SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_022669622.1 NCBI__GCF_000420385.1:WP_022669622.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
42% identity, 67% coverage: 100:309/313 of query aligns to 3:214/214 of 4ymwC

query
sites
4ymwC
I
 
V
G
 
D
Y
 
F
N
 
L
S
 
S
S
 
M
Y
 
V
K
 
K
A
 
Y
G
 
T
P
 
P
L
 
L
L
 
F
M
 
I
-
 
S
G
 
G
L
 
L
Y
 
I
M
 
M
T
 
T
I
 
L
K
 
K
V
 
L
S
 
T
V
 
F
V
 
L
S
 
A
I
 
V
I
 
T
M
 
I
A
 
G
L
 
V
I
 
L
I
 
M
G
 
G
F
 
L
I
 
F
A
 
I
G
 
A
L
 
L
M
 
M
R
 
K
I
 
M
S
 
S
E
 
S
N
 
I
P
 
K
L
 
P
F
 
I
R
 
K
N
 
L
L
 
V
S
 
A
V
 
S
V
 
S
Y
 
Y
I
 
I
E
 
E
I
 
V
I
 
I
R
 
R
G
 
G
T
 
T
P
 
P
L
 
L
L
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
I
 
L
V
 
I
Y
 
Y
F
 
N
F
 
G
V
 
L
G
 
M
T
 
Q
I
 
F
-
 
G
F
 
M
N
 
N
M
 
I
T
 
P
R
 
A
F
 
F
F
 
T
A
 
A
G
 
G
A
 
V
F
 
S
A
 
A
L
 
L
A
 
A
V
 
I
F
x
N
E
 
S
G
 
S
A
 
A
Y
|
Y
I
 
V
A
 
A
E
 
E
I
 
I
I
 
I
R
 
R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
I
 
V
P
 
D
R
 
P
G
 
G
Q
 
Q
T
 
N
E
 
E
A
 
A
S
 
A
L
 
R
A
 
S
L
 
L
G
 
G
M
 
M
N
 
T
Y
 
H
F
 
A
Q
 
M
I
 
A
M
 
M
R
 
R
Y
 
Y
I
 
V
I
 
I
M
 
I
P
 
P
Q
 
Q
A
 
A
I
 
I
K
 
K
R
 
N
V
 
I
L
 
L
P
 
P
A
 
A
L
 
L
A
 
G
G
 
N
Q
x
E
F
 
F
I
 
I
S
 
V
L
 
M
I
 
L
K
 
K
D
x
E
S
 
S
S
 
A
L
 
I
L
 
V
S
 
S
V
 
V
I
 
I
S
 
G
L
 
F
T
 
A
E
 
D
L
 
L
T
 
T
K
 
R
A
 
Q
G
 
A
R
 
D
E
 
I
I
 
I
V
 
Q
S
 
S
S
 
V
T
 
T
F
 
Y
S
 
R
P
 
Y
F
 
F
E
 
E
I
 
P
W
 
Y
F
 
I
S
 
I
V
 
I
A
 
A
A
 
A
L
 
I
Y
 
Y
F
 
F
I
 
V
V
 
M
T
 
T
Y
 
L
S
 
T
L
 
F
S
 
S
L
 
K
L
 
L
D
 
L
R
 
S
Y
 
L
L
 
F
E
 
E
R
 
R
R
 
R
L
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
42% identity, 67% coverage: 100:309/313 of query aligns to 3:214/215 of 4ymtC

query
sites
4ymtC
I
 
V
G
 
D
Y
 
F
N
 
L
S
 
S
S
 
M
Y
 
V
K
 
K
A
 
Y
G
 
T
P
 
P
L
 
L
L
 
F
M
 
I
-
 
S
G
 
G
L
 
L
Y
 
I
M
 
M
T
 
T
I
 
L
K
 
K
V
 
L
S
 
T
V
 
F
V
 
L
S
 
A
I
 
V
I
 
T
M
 
I
A
 
G
L
 
V
I
 
L
I
 
M
G
 
G
F
 
L
I
 
F
A
 
I
G
 
A
L
 
L
M
 
M
R
 
K
I
 
M
S
 
S
E
 
S
N
 
I
P
 
K
L
 
P
F
 
I
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K
N
 
L
L
 
V
S
 
A
V
 
S
V
 
S
Y
 
Y
I
 
I
E
 
E
I
 
V
I
 
I
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R
G
 
G
T
 
T
P
|
P
L
|
L
L
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
I
 
L
V
 
I
Y
 
Y
F
 
N
F
 
G
V
 
L
G
 
M
T
 
Q
I
 
F
-
 
G
F
 
M
N
 
N
M
 
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T
 
P
R
 
A
F
 
F
F
 
T
A
 
A
G
 
G
A
 
V
F
 
S
A
 
A
L
 
L
A
 
A
V
 
I
F
x
N
E
 
S
G
 
S
A
 
A
Y
|
Y
I
 
V
A
 
A
E
 
E
I
 
I
I
 
I
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R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
I
 
V
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D
R
 
P
G
 
G
Q
 
Q
T
 
N
E
 
E
A
 
A
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A
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R
A
 
S
L
 
L
G
 
G
M
 
M
N
 
T
Y
 
H
F
 
A
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M
I
 
A
M
 
M
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R
Y
 
Y
I
 
V
I
 
I
M
 
I
P
 
P
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Q
A
 
A
I
 
I
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L
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A
 
A
L
 
L
A
 
G
G
 
N
Q
x
E
F
 
F
I
 
I
S
 
V
L
x
M
I
 
L
K
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K
D
x
E
S
 
S
S
 
A
L
 
I
L
 
V
S
 
S
V
 
V
I
 
I
S
 
G
L
 
F
T
 
A
E
 
D
L
 
L
T
 
T
K
 
R
A
 
Q
G
 
A
R
 
D
E
 
I
I
 
I
V
 
Q
S
 
S
S
 
V
T
 
T
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Y
S
 
R
P
 
Y
F
 
F
E
 
E
I
 
P
W
 
Y
F
 
I
S
 
I
V
 
I
A
 
A
A
 
A
L
 
I
Y
 
Y
F
 
F
I
 
V
V
 
M
T
 
T
Y
 
L
S
 
T
L
 
F
S
 
S
L
 
K
L
 
L
D
 
L
R
 
S
Y
 
L
L
 
F
E
 
E
R
 
R
R
 
R
L
 
L

Query Sequence

>WP_022669622.1 NCBI__GCF_000420385.1:WP_022669622.1
MRRDSNKWIWHIAFVLVIVGTGFFIYKASLRINYSWNWRAVPSYLVYKATQEIDSPVNGF
VEYVGKNEVVIKSLSKKIIKIKVEHPVVKKGAVVSSGDEIGYNSSYKAGPLLMGLYMTIK
VSVVSIIMALIIGFIAGLMRISENPLFRNLSVVYIEIIRGTPLLVQIFIVYFFVGTIFNM
TRFFAGAFALAVFEGAYIAEIIRAGIQSIPRGQTEASLALGMNYFQIMRYIIMPQAIKRV
LPALAGQFISLIKDSSLLSVISLTELTKAGREIVSSTFSPFEIWFSVAALYFIVTYSLSL
LDRYLERRLAGNE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory