SitesBLAST
Comparing WP_019864780.1 NCBI__GCF_000384075.1:WP_019864780.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
35% identity, 90% coverage: 7:227/246 of query aligns to 5:226/285 of 4yerA
- binding adenosine-5'-diphosphate: F14 (≠ Y16), F17 (≠ K19), N39 (= N41), G40 (= G42), G42 (= G44), K43 (= K45), T44 (= T46), T45 (= T47), T135 (≠ Q137), F136 (≠ L138), S137 (≠ N139)
Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see paper)
34% identity, 80% coverage: 23:220/246 of query aligns to 545:746/1704 of Q8R420
Sites not aligning to the query:
- 292 E→V: Knockin new born mice are healthy and survive into adulthood without overt signs of respiratory distress. Knockin mice show a severe lung phenotype that begins with alveolar inflammatory cell infiltration at the early stage of the mouse life followed by aberrant lung remodeling with characteristics of diffuse parenchymal lung disease (DPLD)- and emphysema-like alveolar disruption in older mice.
Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 15 papers)
33% identity, 77% coverage: 32:220/246 of query aligns to 559:746/1704 of Q99758
- N568 (= N41) to D: in SMDP3; does not affect location in intracellular vesicle membrane; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; does not affect protein expression; does not affect multivesicular bodies and lamellar bodies location; affects multivesicular bodies and lamellar bodies development; loss of phosphatidylcholine transport; does not affect cholesterol transport; dbSNP:rs121909184
- L579 (≠ I52) to P: in SMDP3; uncertain significance
- R605 (≠ L78) to Q: in SMDP3; uncertain significance; dbSNP:rs760006956
- S693 (≠ V166) mutation to L: Does not affect protein oligomerization.
Sites not aligning to the query:
- 43 R → L: in SMDP3; uncertain significance
- 53 N→Q: Does not affect N-glycosylation. Does not affect protein expression. Does not affect lamellar body membrane location.
- 101 L → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; dbSNP:rs121909182
- 124 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→Q: Loss of N-glycosylation. Reduces protein expression by 50%. Affects anterograde trafficking; when associated with Q-140. Reduces protein expression by 85%; when associated with Q-140. Does not affect lamellar body membrane location.
- 140 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N → H: in dbSNP:rs45447801; N→Q: Loss of N-glycosylation. Reduces protein expression by 50%. Affects anterograde trafficking; when associated with Q-124. Reduces protein expression by 85%; when associated with Q-140. Does not affect lamellar body membrane location.
- 173:174 LK→AA: Loss of proteolytic processing.
- 174:175 Cleavage; by CTSL
- 215 Q → K: in SMDP3; loss of lamellar bodies membrane location; loss of proteolytic cleavage; increases cellular free cholesterol and phosphatidylcholine transport; loss of vesicles formation; increases free cholesterol induced cell death; loss of protein oligomerization; dbSNP:rs879159551
- 280 R → C: in SMDP3; uncertain significance; does not affect protein oligomerization; dbSNP:rs201299260
- 288 R → K: in SMDP3; uncertain significance; does not affect protein oligomerization; dbSNP:rs117603931
- 290 L → M: in a breast cancer sample; somatic mutation
- 292 E → V: in SMDP3; uncertain significance; does not affect lamellar bodies membrane location; does not affect proteolytic cleavage; affects lamellar bodies formation; does not affect cholesterol and phosphatidylcholine transport; decreases vesicles formation; does not affect free cholesterol induced cell death; dbSNP:rs149989682
- 766 P → S: in dbSNP:rs45592239
- 801 E → D: in a breast cancer sample; somatic mutation
- 945 N→Q: Does not affect lamellar body membrane location. Does not affect protein expression. Does not affect proteolytic processing.
- 982 L → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs1402761450
- 1069 H → Q: in a breast cancer sample; somatic mutation
- 1076 N → K: in SMDP3; uncertain significance
- 1221 G → S: in SMDP3; does not affect intracellular vesicle membrane location; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; G→A: Decreases ATP hydrolysis activity of 15% compared to the wild-type.; G→T: Decreases ATP hydrolysis activity of 36% compared to the wild-type.; G→V: Decreases ATP hydrolysis activity of 18% compared to the wild-type.
- 1302 G → E: in SMDP3; uncertain significance
- 1388 K → N: in SMDP3; decreases phosphatidylcholine transport; increases protein abundance; does not affect folding in the endoplasmic reticulum; decreases proteolytic processing; affects lamellar bodies development; reduces free cholesterol transport
- 1553 L → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs121909183
- 1580 L → P: in SMDP3; does not affect location in intracellular vesicle membrane; does not affect proteolytic cleavage; does not affect N-glycosylation; loss of ATP hydrolysis activity; decreases ATP binding in vitro; affects the intracellular vesicles development; decreases phosphatidylcholine transport; L→A: Decreases ATP hydrolysis activity of 13% compared to the wild-type.; L→F: Decreases ATP hydrolysis activity of 13% compared to the wild-type.; L→V: Decreases ATP hydrolysis activity of 56% compared to the wild-type.
- 1591 Q → P: in SMDP3; loss of intracellular vesicle membrane location; loss of proteolytic cleavage; does not affect N-glycosylation; dbSNP:rs28936691
7w02A Cryo-em structure of atp-bound abca3 (see paper)
32% identity, 77% coverage: 32:220/246 of query aligns to 524:711/1566 of 7w02A
Sites not aligning to the query:
- binding adenosine-5'-triphosphate: 504, 1277, 1305, 1306, 1307, 1308, 1309, 1310, 1344, 1395, 1398
- binding magnesium ion: 1310, 1344
6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
33% identity, 94% coverage: 7:237/246 of query aligns to 3:233/233 of 6b8bA
- binding adenosine-5'-diphosphate: Y12 (= Y16), R15 (≠ K19), V17 (= V21), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47)
- binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (≠ D91), R90 (≠ L92), R91 (≠ D93)
6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
33% identity, 94% coverage: 7:237/246 of query aligns to 3:233/235 of 6mhzA
- binding adp orthovanadate: Y12 (= Y16), N37 (= N41), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47), Q84 (= Q86), S136 (≠ Q137), S138 (≠ N139), G139 (= G140), G140 (= G141), E162 (= E163), G166 (= G167), H194 (= H196)
6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
33% identity, 94% coverage: 7:237/246 of query aligns to 3:233/234 of 6b89A
- binding adenosine-5'-diphosphate: Y12 (= Y16), R15 (≠ K19), V17 (= V21), N37 (= N41), G38 (= G42), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47)
- binding magnesium ion: T42 (= T46), Q84 (= Q86)
- binding novobiocin: L71 (≠ C75), H72 (≠ K76), P83 (vs. gap), A86 (≠ T88), S87 (≠ T89), F89 (≠ D91), R90 (≠ L92), R91 (≠ D93), L92 (= L94), V101 (≠ H103), Q135 (≠ R136), R149 (= R150)
4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
33% identity, 94% coverage: 7:237/246 of query aligns to 3:233/234 of 4p31A
6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
33% identity, 94% coverage: 7:237/246 of query aligns to 3:233/238 of 6s8nB
6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
33% identity, 94% coverage: 7:237/246 of query aligns to 3:233/238 of 6s8gA
- binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y16), R15 (≠ K19), N37 (= N41), G40 (= G44), K41 (= K45), T42 (= T46), T43 (= T47), Q84 (= Q86), S136 (≠ Q137), S138 (≠ N139), E141 (≠ H142)
8tzjA Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
32% identity, 78% coverage: 7:198/246 of query aligns to 3:198/220 of 8tzjA
Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
30% identity, 86% coverage: 7:217/246 of query aligns to 2:217/276 of Q5M243
- Q90 (≠ D91) mutation to A: No effect on ATPase, 10-fold decrease in riboflavin uptake; when associated with A-97 in EcfA2.
- E163 (= E163) mutation to Q: 10-fold decrease in ATPase and riboflavin uptake; when associated with Q-171 in EcfA2.
P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see 2 papers)
31% identity, 84% coverage: 14:220/246 of query aligns to 555:760/1704 of P34358
- K586 (= K45) mutation to R: Cell corpses not engulfed.
- E639 (≠ D98) mutation to G: Cell corpses not engulfed.
Sites not aligning to the query:
- 126 modified: carbohydrate, N-linked (GlcNAc...) asparagine
- 1012 modified: carbohydrate, N-linked (GlcNAc...) asparagine
- 1045 modified: carbohydrate, N-linked (GlcNAc...) asparagine
- 1417 K→R: Some cell corpses not engulfed.
6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
34% identity, 94% coverage: 7:237/246 of query aligns to 3:233/240 of 6mjpA
Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 2 papers)
32% identity, 93% coverage: 6:234/246 of query aligns to 456:693/715 of Q9JI39
- G497 (= G44) mutation to A: Decreases ATP binding about 50%.
- K498 (= K45) mutation to R: Decreases ATP binding about 50%.
- C547 (≠ L94) modified: S-glutathionyl cysteine; mutation to A: Does not affect ABCB10 glutathionylation.
- G602 (= G141) mutation to D: Affects ATP hydrolysis but not binding.; mutation to V: Affects ATP hydrolysis but not binding.
- E624 (= E163) mutation to Q: Affects ATP hydrolysis but not binding.
- C675 (≠ K216) mutation to A: Prevents ABCB10 glutathionylation.
Sites not aligning to the query:
- 1:82 modified: transit peptide, Mitochondrion
6mbnA Lptb e163q in complex with atp (see paper)
32% identity, 94% coverage: 7:237/246 of query aligns to 4:234/241 of 6mbnA
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm) (see paper)
32% identity, 83% coverage: 21:225/246 of query aligns to 958:1167/1182 of 6fn1A
Sites not aligning to the query:
- binding Zosuquidar: 34, 201, 202, 272, 308, 312, 781, 785, 855, 856, 892, 893, 896, 897
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state (see paper)
32% identity, 83% coverage: 21:225/246 of query aligns to 955:1164/1176 of 7zk4A
- binding adenosine-5'-triphosphate: S975 (≠ N41), G976 (= G42), G978 (= G44), K979 (= K45), S980 (≠ T46), T981 (= T47), Q1021 (= Q86), Q1078 (= Q137), L1079 (= L138), S1080 (≠ N139), G1081 (= G140), G1082 (= G141), Q1083 (≠ H142), H1135 (= H196)
- binding magnesium ion: S980 (≠ T46), Q1021 (= Q86)
Sites not aligning to the query:
- binding adenosine-5'-triphosphate: 364, 367, 372, 392, 393, 395, 396, 397, 398, 438, 493, 495, 496, 497, 498, 947, 949, 950
- binding magnesium ion: 397, 438
- binding cholesterol hemisuccinate: 6, 7, 14, 15, 16, 16, 17, 71, 75, 79, 82, 98, 101, 156, 318, 831, 839, 854, 861, 861
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac (see paper)
32% identity, 83% coverage: 21:225/246 of query aligns to 954:1163/1177 of 7zk6A
- binding adenosine-5'-triphosphate: S974 (≠ N41), G975 (= G42), G977 (= G44), K978 (= K45), S979 (≠ T46), T980 (= T47), Q1020 (= Q86), Q1077 (= Q137), S1079 (≠ N139), G1080 (= G140), G1081 (= G141), Q1082 (≠ H142), H1134 (= H196)
- binding magnesium ion: S979 (≠ T46), Q1020 (= Q86)
Sites not aligning to the query:
- binding adenosine-5'-triphosphate: 364, 366, 367, 372, 393, 395, 396, 397, 398, 438, 495, 497, 498, 946, 948, 949
- binding (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione: 266, 270, 273, 302, 306, 310, 627, 630
- binding (4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione: 38, 273, 299, 310, 630, 631, 634, 851, 855, 881, 885
- binding magnesium ion: 397, 438
- binding cholesterol hemisuccinate: 16, 93, 98, 834, 838
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac (see paper)
32% identity, 83% coverage: 21:225/246 of query aligns to 954:1163/1177 of 7zk5A
- binding adenosine-5'-triphosphate: S974 (≠ N41), G975 (= G42), G977 (= G44), K978 (= K45), S979 (≠ T46), T980 (= T47), Q1020 (= Q86), Q1077 (= Q137), L1078 (= L138), S1079 (≠ N139), G1081 (= G141), Q1082 (≠ H142), H1134 (= H196)
- binding magnesium ion: S979 (≠ T46), Q1020 (= Q86)
Sites not aligning to the query:
- binding adenosine-5'-triphosphate: 364, 366, 367, 372, 392, 393, 395, 396, 397, 398, 438, 493, 495, 496, 497, 498, 550, 946, 948, 949
- binding (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione: 31, 45, 299, 302, 303, 306, 630, 881, 884, 885, 888
- binding magnesium ion: 397, 438
- binding cholesterol hemisuccinate: 3, 6, 7, 14, 17, 79, 98, 156, 164, 185, 186, 189, 193, 194, 197, 318, 830, 834, 838, 850, 853, 860
Query Sequence
>WP_019864780.1 NCBI__GCF_000384075.1:WP_019864780.1
MKPAIALSIENLSFTYSGKKVLDKVGFQIRAGECTVLLGPNGAGKTTLFSLITRLYDSHD
GRIELCGFDLQRQTCKALAKLGIVFQQTTLDLDLSVMDNLYYHASLHGIGRKQAQQQIRQ
ELERLDMWERRLEKIRQLNGGHKRRVEIARALIHKPSLLLLDEPTVGLDVPSRQAIVEYV
HQLSKENGLAVLWASHLIDEIYPDDHLLILHKGHIKANGTVDEVLRLTNTAHIKEAFHNL
TQGEAT
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory