SitesBLAST

5bjvA X-ray structure of the pglf udp-n-acetylglucosamine 4,6-dehydratase from campylobacterjejuni, d396n/k397a variant in complex with udp-n- acrtylglucosamine (see paper)
47% identity, 53% coverage: 270:618/653 of query aligns to 2:339/339 of 5bjvA

query
sites
5bjvA

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binding nicotinamide-adenine-dinucleotide: G31 (= G299), G34 (= G302), T35 (≠ S303), I36 (= I304), D56 (= D324), H57 (≠ Q325), S82 (≠ D351), I83 (= I352), A104 (= A373), A105 (= A374), A106 (= A375), K108 (= K377), N123 (≠ I392), I146 (≠ V415), K162 (= K431), F184 (= F454), G185 (= G455), N186 (= N456), V187 (= V457), S190 (= S460), S191 (≠ N461)
binding uridine-diphosphate-n-acetylglucosamine: K108 (= K377), H109 (= H378), T148 (= T417), G185 (= G455), N186 (= N456), S193 (= S463), V194 (= V464), T209 (= T479), L210 (= L480), T211 (= T481), I215 (= I485), R217 (= R487), R276 (= R549), E279 (= E552)

6bwcC X-ray structure of pen from bacillus thuringiensis (see paper)
38% identity, 42% coverage: 290:564/653 of query aligns to 3:277/327 of 6bwcC

query
sites
6bwcC

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binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G299), T14 (≠ A301), G15 (= G302), T16 (≠ S303), I17 (= I304), S37 (≠ D324), R38 (≠ Q325), S39 (≠ A326), D63 (= D351), I64 (= I352), V83 (≠ A373), A84 (= A374), K87 (= K377), T125 (≠ V415), S127 (≠ T417), Y137 (≠ M427), K141 (= K431), F167 (= F454), V170 (= V457), S173 (= S460), R174 (≠ N461)
binding uridine-diphosphate-n-acetylglucosamine: K87 (= K377), H88 (= H378), S127 (≠ T417), N128 (≠ D418), Y137 (≠ M427), N169 (= N456), S176 (= S463), V177 (= V464), L180 (= L467), T192 (= T479), T194 (= T481), M198 (≠ I485), R200 (= R487), L234 (≠ I522), E265 (= E552)

4j2oC Crystal structure of NADP-bound wbjb from a. Baumannii community strain d1279779 (see paper)
36% identity, 42% coverage: 290:563/653 of query aligns to 2:269/316 of 4j2oC

query
sites
4j2oC

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binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G299), T13 (≠ A301), G14 (= G302), S15 (= S303), F16 (≠ I304), S36 (≠ D324), R37 (≠ Q325), D38 (≠ A326), K41 (≠ Q334), D60 (= D351), V61 (≠ I352), A80 (= A373), A81 (= A374), A82 (= A375), K84 (= K377), T99 (≠ I392), L122 (≠ V415), K138 (= K431), Y164 (≠ F454)

4g5hA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with by-product (see paper)
31% identity, 48% coverage: 290:603/653 of query aligns to 11:320/346 of 4g5hA

query
sites
4g5hA

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L

I

L

R

E

L

L

S

-

G

-

L

-

R

-

Y

F

P

E

E

A

D

D

I

N

D

A

I

I

N

E

V

I

T

I

G

G

L

T

R
|
R

P

H

G

G

E
|
E

K

K

L

K

Y

A

E

E

E

T

L

L

A

T

N

R

G

E

E

E

-
x
Y

-

A

-

Q

-

C

N

E

T

D

L

M

S

G

T

D

Y

Y

H

F

K

R

K

-

I

-

L

V

I

P

S

A

K

D

T

S

R

R

E

D

L

L

D

N

Y

Y

A

S

K

N

-

Y

V

V

K

E

S

T

E

G

I

N

E

E

E

K

L

I

C

T

I

Q

T
x
S

N
x
Y

R
x
E

F
x
Y

Q

N

N

S

N

D

N
|
N

binding nadp nicotinamide-adenine-dinucleotide phosphate: G20 (= G299), T22 (≠ A301), G23 (= G302), S24 (= S303), F25 (≠ I304), S45 (≠ D324), R46 (≠ Q325), D47 (≠ A326), K50 (≠ A329), D69 (= D351), V70 (≠ I352), A89 (= A373), A90 (= A374), A91 (= A375), K93 (= K377), L131 (≠ V415), T133 (= T417), K147 (= K431), Y173 (≠ F454)
binding [(2R,3R,4R,6R)-3-acetamido-6-methyl-4-oxidanyl-5-oxidanylidene-oxan-2-yl] [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: Q94 (≠ H378), V95 (= V379), K135 (= K419), N175 (= N456), S182 (= S463), V183 (= V464), L186 (= L467), T198 (= T479), T200 (= T481), M204 (≠ I485), V240 (≠ I522), R263 (= R549), E266 (= E552), Y278 (vs. gap), S313 (≠ T596), Y314 (≠ N597), E315 (≠ R598), Y316 (≠ F599), N320 (= N603)

3w1vA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with inihibitor (see paper)
32% identity, 45% coverage: 290:584/653 of query aligns to 11:300/347 of 3w1vA

query
sites
3w1vA

F

F

R

D

G

D

E

K

T

I

V

L

L

L

V

I

T

T

G

G

A

G

A

T

G

G

S

S

I

F

G

G

S

N

E

A

L

V

V

M

K

K

Q

R

L

F

S

L

N

D

F

S

D

N

V

I

K

K

H

E

L

I

I

R

L

I

V

F

D

S

Q

R

A

D

E

E

S

K

A

K

L

-

Y

-

D

-

V

-

Q

Q

Q

D

D

D

L

I

K

R

R

K

D

-

G

-

K

K

H

Y

N

N

Y

N

T

S

A

K

I

L

-

K

-

F

-

Y

V

I

A

G

D

D

I

V

R

R

D

D

G

S

L

Q

R

S

I

V

D

E

S

T

I

A

F

M

Q

R

T

-

H

-

K

D

P

V

T

D

M

Y

V

V

F

F

H

H

A

A

Y

L

K
|
K

H
x
Q

V

V

P

P

L

S

M

C

E

E

K

F

A

F

P

P

Y

V

E

E

A

A

I

V

K

K

I

T

N

N

V

I

N

I

G

G

T

T

K

E

L

N

L

V

A

L

D

Q

T

S

A

A

S

I

R

H

Y

Q

N

N

V

V

K

K

F

V

V

I

F

C

V

L

S

S

T

T

D

D

K

K

A

A

V

A

N

Y

P

P

T

I

S

N

V

A

M

M

G

G

A

I

T

S

K

K

R

A

I

M

A

M

E

E

M

K

Y

V

I

F

T

V

C

A

L

K

Q

S

K

R

-

N

-

I

-

R

E

S

S

E

K

Q

T

T

K

L

F

I

I

C

T

G

T

T

R

R

F

Y

G

G

N
|
N

V

V

L

M

G

A

S
|
S

N
x
R

G

G

S
|
S

V
|
V

I

I

P

P

L
|
L

F

F

K

I

K

D

Q

K

I

I

E

K

A

A

G

G

S

E

S

P

L

L

T
|
T

L
x
I

T
|
T

H

D

K

P

D

D

I
x
M

T

T

R
|
R

Y

F

F

L

M

M

T

S

I

L

P

E

E

D

A

A

S

V

Q

E

L

L

V

V

L

V

E

H

A

A

G

F

T

K

M

H

G

A

K

E

G

T

G

G

E

D

I

I

F

M

I

V

F

-

D

Q

M

K

G

A

E

P

S

S

V

S

K

T

I
x
V

F

G

D

D

L

L

A

A

K

T

N

A

M

L

I

L

R

E

L

L

S

-

G

-

L

-

R

-

Y

F

P

E

E

A

D

D

I

N

D

A

I

I

N

E

V

I

T

I

G

G

L

T

R
|
R

P

H

G

G

E
|
E

K

K

L

K

Y

A

E

E

E

T

L

L

A

T

N

R

G

E

E

E

-

Y

-

A

-

Q

-

C

N

E

T

D

L

M

S

G

T

D

Y

Y

H

F

K

R

K

-

I

-

L

V

I

P

S

A

K

D

T

S

R

R

E

D

L

L

D

N

Y

Y

A

S

binding [(2R,3S,4R,5R,6R)-5-acetamido-6-[[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,4-bis(oxidanyl)oxan-2-yl]methylimino-azanylidene-azanium: K93 (= K377), Q94 (≠ H378), N175 (= N456), S179 (= S460), R180 (≠ N461), S182 (= S463), V183 (= V464), L186 (= L467), T198 (= T479), I199 (≠ L480), T200 (= T481), M204 (≠ I485), R206 (= R487), V240 (≠ I522), R263 (= R549), E266 (= E552)

3vvcA Crystal structure of capsular polysaccharide synthesizing enzyme cape , k126e, in apo form (see paper)
34% identity, 42% coverage: 290:563/653 of query aligns to 3:269/318 of 3vvcA

query
sites
3vvcA

F

F

R

D

G

D

E

K

T

I

V

L

L

L

V

I

T

T

G
|
G

A

G

A
x
T

G
|
G

S

S

I
x
F

G

G

S

N

E

A

L

V

V

M

K

K

Q

R

L

F

S

L

N

D

F

S

D

N

V

I

K

K

H

E

L

I

I

R

L

I

V

F

D
x
S

Q
x
R

A
x
D

E

E

S

K

A
x
K

L

-

Y

-

D

-

V

-

Q

Q

Q

D

D

D

L

I

K

R

R

K

D

-

G

-

K

K

H

Y

N

N

Y

N

T

S

A

K

I

L

-

K

-

F

-

Y

V

I

A

G

D
|
D

I
x
V

R
|
R

D

D

G

S

L

Q

R

S

I

V

D

E

S

T

I

A

F

M

Q

R

T

-

H

-

K

D

P

V

T

D

M

Y

V

V

F

F

H

H

A
|
A

Y

L

K
|
K

H

Q

V

V

P

P

L

S

M

C

E

E

K

F

A

F

P

P

Y

V

E

E

A

A

I

V

K

K

I

T

N

N

V

I

N

I

G

G

T

T

K

E

L

N

L

V

A

L

D

Q

T

S

A

A

S

I

R

H

Y

Q

N

N

V

V

K

K

F

V

V

I

F

C

V

L

S
|
S

T
|
T

D

D

K

E

A

A

V

A

N

Y

P

P

T

I

S

N

V

A

M

M

G

G

A

I

T

S

K
|
K

R

A

I

M

A

M

E

E

M

K

Y

V

I

F

T

V

C

A

L

K

Q

S

K

R

-

N

-

I

-

R

E

S

S

E

K

Q

T

T

K

L

F

I

I

C

T

G

T

T

R

R

F
x
Y

G
|
G

N

N

V

V

L

M

G

A

S

S

N

R

G

G

S

S

V

V

I

I

P

P

L

L

F

F

K

I

K

D

Q

K

I

I

E

K

A

A

G

G

S

E

S

P

L

L

T

T

L

I

T

T

H

D

K

P

D

D

I

M

T

T

R

R

Y

F

F

L

M

M

T

S

I

L

P

E

E

D

A

A

S

V

Q

E

L

L

V

V

L

V

E

H

A

A

G

F

T

K

M

H

G

A

K

E

G

T

G

G

E

D

I

I

F

M

I

V

F

-

D

Q

M

K

G

A

E

P

S

S

V

S

K

T

I

V

F

G

D

D

L

L

A

A

K

T

N

A

M

L

I

L

R

E

L

L

S

-

G

-

L

-

R

-

Y

F

P

E

E

A

D

D

I

N

D

A

I

I

N

E

V

I

T

I

G

G

L

T

R

R

P

H

G

G

E

E

K

K

L

K

Y

A

E

E

E

T

L

L

A

T

N

R

G

E

E

E

binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G299), T14 (≠ A301), G15 (= G302), F17 (≠ I304), S37 (≠ D324), R38 (≠ Q325), D39 (≠ A326), K42 (≠ A329), D61 (= D351), V62 (≠ I352), R63 (= R353), A81 (= A373), A82 (= A374), A83 (= A375), K85 (= K377), S124 (= S416), T125 (= T417), K139 (= K431), Y165 (≠ F454), G166 (= G455)

O25511 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
31% identity, 43% coverage: 284:567/653 of query aligns to 2:276/333 of O25511

query
sites
O25511

P

P

N

N

L

H

L

Q

N

N

E

M

F

L

R

D

G

N

E

Q

T

T

V

I

L

L

V

I

T

T

G

G

A

G

A
x
T

G
|
G

S
|
S

I
x
F

G

G

S

K

E

C

L

F

V

V

K

R

Q

K

-

V

L

L

S

D

N

T

F

T

D

N

V

A

K

K

H

K

L

I

I

I

L

V

V

Y

D
x
S

Q
x
R

A
x
D

E
|
E

S
x
L

A
x
K

L

Q

Y

S

D

E

V

M

Q

A

Q

M

D

E

L

F

K

-

R

N

D

D

G

P

K

R

H

M

N

R

Y

F

T

-

A

-

I

F

V

I

A

G

D
|
D

I
x
V

R

R

D

D

G

L

L

E

R

R

I

L

D

N

S

-

I

-

F

Y

Q

A

T

L

H

E

K

G

P

V

T

D

M

I

V

C

F

I

H

H

A
|
A

A

A

Y

L

K
|
K

H

H

V

V

P

P

L

I

M

A

E

E

K

Y

A

N

P

P

Y

L

E

E

A

C

I

I

K

K

I

T

N

N

V

I

N

M

G

G

T

A

K

S

L

N

L

V

A

I

D

N

T

A

A

C

S

L

R

K

Y

N

N

A

V

I

K

S

K

Q

F

V

V

I

F

A

V
x
L

S
|
S

T

T

D

D

K
|
K

A

A

V

A

N

N

P

P

T

I

S

N

V

L

M
x
Y

G

G

A

A

T

T

K
|
K

R

L

I

C

A

S

E

D

-

K

M

L

Y

F

I

V

T

S

C

A

-

N

L

F

Q

K

K

G

E

S

S

S

K

Q

T

T

K

Q

F

F

I

S

T

V

R

R

F

Y

G

G

N

N

V
|
V

L
x
V

G
|
G

S
|
S

N
x
R

G

G

S

S

V

V

I

V

P

P

L

F

F

F

K

K

Q

L

I

V

E

Q

-

N

A

K

G

A

S

S

S

E

L

I

T

P

L

I

T

T

H

D

K

I

D

R

I

M

T

T

R

R

Y

F

F

W

M

I

T

T

I

L

P

D

E

E

A

G

S

V

Q

S

L

F

V

V

L

L

E

K

A

S

G

L

T

K

M

R

G

M

K

H

G

G

E

E

I

I

F

F

I

V

F

P

D

K

M

I

G

-

E

P

S

S

V

M

K

K

I

M

F

T

D

D

L

L

A

A

K

K

N

A

M

L

I

A

R

-

L

-

S

-

G

-

L

-

R

-

Y

-

P

-

E

P

D

N

I

T

D

P

I

T

N

K

V

I

T

I

G

G

L

I

R

R

P

P

G

G

E

E

K

K

L

L

Y

H

E

E

E

V

L

M

L

I

A

P

N

K

G

D

E

E

N

S

T

H

L

L

S

A

TGSF 19:22 (≠ AGSI 301:304) binding NADP(+)
SRDELK 43:48 (≠ DQAESA 324:329) binding NADP(+)
DV 67:68 (≠ DI 351:352) binding NADP(+)
A87 (= A373) binding NADP(+)
K91 (= K377) binding NADP(+)
LS 129:130 (≠ VS 415:416) binding NADP(+)
K133 (= K419) mutation K->A,E: Loss of activity.
Y141 (≠ M427) binding NADP(+)
K145 (= K431) binding NADP(+)
VVGSR 174:178 (≠ VLGSN 457:461) binding NADP(+)

2gnaA Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-gal (see paper)
31% identity, 43% coverage: 288:567/653 of query aligns to 2:272/329 of 2gnaA

query
sites
2gnaA

N

N

E

M

F

L

R

D

G

N

E

Q

T

T

V

I

L

L

V

I

T

T

G
|
G

A

G

A
x
T

G
|
G

S
|
S

I
x
F

G

G

S

K

E

C

L

F

V

V

K

R

Q

K

-

V

L

L

S

D

N

T

F

T

D

N

V

A

K

K

H

K

L

I

I

I

L

V

V

Y

D
x
S

Q
x
R

A
x
D

E

E

S

L

A
x
K

L

Q

Y

S

D

E

V

M

Q

A

Q

M

D

E

L

F

K

-

R

N

D

D

G

P

K

R

H

M

N

R

Y

F

T

-

A

-

I

F

V

I

A

G

D
|
D

I
x
V

R

R

D

D

G

L

L

E

R

R

I

L

D

N

S

-

I

-

F

Y

Q

A

T

L

H

E

K

G

P

V

T

D

M

I

V

C

F

I

H

H

A
|
A

Y

L

K
|
K

H

H

V

V

P

P

L

I

M

A

E

E

K

Y

A

N

P

P

Y

L

E

E

A

C

I

I

K

K

I

T

N

N

V

I

N

M

G

G

T

A

K

S

L

N

L

V

A

I

D

N

T

A

A

C

S

L

R

K

Y

N

N

A

V

I

K

S

K

Q

F

V

V

I

F

A

V
x
L

S
|
S

T

T

D

D

K

K

A

A

V

A

N

N

P

P

T

I

S

N

V

L

M
x
Y

G

G

A

A

T

T

K
|
K

R

L

I

C

A

S

E

D

-

K

M

L

Y

F

I

V

T

S

C

A

-

N

L

F

Q

K

K

G

E

S

S

S

K

Q

T

T

K

Q

F

F

I

S

T

V

R

R

F
x
Y

G
|
G

N

N

V
|
V

L

V

G

G

S

S

N

R

G

G

S
|
S

V
|
V

I

V

P

P

L

F

F

F

K

K

Q

L

I

V

E

Q

-

N

A

K

G

A

S

S

S

E

L

I

T

P

L

I

T
|
T

H

D

K

I

D

R

I
x
M

T

T

R
|
R

Y

F

F

W

M

I

T

T

I

L

P

D

E

E

A

G

S

V

Q

S

L

F

V

V

L

L

E

K

A

S

G

L

T

K

M

R

G

M

K

H

G

G

E

E

I

I

F

F

I

V

F

P

D

K

M

I

G

-

E

P

S

S

V

M

K

K

I
x
M

F

T

D

D

L

L

A

A

K

K

N

A

M

L

I

A

R

-

L

-

S

-

G

-

L

-

R

-

Y

-

P

-

E

P

D

N

I

T

D

P

I

T

N

K

V

I

T

I

G

G

L

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

Y

H

E

E

E

V

L

M

L

I

A

P

N

K

G

D

E

E

N

S

T

H

L

L

S

A

binding galactose-uridine-5'-diphosphate: K87 (= K377), S176 (= S463), V177 (= V464), T195 (= T481), M199 (≠ I485), R201 (= R487), M235 (≠ I522), R254 (= R549), E257 (= E552)
binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G299), T15 (≠ A301), G16 (= G302), S17 (= S303), F18 (≠ I304), S39 (≠ D324), R40 (≠ Q325), D41 (≠ A326), K44 (≠ A329), D63 (= D351), V64 (≠ I352), A83 (= A373), A84 (= A374), A85 (= A375), K87 (= K377), L125 (≠ V415), S126 (= S416), Y137 (≠ M427), K141 (= K431), Y167 (≠ F454), G168 (= G455), V170 (= V457)

2gn9A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glc (see paper)
31% identity, 43% coverage: 288:567/653 of query aligns to 2:272/329 of 2gn9A

query
sites
2gn9A

N

N

E

M

F

L

R

D

G

N

E

Q

T

T

V

I

L

L

V

I

T

T

G
|
G

A

G

A
x
T

G
|
G

S
|
S

I
x
F

G

G

S

K

E

C

L

F

V

V

K

R

Q

K

-

V

L

L

S

D

N

T

F

T

D

N

V

A

K

K

H

K

L

I

I

I

L

V

V

Y

D

S

Q
x
R

A
x
D

E

E

S

L

A
x
K

L

Q

Y

S

D

E

V

M

Q

A

Q

M

D

E

L

F

K

-

R

N

D

D

G

P

K

R

H

M

N

R

Y

F

T

-

A

-

I

F

V

I

A

G

D
|
D

I
x
V

R

R

D

D

G

L

L

E

R

R

I

L

D

N

S

-

I

-

F

Y

Q

A

T

L

H

E

K

G

P

V

T

D

M

I

V

C

F

I

H

H

A
|
A

Y

L

K
|
K

H

H

V

V

P

P

L

I

M

A

E

E

K

Y

A

N

P

P

Y

L

E

E

A

C

I

I

K

K

I

T

N

N

V

I

N

M

G

G

T

A

K

S

L

N

L

V

A

I

D

N

T

A

A

C

S

L

R

K

Y

N

N

A

V

I

K

S

K

Q

F

V

V

I

F

A

V
x
L

S
|
S

T
|
T

D

D

K
|
K

A

A

V

A

N

N

P

P

T

I

S

N

V

L

M
x
Y

G

G

A

A

T

T

K
|
K

R

L

I

C

A

S

E

D

-

K

M

L

Y

F

I

V

T

S

C

A

-

N

L

F

Q

K

K

G

E

S

S

S

K

Q

T

T

K

Q

F

F

I

S

T

V

R

R

F
x
Y

G
|
G

N
|
N

V
|
V

L

V

G

G

S

S

N
x
R

G

G

S
|
S

V
|
V

I

V

P

P

L

F

F

F

K

K

Q

L

I

V

E

Q

-

N

A

K

G

A

S

S

S

E

L

I

T
x
P

L

I

T
|
T

H

D

K

I

D

R

I
x
M

T

T

R
|
R

Y

F

F

W

M

I

T

T

I

L

P

D

E

E

A

G

S

V

Q

S

L

F

V

V

L

L

E

K

A

S

G

L

T

K

M

R

G

M

K

H

G

G

E

E

I

I

F

F

I

V

F

P

D

K

M

I

G

-

E

P

S

S

V

M

K

K

I
x
M

F

T

D

D

L

L

A

A

K

K

N

A

M

L

I

A

R

-

L

-

S

-

G

-

L

-

R

-

Y

-

P

-

E

P

D

N

I

T

D

P

I

T

N

K

V

I

T

I

G

G

L

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

Y

H

E

E

E

V

L

M

L

I

A

P

N

K

G

D

E

E

N

S

T

H

L

L

S

A

binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G299), T15 (≠ A301), G16 (= G302), S17 (= S303), F18 (≠ I304), R40 (≠ Q325), D41 (≠ A326), K44 (≠ A329), D63 (= D351), V64 (≠ I352), A83 (= A373), A84 (= A374), A85 (= A375), K87 (= K377), L125 (≠ V415), S126 (= S416), K141 (= K431), Y167 (≠ F454), G168 (= G455), V170 (= V457), R174 (≠ N461)
binding uridine-5'-diphosphate-glucose: K87 (= K377), T127 (= T417), K129 (= K419), Y137 (≠ M427), N169 (= N456), S176 (= S463), V177 (= V464), P193 (≠ T479), T195 (= T481), M199 (≠ I485), R201 (= R487), M235 (≠ I522), R254 (= R549), E257 (= E552)

2gn6A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp-glcnac (see paper)
31% identity, 43% coverage: 288:567/653 of query aligns to 2:272/329 of 2gn6A

query
sites
2gn6A

N

N

E

M

F

L

R

D

G

N

E

Q

T

T

V

I

L

L

V

I

T

T

G
|
G

A

G

A
x
T

G
|
G

S
|
S

I
x
F

G

G

S

K

E

C

L

F

V

V

K

R

Q

K

-

V

L

L

S

D

N

T

F

T

D

N

V

A

K

K

H

K

L

I

I

I

L

V

V

Y

D

S

Q
x
R

A
x
D

E

E

S

L

A
x
K

L

Q

Y

S

D

E

V

M

Q

A

Q

M

D

E

L

F

K

-

R

N

D

D

G

P

K

R

H

M

N

R

Y

F

T

-

A

-

I

F

V

I

A

G

D
|
D

I
x
V

R

R

D

D

G

L

L

E

R

R

I

L

D

N

S

-

I

-

F

Y

Q

A

T

L

H

E

K

G

P

V

T

D

M

I

V

C

F

I

H

H

A

A

A
|
A

Y

L

K
|
K

H

H

V

V

P

P

L

I

M

A

E

E

K

Y

A

N

P

P

Y

L

E

E

A

C

I

I

K

K

I

T

N

N

V

I

N

M

G

G

T

A

K

S

L

N

L

V

A

I

D

N

T

A

A

C

S

L

R

K

Y

N

N

A

V

I

K

S

K

Q

F

V

V

I

F

A

V

L

S
|
S

T

T

D
|
D

K
|
K

A

A

V

A

N

N

P

P

T

I

S

N

V

L

M
x
Y

G

G

A

A

T

T

K
|
K

R

L

I

C

A

S

E

D

-

K

M

L

Y

F

I

V

T

S

C

A

-

N

L

F

Q

K

K

G

E

S

S

S

K

Q

T

T

K

Q

F

F

I

S

T

V

R

R

F
x
Y

G
|
G

N
|
N

V
|
V

L

V

G

G

S
|
S

N
x
R

G
|
G

S
|
S

V
|
V

I

V

P

P

L

F

F

F

K

K

Q

L

I

V

E

Q

-

N

A

K

G

A

S

S

S

E

L

I

T
x
P

L
x
I

T

T

H

D

K

I

D

R

I
x
M

T

T

R
|
R

Y

F

F

W

M

I

T

T

I

L

P

D

E

E

A

G

S

V

Q

S

L

F

V

V

L

L

E

K

A

S

G

L

T

K

M

R

G

M

K

H

G

G

E

E

I

I

F

F

I

V

F

P

D

K

M

I

G

-

E

P

S

S

V

M

K

K

I
x
M

F

T

D

D

L

L

A

A

K

K

N

A

M

L

I

A

R

-

L

-

S

-

G

-

L

-

R

-

Y

-

P

-

E

P

D

N

I

T

D

P

I

T

N

K

V

I

T

I

G

G

L

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

Y

H

E

E

E

V

L

M

L

I

A

P

N

K

G

D

E

E

N

S

T

H

L

L

S

A

binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G299), T15 (≠ A301), G16 (= G302), S17 (= S303), F18 (≠ I304), R40 (≠ Q325), D41 (≠ A326), K44 (≠ A329), D63 (= D351), V64 (≠ I352), A84 (= A374), A85 (= A375), K87 (= K377), S126 (= S416), Y137 (≠ M427), K141 (= K431), Y167 (≠ F454), G168 (= G455), V170 (= V457), S173 (= S460), R174 (≠ N461)
binding uridine-diphosphate-n-acetylglucosamine: K87 (= K377), D128 (= D418), K129 (= K419), N169 (= N456), G175 (= G462), S176 (= S463), V177 (= V464), P193 (≠ T479), I194 (≠ L480), M199 (≠ I485), R201 (= R487), M235 (≠ I522), R254 (= R549), E257 (= E552)

2gn4A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADPH and udp-glcnac (see paper)
31% identity, 43% coverage: 288:567/653 of query aligns to 2:272/329 of 2gn4A

query
sites
2gn4A

N

N

E

M

F

L

R

D

G

N

E

Q

T

T

V

I

L

L

V

I

T

T

G
|
G

A

G

A
x
T

G
|
G

S
|
S

I
x
F

G

G

S

K

E

C

L

F

V

V

K

R

Q

K

-

V

L

L

S

D

N

T

F

T

D

N

V

A

K

K

H

K

L

I

I

I

L

V

V

Y

D
x
S

Q
x
R

A
x
D

E

E

S

L

A
x
K

L

Q

Y

S

D

E

V

M

Q

A

Q

M

D

E

L

F

K

-

R

N

D

D

G

P

K

R

H

M

N

R

Y

F

T

-

A

-

I

F

V

I

A

G

D
|
D

I
x
V

R

R

D

D

G

L

L

E

R

R

I

L

D

N

S

-

I

-

F

Y

Q

A

T

L

H

E

K

G

P

V

T

D

M

I

V

C

F

I

H

H

A
|
A

Y

L

K
|
K

H

H

V

V

P

P

L

I

M

A

E

E

K

Y

A

N

P

P

Y

L

E

E

A

C

I

I

K

K

I
x
T

N

N

V

I

N

M

G

G

T

A

K

S

L

N

L

V

A

I

D

N

T

A

A

C

S

L

R

K

Y

N

N

A

V

I

K

S

K

Q

F

V

V

I

F

A

V
x
L

S
|
S

T
|
T

D
|
D

K
|
K

A

A

V

A

N

N

P

P

T

I

S

N

V

L

M
x
Y

G

G

A

A

T

T

K
|
K

R

L

I

C

A

S

E

D

-

K

M

L

Y

F

I

V

T

S

C

A

-

N

L

F

Q

K

K

G

E

S

S

S

K

Q

T

T

K

Q

F

F

I

S

T

V

R

R

F
x
Y

G
|
G

N
|
N

V
|
V

L

V

G

G

S
|
S

N
x
R

G

G

S
|
S

V
|
V

I

V

P

P

L

F

F

F

K

K

Q

L

I

V

E

Q

-

N

A

K

G

A

S

S

S

E

L

I

T
x
P

L

I

T
|
T

H

D

K

I

D

R

I
x
M

T

T

R
|
R

Y

F

F

W

M

I

T

T

I

L

P

D

E

E

A

G

S

V

Q

S

L

F

V

V

L

L

E

K

A

S

G

L

T

K

M

R

G

M

K

H

G

G

E

E

I

I

F

F

I

V

F

P

D

K

M

I

G

-

E

P

S

S

V

M

K

K

I
x
M

F

T

D

D

L

L

A

A

K

K

N

A

M

L

I

A

R

-

L

-

S

-

G

-

L

-

R

-

Y

-

P

-

E

P

D

N

I

T

D

P

I

T

N

K

V

I

T

I

G

G

L

I

R
|
R

P

P

G

G

E
|
E

K

K

L

L

Y

H

E

E

E

V

L

M

L

I

A

P

N

K

G

D

E

E

N

S

T

H

L

L

S

A

binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G13 (= G299), T15 (≠ A301), G16 (= G302), S17 (= S303), F18 (≠ I304), S39 (≠ D324), R40 (≠ Q325), D41 (≠ A326), K44 (≠ A329), D63 (= D351), V64 (≠ I352), A83 (= A373), A84 (= A374), A85 (= A375), K87 (= K377), T102 (≠ I392), L125 (≠ V415), S126 (= S416), T127 (= T417), Y137 (≠ M427), K141 (= K431), Y167 (≠ F454), G168 (= G455), V170 (= V457), S173 (= S460), R174 (≠ N461)
binding uridine-diphosphate-n-acetylglucosamine: K87 (= K377), T127 (= T417), D128 (= D418), K129 (= K419), Y137 (≠ M427), N169 (= N456), S176 (= S463), V177 (= V464), P193 (≠ T479), T195 (= T481), M199 (≠ I485), R201 (= R487), M235 (≠ I522), R254 (= R549), E257 (= E552)

2gn8A Crystal structure of udp-glcnac inverting 4,6-dehydratase in complex with NADP and udp (see paper)
31% identity, 42% coverage: 293:567/653 of query aligns to 5:270/327 of 2gn8A

query
sites
2gn8A

E

Q

T

T

V

I

L

L

V

I

T

T

G
|
G

A

G

A
x
T

G
|
G

S
|
S

I
x
F

G

G

S

K

E

C

L

F

V

V

K

R

Q

K

-

V

L

L

S

D

N

T

F

T

D

N

V

A

K

K

H

K

L

I

I

I

L

V

V

Y

D
x
S

Q
x
R

A
x
D

E

E

S

L

A
x
K

L

Q

Y

S

D

E

V

M

Q

A

Q

M

D

E

L

F

K

-

R

N

D

D

G

P

K

R

H

M

N

R

Y

F

T

-

A

-

I

F

V

I

A

G

D
|
D

I
x
V

R

R

D

D

G

L

L

E

R

R

I

L

D

N

S

-

I

-

F

Y

Q

A

T

L

H

E

K

G

P

V

T

D

M

I

V

C

F

I

H

H

A
|
A

Y

L

K
|
K

H

H

V

V

P

P

L

I

M

A

E

E

K

Y

A

N

P

P

Y

L

E

E

A

C

I

I

K

K

I
x
T

N

N

V

I

N

M

G

G

T

A

K

S

L

N

L

V

A

I

D

N

T

A

A

C

S

L

R

K

Y

N

N

A

V

I

K

S

K

Q

F

V

V

I

F

A

V
x
L

S
|
S

T

T

D

D

K
|
K

A

A

V

A

N

N

P

P

T

I

S

N

V

L

M

Y

G

G

A

A

T

T

K
|
K

R

L

I

C

A

S

E

D

-

K

M

L

Y

F

I

V

T

S

C

A

-

N

L

F

Q

K

K

G

E

S

S

S

K

Q

T

T

K

Q

F

F

I

S

T

V

R

R

F
x
Y

G
|
G

N
|
N

V
|
V

L

V

G

G

S
|
S

N
x
R

G

G

S

S

V
|
V

I

V

P

P

L

F

F

F

K

K

Q

L

I

V

E

Q

-

N

A

K

G

A

S

S

S

E

L

I

T
x
P

L
x
I

T
|
T

H

D

K

I

D

R

I
x
M

T

T

R
|
R

Y

F

F

W

M

I

T

T

I

L

P

D

E

E

A

G

S

V

Q

S

L

F

V

V

L

L

E

K

A

S

G

L

T

K

M

R

G

M

K

H

G

G

E

E

I

I

F

F

I

V

F

P

D

K

M

I

G

-

E

P

S

S

V

M

K

K

I
x
M

F

T

D

D

L

L

A

A

K

K

N

A

M

L

I

A

R

-

L

-

S

-

G

-

L

-

R

-

Y

-

P

-

E

P

D

N

I

T

D

P

I

T

N

K

V

I

T

I

G

G

L

I

R
|
R

P

P

G

G

E

E

K

K

L

L

Y

H

E

E

E

V

L

M

L

I

A

P

N

K

G

D

E

E

N

S

T

H

L

L

S

A

binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G299), T13 (≠ A301), G14 (= G302), S15 (= S303), F16 (≠ I304), S37 (≠ D324), R38 (≠ Q325), D39 (≠ A326), K42 (≠ A329), D61 (= D351), V62 (≠ I352), A81 (= A373), A82 (= A374), A83 (= A375), K85 (= K377), T100 (≠ I392), L123 (≠ V415), S124 (= S416), K139 (= K431), Y165 (≠ F454), G166 (= G455), V168 (= V457), S171 (= S460), R172 (≠ N461)
binding uridine-5'-diphosphate: K127 (= K419), N167 (= N456), V175 (= V464), P191 (≠ T479), I192 (≠ L480), T193 (= T481), M197 (≠ I485), R199 (= R487), M233 (≠ I522), R252 (= R549)

4tqgA Crystal structure of megavirus udp-glcnac 4,6-dehydratase, 5-epimerase mg534 (see paper)
29% identity, 42% coverage: 289:563/653 of query aligns to 2:250/297 of 4tqgA

query
sites
4tqgA

E

Q

F

I

R

N