SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_022528026.1 NCBI__GCF_000469325.1:WP_022528026.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
42% identity, 95% coverage: 20:508/515 of query aligns to 2:488/501 of P04983

query
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P04983

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K43 (= K61) mutation to R: Loss of transport.

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 42% coverage: 22:238/515 of query aligns to 4:229/254 of 1g6hA

query
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1g6hA

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binding adenosine-5'-diphosphate: F14 (= F32), F17 (≠ N35), N39 (= N57), G40 (= G58), G42 (= G60), K43 (= K61), S44 (= S62), T45 (= T63)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 42% coverage: 22:238/515 of query aligns to 4:229/253 of 1g9xB

query
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1g9xB

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binding adenosine-5'-diphosphate: F14 (= F32), F17 (≠ N35), G40 (= G58), S41 (≠ A59), G42 (= G60), K43 (= K61), S44 (= S62), T45 (= T63)
binding magnesium ion: S44 (= S62), E176 (= E185)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
28% identity, 42% coverage: 22:238/515 of query aligns to 1:220/343 of P30750

query
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P30750

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40:46 (vs. 57:63, 86% identical) binding ATP
E166 (= E185) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 2 papers)
28% identity, 47% coverage: 19:260/515 of query aligns to 8:249/265 of P07821

query
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P07821

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Q

T

P

R

P

D

S

E

E

G

G

K

E

F

I

Y

L

L

L

D

D

G

A

K

Q

E

P

V

L

S

E

F

S

Q

W

G

S

P

S

K

K

D

-

A

A

L

F

E

A

N

R

G

K

I

V

A

A

M

Y

V

L

H

P

Q

Q

E

Q

L

L

N

P

Q

P

A

A

L

E

D

G

R

M

S

T

V

V

V

R

D

E

N

L

L

V

F

A

L

I

G

G

R

R

Y

Y

P

P

V

W

N

H

A

G

-

A

-

L

-

G

-

R

L

F

G

G

V

A

V

A

D

D

E

-

R

-

Q

-

M

-

R

R

R

E

E

K

A

V

T

E

E

E

L

A

F

I

R

S

R

L

L

V

G

G

M

L

T

K

V

P

N

L

L

A

T

H

Q

R

P

L

M

V

R

D

K

S

M

L

S

S

V

G

S

G

Q

E

R

R

Q

Q

M

R

V

A

E

W

I

I

A

A

K

M

A

L

I

V

S

A

Y

Q

H

D

S

S

K

R

V

C

I

L

V

L

L

L

D
|
D

E
|
E

P

P

T

T

S

S

S

A

L

L

-

D

M

I

A

A

Q

H

E

Q

V

V

D

D

K

V

L

L

F

S

D

L

M

V

V

H

R

R

M

L

L

S

K

Q

K

E

Q

R

G

G

I

L

S

T

I

V

I

I

F

A

I

V

S

L

H

H

K

D

M

I

D

N

E

M

V

A

F

A

Q

R

I

Y

C

C

D

D

E

Y

V

L

S

V

V

A

L

L

R

R

D

G

G

G

H

E

L

M

V

I

M

A

T

Q

K

G

K

T

T

P

A

A

D

E

T

I

N

M

M

R

N

G

E

E

L

T

V

L

K

E

A

M

M

I

V

Y

G

G

R

I

P

P

L

M

K50 (= K61) mutation to Q: Lack of activity.
D172 (= D184) mutation to E: Lack of activity.
E173 (= E185) mutation to A: Lack of activity.

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
28% identity, 42% coverage: 22:238/515 of query aligns to 2:221/344 of 6cvlD

query
sites
6cvlD

M

M

L

I

S

K

I

L

R

S

G

N

L

I

S

T

K

K

S

V

F
|
F

G

H

R
x
Q

N

G

-

T

-

R

-

T

-
x
I

R

Q

V

A

L

L

D

N

H

N

I

V

D

S

M

L

D

H

V

V

K

P

K

A

G

G

S

Q

V

I

M

Y

G

G

L

V

M

I

G

G

E

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

M

L

M

I

K

R

C

C

L

V

F

N

G

L

I

L

K

E

T

R

R

P

D

T

E

E

G

G

K

S

F

V

Y

L

L

V

D

D

G

G

K

Q

E

E

V

L

S

T

F

T

Q

L

G

S

P

E

K

S

D

E

A

L

L

T

E

K

-

A

-

R

N

R

G

Q

I

I

A

G

M

M

V

I

H

F

Q

Q

E

H

L

F

N

N

Q

L

A

L

L

S

D

S

R

R

S

T

V

V

V

F

D

G

N

N

L

V

F

A

L

L

G

-

R

-

Y

-

P

P

V

L

N

E

A

-

L

L

G

D

V

N

V

T

D

P

E

K

R

D

Q

E

M

V

R

K

R

R

E

R

A

V

T

T

E

E

L

L

F

L

R

S

R

L

L

V

G

G

M

L

T

G

V

D

N

K

L

H

T

D

Q

S

P

Y

M

P

R

S

K
x
N

M

L

S
|
S

V

G

S

G

Q
|
Q

R

K

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

S

H

N

S

P

K

K

V

V

I

L

V

L

L

C

D

D

E

Q

P

A

T

T

S

S

S

A

L

L

M

D

A

P

Q

A

E

T

V

T

D

R

K

S

L

I

F

L

D

E

M

L

V

L

R

K

M

D

L

I

K

N

K

R

Q

R

-

L

G

G

I

L

S

T

I

I

I

L

F

L

I

I

S

T

H
|
H

K

E

M

M

D

D

E

V

V

V

F

K

Q

R

I

I

C

C

D

D

E

C

V

V

S

A

V

V

L

I

R

S

D

N

G

G

H

E

L

L

V

I

binding phosphothiophosphoric acid-adenylate ester: F12 (= F32), Q14 (≠ R34), I19 (vs. gap), S41 (≠ N57), G42 (= G58), A43 (= A59), G44 (= G60), K45 (= K61), S46 (= S62), T47 (= T63), N141 (≠ K159), S143 (= S161), Q146 (= Q164), H200 (= H217)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
28% identity, 42% coverage: 22:238/515 of query aligns to 2:221/344 of 3tuzC

query
sites
3tuzC

M

M

L

I

S

K

I

L

R

S

G

N

L

I

S

T

K

K

S

V

F
|
F

G

H

R
x
Q

N

G

-

T

-

R

-

T

-

I

R

Q

V

A

L

L

D

N

H

N

I

V

D

S

M

L

D

H

V

V

K

P

K

A

G

G

S

Q

V

I

M

Y

G

G

L

V

M

I

G

G

E

A

N

S

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

M

L

M

I

K

R

C

C

L

V

F

N

G

L

I

L

K

E

T

R

R

P

D

T

E

E

G

G

K

S

F

V

Y

L

L

V

D

D

G

G

K

Q

E

E

V

L

S

T

F

T

Q

L

G

S

P

E

K

S

D

E

A

L

L

T

E

K

-

A

-

R

N

R

G

Q

I

I

A

G

M

M

V

I

H

F

Q

Q

E

H

L

F

N

N

Q

L

A

L

L

S

D

S

R

R

S

T

V

V

V

F

D

G

N

N

L

V

F

A

L

L

G

-

R

-

Y

-

P

P

V

L

N

E

A

-

L

L

G

D

V

N

V

T

D

P

E

K

R

D

Q

E

M

V

R

K

R

R

E

R

A

V

T

T

E

E

L

L

F

L

R

S

R

L

L

V

G

G

M

L

T

G

V

D

N

K

L

H

T

D

Q

S

P

Y

M

P

R

S

K

N

M

L

S

S

V

G

S

G

Q

Q

R

K

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

S

H

N

S

P

K

K

V

V

I

L

V

L

L

C

D

D

E

Q

P

A

T

T

S

S

S

A

L

L

M

D

A

P

Q

A

E

T

V

T

D

R

K

S

L

I

F

L

D

E

M

L

V

L

R

K

M

D

L

I

K

N

K

R

Q

R

-

L

G

G

I

L

S

T

I

I

I

L

F

L

I

I

S

T

H

H

K

E

M

M

D

D

E

V

V

V

F

K

Q

R

I

I

C

C

D

D

E

C

V

V

S

A

V

V

L

I

R

S

D

N

G

G

H

E

L

L

V

I

binding adenosine-5'-diphosphate: F12 (= F32), Q14 (≠ R34), G42 (= G58), G44 (= G60), K45 (= K61), S46 (= S62), T47 (= T63)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
28% identity, 42% coverage: 22:238/515 of query aligns to 2:221/344 of 3tuiC

query
sites
3tuiC

M

M

L

I

S

K

I

L

R

S

G

N

L

I

S

T

K

K

S

V

F
|
F

G

H

R

Q

N

G

-

T

-

R

-

T

-

I

R

Q

V

A

L

L

D

N

H

N

I

V

D

S

M

L

D

H

V

V

K

P

K

A

G

G

S

Q

V

I

M

Y

G

G

L

V

M

I

G

G

E

A

N

S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

M

L

M

I

K

R

C

C

L

V

F

N

G

L

I

L

K

E

T

R

R

P

D

T

E

E

G

G

K

S

F

V

Y

L

L

V

D

D

G

G

K

Q

E

E

V

L

S

T

F

T

Q

L

G

S

P

E

K

S

D

E

A

L

L

T

E

K

-

A

-

R

N

R

G

Q

I

I

A

G

M

M

V

I

H

F

Q

Q

E

H

L

F

N

N

Q

L

A

L

L

S

D

S

R

R

S

T

V

V

V

F

D

G

N

N

L

V

F

A

L

L

G

-

R

-

Y

-

P

P

V

L

N

E

A

-

L

L

G

D

V

N

V

T

D

P

E

K

R

D

Q

E

M

V

R

K

R

R

E

R

A

V

T

T

E

E

L

L

F

L

R

S

R

L

L

V

G

G

M

L

T

G

V

D

N

K

L

H

T

D

Q

S

P

Y

M

P

R

S

K

N

M

L

S

S

V

G

S

G

Q

Q

R

K

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

S

H

N

S

P

K

K

V

V

I

L

V

L

L

C

D

D

E

Q

P

A

T

T

S

S

S

A

L

L

M

D

A

P

Q

A

E

T

V

T

D

R

K

S

L

I

F

L

D

E

M

L

V

L

R

K

M

D

L

I

K

N

K

R

Q

R

-

L

G

G

I

L

S

T

I

I

I

L

F

L

I

I

S

T

H

H

K

E

M

M

D

D

E

V

V

V

F

K

Q

R

I

I

C

C

D

D

E

C

V

V

S

A

V

V

L

I

R

S

D

N

G

G

H

E

L

L

V

I

binding adenosine-5'-diphosphate: F12 (= F32), G42 (= G58), A43 (= A59), G44 (= G60), K45 (= K61), S46 (= S62), T47 (= T63)

3c4jA Abc protein artp in complex with atp-gamma-s
27% identity, 43% coverage: 22:245/515 of query aligns to 3:224/242 of 3c4jA

query
sites
3c4jA

M

M

L

I

S

D

I

V

R

H

G

Q

L

L

S

K

K

K

S

S

F
|
F

G

G

R

S

N

L

R

E

V
|
V

L

L

D

K

H

G

I

I

D

N

M

V

D

H

V

I

K

R

K

E

G

G

S

E

V

V

M

V

G

V

L

V

M

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

M

F

M

L

K

R

C

C

L

L

F

N

G

L

I

L

K

E

T

D

R

F

D

D

E

E

G

G

K

E

F

I

Y

I

L

I

D

D

G

G

K

I

E

N

V

L

S

K

F

A

Q

K

G

D

P

T

K

N

-

L

D

N

A

K

L

V

E

R

N

E

G

E

I

V

A

G

M

M

V

V

H

F

Q

Q

E

R

L

F

N

N

Q

L

A

F

L

P

D

H

R

M

S

T

V

V

V

L

D

N

N

N

L

I

F

T

L

L

G

A

R

P

Y

M

P

K

V

V

N

R

A

K

L

W

G

-

V

-

V

-

D

P

E

R

R

E

Q

K

M

A

R

E

R

A

E

K

A

A

T

M

E

E

L

L

F

L

R

D

R

K

L

V

G

G

M

L

T

K

V

D

N

K

L

A

T

H

Q

A

P

Y

M

P

R

D

K

S

M

L

S

S

V

G

S

G

Q

Q

R

A

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

M

H

E

S

P

K

K

V

I

I

M

V

L

L

F

D

D

E

E

P

P

T

T

S

S

S

A

L

L

M

D

A

P

Q

E

E

M

V

V

D

G

K

E

L

V

F

L

D

S

M

V

V

M

R

K

M

Q

L

L

K

A

K

N

Q

E

G

G

I

M

S

T

I

M

I

V

F

V

I

V

S

T

H

H

K

E

M

M

D

G

E

F

V

A

F

R

Q

E

I

V

C

G

D

D

E

R

V

V

S

L

V

F

L

M

R

D

D

G

G

G

H

Y

L

I

V

I

M

E

T

E

K

G

K

K

T

P

A

E

D

D

binding phosphothiophosphoric acid-adenylate ester: F13 (= F32), V18 (= V37), S38 (≠ N57), G39 (= G58), S40 (≠ A59), G41 (= G60), K42 (= K61), S43 (= S62), T44 (= T63)

3c41J Abc protein artp in complex with amp-pnp/mg2+
27% identity, 43% coverage: 22:245/515 of query aligns to 3:224/242 of 3c41J

query
sites
3c41J

M

M

L

I

S

D

I

V

R

H

G

Q

L

L

S

K

K

K

S

S

F
|
F

G

G

R

S

N

L

R

E

V
|
V

L

L

D

K

H

G

I

I

D

N

M

V

D

H

V

I

K

R

K

E

G

G

S

E

V

V

M

V

G

V

L

V

M

I

G

G

E

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

M

F

M

L

K

R

C

C

L

L

F

N

G

L

I

L

K

E

T

D

R

F

D

D

E

E

G

G

K

E

F

I

Y

I

L

I

D

D

G

G

K

I

E

N

V

L

S

K

F

A

Q

K

G

D

P

T

K

N

-

L

D

N

A

K

L

V

E

R

N

E

G

E

I

V

A

G

M

M

V

V

H

F

Q

Q

E

R

L

F

N

N

Q

L

A

F

L

P

D

H

R

M

S

T

V

V

V

L

D

N

N

N

L

I

F

T

L

L

G

A

R

P

Y

M

P

K

V

V

N

R

A

K

L

W

G

-

V

-

V

-

D

P

E

R

R

E

Q

K

M

A

R

E

R

A

E

K

A

A

T

M

E

E

L

L

F

L

R

D

R

K

L

V

G

G

M

L

T

K

V

D

N

K

L

A

T

H

Q

A

P

Y

M

P

R

D

K

S

M

L

S

S

V

G

S

G

Q

Q

R

A

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

M

H

E

S

P

K

K

V

I

I

M

V

L

L

F

D
|
D

E

E

P

P

T

T

S

S

S

A

L

L

M

D

A

P

Q

E

E

M

V

V

D

G

K

E

L

V

F

L

D

S

M

V

V

M

R

K

M

Q

L

L

K

A

K

N

Q

E

G

G

I

M

S

T

I

M

I

V

F

V

I

V

S

T

H

H

K

E

M

M

D

G

E

F

V

A

F

R

Q

E

I

V

C

G

D

D

E

R

V

V

S

L

V

F

L

M

R

D

D

G

G

G

H

Y

L

I

V

I

M

E

T

E

K

G

K

K

T

P

A

E

D

D

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F32), V18 (= V37), S38 (≠ N57), G39 (= G58), G41 (= G60), K42 (= K61), S43 (= S62), T44 (= T63)
binding magnesium ion: S43 (= S62), D163 (= D184)

2olkA Abc protein artp in complex with adp-beta-s
27% identity, 43% coverage: 22:245/515 of query aligns to 3:224/242 of 2olkA

query
sites
2olkA

M

M

L

I

S

D

I

V

R

H

G

Q

L

L

S

K

K

K

S

S

F
|
F

G

G

R

S

N

L

R

E

V
|
V

L

L

D

K

H

G

I

I

D

N

M

V

D

H

V

I

K

R

K

E

G

G

S

E

V

V

M

V

G

V

L

V

M

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

M

F

M

L

K

R

C

C

L

L

F

N

G

L

I

L

K

E

T

D

R

F

D

D

E

E

G

G

K

E

F

I

Y

I

L

I

D

D

G

G

K

I

E

N

V

L

S

K

F

A

Q

K

G

D

P

T

K

N

-

L

D

N

A

K

L

V

E

R

N

E

G

E

I

V

A

G

M

M

V

V

H

F

Q

Q

E

R

L

F

N

N

Q

L

A

F

L

P

D

H

R

M

S

T

V

V

V

L

D

N

N

N

L

I

F

T

L

L

G

A

R

P

Y

M

P

K

V

V

N

R

A

K

L

W

G

-

V

-

V

-

D

P

E

R

R

E

Q

K

M

A

R

E

R

A

E

K

A

A

T

M

E

E

L

L

F

L

R

D

R

K

L

V

G

G

M

L

T

K

V

D

N

K

L

A

T

H

Q

A

P

Y

M

P

R

D

K

S

M

L

S

S

V

G

S

G

Q

Q

R

A

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

M

H

E

S

P

K

K

V

I

I

M

V

L

L

F

D

D

E

E

P

P

T

T

S

S

S

A

L

L

M

D

A

P

Q

E

E

M

V

V

D

G

K

E

L

V

F

L

D

S

M

V

V

M

R

K

M

Q

L

L

K

A

K

N

Q

E

G

G

I

M

S

T

I

M

I

V

F

V

I

V

S

T

H

H

K

E

M

M

D

G

E

F

V

A

F

R

Q

E

I

V

C

G

D

D

E

R

V

V

S

L

V

F

L

M

R

D

D

G

G

G

H

Y

L

I

V

I

M

E

T

E

K

G

K

K

T

P

A

E

D

D

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F32), V18 (= V37), S38 (≠ N57), G39 (= G58), S40 (≠ A59), G41 (= G60), K42 (= K61), S43 (= S62), T44 (= T63)

2oljA Abc protein artp in complex with adp/mg2+
27% identity, 43% coverage: 22:245/515 of query aligns to 3:224/242 of 2oljA

query
sites
2oljA

M

M

L

I

S

D

I

V

R

H

G

Q

L

L

S

K

K

K

S

S

F
|
F

G

G

R

S

N

L

R

E

V
|
V

L

L

D

K

H

G

I

I

D

N

M

V

D

H

V

I

K

R

K

E

G

G

S

E

V

V

M

V

G

V

L

V

M

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

M

F

M

L

K

R

C

C

L

L

F

N

G

L

I

L

K

E

T

D

R

F

D

D

E

E

G

G

K

E

F

I

Y

I

L

I

D

D

G

G

K

I

E

N

V

L

S

K

F

A

Q

K

G

D

P

T

K

N

-

L

D

N

A

K

L

V

E

R

N

E

G

E

I

V

A

G

M

M

V

V

H

F

Q

Q

E

R

L

F

N

N

Q

L

A

F

L

P

D

H

R

M

S

T

V

V

V

L

D

N

N

N

L

I

F

T

L

L

G

A

R

P

Y

M

P

K

V

V

N

R

A

K

L

W

G

-

V

-

V

-

D

P

E

R

R

E

Q

K

M

A

R

E

R

A

E

K

A

A

T

M

E

E

L

L

F

L

R

D

R

K

L

V

G

G

M

L

T

K

V

D

N

K

L

A

T

H

Q

A

P

Y

M

P

R

D

K

S

M

L

S

S

V

G

S

G

Q

Q

R

A

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

M

H

E

S

P

K

K

V

I

I

M

V

L

L

F

D

D

E

E

P

P

T

T

S

S

S

A

L

L

M

D

A

P

Q

E

E

M

V

V

D

G

K

E

L

V

F

L

D

S

M

V

V

M

R

K

M

Q

L

L

K

A

K

N

Q

E

G

G

I

M

S

T

I

M

I

V

F

V

I

V

S

T

H

H

K

E

M

M

D

G

E

F

V

A

F

R

Q

E

I

V

C

G

D

D

E

R

V

V

S

L

V

F

L

M

R

D

D

G

G

G

H

Y

L

I

V

I

M

E

T

E

K

G

K

K

T

P

A

E

D

D

binding adenosine-5'-diphosphate: F13 (= F32), V18 (= V37), S38 (≠ N57), G39 (= G58), S40 (≠ A59), G41 (= G60), K42 (= K61), S43 (= S62), T44 (= T63)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
27% identity, 42% coverage: 22:238/515 of query aligns to 2:215/241 of 4u00A

query
sites
4u00A

M

I

L

I

S

R

I

I

R

R

G

N

L

L

S

H

K

K

S

W

F
|
F

G

G

R

P

N

L

R

H

V
|
V

L

L

D

K

H

G

I

I

D

H

M

L

D

E

V

V

K

A

K

P

G

G

S

E

V

K

M

L

G

V

L

I

M

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

M

L

M

I

K

R

C

T

L

I

F

N

G

R

I

L

K

E

T

D

R

F

D

Q

E

E

G

G

K

E

F

V

Y

V

L

V

D

D

G

G

K

L

E

S

V

V

S

K

F

D

Q

D

G

R

P

A

K

L

D

R

A

E

L

I

E

R

N

R

G

E

I

V

A

G

M

M

V

V

H

F

Q

Q

E

Q

L

F

N

N

Q

L

A

F

L

P

D

H

R

M

S

T

V

V

V

L

D

E

N

N

L

V

F

T

L

L

G

A

-

P

-

M

-

R

-

V

-

R

R

R

Y

W

P

P

V

-

N

-

A

-

L

-

G

-

V

-

V

-

D

-

E

R

R

E

Q

K

M

A

R

E

R

K

E

K

A

A

T

L

E

E

L

L

F

L

R

E

R

R

L

V

G

G

M

I

T

L

V

D

N

Q

L

A

T

R

Q

K

P

Y

M

P

R

A

K

Q

M

L

S

S

V

G

S

G

Q

Q

R

Q

Q

Q

M

R

V

V

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

M

H

E

S

P

K

K

V

I

I

M

V

L

L

F

D

D

E

E

P

P

T

T

S

S

S

A

L

L

M

D

A

P

Q

E

E

M

V

V

D

G

K

E

L

V

F

L

D

D

M

V

V

M

R

R

M

D

L

L

K

A

K

Q

Q

G

G

G

I

M

S

T

I

M

I

V

F

V

I

V

S

T

H

H

K

E

M

M

D

G

E

F

V

A

F

R

Q

E

I

V

C

A

D

D

E

R

V

V

S

V

V

F

L

M

R

D

D

G

G

G

H

Q

L

I

V

V

binding adenosine-5'-diphosphate: F12 (= F32), V17 (= V37), S37 (≠ N57), G38 (= G58), S39 (≠ A59), G40 (= G60), K41 (= K61), S42 (= S62), T43 (= T63)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
25% identity, 42% coverage: 22:238/515 of query aligns to 1:215/240 of 4ymuJ

query
sites
4ymuJ

M

M

L

I

S

F

I

V

R

N

G

D

L

V

S

Y

K

K

S

N

F
|
F

G

G

R

S

N

L

R

E

V
|
V

L

L

D

K

H

G

I

V

D

T

M

L

D

K

V

V

K

N

K

K

G

G

S

E

V

V

M

V

G

V

L

I

M

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

M

L

M

L

K

R

C

C

L

I

F

N

G

L

I

L

K

E

T

E

R

P

D

T

E

K

G

G

K

E

F

V

Y

F

L

I

D

D

G

G

K

V

E

K

V

I

S

N

F

N

Q

G

G

K

P

V

K

N

-

I

D

N

A

K

L

V

E

R

N

Q

G

K

I

V

A

G

M

M

V

V

H

F

Q

Q

E

H

L

F

N

N

Q

L

A

F

L

P

D

H

R

L

S

T

V

A

V

I

D

E

N

N

L

I

F

T

L

L

G

A

R

P

Y

V

P

K

V

V

N

K

A

K

L

M

G

-

V

-

V

-

D

N

E

K

R

K

Q

E

M

A

R

E

R

E

E

L

A

A

T

V

E

D

L

L

F

L

R

A

R

K

L

V

G

G

M

L

T

L

V

D

N

K

L

K

T

D

Q

Q

P

Y

M

P

R

I

K

K

M

L

S

S

V

G

S

G

Q

Q

R

K

Q

Q

M

R

V

L

E

A

I

I

A

A

K

R

A

A

I

L

S

A

Y

M

H

Q

S

P

K

E

V

V

I

M

V

L

L

F

D

D

E
|
E

P

P

T

T

S

S

S

A

L

L

M

D

A

P

Q

E

E

M

V

V

D

K

K

E

L

V

F

L

D

N

M

V

V

M

R

K

M

Q

L

L

K

A

K

N

Q

E

G

G

I

M

S

T

I

M

I

V

F

V

I

V

S

T

H
|
H

K

E

M

M

D

G

E

F

V

A

F

R

Q

E

I

V

C

G

D

D

E

R

V

V

S

I

V

F

L

M

R

D

D

D

G

G

H

V

L

I

V

V

binding adenosine-5'-triphosphate: F11 (= F32), V16 (= V37), S36 (≠ N57), G37 (= G58), S38 (≠ A59), G39 (= G60), K40 (= K61), S41 (= S62), T42 (= T63), E162 (= E185), H194 (= H217)
binding magnesium ion: S41 (= S62), E162 (= E185)

8k1pB Mycobacterial efflux pump, adp+vanadate bound state
30% identity, 42% coverage: 21:238/515 of query aligns to 2:208/213 of 8k1pB

query
sites
8k1pB

V

V

M

P

L

I

S

E

I

I

R

R

G

G

L

L

S

T

K

K

S

H

F
|
F

G

G

R

S

N

V

R

R

V

A

L

L

D

D

H

G

I

L

D

D

M

L

D

T

V

V

K

R

K

E

G

G

S

E

V

V

M

H

G

G

L

F

M

L

G

G

E

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

M

T

M

L

K

R

C

I

L

L

F

L

G

G

I

L

K

V

T

K

R

A

D

D

E

G

G

G

K

S

F

V

Y

R

L

L

D

L

G

G

K

G

E

D

V

P

S

W

F

-

Q

-

G

-

P

-

K

T

D

D

A

A

L

V

E

D

N

-

G

-

I

-

A

-

M

-

V

L

H

H

Q

R

E

H

L

I

N

A

Q

Y

A

V

L

P

D

G

R

D

S

V

V

T

V

L

D

W

N

P

L

S

F

L

L

T

G

G

R

G

Y

E

P

T

V

I

N

D

A

L

L

L

-

A

-

R

-

M

-

R

G

G

V

G

V

I

D

D

E

-

R

-

Q

N

M

A

R

R

R

R

E

-

A

-

T

A

E

E

L

L

F

I

R

E

R

R

L

F

G

G

M

L

T

-

V

-

N

D

L

P

T

T

Q

K

P

K

M

A

R

R

K
x
T

M

Y

S
|
S

V

K

S

G

Q

N

R

R

Q

Q

M

K

V

V

E

S

I

L

A

I

K

S

A

A

I

L

S

S

Y

S

H

H

S

A

K

T

V

L

I

L

V

L

L

L

D

D

E

E

P

P

T

S

S

S

S

G

L

L

M

D

A

P

Q

L

E

M

V

E

D

N

K

V

L

F

F

Q

D

Q

M

C

V

I

R

G

M

E

L

A

K

R

K

Q

Q

R

G

G

I

V

S

T

I

V

I

L

F

L

I

S

S

S

H

H

K

I

M

L

D

A

E

E

V

T

F

E

Q

A

I

L

C

C

D

E

E

K

V

V

S

T

V

I

L

I

R

R

D

A

G

G

H

K

L

T

V

V

binding adenosine-5'-diphosphate: F13 (= F32), N38 (= N57), G39 (= G58), A40 (= A59), G41 (= G60), K42 (= K61), S43 (= S62), T44 (= T63)
binding adenosine-5'-triphosphate: T129 (≠ K159), S131 (= S161)

8k1oB Mycobacterial efflux pump, amppnp bound state
30% identity, 42% coverage: 21:238/515 of query aligns to 4:210/215 of 8k1oB

query
sites
8k1oB

V

V

M

P

L

I

S

E

I

I

R

R

G

G

L

L

S

T

K

K

S

H

F

F

G

G

R

S

N

V

R

R

V

A

L

L

D

D

H

G

I

L

D

D

M

L

D

T

V

V

K

R

K

E

G

G

S

E

V

V

M

H

G

G

L

F

M

L

G

G

E

P

N
|
N

G

G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

M

T

M

L

K

R

C

I

L

L

F

L

G

G

I

L

K

V

T

K

R

A

D

D

E

G

G

G

K

S

F

V

Y

R

L

L

D

L

G

G

K

G

E

D

V

P

S

W

F

-

Q

-

G

-

P

-

K

T

D

D

A

A

L

V

E

D

N

-

G

-

I

-

A

-

M

-

V

L

H

H

Q

R

E

H

L

I

N

A

Q

Y

A

V

L

P

D

G

R

D

S

V

V

T

V

L

D

W

N

P

L

S

F

L

L

T

G

G

R

G

Y

E

P

T

V

I

N

D

A

L

L

L

-

A

-

R

-

M

-

R

G

G

V

G

V

I

D

D

E

-

R

-

Q

N

M

A

R

R

R

R

E

-

A

-

T

A

E

E

L

L

F

I

R

E

R

R

L

F

G

G

M

L

T

-

V

-

N

D

L

P

T

T

Q

K

P

K

M

A

R

R

K
x
T

M

Y

S
|
S

V

K

S

G

Q

N

R

R

Q

Q

M

K

V

V

E

S

I

L

A

I

K

S

A

A

I

L

S

S

Y

S

H

H

S

A

K

T

V

L

I

L

V

L

L

L

D

D

E

E

P

P

T

S

S

S

S

G

L

L

M

D

A

P

Q

L

E

M

V

E

D

N

K

V

L

F

F

Q

D

Q

M

C

V

I

R

G

M

E

L

A

K

R

K

Q

Q

R

G

G

I

V

S

T

I

V

I

L

F

L

I

S

S

S

H

H

K

I

M

L

D

A

E

E

V

T

F

E

Q

A

I

L

C

C

D

E

E

K

V

V

S

T

V

I

L

I

R

R

D

A

G

G

H

K

L

T

V

V

binding phosphoaminophosphonic acid-adenylate ester: N40 (= N57), G43 (= G60), K44 (= K61), S45 (= S62), T46 (= T63), T131 (≠ K159), S133 (= S161)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
27% identity, 46% coverage: 21:257/515 of query aligns to 2:242/353 of 1oxvD

query
sites
1oxvD

V

V

M

R

L

I

S

I

I

V

R

K

G

N

L

V

S

S

K

K

S

V

F
|
F

G

K

R

K

N

G

R

K

V

V

-

V

-

A

L

L

D

D

H

N

I

V

D

N

M

I

D

N

V

I

K

E

K

N

G

G

S

E

V

R

M

F

G

G

L

I

M

L

G

G

E

P

N
x
S

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

M

F

M

M

K

R

C

I

L

I

F

A

G

G

I

L

K

D

T

V

R

P

D

S

E

T

G

G

K

E

F

L

Y

Y

L

F

D

D

G

D

K

R

E

L

V

V

S

A

F

S

Q

N

G

G

-

K

-

L

-

I

-

V

-

P

P

P

K

E

D

D

A

-

L

-

E

-

N

R

G

K

I

I

A

G

M

M

V

V

H

F

Q
|
Q

E

T

L

W

N

A

Q

L

A

Y

L

P

D

N

R

L

S

T

V

A

V

F

D

E

N

N

L

I

F

-

L

-

G

-

R

A

Y

F

P

P

V

L

N

T

A

N

L

M

G

K

V

M

V

S

D

K

E

E

R

-

Q

E

M

I

R

R

R

K

E

R

A

V

T

E

E

E

L

V

F

A

R

K

R

I

L

L

G

D

M

I

T

H

V

H

N

V

L

L

T

N

Q

H

P

F

M

P

R

R

K

E

M

L

S

S

V

G

S

G

Q

Q

R

Q

Q

Q

M

R

V

V

E

A

I

L

A

A

K

R

A

A

I

L

S

V

Y

K

H

D

S

P

K

S

V

L

I

L

V

L

L

L

D

D

E
|
E

P

P

T

F

S

S

S

N

L

L

M

D

A

A

Q

R

E

M

V

R

D

D

K

S

L

A

F

R

D

A

M

L

V

V

R

K

M

E

L

V

K

Q

K

S

Q

R

-

L

G

G

I

V

S

T

I

L

I

L

F

V

I

V

S

S

H

H

K

D

M

P

D

A

E

D

V

I

F

F

Q

A

I

I

C

A

D

D

E

R

V

V

S

G

V

V

L

L

R

V

D

K

G

G

H

K

L

L

V

V

M

Q

T

V

K

G

K

K

T

P

A

E

D

D

T

L

N

Y

M

D

N

N

E

P

L

V

-

S

-

I

-

Q

V

V

K

A

A

S

M

L

V

I

G

G

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F32), S40 (≠ N57), G41 (= G58), G43 (= G60), K44 (= K61), T45 (≠ S62), T46 (= T63), Q89 (= Q104), E166 (= E185)
binding magnesium ion: T45 (≠ S62), Q89 (= Q104)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
27% identity, 46% coverage: 21:257/515 of query aligns to 2:242/353 of 1oxvA

query
sites
1oxvA

V

V

M

R

L

I

S

I

I

V

R

K

G

N

L

V

S

S

K

K

S

V

F
|
F

G

K

R

K

N

G

R

K

V

V

-

V

-

A

L

L

D

D

H

N

I

V

D

N

M

I

D

N

V

I

K

E

K

N

G

G

S

E

V

R

M

F

G

G

L

I

M

L

G

G

E

P

N
x
S

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

M

F

M

M

K

R

C

I

L

I

F

A

G

G

I

L

K

D

T

V

R

P

D

S

E

T

G

G

K

E

F

L

Y

Y

L

F

D

D

G

D

K

R

E

L

V

V

S

A

F

S

Q

N

G

G

-

K

-

L

-

I

-

V

-

P

P

P

K

E

D

D

A

-

L

-

E

-

N

R

G

K

I

I

A

G

M

M

V

V

H

F

Q

Q

E

T

L

W

N

A

Q

L

A

Y

L

P

D

N

R

L

S

T

V

A

V

F

D

E

N

N

L

I

F

-

L

-

G

-

R

A

Y

F

P

P

V

L

N

T

A

N

L

M

G

K

V

M

V

S

D

K

E

E

R

-

Q

E

M

I

R

R

R

K

E

R

A

V

T

E

E

E

L

V

F

A

R

K

R

I

L

L

G

D

M

I

T

H

V

H

N

V

L

L

T

N

Q

H

P

F

M

P

R

R

K

E

M

L

S

S

V

G

S

G

Q

Q

R

Q

Q

Q

M

R

V

V

E

A

I

L

A

A

K

R

A

A

I

L

S

V

Y

K

H

D

S

P

K

S

V

L

I

L

V

L

L

L

D

D

E
|
E

P

P

T

F

S

S

S

N

L

L

M

D

A

A

Q

R

E

M

V

R

D

D

K

S

L

A

F

R

D

A

M

L

V

V

R

K

M

E

L

V

K

Q

K

S

Q

R

-

L

G

G

I

V

S

T

I

L

I

L

F

V

I

V

S

S

H

H

K

D

M

P

D

A

E

D

V

I

F

F

Q

A

I

I

C

A

D

D

E

R

V

V

S

G

V

V

L

L

R

V

D

K

G

G

H

K

L

L

V

V

M

Q

T

V

K

G

K

K

T

P

A

E

D

D

T

L

N

Y

M

D

N

N

E

P

L

V

-

S

-

I

-

Q

V

V

K

A

A

S

M

L

V

I

G

G

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F32), S40 (≠ N57), G41 (= G58), G43 (= G60), K44 (= K61), T45 (≠ S62), T46 (= T63), E166 (= E185)

1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
27% identity, 46% coverage: 21:257/515 of query aligns to 2:242/353 of 1oxuA

query
sites
1oxuA

V

V

M

R

L

I

S

I

I

V

R

K

G

N

L

V

S

S

K

K

S

V

F
|
F

G

K

R

K

N

G

R

K

V

V

-

V

-
x
A

L

L

D

D

H

N

I

V

D

N

M

I

D

N

V

I

K

E

K

N

G

G

S

E

V

R

M

F

G

G

L

I

M

L

G

G

E

P

N

S

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

M

F

M

M

K

R

C

I

L

I

F

A

G

G

I

L

K

D

T

V

R

P

D

S

E

T

G

G

K

E

F

L

Y

Y

L

F

D

D

G

D

K

R

E

L

V

V

S

A

F

S

Q

N

G

G

-

K

-

L

-

I

-

V

-

P

P

P

K

E

D

D

A

-

L

-

E

-

N

R

G

K

I

I

A

G

M

M

V

V

H

F

Q

Q

E

T

L

W

N

A

Q

L

A

Y

L

P

D

N

R

L

S

T

V

A

V

F

D

E

N

N

L

I

F

-

L

-

G

-

R

A

Y

F

P

P

V

L

N

T

A

N

L

M

G

K

V

M

V

S

D

K

E