SitesBLAST
Comparing WP_022601312.1 NCBI__GCF_000473955.1:WP_022601312.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8swtA Structure of bacteroides fragilis pnp bound to transition state analog immucillin h and sulfate (see paper)
71% identity, 100% coverage: 1:269/270 of query aligns to 10:277/278 of 8swtA
- binding 1,4-dideoxy-4-aza-1-(s)-(9-deazahypoxanthin-9-yl)-d-ribitol: H90 (= H81), Y92 (= Y83), A120 (= A111), S121 (≠ A112), G122 (= G113), F198 (= F190), E199 (= E191), Y204 (= Y196), G216 (= G208), M217 (= M209), D241 (= D233), H253 (= H245)
4lnaA Crystal structure of purine nucleoside phosphorylase i from spirosoma linguale dsm 74, nysgrc target 029362
54% identity, 99% coverage: 1:267/270 of query aligns to 2:266/269 of 4lnaA
- active site: T29 (= T28), H79 (= H81), Y81 (= Y83), E82 (= E84), A109 (= A111), M208 (= M209), S209 (= S210), D232 (= D233), C234 (≠ G235), L244 (≠ H245)
- binding adenine: A110 (= A112), G111 (= G113), E190 (= E191), M208 (= M209), D232 (= D233)
P46354 Purine nucleoside phosphorylase 1; PNP 1; Inosine phosphorylase; Inosine-guanosine phosphorylase; Purine nucleoside phosphorylase I; PNP I; Pu-NPase I; EC 2.4.2.1 from Bacillus subtilis (strain 168) (see paper)
51% identity, 100% coverage: 1:270/270 of query aligns to 1:270/271 of P46354
- S28 (≠ T28) modified: Phosphoserine
4nsnA Crystal structure of purine nucleoside phosphorylase from porphyromonas gingivalis atcc 33277, nysgrc target 030972, orthorhombic symmetry
54% identity, 97% coverage: 7:267/270 of query aligns to 10:270/273 of 4nsnA
- active site: S31 (≠ T28), H62 (= H59), H84 (= H81), Y86 (= Y83), E87 (= E84), A114 (= A111), M211 (= M209), S212 (= S210), N235 (≠ D233), E248 (= E246)
- binding adenine: A114 (= A111), A115 (= A112), G116 (= G113), Y192 (≠ F190), E193 (= E191), Y198 (= Y196), G210 (= G208), M211 (= M209), T234 (= T232), N235 (≠ D233)
4m1eB Crystal structure of purine nucleoside phosphorylase i from planctomyces limnophilus dsm 3776, nysgrc target 029364.
46% identity, 99% coverage: 4:270/270 of query aligns to 6:272/273 of 4m1eB
- active site: T30 (= T28), H61 (= H59), H83 (= H81), Y85 (= Y83), E86 (= E84), A113 (= A111), M211 (= M209), S212 (= S210), D235 (= D233), C237 (≠ G235), L247 (≠ H245)
- binding pyridine-2-carboxylic acid: N118 (= N116), Q120 (≠ T118), R169 (≠ F167), H178 (≠ Y176), P180 (≠ Q178), P180 (≠ Q178)
- binding adenine: A114 (= A112), G115 (= G113), E193 (= E191), V209 (= V207), D235 (= D233)
8swuA Structure of clostridium perfringens pnp bound to transition state analog immucillin h and sulfate (see paper)
49% identity, 97% coverage: 4:266/270 of query aligns to 7:269/269 of 8swuA
- binding 1,4-dideoxy-4-aza-1-(s)-(9-deazahypoxanthin-9-yl)-d-ribitol: Y82 (= Y83), A110 (= A111), A111 (= A112), G112 (= G113), Y189 (≠ F190), E190 (= E191), M208 (= M209), N232 (≠ D233), H244 (= H245), V247 (= V248)
4ns1A Crystal structure of purine nucleoside phosphorylase from porphyromonas gingivalis atcc 33277, nysgrc target 30972
52% identity, 97% coverage: 7:267/270 of query aligns to 10:265/268 of 4ns1A
- active site: S31 (≠ T28), H79 (= H81), Y81 (= Y83), E82 (= E84), A109 (= A111), M206 (= M209), S207 (= S210), N230 (≠ D233), E243 (= E246)
- binding 2'-deoxyadenosine-5'-monophosphate: A109 (= A111), G111 (= G113), E188 (= E191), Y193 (= Y196), I204 (≠ V207), G205 (= G208), M206 (= M209), T229 (= T232), N230 (≠ D233)
1a9sA Bovine purine nucleoside phosphorylase complexed with inosine and sulfate (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 8:271/282 of 1a9sA
- active site: S33 (≠ T28), H64 (= H59), H86 (= H81), Y88 (= Y83), E89 (= E84), A116 (= A111), M219 (= M209), S220 (= S210), N243 (vs. gap), V245 (vs. gap), H257 (= H245)
- binding inosine: Y88 (= Y83), A116 (= A111), G118 (= G113), F200 (= F190), E201 (= E191), M219 (= M209), T242 (= T232), N243 (vs. gap), H257 (= H245), V260 (= V248)
1a9qA Bovine purine nucleoside phosphorylase complexed with inosine (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 8:271/282 of 1a9qA
- active site: S33 (≠ T28), H64 (= H59), H86 (= H81), Y88 (= Y83), E89 (= E84), A116 (= A111), M219 (= M209), S220 (= S210), N243 (vs. gap), V245 (vs. gap), H257 (= H245)
- binding hypoxanthine: A117 (= A112), G118 (= G113), F200 (= F190), E201 (= E191), M219 (= M209), N243 (vs. gap)
1a9pA Bovine purine nucleoside phosphorylase complexed with 9-deazainosine and phosphate (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 8:271/289 of 1a9pA
- active site: S33 (≠ T28), H64 (= H59), H86 (= H81), Y88 (= Y83), E89 (= E84), A116 (= A111), M219 (= M209), S220 (= S210), N243 (vs. gap), V245 (vs. gap), H257 (= H245)
- binding 9-deazainosine: H86 (= H81), Y88 (= Y83), A116 (= A111), G118 (= G113), F200 (= F190), E201 (= E191), M219 (= M209), N243 (vs. gap), H257 (= H245), E259 (= E247)
- binding phosphate ion: G32 (= G27), S33 (≠ T28), H64 (= H59), R84 (= R79), H86 (= H81), N115 (= N110), S220 (= S210)
1a9oA Bovine purine nucleoside phosphorylase complexed with phosphate (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 8:271/289 of 1a9oA
- active site: S33 (≠ T28), H64 (= H59), H86 (= H81), Y88 (= Y83), E89 (= E84), A116 (= A111), M219 (= M209), S220 (= S210), N243 (vs. gap), V245 (vs. gap), H257 (= H245)
- binding phosphate ion: G32 (= G27), R84 (= R79), N115 (= N110), S220 (= S210)
1b8oA Purine nucleoside phosphorylase (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 6:269/280 of 1b8oA
- active site: S31 (≠ T28), H62 (= H59), H84 (= H81), Y86 (= Y83), E87 (= E84), A114 (= A111), M217 (= M209), S218 (= S210), N241 (vs. gap), V243 (vs. gap), H255 (= H245)
- binding 1,4-dideoxy-4-aza-1-(s)-(9-deazahypoxanthin-9-yl)-d-ribitol: H84 (= H81), Y86 (= Y83), A114 (= A111), G116 (= G113), F198 (= F190), E199 (= E191), M217 (= M209), N241 (vs. gap), H255 (= H245), V258 (= V248)
- binding phosphate ion: G30 (= G27), S31 (≠ T28), R82 (= R79), H84 (= H81), N113 (= N110), S218 (= S210)
1a9tA Bovine purine nucleoside phosphorylase complexed with 9-deazainosine and phosphate (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 8:271/284 of 1a9tA
- active site: S33 (≠ T28), H64 (= H59), H86 (= H81), Y88 (= Y83), E89 (= E84), A116 (= A111), M219 (= M209), S220 (= S210), N243 (vs. gap), V245 (vs. gap), H257 (= H245)
- binding hypoxanthine: A116 (= A111), A117 (= A112), G118 (= G113), F200 (= F190), E201 (= E191), V217 (= V207), N243 (vs. gap)
- binding 1-O-phosphono-alpha-D-ribofuranose: S33 (≠ T28), R84 (= R79), H86 (= H81), Y88 (= Y83), N115 (= N110), A116 (= A111), F200 (= F190), M219 (= M209), S220 (= S210), V260 (= V248)
1b8nA Purine nucleoside phosphorylase (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 7:270/278 of 1b8nA
- active site: S32 (≠ T28), H63 (= H59), H85 (= H81), Y87 (= Y83), E88 (= E84), A115 (= A111), M218 (= M209), S219 (= S210), N242 (vs. gap), V244 (vs. gap), H256 (= H245)
- binding 1,4-dideoxy-1,4-imino-1-(s)-(9-deazaguanin-9-yl)-d-ribitol: H85 (= H81), Y87 (= Y83), A115 (= A111), G117 (= G113), F199 (= F190), E200 (= E191), V216 (= V207), G217 (= G208), M218 (= M209), N242 (vs. gap), H256 (= H245), V259 (= V248)
P55859 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Bos taurus (Bovine) (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 8:271/289 of P55859
- S33 (≠ T28) binding phosphate
- H64 (= H59) binding phosphate
- RFH 84:86 (= RFH 79:81) binding phosphate
- Y88 (= Y83) binding a purine D-ribonucleoside
- A116 (= A111) binding phosphate
- E201 (= E191) binding a purine D-ribonucleoside
- M219 (= M209) binding a purine D-ribonucleoside
- S220 (= S210) binding phosphate
- N243 (vs. gap) binding a purine D-ribonucleoside
- H257 (= H245) binding a purine D-ribonucleoside
1fxuA Purine nucleoside phosphorylase from calf spleen in complex with n(7)- acycloguanosine inhibitor and a phosphate ion (see paper)
49% identity, 95% coverage: 3:259/270 of query aligns to 5:265/278 of 1fxuA