SitesBLAST

4ea8A X-ray crystal structure of perb from caulobacter crescentus in complex with coenzyme a and gdp-n-acetylperosamine at 1 angstrom resolution (see paper)
31% identity, 58% coverage: 67:177/191 of query aligns to 84:205/207 of 4ea8A

query
sites
4ea8A

H

H

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F

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binding coenzyme a: H145 (vs. gap), F163 (= F135), G165 (= G137), V166 (≠ S138), A184 (= A156)

Sites not aligning to the query:

binding coenzyme a: 206
binding GDP-N-acetylperosamine: 14, 15, 16, 35, 36, 37, 50, 68, 69

7ra4A Crystal structure of neisseria gonorrhoeae serine acetyltransferase (cyse) in complex with serine (see paper)
30% identity, 59% coverage: 66:178/191 of query aligns to 129:243/243 of 7ra4A

query
sites
7ra4A

Y

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binding serine: D156 (vs. gap), H157 (= H94), R191 (vs. gap), H192 (≠ R127)

Sites not aligning to the query:

binding serine: 91, 92

4h7oA Crystal structure of serine acetyltransferase from vibrio cholerae o1 biovar el tor n16961
30% identity, 62% coverage: 67:185/191 of query aligns to 127:247/258 of 4h7oA

query
sites
4h7oA

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binding arginine: Y127 (≠ H67), Q131 (≠ L71)
binding cysteine: D153 (≠ H94), H154 (≠ N95), G180 (≠ H120), R188 (vs. gap), H189 (≠ R127)

Sites not aligning to the query:

8i04A Crystal structure of serine acetyltransferase from salmonella typhimurium complexed with serine (see paper)
27% identity, 85% coverage: 23:185/191 of query aligns to 88:247/258 of 8i04A

query
sites
8i04A

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binding serine: D88 (= D23), P89 (≠ T24), D153 (≠ H94), H154 (≠ N95), G180 (≠ H120), R188 (vs. gap), H189 (≠ R127)

4eaaA X-ray crystal structure of the h141n mutant of perosamine n- acetyltransferase from caulobacter crescentus in complex with coa and gdp-perosamine (see paper)
30% identity, 58% coverage: 67:177/191 of query aligns to 86:207/210 of 4eaaA

query
sites
4eaaA

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binding coenzyme a: P150 (vs. gap), F165 (= F135), V168 (≠ S138), A186 (= A156), I201 (≠ V171)

Sites not aligning to the query:

binding coenzyme a: 208
binding GDP-perosamine: 14, 15, 16, 35, 36, 37, 52, 70, 71

8i09A Crystal structure of serine acetyltransferase from salmonella typhimurium complexed with butyl gallate (see paper)
27% identity, 83% coverage: 23:180/191 of query aligns to 91:245/246 of 8i09A

query
sites
8i09A

D
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binding cysteine: D91 (= D23), D156 (≠ H94), H157 (≠ N95), G164 (vs. gap), R191 (vs. gap), H192 (≠ R127)
binding butyl 3,4,5-tris(oxidanyl)benzoate: G183 (≠ H120), T184 (≠ D121), G202 (= G137), K218 (≠ V153), I219 (≠ V154), G220 (≠ A155), L226 (≠ I161), A236 (≠ V171)

1t3dA Crystal structure of serine acetyltransferase from e.Coli at 2.2a (see paper)
27% identity, 84% coverage: 23:183/191 of query aligns to 92:249/262 of 1t3dA

query
sites
1t3dA

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binding cysteine: D92 (= D23), P93 (≠ T24), D157 (≠ H94), G184 (≠ H120), R192 (vs. gap), H193 (≠ R127)

8i06A Crystal structure of serine acetyltransferase from salmonella typhimurium complexed with coa (see paper)
28% identity, 82% coverage: 23:178/191 of query aligns to 92:244/244 of 8i06A

query
sites
8i06A

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V

binding coenzyme a: H158 (≠ N95), L177 (≠ N113), Q178 (= Q114), G203 (= G137), A204 (≠ S138), G221 (≠ A155), A222 (= A156), T235 (= T169), A237 (≠ V171)
binding cysteine: P93 (≠ T24), H158 (≠ N95)

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
41% identity, 39% coverage: 105:178/191 of query aligns to 97:182/203 of P07464

query
sites
P07464

T

T

I

I

G

G

D

D

N

N

F

V

T

L

V

I

N

A

Q

P

G

N

V

V

T

T

-

L

-

S

-

V

-

T

-

G

-
x
H

-

P

V

V

D

H

H

H

D

E

W

L

R

R

R

K

N

N

G

G

R

E

-

M

-

Y

-

S

-

F

P

P

-

I

A

T

I

I

G

G

N

N

V

V

F

W

L

I

G

G

S
|
S

G

H

S

V

K

V

V

I

L

N

G

P

H

G

I

V

T

T

L

I

G

G

D

D

N

N

V

S

V

V

V

I

A

G

A
|
A

N

G

A

S

L

I

V

V

I
x
T

D
x
K

S

D

I

I

P

P

D

P

N

N

C

V

T

V

V

A

G

G

V

V

P

P

A

C

R
|
R

I

V

I

I

H115 (vs. gap) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (= S138) binding in other chain
A160 (= A156) binding in other chain
TK 165:166 (≠ ID 161:162) binding acetyl-CoA
R180 (= R176) binding acetyl-CoA

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding substrate
71 binding substrate
85 binding in other chain; binding in other chain
93 binding substrate
183 binding in other chain

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
41% identity, 39% coverage: 105:178/191 of query aligns to 96:181/201 of 1krvA

query
sites
1krvA

T

T

I

I

G

G

D

D

N

N

F

V

T

L

V

I

N
x
A

Q

P

G

N

V

V

T

T

-

L

-
x
S

-

V

-
x
T

-

G

-

H

-

P

V

V

D

H

H

H

D

E

W

L

R

R

R

K

N

N

G

G

R

E

-
x
M

-

Y

-

S

-

F

P

P

-

I

A

T

I

I

G

G

N

N

V

V

F
x
W

L

I

G
|
G

S
|
S

G

H

S

V

K

V

V

I

L
x
N

G

P

H

G

I

V

T

T

L

I

G

G

D

D

N

N

V

S

V

V

V

I

A

G

A
|
A

N

G

A

S

L

I

V

V

I

T

D

K

S

D

I

I

P

P

D

P

N

N

C

V

T

V

V

A

G

G

V

V

P
|
P

A

C

R
|
R

I

V

I

I

binding 4-nitrophenyl beta-D-galactopyranoside: M126 (vs. gap)
binding coenzyme a: A104 (≠ N113), S110 (vs. gap), T112 (vs. gap), W138 (≠ F135), G140 (= G137), S141 (= S138), N146 (≠ L143), A159 (= A156), P177 (= P174), R179 (= R176)

Sites not aligning to the query:

binding 4-nitrophenyl beta-D-galactopyranoside: 16, 25, 70, 82, 84, 90, 92
binding coenzyme a: 182

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
41% identity, 39% coverage: 105:178/191 of query aligns to 96:181/201 of 1kruA

query
sites
1kruA

T

T

I

I

G

G

D

D

N

N

F

V

T
x
L

V

I

N

A

Q

P

G

N

V

V

T

T

-

L

-

S

-

V

-

T

-

G

-
x
H

-

P

V

V

D

H

H

H

D

E

W

L

R

R

R

K

N

N

G

G

R

E

-
x
M

-

Y

-

S

-

F

P

P

-

I

A

T

I

I

G

G

N

N

V

V

F
x
W

L

I

G
|
G

S
|
S

G

H

S

V

K

V

V

I

L

N

G

P

H

G

I

V

T

T

L

I

G

G

D

D

N

N

V

S

V

V

V

I

A
x
G

A
|
A

N

G

A

S

L

I

V

V

I

T

D

K

S

D

I

I

P

P

D

P

N

N

C

V

T

V

V

A

G

G

V

V

P
|
P

A

C

R

R

I

V

I

I

binding coenzyme a: H114 (vs. gap), W138 (≠ F135), G140 (= G137), S141 (= S138), G158 (≠ A155), A159 (= A156), P177 (= P174)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: L102 (≠ T111), H114 (vs. gap), M126 (vs. gap)

Sites not aligning to the query:

binding coenzyme a: 182
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: 16, 22, 25, 62, 70, 82, 82, 84, 90, 92

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
41% identity, 39% coverage: 105:178/191 of query aligns to 96:181/200 of 1krrA

query
sites
1krrA

T

T

I

I

G

G

D

D

N

N

F

V

T

L

V
x
I

N
x
A

Q
x
P

G

N

V

V

T

T

-

L

-

S

-

V

-
x
T

-

G

-
x
H

-

P

V

V

D

H

H

H

D

E

W

L

R

R

R

K

N

N

G

G

R

E

-

M

-

Y

-

S

-

F

P

P

-

I

A

T

I

I

G

G

N

N

V

V

F

W

L

I

G
|
G

S
|
S

G

H

S

V

K

V

V

I

L
x
N

G

P

H

G

I

V

T

T

L

I

G

G

D

D

N

N

V

S

V

V

V

I

A
x
G

A
|
A

N

G

A

S

L

I

V

V

I

T

D

K

S

D

I

I

P

P

D

P

N

N

C

V

T

V

V

A

V
x
A

G

G

V

V

P
|
P

A

C

R

R

I

V

I

I

binding acetyl coenzyme *a: I103 (≠ V112), A104 (≠ N113), P105 (≠ Q114), T112 (vs. gap), H114 (vs. gap), G140 (= G137), S141 (= S138), N146 (≠ L143), G158 (≠ A155), A159 (= A156), A174 (≠ V171), P177 (= P174)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84, 182

1sstA Serine acetyltransferase- complex with coa (see paper)
30% identity, 52% coverage: 79:178/191 of query aligns to 138:233/233 of 1sstA

query
sites
1sstA

I

V

H

D

I

I

N

H

R

P

K

A

V

A

P

K

I

I

G

G

D

H

G

G

F

I

I

M

I

F

H

D

N
x
H

F

A

S

T

C

G

I

I

R

V

I

V

N

G

A

E

E

T

T

S

I

V

G

I

D

E

N

N

-

D

F

V

T

S

V

I

N
x
L

Q

Q

G

G

V

V

T

T

V

L

D

G

H

-

D

-

W

-

R

-

N
x
G

G
x
T

R

H

P

P

A

K

I

V

G

R

N

E

N

G

V

V

F

M

L

I

G

G

S
x
A

G

G

S

A

K

K

V

I

L
|
L

G

G

H

N

I

I

T

E

L

V

G

G

D

K

N

Y

V

A

V
x
K

V

I

A
x
G

A
|
A

N

N

A

S

L
x
V

V

V

I
x
L

D

N

S

P

I

V

P

P

D

E

N

Y

C

A

T
|
T

V

A

V
x
A

G

G

V
|
V

P
|
P

A

A

R

R

I

I

I
x
V

binding coenzyme a: H154 (≠ N95), L173 (≠ N113), G180 (≠ N125), T181 (≠ G126), A193 (≠ S138), L198 (= L143), K208 (≠ V153), G210 (≠ A155), A211 (= A156), V214 (≠ L159), L216 (≠ I161), T224 (= T169), A226 (≠ V171), V228 (= V173), P229 (= P174), V233 (≠ I178)

P71063 UDP-N-acetylbacillosamine N-acetyltransferase; EC 2.3.1.203 from Bacillus subtilis (strain 168) (see paper)
31% identity, 55% coverage: 81:185/191 of query aligns to 99:214/216 of P71063

query
sites
P71063

I

V

N

S

R

K

K

S

V

A

P

V

I

I

G

G

D

E

G

G

F

T

I

V

I

I

H

M

N

A

F

G

S

A

C

I

I

I

R

Q

I

A

N

D

A

A

E

R

T

-

I

I

G

G

D

A

N

H

F

C

T

I

V

I

N

N

Q

T

G

G

V

A

T

V

V

A

D

E

H

H

D

D

W

N

R

Q

-

I

-

S

-

D

-

Y

-

V

-
x
H

-

L

-

S

-

P

-

R

-

A

-

T

R

L

N

S

G

G

R

A

P

V

A

S

I

V

G

Q

N

E

N

G

V

A

F

H

L

V

G

G

S

T

G

G

S

A

K

S

V

V

L

I

G

P

H

Q

I

I

T

I

L

I

G

G

D

A

N

W

V

S

V

I

V

V

A

G

A

A

N

G

A

S

L

A

V

V

I

I

D

R

S

S

I

I

P

P

D

D

N

R

C

V

T

T

V

A

G

G

V

A

P

P

A

A

R

R

I

I

S

S

R

S

D

I

A

Q

S

T

S

S

N

N

H146 (vs. gap) mutation to L: Loss of activity. Affects the oligomeric state.

4n69A Soybean serine acetyltransferase complexed with serine (see paper)
30% identity, 52% coverage: 79:178/191 of query aligns to 141:243/243 of 4n69A

query
sites
4n69A

I

V

H

D

I

I

N

H

R

P

K

A

V

A

P

R

I

I

G

G

D

K

G

G

F

I

I

L

I

F

-

D

H

H

N

A

F

T

S

G

C

V

I

V

R

V

I

G

N

E

A

T

E

A

T

V

I

I

G

G

D

N

N

N

F

V

T

S

V

I

N

L

Q

H

G

H

V

V

T

T

V

L

D

G

H
x
G

D

T

W

G

R

K

R

V

N

G

G

G

-

D

-
x
R

R
x
H

P

P

A

K

I

I

G

G

N

D

N

G

V

V

F

L

L

I

G

G

S

A

G

G

S

A

K

T

V

I

L

L

G

G

H

N

I

I

T

K

L

I

G

G

D

E

N

G

V

A

V

K

V

V

A

G

A

A

N

G

A

S

L

V

V

V

I

L

D

I

S

D

I

V

P

P

D

P

N

R

C

T

T

T

V

A

V

V

G

G

V

N

P

P

A

A

R

R

I

L

I

V

binding serine: G183 (≠ H120), R191 (vs. gap), H192 (≠ R127)

Query Sequence

>WP_020562826.1 NCBI__GCF_000372865.1:WP_020562826.1
MVSLIDAIKSDFARKSGHYFLVDTFFERYVKTALQLGTLAVVVYRFGAWAEHIRFAPARW
SCLVLYHFFNLLSETLTGIHINRKVPIGDGFIIHNFSCIRINAETIGDNFTVNQGVTVDH
DWRRNGRPAIGNNVFLGSGSKVLGHITLGDNVVVAANALVIDSIPDNCTVVGVPARIISR
DASSNYLQLKK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory