SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_020174915.1 NCBI__GCF_000385335.1:WP_020174915.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
86% identity, 100% coverage: 1:166/166 of query aligns to 1:166/166 of P19921

query
sites
P19921

M

M

S

A

K

K

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A

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N

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F

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C
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C

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D

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C

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C

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T

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V

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D

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D

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C
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C

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M

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V

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A

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N

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G

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E

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M

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A

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P

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D

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E

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R

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C

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E

A

A

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E

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I

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F

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G

N

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C

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R

C
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C

T

T

G

G

Y

Y

Q

Q

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N

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I

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V

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K

A

A

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I

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Q

Y

Y

A

A

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E

C42 (= C42) binding [2Fe-2S] cluster
C47 (= C47) binding [2Fe-2S] cluster
C50 (= C50) binding [2Fe-2S] cluster
C62 (= C62) binding [2Fe-2S] cluster
C102 (= C102) binding [2Fe-2S] cluster
C105 (= C105) binding [2Fe-2S] cluster
C137 (= C137) binding [2Fe-2S] cluster
C139 (= C139) binding [2Fe-2S] cluster

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
86% identity, 97% coverage: 3:163/166 of query aligns to 1:161/161 of 1n5wA

query
sites
1n5wA

K

K

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A

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N

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A

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T

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A

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I

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G

C
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C

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D

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T

T
x
S

H
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H

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C

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G

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C

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T

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V

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D

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L

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D

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C

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T

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M

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V

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N

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G

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S

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M

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D

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E

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F

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R

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M

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M

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H

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G

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L

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Q

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C

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Y

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P

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G

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M

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M

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H

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N

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A

E

E

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R

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F

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G

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G

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C

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T

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G

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Y

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N

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A

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E

binding flavin-adenine dinucleotide: S43 (≠ T45), H44 (= H46)
binding fe2/s2 (inorganic) cluster: I38 (= I40), G39 (= G41), C40 (= C42), S43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C135 (= C137), C137 (= C139)

1n5wD Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
87% identity, 95% coverage: 3:160/166 of query aligns to 1:158/158 of 1n5wD

query
sites
1n5wD

K

K

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A

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G

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Y

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N

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Q

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Y

A

A

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P

binding flavin-adenine dinucleotide: S43 (≠ T45), H44 (= H46)
binding fe2/s2 (inorganic) cluster: C40 (= C42), S43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C135 (= C137), C137 (= C139)
binding pterin cytosine dinucleotide: Q99 (= Q101), C137 (= C139)

1ffuD Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
69% identity, 93% coverage: 2:156/166 of query aligns to 1:154/156 of 1ffuD

query
sites
1ffuD

S

A

K

K

I

K

H

I

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M

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T

N

V

V

N

N

G

G

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E

E

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x
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H

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A

A

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C

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T

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V

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D

L

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D

D

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G

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Q

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D

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G

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G

M

L

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A

A

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N

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K

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F

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G

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M

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M

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E

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E

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A

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M

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G

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M

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G

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Y

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binding fe2/s2 (inorganic) cluster: C41 (= C42), S44 (≠ T45), H45 (= H46), C46 (= C47), G47 (= G48), C49 (= C50), C61 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C135 (= C137), C137 (= C139)

1ffvA Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
70% identity, 91% coverage: 6:156/166 of query aligns to 4:153/155 of 1ffvA

query
sites
1ffvA

V

I

Q

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M

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T

N

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N

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G

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T

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I

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C

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T

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V

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D

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A

A

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N

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H

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A

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Q

E

E

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F

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Y

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Q

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T

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P

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G

M

M

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L

M

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R

A

A

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Y

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F

L

L

Q

Q

E

E

N

N

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P

D

N

P

P

T

T

E

E

A

A

E

E

I

I

R

R

F

M

G

G

I

M

A

T

G

G

N

N

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C
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C

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C

T

T

G

G

Y

Y

Q

Q

N

N

I

I

V

V

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K

A

A

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Q

Q

Y

Y

A

A

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L

binding fe2/s2 (inorganic) cluster: I38 (= I40), C40 (= C42), S43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), C60 (= C62), C99 (= C102), G100 (= G103), C102 (= C105), C134 (= C137), C136 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q98 (= Q101), C136 (= C139)

4zohC Crystal structure of glyceraldehyde oxidoreductase (see paper)
61% identity, 93% coverage: 3:157/166 of query aligns to 9:161/161 of 4zohC

query
sites
4zohC

K

K

I

V

H

K

V

I

Q

T

M

L

T

K

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I

N

N

G

G

E

E

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K

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Y

E

E

A

T

L

E

V

V

E

E

P

P

R

R

T

R

L

L

I

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H

H

F

V

I

L

R

R

E

E

Q

-

L

L

M

G

L

F

T

T

G

G

A

V

H

H

I

I

G

G

C
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C

D

D

T

T

T
x
S

H

N

C
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C

G
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G

A

A

C
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C

T

T

V

V

D

I

L

M

D

N

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G

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K

S

S

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V

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K

S

S

C
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C

T

T

M

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F

L

T

A

V

V

Q

E

A

A

D

D

G

G

A

A

S

E

I

I

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L

T

T

I

V

E

E

G

G

M

L

A

A

A

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P

K

D

D

G

G

T

K

L

L

H

H

A

P

L

I

Q

Q

E

E

G

A

F

F

R

W

M

E

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N

H

H

G

A

L

L

Q
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Q

C
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C

G
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G

F

Y

C
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C

T

T

P

P

G

G

M

M

I

I

L

M

R

E

A

A

H

Y

R

W

L

L

Q

R

E

E

N

K

P

P

D

N

P

P

T

T

E

E

A

E

E

E

I

I

R

R

F

E

G

G

I

I

A

S

G

G

N

N

I

L

C
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C

R

R

C
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C

T

T

G

G

Y

Y

Q

Q

N

N

I

I

V

V

K

K

A

A

I

I

Q

K

Y

A

A

A

A

E

K

K

I

L

N

S

binding fe2/s2 (inorganic) cluster: C47 (= C42), S50 (≠ T45), C52 (= C47), G53 (= G48), C55 (= C50), C67 (= C62), C106 (= C102), G107 (= G103), C109 (= C105), C141 (= C137), C143 (= C139)
binding pterin cytosine dinucleotide: Q105 (= Q101), C143 (= C139)

1t3qA Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
47% identity, 88% coverage: 4:149/166 of query aligns to 4:148/162 of 1t3qA

query
sites
1t3qA

I

M

H

R

V

I

Q

S

M

A

T

T

V

I

N

N

G

G

E

K

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P

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R

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V

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F

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Y

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V

E

E

P

P

R

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T

M

L

H

L

L

I

A

H

D

F

A

I

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R

R

E

E

Q

V

L

V

M

G

L

L

T

T

G

G

A

T

H

K

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I

G

G

C
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C

D
x
E

T

Q

T
x
G

H

V

C
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C

G
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G

A

S

C
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C

T

T

V

I

D

L

L

I

D

D

G

G

R

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M

K
x
R

S

S

C
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C

T

L

M

T

F

L

T

A

V

V

Q

Q

A

A

D

E

G

G

A

C

S

S

I

I

T

E

T

T

I

V

E

E

G

G

M

L

A

S

A

Q

P

G

D

E

G

-

T

K

L

L

H

N

A

A

L

L

Q

Q

E

D

G

S

F

F

R

R

M

R

T

H

H

H

G

A

L

L

Q
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Q

C
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C

G
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G

F

F

C
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C

T

T

P

A

G

G

M

M

I

L

L

A

R

T

A

A

H

R

R

S

L

I

L

L

Q

A

E

E

N

N

P

P

D

A

P

P

T

S

E

R

A

D

E

E

I

V

R

R

F

E

G

V

I

M

A

S

G

G

N

N

I

L

C
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C

R

R

C
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C

T

T

G

G

Y

Y

Q

E

N

T

I

I

V

I

K

D

A

A

I

I

binding fe2/s2 (inorganic) cluster: I40 (= I40), C42 (= C42), E43 (≠ D43), G45 (≠ T45), C47 (= C47), G48 (= G48), C50 (= C50), R60 (≠ K60), C62 (= C62), C101 (= C102), G102 (= G103), C104 (= C105), C136 (= C137), C138 (= C139)
binding pterin cytosine dinucleotide: Q100 (= Q101), C138 (= C139)

3hrdD Crystal structure of nicotinate dehydrogenase (see paper)
45% identity, 93% coverage: 1:155/166 of query aligns to 1:154/160 of 3hrdD

query
sites
3hrdD

M

M

S

N

K

K

I

I

H

T

V

I

Q

N

M

L

T

N

V

L

N

N

G

G

E

E

P

A

V

R

E

S

A

I

L

V

V

T

E

E

P

P

R

N

T

K

L

R

L

L

I

L

H

D

F

L

I

L

R

R

E

E

Q

D

L

F

M

G

L

L

T

T

G

S

A

V

H

K

I
x
E

G

G

C
|
C

D
x
S

T
x
E

T
x
G

H
x
E

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

D

I

L

F

D

N

G

G

R

D

S

P

V

V

K

T

S

T

C
|
C

T

C

M

M

F

L

T

A

V

G

Q

Q

A

A

D

D

G

E

A

S

S

T

I

I

T

I

T

T

I

L

E

E

G

G

M

V

A

A

A

-

P

E

D

D

G

G

T

K

L

P

H

S

A

L

L

L

Q

Q

E

Q

G

C

F

F

R

L

M

E

T

A

H

G

G

A

L

V

Q
|
Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

P

G

G

M

M

I

I

L

L

R

T

A

A

H

K

R

A

L

L

Q

D

E

K

N

N

P

P

D

D

P

P

T

T

E

D

A

E

E

E

I

I

R

T

F

V

G

A

I

M

A

S

G

G

N

N

I

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

I

N

K

I

I

V

H

K

A

A

A

I

V

Q

R

Y

Y

A

A

A

V

A

E

K

R

binding flavin-adenine dinucleotide: E44 (≠ T44), G45 (≠ T45), E46 (≠ H46)
binding fe2/s2 (inorganic) cluster: E40 (≠ I40), C42 (= C42), S43 (≠ D43), G45 (≠ T45), C47 (= C47), G48 (= G48), C50 (= C50), C62 (= C62), Q100 (= Q101), C101 (= C102), G102 (= G103), C104 (= C105), C136 (= C137), C138 (= C139)
binding pterin cytosine dinucleotide: Q100 (= Q101), C138 (= C139)

Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
45% identity, 93% coverage: 1:155/166 of query aligns to 1:154/157 of Q0QLF3

query
sites
Q0QLF3

M

M

S

N

K

K

I

I

H

T

V

I

Q

N

M

L

T

N

V

L

N

N

G

G

E

E

P

A

V

R

E

S

A

I

L

V

V

T

E

E

P

P

R

N

T

K

L

R

L

L

I

L

H

D

F

L

I

L

R

R

E

E

Q

D

L

F

M

G

L

L

T

T

G

S

A

V

H

K

I

E

G

G

C
|
C

D

S

T

E

T

G

H

E

C
|
C

G

G

A

A

C
|
C

T

T

V

V

D

I

L

F

D

N

G

G

R

D

S

P

V

V

K

T

S

T

C
|
C

T

C

M

M

F

L

T

A

V

G

Q

Q

A

A

D

D

G

E

A

S

S

T

I

I

T

I

T

T

I

L

E

E

G

G

M

V

A

A

A

E

P

-

D

D

G

G

T

K

L

P

H

S

A

L

L

L

Q

Q

E

Q

G

C

F

F

R

L

M

E

T

A

H

G

G

A

L

V

Q

Q

C
|
C

G

G

F

Y

C
|
C

T

T

P

P

G

G

M

M

I

I

L

L

R

T

A

A

H

K

R

A

L

L

Q

D

E

K

N

N

P

P

D

D

P

P

T

T

E

D

A

E

E

E

I

I

R

T

F

V

G

A

I

M

A

S

G

G

N

N

I

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

I

N

K

I

I

V

H

K

A

A

A

I

V

Q

R

Y

Y

A

A

A

V

A

E

K

R

C42 (= C42) binding [2Fe-2S] cluster
C47 (= C47) binding [2Fe-2S] cluster
C50 (= C50) binding [2Fe-2S] cluster
C62 (= C62) binding [2Fe-2S] cluster
C101 (= C102) binding [2Fe-2S] cluster
C104 (= C105) binding [2Fe-2S] cluster
C136 (= C137) binding [2Fe-2S] cluster
C138 (= C139) binding [2Fe-2S] cluster

1sb3C Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
46% identity, 90% coverage: 6:154/166 of query aligns to 5:152/161 of 1sb3C

query
sites
1sb3C

V

L

Q

R

M

L

T

T

V

L

N

N

G

G

E

R

P

A

V

R

E

E

A

D

L

L

V

V

E

P

P

D

R

N

T

M

L

L

I

L

H

D

F

Y

I

L

R

R

E

E

Q

T

L

V

M

G

L

L

T

T

G

G

A

T

H

K

I
x
Q

G

G

C
|
C

D

D

T

G

T
x
G

H

E

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

D

L

L

V

D

D

G

D

R

R

S

P

V

R

K

L

S

A

C
|
C

T

S

M

T

F

L

T

A

V

H

Q

Q

A

V

D

A

G

G

A

K

S

K

I

V

T

E

T

T

I

V

E

E

G

S

M

L

A

A

A

T

P

-

D

Q

G

G

T

T

L

L

H

S

A

K

L

L

Q

Q

E

A

G

A

F

F

R

H

M

E

T

K

H

L

G

G

L

T

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

M

M

I

I

L

M

R

A

A

S

H

E

R

A

L

L

Q

R

E

K

N

N

P

P

D

S

P

P

T

S

E

R

A

D

E

E

I

I

R

K

F

A

G

A

I

L

A

A

G

G

N

N

I

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

V

N

K

I

I

V

I

K

K

A

S

I

V

Q

E

Y

T

A

A

binding fe2/s2 (inorganic) cluster: Q39 (≠ I40), C41 (= C42), G44 (≠ T45), C46 (= C47), G47 (= G48), C49 (= C50), C61 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C135 (= C137), C137 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C137 (= C139)

5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
44% identity, 93% coverage: 3:156/166 of query aligns to 2:155/157 of 5y6qA

query
sites
5y6qA

K

R

I

I

H

S

V

L

Q

T

M

M

T

Q

V

V

N

N

G

G

E

Q

P

P

V

Y

E

P

A

M

L

E

V

I

E

D

P

P

R

R

T

V

L

T

L

L

I

L

H

D

F

A

I

L

R

R

E

E

Q

H

L

L

M

N

L

L

T

T

G

G

A

T

H

K

I

K

G
|
G

C
|
C

D
|
D

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

D

L

L

V

D

N

G

G

R

Q

S

R

V

V

K

L

S

S

C
|
C

T

L

M

T

F

L

T

A

V

A

Q

Q

A

A

D

D

G

G

A

A

S

E

I

V

T

T

T

S

I

I

E

E

G

G

M

L

A

Q

A

S

P

A

D

S

G

G

T

E

L

L

H

H

A

P

L

V

Q

Q

E

R

G

C

F

F

R

V

M

E

T

N

H

D

G

A

L

F

Q
|
Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

P

G

G

M

Q

I

I

L

M

R

S

A

A

H

V

R

A

L

C

L

I

Q

K

E

E

N

G

P

H

D

A

P

G

T

S

E

D

A

D

E

E

I

I

R

R

F

E

G

Y

I

M

A

S

G

G

N

N

I

L

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

Q

P

N

H

I

I

V

I

K

D

A

A

I

I

Q

K

Y

Q

A

A

K

E

I

M

binding fe2/s2 (inorganic) cluster: G40 (= G41), C41 (= C42), D42 (= D43), G44 (≠ T45), C46 (= C47), G47 (= G48), C49 (= C50), C61 (= C62), C101 (= C102), G102 (= G103), C104 (= C105), C136 (= C137), C138 (= C139)
binding pterin cytosine dinucleotide: Q100 (= Q101), C138 (= C139)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of 4usaA

query
sites
4usaA

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I
x
V

G

G

C
|
C

D
x
E

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ I40), C40 (= C42), E41 (≠ D43), G43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 531, 532, 535, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of 4us9A

query
sites
4us9A

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I
x
V

G

G

C
|
C

D
x
E

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ I40), C40 (= C42), E41 (≠ D43), G43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 257, 258, 752
binding bicarbonate ion: 460, 498, 531, 532, 535, 539, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of 4us8A

query
sites
4us8A

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I
x
V

G

G

C
|
C

D
x
E

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ I40), C40 (= C42), E41 (≠ D43), G43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 532, 535, 539
binding benzaldehyde: 255, 255, 394, 425, 425, 425, 425, 497, 497, 501, 531, 535, 535, 626, 626, 626, 694, 696, 697
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of 4c7yA

query
sites
4c7yA

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I

V

G

G

C
|
C

D
x
E

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

binding fe2/s2 (inorganic) cluster: C40 (= C42), E41 (≠ D43), G43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 535, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of 3fc4A

query
sites
3fc4A

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I
x
V

G

G

C
|
C

D
x
E

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ I40), C40 (= C42), E41 (≠ D43), G43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of 3fahA

query
sites
3fahA

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I
x
V

G

G

C
|
C

D
x
E

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ I40), C40 (= C42), E41 (≠ D43), G43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding glycerol: 416, 535, 622, 683, 696, 697, 869, 884, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

1sijA Crystal structure of the aldehyde dehydrogenase (a.K.A. Aor or mop) of desulfovibrio gigas covalently bound to [aso3]- (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of 1sijA

query
sites
1sijA

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I
x
V

G

G

C
|
C

D
x
E

T

Q

T
x
G

H

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ I40), C40 (= C42), E41 (≠ D43), G43 (≠ T45), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), Q99 (= Q101), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding arsenite: 535, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 698, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

Q46509 Aldehyde oxidoreductase; Molybdenum iron sulfur protein; EC 1.2.99.7 from Megalodesulfovibrio gigas (Desulfovibrio gigas) (see paper)
47% identity, 93% coverage: 4:158/166 of query aligns to 2:158/907 of Q46509

query
sites
Q46509

I

I

H

Q

V

K

Q

V

M

I

T

T

V

V

N

N

G

G

E

I

P

E

V

Q

E

N

A

L

L

F

V

V

E

D

P

A

R

E

T

A

L

L

I

S

H

D

F

V

I

L

R

R

E

Q

Q

Q

L

L

M

G

L

L

T

T

G

G

A

V

H

K

I

V

G

G

C
|
C

D

E

T

Q

T

G

H

Q

C
|
C

G

G

A

A

C
|
C

T

S

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K

R

S

A

C
|
C

-

V

T

T

M

K

F

M

T

K

V

R

Q

V

A

A

D

D

G

G

A

A

S

Q

I

I

T

T

I

I

E

E

G

G

M

V

A

G

A

Q

P

P

D

E

G

-

T

N

L

L

H

H

A

P

L

L

Q

Q

E

K

G

A

F

W

R

V

M

L

T

H

H

G

G

G

L

A

Q

Q

C
|
C

G

G

F

F

C
|
C

T

S

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

G

L

L

Q

D

E

T

N

N

P

A

D

D

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

V

I

I

N

N

G

G

C40 (= C42) binding [2Fe-2S] cluster
C45 (= C47) binding [2Fe-2S] cluster
C48 (= C50) binding [2Fe-2S] cluster
C60 (= C62) binding [2Fe-2S] cluster
C100 (= C102) binding [2Fe-2S] cluster
C103 (= C105) binding [2Fe-2S] cluster
C137 (= C137) binding [2Fe-2S] cluster
C139 (= C139) binding [2Fe-2S] cluster

1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
46% identity, 91% coverage: 8:158/166 of query aligns to 6:158/906 of 1dgjA

query
sites
1dgjA

M

L

T

I

V

V

N

N

G

G

E

M

P

A

V

R

E

R

A

L

L

L

V

V

E

S

P

P

R

N

T

D

L

L

I

V

H

D

F

V

I

L

R

R

E

S

Q

Q

L

L

M

Q

L

L

T

T

G

S

A

V

H

K

I
x
V

G
|
G

C
|
C

D
x
G

T

K

T
x
G

H
x
Q

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

D

I

L

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

T

I

M

I

-

K

F

M

T

S

V

R

Q

V

A

A

D

E

G

N

A

A

S

S

I

V

T

T

I

L

E

E

G

G

M

I

A

G

A

A

P

P

D

D

G

-

T

C

L

L

H

H

A

P

L

L

Q

Q

E

H

G

A

F

W

R

I

M

Q

T

H

H

G

G

A

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

M

F

I

I

L

V

R

S

A

A

H

K

R

A

L

L

Q

D

E

E

N

N

P

V

D

A

P

P

T

S

E

R

A

E

E

D

I

V

R

R

-

D

-

W

F

F

G

Q

I

K

A

H

G

H

N

N

I

I

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

Q

K

N

P

I

L

V

V

K

D

A

A

I

V

Q

M

Y

D

A

A

K

I

I

L

N

R

G

G

binding fe2/s2 (inorganic) cluster: V38 (≠ I40), G39 (= G41), C40 (= C42), G41 (≠ D43), G43 (≠ T45), Q44 (≠ H46), C45 (= C47), G46 (= G48), C48 (= C50), R58 (≠ K60), C60 (= C62), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding pterin cytosine dinucleotide: Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 391, 427, 503, 507, 535, 869, 870
binding molybdenum (iv)oxide: 424, 535, 698, 869
binding pterin cytosine dinucleotide: 423, 424, 535, 652, 655, 656, 657, 658, 697, 698, 700, 702, 703, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

Query Sequence

>WP_020174915.1 NCBI__GCF_000385335.1:WP_020174915.1
MSKIHVQMTVNGEPVEALVEPRTLLIHFIREQLMLTGAHIGCDTTHCGACTVDLDGRSVK
SCTMFTVQADGASITTIEGMAAPDGTLHALQEGFRMTHGLQCGFCTPGMILRAHRLLQEN
PDPTEAEIRFGIAGNICRCTGYQNIVKAIQYAAAKINGTPYQEAAE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory