyridoxal phosphate)lysine; alternate
- S82 (= S78) active site, Proton acceptor; mutation to A: Loss of racemase activity. Reduces D-serine dehydratase activity by 99%. Slightly reduced L-serine dehydratase activity.
- N84 (= N80) binding pyridoxal 5'-phosphate
- G183 (= G179) binding pyridoxal 5'-phosphate
- G184 (= G180) binding pyridoxal 5'-phosphate
- G185 (= G181) binding pyridoxal 5'-phosphate
- G186 (= G182) binding pyridoxal 5'-phosphate
- L187 (= L183) binding pyridoxal 5'-phosphate
- E208 (= E204) binding Mg(2+)
- G212 (≠ A208) binding Mg(2+)
- D214 (= D210) binding Mg(2+)
- S308 (= S303) binding pyridoxal 5'-phosphate
1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp (see paper)
42% identity, 96% coverage: 4:308/319 of query aligns to 3:308/318 of 1wtcA
- active site: K52 (= K53), S77 (= S78), E203 (= E204), G207 (≠ A208), D209 (= D210), G231 (= G232), I302 (≠ L302), S303 (= S303)
- binding phosphomethylphosphonic acid adenylate ester: N20 (≠ H21), K47 (= K48), M48 (≠ V49), A109 (= A110), A110 (= A111), Y114 (= Y115)
- binding magnesium ion: E203 (= E204), G207 (≠ A208), D209 (= D210)
- binding pyridoxal-5'-phosphate: F51 (= F52), K52 (= K53), N79 (= N80), G178 (= G179), G179 (= G180), G180 (= G181), G181 (= G182), G231 (= G232), E276 (= E276), T278 (≠ S278), S303 (= S303)
1v71A Crystal structure of s.Pombe serine racemase
42% identity, 96% coverage: 4:308/319 of query aligns to 3:308/318 of 1v71A
- active site: K52 (= K53), S77 (= S78), E203 (= E204), G207 (≠ A208), D209 (= D210), G231 (= G232), I302 (≠ L302), S303 (= S303)
- binding magnesium ion: E203 (= E204), G207 (≠ A208), D209 (= D210)
- binding pyridoxal-5'-phosphate: F51 (= F52), K52 (= K53), N79 (= N80), G178 (= G179), G179 (= G180), G180 (= G181), G181 (= G182), G231 (= G232), E276 (= E276), T278 (≠ S278), S303 (= S303), G304 (= G304)
2zr8A Crystal structure of modified serine racemase complexed with serine (see paper)
42% identity, 96% coverage: 4:308/319 of query aligns to 4:309/319 of 2zr8A
- active site: K53 (= K53), S78 (= S78), E204 (= E204), G208 (≠ A208), D210 (= D210), G232 (= G232), I303 (≠ L302), S304 (= S303)
- binding magnesium ion: E204 (= E204), G208 (≠ A208), D210 (= D210)
- binding n-(5'-phosphopyridoxyl)-d-alanine: F52 (= F52), K53 (= K53), S77 (= S77), S78 (= S78), N80 (= N80), H81 (= H81), P147 (= P147), G179 (= G179), G180 (= G180), G181 (= G181), G182 (= G182), G232 (= G232), E277 (= E276), T279 (≠ S278), S304 (= S303)
- binding serine: S78 (= S78), R129 (= R129), D231 (= D231), G232 (= G232), A233 (≠ L233), Q234 (≠ R234), T235 (≠ G235)
Query Sequence
>WP_018231145.1 NCBI__GCF_000378965.1:WP_018231145.1
MPAPVLADIREAARRIRPHVHRTPVFTCTSLDHWLGARILLKCENLQKVGAFKIRGATNA
VCSLGDEEAARGVATHSSGNHGQALALAAHTRGIPAHVVMPHDVPEVKKAAVAGYGARVR
YCEPSVRAREEALAELVAETGATVIHPYNDHRIIAGQGTAALELLEDHPDLDAIIAPVGG
GGLLSGTAIAARALSPDIRILGAEPAGADDAIRSLAAGHIIPCAQPRTVADGLRGTLGSL
TFPVLHEHVERILPAGEAAIIEAMRFVWERTKLIIEPSAAVPVAALRESPRTCAGLKVGI
ILSGGNVDPDHLPWSPENR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory