SitesBLAST

431:434 CINC→SINS: No rescue in complementation test of the nonphotochemical quenching (NPQ) phenotype observed in disrupted plants.
859 E→K: In soq1-2; high light intensity-dependent and irreversible nonphotochemical quenching (NPQ) due to a decrease in chlorophyll excited-state lifetime.

7ocsC Mannitol-1-phosphate bound to the phosphatase domain of the bifunctional mannitol-1-phosphate dehydrogenase/phosphatase mtld-d16a from acinetobacter baumannii (see paper)
28% identity, 86% coverage: 5:190/216 of query aligns to 11:198/572 of 7ocsC

query
sites
7ocsC

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binding D-Mannitol-1-phosphate: M16 (= M10), D17 (= D11), E24 (= E18), R27 (≠ Y21), L31 (≠ N25), C51 (≠ L44), L52 (≠ A45), G53 (= G46), L54 (≠ A47), R77 (≠ Q66), T117 (≠ S109), S118 (= S110), K150 (= K142)

7ocqB Nadh bound to the dehydrogenase domain of the bifunctional mannitol-1- phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
29% identity, 88% coverage: 5:193/216 of query aligns to 11:196/679 of 7ocqB

query
sites
7ocqB

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binding magnesium ion: D15 (= D9), D17 (= D11), D170 (= D167)

Sites not aligning to the query:

binding 1,4-dihydronicotinamide adenine dinucleotide: 245, 246, 247, 248, 249, 274, 275, 329, 330, 334, 363, 403, 405, 407, 591, 594

7ocnA Crystal structure of the bifunctional mannitol-1-phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
28% identity, 88% coverage: 5:193/216 of query aligns to 11:201/690 of 7ocnA

query
sites
7ocnA

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binding magnesium ion: D15 (= D9), D17 (= D11), D175 (= D167)

7ocrB NADPH and fructose-6-phosphate bound to the dehydrogenase domain of the bifunctional mannitol-1-phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
28% identity, 88% coverage: 5:193/216 of query aligns to 11:195/675 of 7ocrB

query
sites
7ocrB

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binding magnesium ion: D15 (= D9), D17 (= D11), D169 (= D167)

Sites not aligning to the query:

binding fructose -6-phosphate: 362, 403, 508, 513, 516, 587, 590, 594, 595, 601
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: 244, 246, 247, 248, 273, 274, 329, 330, 333, 361, 362, 406, 587, 590

7ocqA Nadh bound to the dehydrogenase domain of the bifunctional mannitol-1- phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
28% identity, 88% coverage: 5:193/216 of query aligns to 11:201/686 of 7ocqA

query
sites
7ocqA

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binding magnesium ion: D15 (= D9), D17 (= D11), D175 (= D167)

Sites not aligning to the query:

binding [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonyl-4~{H}-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4,5-tris(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate: 252, 253, 254, 279, 280, 335, 369, 370

7ocpA NADPH bound to the dehydrogenase domain of the bifunctional mannitol- 1-phosphate dehydrogenase/phosphatase mtld from acinetobacter baumannii (see paper)
28% identity, 88% coverage: 5:193/216 of query aligns to 11:201/688 of 7ocpA

query
sites
7ocpA

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binding magnesium ion: D15 (= D9), D17 (= D11), D175 (= D167)

Sites not aligning to the query:

binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: 250, 251, 253, 254, 279, 280, 334, 335, 336, 339, 369, 370

4c4sA Structure of beta-phosphoglucomutase in complex with an alpha- fluorophosphonate analogue of beta-glucose-1-phosphate and magnesium trifluoride (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:185/215 of 4c4sA

query
sites
4c4sA

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N
x
W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L
|
L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

K

-

I

-

F

-

F

L

Q

Q

K

K

Y

I

F

L

P

D

G

L

E

K

-

V

K

S

A

A

Q

E

E

E

F

F

L

K

D

E

-

L

-

A

-

K

-

R

-

K

-

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N

K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S111 (= S109), A112 (vs. gap), K142 (= K142), E166 (= E166), D167 (= D167)
binding (1R)-1,5-anhydro-1-[(S)-fluoro(phosphono)methyl]-D-glucitol: D10 (= D11), H20 (≠ Y21), W24 (≠ N25), L44 (= L44), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S113 (= S110)
binding magnesium ion: D8 (= D9), D10 (= D11), D167 (= D167)
binding trifluoromagnesate: D8 (= D9), L9 (≠ M10), D10 (= D11), S111 (= S109), A112 (vs. gap), K142 (= K142)

2wf9A Structure of beta-phosphoglucomutase inhibited with glucose-6- phosphate, and beryllium trifluoride, crystal form 2 (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/221 of 2wf9A

query
sites
2wf9A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y
x
N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding beryllium trifluoride ion: D8 (= D9), L9 (≠ M10), D10 (= D11), S114 (= S109), A115 (vs. gap), K145 (= K142)
binding 6-O-phosphono-beta-D-glucopyranose: D10 (= D11), H20 (≠ Y21), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S116 (= S110), K117 (≠ N111), N118 (≠ Y112)
binding 6-O-phosphono-alpha-D-glucopyranose: D10 (= D11), H20 (≠ Y21), G46 (= G46), V47 (≠ A47), R49 (≠ N49), A115 (vs. gap), S116 (= S110), K117 (≠ N111), N118 (≠ Y112)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)

1o03A Structure of pentavalent phosphorous intermediate of an enzyme catalyzed phosphoryl transfer reaction observed on cocrystallization with glucose 6-phosphate (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/221 of 1o03A

query
sites
1o03A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding 1,6-di-O-phosphono-alpha-D-glucopyranose: D8 (= D9), L9 (≠ M10), D10 (= D11), H20 (≠ Y21), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S114 (= S109), A115 (vs. gap), S116 (= S110), K117 (≠ N111), K145 (= K142)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)

1lvhA The structure of phosphorylated beta-phosphoglucomutase from lactoccocus lactis to 2.3 angstrom resolution (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/221 of 1lvhA

query
sites
1lvhA

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y

H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G

G

A

V

A

S

N

R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S

S

N

K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)

6h91A Phosphorylated beta-phosphoglucomutase from lactococcus lactis in an open conformer to 2.4 a
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/218 of 6h91A

query
sites
6h91A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M

L

D
|
D

G

G

V

V

L

I

V

T

D

D

S

T

E

A

R

E

M

Y

Y

H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A

K

G

G

A

V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S

S

-

A

S

S

N
x
K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K

K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E

E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)
binding acetylphosphate: R49 (≠ N49), K117 (≠ N111)

4c4rA Structure of beta-phosphoglucomutase in complex with a phosphonate analogue of beta-glucose-1-phosphate and magnesium trifluoride (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/218 of 4c4rA

query
sites
4c4rA

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N
x
W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L
|
L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A
x
S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)
binding trifluoromagnesate: D8 (= D9), L9 (≠ M10), D10 (= D11), S114 (= S109), A115 (vs. gap), K145 (= K142)
binding (1R)-1,5-anhydro-1-(phosphonomethyl)-D-glucitol: D10 (= D11), H20 (≠ Y21), W24 (≠ N25), L44 (= L44), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S52 (≠ A52), S116 (= S110), K117 (≠ N111)

3zi4A The structure of beta-phosphoglucomutase inhibited with glucose-6- phosphate and scandium tetrafluoride (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/218 of 3zi4A

query
sites
3zi4A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding 6-O-phosphono-beta-D-glucopyranose: D10 (= D11), H20 (≠ Y21), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S116 (= S110), K117 (≠ N111)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)
binding Scandium Tetrafluoride: D8 (= D9), L9 (≠ M10), D10 (= D11), S114 (= S109), A115 (vs. gap), K145 (= K142)

2wf8A Structure of beta-phosphoglucomutase inhibited with glucose-6- phosphate, glucose-1-phosphate and beryllium trifluoride (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/218 of 2wf8A

query
sites
2wf8A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N
x
W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L
|
L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A
x
S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding beryllium trifluoride ion: D8 (= D9), L9 (≠ M10), D10 (= D11), S114 (= S109), A115 (vs. gap), K145 (= K142)
binding 6-O-phosphono-beta-D-glucopyranose: D10 (= D11), H20 (≠ Y21), G46 (= G46), V47 (≠ A47), R49 (≠ N49), A115 (vs. gap), S116 (= S110), K117 (≠ N111)
binding 1-O-phosphono-alpha-D-glucopyranose: D10 (= D11), H20 (≠ Y21), W24 (≠ N25), L44 (= L44), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S52 (≠ A52), A115 (vs. gap), S116 (= S110), K117 (≠ N111)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)

2wf7A Structure of beta-phosphoglucomutase inhibited with glucose-6- phosphonate and aluminium tetrafluoride (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/218 of 2wf7A

query
sites
2wf7A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y

H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y
x
N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding tetrafluoroaluminate ion: D8 (= D9), L9 (≠ M10), D10 (= D11), S114 (= S109), K145 (= K142)
binding 6,7-dideoxy-7-phosphono-beta-D-gluco-heptopyranose: D10 (= D11), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S116 (= S110), K117 (≠ N111), N118 (≠ Y112)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)

2wf6A Structure of beta-phosphoglucomutase inhibited with glucose-6- phosphate and aluminium tetrafluoride (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/218 of 2wf6A

query
sites
2wf6A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y

H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding tetrafluoroaluminate ion: D8 (= D9), L9 (≠ M10), D10 (= D11), S114 (= S109), K145 (= K142)
binding 6-O-phosphono-beta-D-glucopyranose: D10 (= D11), G46 (= G46), V47 (≠ A47), R49 (≠ N49), S116 (= S110), K117 (≠ N111)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)

2wf5A Structure of beta-phosphoglucomutase inhibited with glucose-6- phosphate and trifluoromagnesate (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/218 of 2wf5A

query
sites
2wf5A

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G
|
G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N

K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding 6-O-phosphono-beta-D-glucopyranose: D10 (= D11), H20 (≠ Y21), G46 (= G46), V47 (≠ A47), R49 (≠ N49), A115 (vs. gap), S116 (= S110)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)
binding trifluoromagnesate: D8 (= D9), L9 (≠ M10), D10 (= D11), S114 (= S109), A115 (vs. gap), K145 (= K142)

6qzgA Beta-glucose 1,6-bisphosphonate bound to wild type beta- phosphoglucomutse in an open conformation.
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/219 of 6qzgA

query
sites
6qzgA

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S

T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N

W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A

K

G
|
G

A

V

A

S

N

R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y

N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E

E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

binding 3,7-anhydro-1,2,8-trideoxy-1,8-diphosphono-D-glycero-D-gulo-octitol: D8 (= D9), L9 (≠ M10), D10 (= D11), H20 (≠ Y21), G46 (= G46), S114 (= S109), A115 (vs. gap), S116 (= S110), K117 (≠ N111), K145 (= K142)
binding magnesium ion: D8 (= D9), D10 (= D11), D170 (= D167)

1z4nA Structure of beta-phosphoglucomutase with inhibitor bound alpha- galactose 1-phosphate cocrystallized with fluoride (see paper)
34% identity, 85% coverage: 3:185/216 of query aligns to 2:188/219 of 1z4nA

query
sites
1z4nA

F

F

D

K

G

A

V

V

I

L

F

F

D
|
D

M
x
L

D
|
D

G

G

V

V

L

I

V

T

D

D

S
x
T

E

A

R

E

M

Y

Y
x
H

L

F

R

R

A

A

N
x
W

L

K

A

A

A

L

G

A

Q

E

A

E

Q

I

G

G

L

I

T

N

L

G

T

V

A

D

A

R

D

Q

Y

F

-

N

A

E

P

Q

L

L

A
x
K

G

G

A
x
V

A

S

N
x
R

A

E

D

D

A

S

-

L

-

Q

K

K

I

I

F

L

-

D

-

L

F

A

Q

D

K

K

Y

K

F

V

P

S

G

A

E

E

K

E

A

F

Q

K

E

E

F

L

L

A

-

K

-

R

-

K

D

N

D

D

T

N

Y

Y

A

V

L

K

V

M

D

I

Q

Q

Y

D

V

V

A

S

A

P

G

A

D

D

L

-

K

-

I

V

K

Y

P

P

G

G

V

I

K

L

T

Q

L

L

T

K

T

D

L

L

H

R

Q

S

K

N

G

K

I

I

P

K

L

I

A

A

V

L

G

A

S
|
S

-
x
A

S
|
S

N
x
K

Y
x
N

G

G

R

P

T

F

V

L

N

L

E

E

F

R

L

M

T

N

A

L

V

T

G

G

I

Y

K

-

D

-

A

-

F

F

D

D

H

A

I

I

I

A

T

D

S

P

D

A

D

E

V

V

A

A

G

S

K
|
K

P

P

A

A

P

P

D

D

I

I

F

F

L

I

A

A

H

H

A

A

L

V

H

G

I

V

A

A

P

P

A

S

R

E

A

S

L

I

V

G

V

L

E
|
E

D
|
D

S

S

A

Q

N

A

G

G

V

I

Q

Q

A

A

A

I

L

K

N

D

A

S

R

G

M

A

T

L

P

P

V

I

L

G

V

V

active site: D8 (= D9), L9 (≠ M10), D10 (= D11), T16 (≠ S17), K45 (≠ A45), S114 (= S109), A115 (vs. gap), K145 (= K142), E169 (= E166), D170 (= D167)
binding 1-O-phosphono-alpha-D-galactopyranose: H20 (≠ Y21), W24 (≠ N25), V47 (≠ A47), R49 (≠ N49), S116 (= S110), K117 (≠ N111), N118 (≠ Y112)
binding magnesium ion: D8 (= D9), D10 (= D11), E169 (= E166), D170 (= D167)

Query Sequence

>WP_022528084.1 NCBI__GCF_000469325.1:WP_022528084.1
MKFDGVIFDMDGVLVDSERMYLRANLAAGQAQGLTLTAADYAPLAGAANADAKIFFQKYF
PGEKAQEFLDDTYALVDQYVAAGDLKIKPGVKTLLTTLHQKGIPLAVGSSNYGRTVNEFL
TAVGIKDAFDHIITSDDVAAGKPAPDIFLAAAHALHIAPARALVVEDSANGVQAALNARM
TPVLVPDLRSAEEILTPIPQPVLVAPRITHIAHLFD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory