SitesBLAST
Comparing WP_022601195.1 NCBI__GCF_000473955.1:WP_022601195.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3eq6A Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in a ternary complex with products (see paper)
38% identity, 96% coverage: 25:551/551 of query aligns to 4:533/533 of 3eq6A
- active site: T185 (= T203), T328 (= T346), E329 (= E347), N431 (≠ K449), R436 (= R454), K521 (= K539)
- binding adenosine monophosphate: G302 (= G320), E303 (= E321), S304 (≠ A322), E323 (= E341), S324 (≠ G342), Y325 (≠ F343), G326 (= G344), Q327 (= Q345), T328 (= T346), D410 (= D428), F422 (= F440), R425 (= R443), R436 (= R454)
- binding Butyryl Coenzyme A: W229 (= W247), F255 (= F273), I277 (≠ T295), V301 (≠ A319), S433 (= S451), G434 (= G452), Y435 (= Y453), P501 (= P519), Y502 (= Y520), Y504 (= Y522), R506 (= R524)
2wd9A Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with ibuprofen (see paper)
38% identity, 96% coverage: 25:551/551 of query aligns to 4:533/533 of 2wd9A
- active site: T185 (= T203), T328 (= T346), E329 (= E347), N431 (≠ K449), R436 (= R454), K521 (= K539)
- binding ibuprofen: I230 (≠ G248), L231 (≠ K249), G326 (= G344), Q327 (= Q345), T328 (= T346), R436 (= R454)
2vzeA Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with amp (see paper)
38% identity, 96% coverage: 25:551/551 of query aligns to 4:533/533 of 2vzeA
- active site: T185 (= T203), T328 (= T346), E329 (= E347), N431 (≠ K449), R436 (= R454), K521 (= K539)
- binding adenosine monophosphate: W229 (= W247), G302 (= G320), E303 (= E321), S304 (≠ A322), E323 (= E341), Y325 (≠ F343), G326 (= G344), Q327 (= Q345), T328 (= T346), D410 (= D428), F422 (= F440), R425 (= R443), R436 (= R454)
3c5eA Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with atp (see paper)
38% identity, 96% coverage: 25:551/551 of query aligns to 7:536/536 of 3c5eA
- active site: T188 (= T203), T331 (= T346), E332 (= E347), N434 (≠ K449), R439 (= R454), K524 (= K539)
- binding adenosine-5'-triphosphate: T188 (= T203), S189 (= S204), G190 (= G205), T191 (= T206), S192 (≠ T207), G305 (= G320), E306 (= E321), S307 (≠ A322), G329 (= G344), Q330 (= Q345), T331 (= T346), D413 (= D428), F425 (= F440), R428 (= R443), K524 (= K539)
- binding magnesium ion: M450 (= M465), H452 (= H467), V455 (= V470)
3b7wA Crystal structure of human acyl-coa synthetase medium-chain family member 2a, with l64p mutation (see paper)
38% identity, 96% coverage: 25:551/551 of query aligns to 8:537/537 of 3b7wA
Q08AH3 Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Acyl-CoA synthetase medium-chain family member 2A; Benzoate--CoA ligase; Butyrate--CoA ligase 2A; Butyryl-coenzyme A synthetase 2A; Middle-chain acyl-CoA synthetase 2A; EC 6.2.1.2; EC 6.2.1.25 from Homo sapiens (Human) (see 4 papers)
38% identity, 96% coverage: 25:551/551 of query aligns to 40:569/577 of Q08AH3
- Q139 (≠ L118) binding CoA
- 221:229 (vs. 203:211, 78% identical) binding ATP
- ESYGQT 359:364 (≠ EGFGQT 341:346) binding ATP
- T364 (= T346) binding substrate
- D446 (= D428) binding ATP
- R461 (= R443) binding ATP
- SGY 469:471 (= SGY 451:453) binding CoA
- R472 (= R454) binding substrate
- R501 (= R483) binding CoA
- S513 (≠ K495) to L: in dbSNP:rs1133607
- K532 (= K514) binding CoA
- YPR 540:542 (= YPR 522:524) binding CoA
- K557 (= K539) binding ATP
3dayA Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in complex with amp-cpp (see paper)
38% identity, 96% coverage: 25:551/551 of query aligns to 8:535/535 of 3dayA
- active site: T189 (= T203), T332 (= T346), E333 (= E347), N435 (≠ K449), R440 (= R454), K523 (= K539)
- binding diphosphomethylphosphonic acid adenosyl ester: T189 (= T203), S190 (= S204), G191 (= G205), T192 (= T206), S193 (≠ T207), K197 (= K211), G306 (= G320), E307 (= E321), S308 (≠ A322), Y329 (≠ F343), G330 (= G344), Q331 (= Q345), T332 (= T346), D414 (= D428), F426 (= F440), R429 (= R443), K523 (= K539)
- binding magnesium ion: M451 (= M465), H453 (= H467), V456 (= V470)
3gpcA Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in a complex with coa (see paper)
38% identity, 96% coverage: 25:551/551 of query aligns to 5:532/532 of 3gpcA
- active site: T186 (= T203), T327 (= T346), E328 (= E347), N430 (≠ K449), R435 (= R454), K520 (= K539)
- binding coenzyme a: G301 (= G320), E302 (= E321), S303 (≠ A322), E322 (= E341), Y324 (≠ F343), G325 (= G344), Q326 (= Q345), T327 (= T346), D409 (= D428), F421 (= F440), R424 (= R443), T516 (= T535), K520 (= K539), Q522 (≠ R541)
- binding magnesium ion: H448 (= H467), V451 (= V470)
8biqA Crystal structure of acyl-coa synthetase from metallosphaera sedula in complex with acetyl-amp
38% identity, 97% coverage: 12:545/551 of query aligns to 15:542/562 of 8biqA