SitesBLAST
Comparing WP_020174657.1 NCBI__GCF_000385335.1:WP_020174657.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6vw7D Formate dehydrogenase fdsabg subcomplex fdsbg from c. Necator - nadh bound (see paper)
68% identity, 97% coverage: 5:509/520 of query aligns to 7:510/514 of 6vw7D
- binding flavin mononucleotide: G154 (= G153), G156 (= G155), K165 (= K164), N182 (= N181), E185 (= E184), G273 (= G272), E274 (= E273), E275 (= E274), N309 (= N308), N310 (= N309), S313 (= S312), A490 (= A489), M491 (≠ L490)
- binding 1,4-dihydronicotinamide adenine dinucleotide: A158 (= A157), F160 (= F159), K165 (= K164), T168 (= T167), E275 (= E274), L295 (= L294)
- binding iron/sulfur cluster: V271 (= V270), V289 (= V288), S442 (= S441), C443 (= C442), G444 (= G443), K445 (= K444), C446 (= C445), C449 (= C448), L488 (= L487), C489 (= C488), M491 (≠ L490), G492 (= G491)
6tg9B Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
65% identity, 98% coverage: 3:509/520 of query aligns to 1:492/493 of 6tg9B
- binding flavin mononucleotide: G146 (= G153), R147 (= R154), G148 (= G155), N174 (= N181), D176 (= D183), E177 (= E184), Y254 (= Y269), G257 (= G272), E258 (= E273), N293 (= N308), N294 (= N309), S297 (= S312)
- binding 1,4-dihydronicotinamide adenine dinucleotide: F152 (= F159), K157 (= K164), E258 (= E273), E259 (= E274), L279 (= L294), K466 (= K483), L470 (= L487)
- binding iron/sulfur cluster: S426 (= S441), C427 (= C442), G428 (= G443), T429 (≠ K444), C430 (= C445), C433 (= C448), L470 (= L487), C471 (= C488), G474 (= G491)
8oh5B Cryo-em structure of the electron bifurcating transhydrogenase stnabc complex from sporomusa ovata (state 2) (see paper)
43% identity, 98% coverage: 3:509/520 of query aligns to 1:509/584 of 8oh5B
- binding fe2/s2 (inorganic) cluster: C10 (≠ A12), C41 (≠ S43), C45 (≠ H47)
- binding flavin mononucleotide: R154 (= R154), K164 (= K164), N181 (= N181), F269 (≠ Y269), E273 (= E273), E274 (= E274), I307 (= I307), N308 (= N308), N309 (= N309), G489 (≠ A489), L490 (= L490)
- binding nicotinamide-adenine-dinucleotide: G155 (= G155), G156 (= G156), F159 (= F159), F163 (≠ I163), E273 (= E273), E274 (= E274), K291 (= K291), F294 (≠ L294), G413 (= G413)
- binding iron/sulfur cluster: P288 (≠ V288), C442 (= C442), G443 (= G443), C445 (= C445), C448 (= C448), C488 (= C488), L490 (= L490), G491 (= G491)
- binding zinc ion: C425 (≠ D425)
Sites not aligning to the query:
- binding iron/sulfur cluster: 531, 536, 540, 542, 546, 547, 548, 559, 566, 567, 568, 569, 572
- binding zinc ion: 512, 518, 523
7q4vB Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
43% identity, 98% coverage: 4:514/520 of query aligns to 7:529/599 of 7q4vB
- binding fe2/s2 (inorganic) cluster: C11 (≠ P8), C16 (≠ A13), C48 (≠ S43), F49 (≠ R44), L51 (≠ M46), C52 (≠ H47)
- binding flavin mononucleotide: G166 (= G153), G168 (= G155), N196 (= N181), D198 (= D183), F284 (≠ Y269), G287 (= G272), E288 (= E273), E289 (= E274), N324 (= N309)
- binding iron/sulfur cluster: C457 (= C442), G458 (= G443), K459 (= K444), C460 (= C445), C463 (= C448), C503 (= C488), G506 (= G491)
- binding zinc ion: C440 (≠ D425), H527 (≠ K512)
Sites not aligning to the query:
- binding iron/sulfur cluster: 544, 551, 552, 553, 554, 555, 556, 557, 561, 562, 574, 581, 583, 584, 585, 586, 587, 591, 593, 595
- binding zinc ion: 533
8a6tB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
48% identity, 80% coverage: 95:509/520 of query aligns to 141:555/630 of 8a6tB
- binding flavin mononucleotide: G201 (= G155), N227 (= N181), E230 (= E184), N355 (= N309), G535 (≠ A489), L536 (= L490)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: S320 (≠ E274), R337 (≠ K291), R340 (≠ L294), T341 (≠ P295), N342 (≠ A296), S433 (≠ L387)
- binding iron/sulfur cluster: S487 (= S441), C488 (= C442), G489 (= G443), C491 (= C445), C494 (= C448), C534 (= C488), L536 (= L490), G537 (= G491)
- binding zinc ion: C471 (≠ D425)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 31, 33, 36, 82, 85, 86
- binding iron/sulfur cluster: 575, 577, 582, 583, 585, 588, 592, 596, 597, 607, 612, 618, 622, 624, 626, 627
- binding zinc ion: 558, 564
7p8nB Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
43% identity, 98% coverage: 3:509/520 of query aligns to 26:541/613 of 7p8nB
- binding fe2/s2 (inorganic) cluster: C31 (≠ P8), G33 (≠ D10), T34 (≠ A11), C36 (≠ A13), C67 (≠ S43), C68 (≠ R44), G69 (= G45), R70 (≠ M46), C71 (≠ H47)
- binding flavin mononucleotide: G185 (= G153), R186 (= R154), G187 (= G155), N213 (= N181), D215 (= D183), E216 (= E184), G217 (= G185), F301 (≠ Y269), G304 (= G272), E305 (= E273), E306 (= E274), N340 (= N308), N341 (= N309), G521 (≠ A489), L522 (= L490)
- binding iron/sulfur cluster: P320 (≠ V288), S473 (= S441), C474 (= C442), G475 (= G443), K476 (= K444), C477 (= C445), C480 (= C448), L519 (= L487), C520 (= C488), L522 (= L490), G523 (= G491)
- binding zinc ion: C457 (≠ D425)
Sites not aligning to the query:
- binding iron/sulfur cluster: 560, 567, 570, 571, 573, 577, 590, 592, 597, 599, 600, 601, 603, 607
- binding zinc ion: 544, 549, 554
7t30B Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
47% identity, 79% coverage: 101:509/520 of query aligns to 1:410/425 of 7t30B
- binding fe2/s2 (inorganic) cluster: C326 (≠ D425), C364 (≠ I463)
- binding flavin mononucleotide: G54 (= G153), G56 (= G155), K65 (= K164), N82 (= N181), D84 (= D183), E85 (= E184), G173 (= G272), E175 (= E274), N210 (= N309), G390 (≠ A489), L391 (= L490)
- binding nicotinamide-adenine-dinucleotide: G56 (= G155), G57 (= G156), A58 (= A157), F60 (= F159), K65 (= K164), F68 (≠ T167), E85 (= E184), E175 (= E274), R192 (≠ K291), F195 (≠ L294), I312 (≠ L411), M313 (≠ I412), S315 (≠ H414)
- binding iron/sulfur cluster: S342 (= S441), C343 (= C442), G344 (= G443), C346 (= C445), C349 (= C448), S387 (= S486), C389 (= C488), L391 (= L490), G392 (= G491)
Sites not aligning to the query:
7t2rB Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn-free apo state (see paper)
47% identity, 79% coverage: 101:509/520 of query aligns to 1:410/425 of 7t2rB
Sites not aligning to the query:
7q4vF Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
47% identity, 77% coverage: 118:515/520 of query aligns to 1:401/470 of 7q4vF
- binding flavin mononucleotide: G37 (= G153), G39 (= G155), N67 (= N181), G158 (= G272), E159 (= E273), E160 (= E274), G375 (≠ A489)
- binding nicotinamide-adenine-dinucleotide: G40 (= G156), F43 (= F159), K48 (= K164), R177 (≠ K291), F180 (≠ L294), M297 (≠ L411)
- binding iron/sulfur cluster: S327 (= S441), C328 (= C442), G329 (= G443), K330 (= K444), C331 (= C445), C334 (= C448), L373 (= L487), C374 (= C488)
- binding zinc ion: C311 (≠ D425), H398 (≠ K512)
Sites not aligning to the query:
- binding iron/sulfur cluster: 415, 417, 422, 424, 425, 426, 427, 428, 432, 433, 437, 445, 452, 454, 455, 456, 457, 458, 462, 463, 467
- binding zinc ion: 404, 409
8a5eB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state (see paper)
48% identity, 71% coverage: 140:509/520 of query aligns to 1:372/447 of 8a5eB
- binding flavin mononucleotide: G14 (= G153), G16 (= G155), N44 (= N181), G135 (= G272), E137 (= E274), N171 (= N308), N172 (= N309), G352 (≠ A489)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G16 (= G155), G17 (= G156), F20 (= F159), K25 (= K164), F28 (≠ T167), D49 (= D186), R154 (≠ K291), F157 (≠ L294), S250 (≠ L387)
- binding iron/sulfur cluster: P151 (≠ V288), C305 (= C442), G306 (= G443), K307 (= K444), C308 (= C445), C311 (= C448), C351 (= C488), G354 (= G491)
- binding zinc ion: C288 (≠ D425)
Sites not aligning to the query:
- binding iron/sulfur cluster: 392, 399, 401, 402, 403, 405, 409, 410, 414, 429, 431, 432, 433, 435, 439, 440, 444
- binding zinc ion: 375, 381, 386
8qh7B Crystal structure of respiratory complex i subunits nuoef from aquifex aeolicus bound to reduced 3-acetylpyridine adenine dinucleotide (without reducing agent) (see paper)
42% identity, 80% coverage: 97:514/520 of query aligns to 5:417/417 of 8qh7B
- binding acetyl pyridine adenine dinucleotide, reduced: G65 (= G155), G66 (= G156), A67 (= A157), F69 (= F159), K74 (= K164), E93 (= E184), E95 (≠ D186), Y178 (= Y269), E183 (= E274), Y203 (≠ L294)
- binding 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2h-benzo[g]pteridin-1-id-10(5h)-yl)-5-o-phosphonato-d-ribitol: G63 (= G153), G65 (= G155), K74 (= K164), N90 (= N181), D92 (= D183), E93 (= E184), G181 (= G272), E182 (= E273), V216 (≠ I307), N217 (= N308), N218 (= N309), T221 (≠ S312)
- binding iron/sulfur cluster: P197 (≠ V288), T344 (≠ S441), C345 (= C442), G346 (= G443), Q347 (≠ K444), C348 (= C445), C351 (= C448), S389 (= S486), I390 (≠ L487), C391 (= C488), L393 (= L490), G394 (= G491)
8qg1B Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to adp-ribose (see paper)
42% identity, 80% coverage: 97:514/520 of query aligns to 5:417/417 of 8qg1B
- binding adenosine-5-diphosphoribose: G66 (= G156), A67 (= A157), F69 (= F159), K74 (= K164), E183 (= E274), Y203 (≠ L294)
- binding flavin mononucleotide: G63 (= G153), G65 (= G155), K74 (= K164), N90 (= N181), D92 (= D183), E93 (= E184), Y178 (= Y269), G181 (= G272), E182 (= E273), V216 (≠ I307), N217 (= N308), N218 (= N309), T221 (≠ S312)
- binding iron/sulfur cluster: P197 (≠ V288), T344 (≠ S441), C345 (= C442), G346 (= G443), Q347 (≠ K444), C348 (= C445), C351 (= C448), I390 (≠ L487), C391 (= C488), L393 (= L490), G394 (= G491)
6hl3B Wild-type nuoef from aquifex aeolicus - oxidized form bound to NAD+ (see paper)
43% identity, 79% coverage: 97:509/520 of query aligns to 5:412/416 of 6hl3B
- binding flavin mononucleotide: G63 (= G153), G65 (= G155), K74 (= K164), N90 (= N181), D92 (= D183), E93 (= E184), G181 (= G272), E182 (= E273), E183 (= E274), V216 (≠ I307), N217 (= N308), N218 (= N309), T221 (≠ S312)
- binding nicotinamide-adenine-dinucleotide: G65 (= G155), G66 (= G156), A67 (= A157), F69 (= F159), K74 (= K164), E95 (≠ D186), Y178 (= Y269), E183 (= E274), K200 (= K291), Y203 (≠ L294)
- binding iron/sulfur cluster: I179 (≠ V270), P197 (≠ V288), T344 (≠ S441), C345 (= C442), G346 (= G443), Q347 (≠ K444), C348 (= C445), C351 (= C448), S389 (= S486), I390 (≠ L487), C391 (= C488), L393 (= L490), G394 (= G491)
6hl2B Wild-type nuoef from aquifex aeolicus - oxidized form (see paper)
43% identity, 79% coverage: 97:509/520 of query aligns to 5:412/416 of 6hl2B
- binding flavin mononucleotide: G63 (= G153), G65 (= G155), K74 (= K164), N90 (= N181), E93 (= E184), G181 (= G272), E182 (= E273), E183 (= E274), V216 (≠ I307), N217 (= N308), N218 (= N309), T221 (≠ S312)
- binding iron/sulfur cluster: P197 (≠ V288), T344 (≠ S441), C345 (= C442), G346 (= G443), Q347 (≠ K444), C348 (= C445), C351 (= C448), S389 (= S486), I390 (≠ L487), C391 (= C488), G394 (= G491)
6saqB Wild-type nuoef from aquifex aeolicus bound to nadh-oh (see paper)
42% identity, 81% coverage: 97:515/520 of query aligns to 6:419/419 of 6saqB
- binding flavin mononucleotide: G64 (= G153), G66 (= G155), K75 (= K164), N91 (= N181), D93 (= D183), E94 (= E184), Y179 (= Y269), G182 (= G272), E183 (= E273), N218 (= N308), N219 (= N309), T222 (≠ S312)
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[[(1~{E},3~{Z})-5-azanyl-4-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-methanoyl-amino]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate: G66 (= G155), G67 (= G156), A68 (= A157), F70 (= F159), K75 (= K164), E94 (= E184), E96 (≠ D186), T99 (= T189), E184 (= E274), Y204 (≠ L294), T318 (≠ H414)
- binding iron/sulfur cluster: P198 (≠ V288), T345 (≠ S441), C346 (= C442), G347 (= G443), Q348 (≠ K444), C349 (= C445), C352 (= C448), I391 (≠ L487), C392 (= C488), G395 (= G491)
6q9cB Crystal structure of aquifex aeolicus nadh-quinone oxidoreductase subunits nuoe and nuof bound to nadh under anaerobic conditions (see paper)
42% identity, 80% coverage: 97:514/520 of query aligns to 6:418/418 of 6q9cB
- binding flavin mononucleotide: G64 (= G153), G66 (= G155), K75 (= K164), N91 (= N181), D93 (= D183), E94 (= E184), G182 (= G272), E183 (= E273), E184 (= E274), V217 (≠ I307), N218 (= N308), N219 (= N309), T222 (≠ S312), G393 (≠ A489)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G66 (= G155), G67 (= G156), A68 (= A157), F70 (= F159), K75 (= K164), E94 (= E184), E96 (≠ D186), Y179 (= Y269), E184 (= E274), Y204 (≠ L294)
- binding iron/sulfur cluster: P198 (≠ V288), T345 (≠ S441), C346 (= C442), G347 (= G443), Q348 (≠ K444), C349 (= C445), C352 (= C448), I391 (≠ L487), C392 (= C488), L394 (= L490), G395 (= G491)
8qgwB Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to oxidized 3-acetylpyridine adenine dinucleotide (see paper)
42% identity, 80% coverage: 97:514/520 of query aligns to 5:417/418 of 8qgwB
- binding 3-acetylpyridine adenine dinucleotide: G66 (= G156), A67 (= A157), F69 (= F159), K74 (= K164), E183 (= E274), Y203 (≠ L294)
- binding flavin mononucleotide: G63 (= G153), G65 (= G155), K74 (= K164), N90 (= N181), E93 (= E184), Y178 (= Y269), G181 (= G272), E182 (= E273), E183 (= E274), V216 (≠ I307), N217 (= N308), N218 (= N309), T221 (≠ S312)
- binding iron/sulfur cluster: P197 (≠ V288), T344 (≠ S441), C345 (= C442), G346 (= G443), Q347 (≠ K444), C348 (= C445), C351 (= C448), I390 (≠ L487), C391 (= C488), L393 (= L490), G394 (= G491)
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
42% identity, 80% coverage: 105:518/520 of query aligns to 14:429/437 of 4hea1
- binding flavin mononucleotide: G63 (= G153), K74 (= K164), N91 (= N181), D93 (= D183), Y179 (= Y269), G182 (= G272), E183 (= E273), N218 (= N308), N219 (= N309), L401 (= L490)
- binding iron/sulfur cluster: I180 (≠ V270), P198 (≠ V288), S351 (= S441), C352 (= C442), G353 (= G443), K354 (= K444), C355 (= C445), C358 (= C448), F398 (≠ L487), C399 (= C488), L401 (= L490)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
42% identity, 80% coverage: 105:518/520 of query aligns to 14:429/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G153), G65 (= G155), N91 (= N181), D93 (= D183), G182 (= G272), E183 (= E273), E184 (= E274), N218 (= N308), N219 (= N309), T222 (≠ S312), P400 (≠ A489)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G155), G66 (= G156), F69 (= F159), K74 (= K164), F77 (≠ T167), E96 (≠ D186), Y179 (= Y269), E184 (= E274), K201 (= K291), F204 (≠ L294), T324 (≠ H414)
- binding iron/sulfur cluster: S351 (= S441), C352 (= C442), K354 (= K444), C355 (= C445), C358 (= C448), F398 (≠ L487), C399 (= C488), L401 (= L490), A402 (≠ G491)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
42% identity, 80% coverage: 105:518/520 of query aligns to 15:430/438 of Q56222
- K75 (= K164) binding FMN
- NADES 92:96 (≠ NADEG 181:185) binding FMN
- YICGEE 180:185 (≠ YVCGEE 269:274) binding FMN
- INN 218:220 (= INN 307:309) binding FMN
- C353 (= C442) binding [4Fe-4S] cluster
- C356 (= C445) binding [4Fe-4S] cluster
- C359 (= C448) binding [4Fe-4S] cluster
- C400 (= C488) binding [4Fe-4S] cluster
Query Sequence
>WP_020174657.1 NCBI__GCF_000385335.1:WP_020174657.1
MSIRIYVPRDAAAIAVGAEKLVAAIEKEAAARKIDVEIVRNGSRGMHWLEPLVEVVTPQG
RVGYGPVAARDVPGLFDAKFHEGAAAHALHQGLVEQIPFFAKQTRLTFARCGLIDPRSLD
DYRAHGGYVGLEKALTAGPVSIVDQVFKSGLRGRGGAGFPTGIKWKTVAEAKGSQKYIVC
NADEGDSGTFADRMIMEGDPFLLVEGMTIAGLAVGATRGYIYLRSEYPHAKVALEAAIEA
ASRAGYLGDTILGFPQAFHLEVRVGAGAYVCGEETSLLESLEGKRGLVRAKPPLPAHVGL
FGKPTVINNVLSLAAVPFILAEGPEAYAAFGMGRSRGTMPIQLAGNLKYGGLFEVAFGIT
LGELVDEIGGGPFTGRPVKAVQVGGPLGAYFPRALFDTPFDYESFAAKDGLIGHGGVVVF
DDSADMLKQARFAFEFCSHESCGKCTPCRIGSTRGHEVLDKVIEGKSPESNMALVEDLCQ
TMKLGSLCALGGFTPYPVLSAITHFPEDFAPKKRHLEPAE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory