SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_022947184.1 NCBI__GCF_000421465.1:WP_022947184.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
45% identity, 97% coverage: 3:559/576 of query aligns to 12:571/598 of 6desA

query
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6desA

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active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), I38 (≠ V29), E59 (= E50), T82 (= T73), F121 (= F112), Q122 (= Q113), E123 (= E114), K171 (= K162), K229 (≠ E224), M265 (= M259), V292 (= V286), V408 (= V394), L433 (= L419), G434 (= G420), M436 (= M422), D461 (≠ E447), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), M493 (= M479), V494 (= V480), W497 (= W483), L519 (= L506), N524 (≠ G511), V525 (≠ H512)
binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M259), D290 (= D284), R291 (= R285), W497 (= W483)
binding flavin-adenine dinucleotide: R161 (= R152), G218 (= G213), A219 (≠ G214), G220 (= G215), N223 (≠ L218), T245 (= T239), L246 (= L240), Q247 (≠ M241), L263 (= L257), G285 (= G279), A286 (= A280), R287 (= R281), D289 (= D283), R291 (= R285), V292 (= V286), E318 (≠ D303), I319 (≠ V304), N323 (≠ S308), D337 (≠ Q322), V338 (= V323), Q412 (= Q398), M413 (= M399), G431 (= G417)
binding magnesium ion: D461 (≠ E447), N488 (= N474), E490 (≠ Y476)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V394), G409 (= G395), Q410 (= Q396), H411 (= H397), G434 (= G420), M436 (= M422), G460 (= G446), D461 (≠ E447), A462 (= A448), S463 (= S449), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), G492 (= G478), M493 (= M479), V494 (= V480)

6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
45% identity, 97% coverage: 3:559/576 of query aligns to 12:571/598 of 6depA

query
sites
6depA

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active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), I38 (≠ V29), E59 (= E50), T82 (= T73), F121 (= F112), Q122 (= Q113), E123 (= E114), K171 (= K162), K229 (≠ E224), M265 (= M259), V292 (= V286), V408 (= V394), L433 (= L419), G434 (= G420), M436 (= M422), D461 (≠ E447), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), M493 (= M479), V494 (= V480), W497 (= W483), L519 (= L506), N524 (≠ G511), V525 (≠ H512)
binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D284), R291 (= R285), M493 (= M479), W497 (= W483)
binding flavin-adenine dinucleotide: R161 (= R152), G218 (= G213), A219 (≠ G214), G220 (= G215), N223 (≠ L218), T245 (= T239), L246 (= L240), Q247 (≠ M241), L263 (= L257), G264 (= G258), G285 (= G279), A286 (= A280), R287 (= R281), D289 (= D283), R291 (= R285), V292 (= V286), E318 (≠ D303), I319 (≠ V304), N323 (≠ S308), D337 (≠ Q322), V338 (= V323), M413 (= M399), G431 (= G417)
binding magnesium ion: D461 (≠ E447), N488 (= N474), E490 (≠ Y476)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V394), G409 (= G395), Q410 (= Q396), H411 (= H397), G434 (= G420), M436 (= M422), G460 (= G446), D461 (≠ E447), A462 (= A448), S463 (= S449), M466 (= M452), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), G492 (= G478), M493 (= M479), V494 (= V480)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V394), G409 (= G395), Q410 (= Q396), H411 (= H397), G434 (= G420), M436 (= M422), G460 (= G446), D461 (≠ E447), A462 (= A448), S463 (= S449), M466 (= M452), N488 (= N474), E490 (≠ Y476), Q491 (≠ M477), G492 (= G478), M493 (= M479), V494 (= V480)

6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
45% identity, 97% coverage: 3:559/576 of query aligns to 14:573/600 of 6derA

query
sites
6derA

L

L

S

T

G

G

A

G

E

E

I

I

V

F

I

H

Q

E

A

M

L

M

K

L

D

R

E

H

G

K

V

V

E

D

F

T

I

V

F

F

G

G

Y
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Y

P

A

G
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G

A
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A

V
x
I

L

L

H

P

I

V

Y

F

D

D

A

A

L

I

F

Y

G

N

Q

S

E

D

D

K

V

F

K

K

H

F

V

V

L

L

V

P

R

R

H

H

E
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E

Q

Q

G

G

A

A

A

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

P

P

G

G

V

V

L

L

A

V

T
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T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

H

L

M

M

D

D

S

G

I

V

P

P

L

L

V

V

L

F

T

S

G

G

Q

Q

V

V

A

P

T

T

P

T

V

A

I

I

G

G

S

T

D

D

A

A

F
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F

Q
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Q

E
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E

C

A

D

D

T

I

V

V

G

G

I

I

T

S

L

R

P

S

C

C

V

T

K

K

H

W

N

N

F

V

L

M

V

V

K

K

D

N

R

V

R

A

Q

E

L

L

A

P

E

R

T

R

I

I

K

N

K

E

A

A

F

F

Y

E

I

I

A

A

T

T

G

G

R
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R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
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K

D

D

V

V

T

T

D

A

P

S

N

I

V

L

K

R

I

-

P

-

Y

E

H

S

Y

I

P

P

D

I

N

N

V

T

S

T

L

L

R

P

S

S

Y

A

R

V

P

S

K

E

I

F

Q

-

G

-

N

T

P

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R

E

Q

A

I

I

R

K

K

R

A

A

E

N

L

I

I

L

L

N

E

K

A

A

R

K

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P

M

I

L

I

Y

Y

T

A

G
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G

G
x
A

G
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G

V

I

I

L

L
x
N

G

N

E

E

A

Q

A

G

A

P

E
x
K

-

L

L

L

T

K

E

E

L

L

T

A

R

D

W

K

L

A

G

N

F

I

P

P

I

V

T

T

N

T

T
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T

L
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L

M
x
Q

G

G

L

L

G

G

A

A

Y

F

P

D

G

Q

A

R

D

D

R

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Q

K

F

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L

L

G

D

M

M

L
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L

G

G

M
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M

H
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H

G

G

T

S

F

A

E

A

A

A

N

N

M

T

A

A

M

I

H

Q

E

N

C

A

D

D

V

C

L

I

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I

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L

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G

A
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A

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R

F

F

D
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D

D

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R

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V

T

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G

G

K

N

L

I

D

S

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K

F

F

C

A

P

P

Y

E

A

A

K

K

-

L

-

A

-

S

-

E

-

G

-

R

-

G

I

I

I

L

H

H

I

F

D
x
E

V
x
I

D

S

P

P

A

K

S
x
N

I

I

A

N

K

K

T

V

V

V

P

E

V

A

D

T

I

E

P

A

I

I

V

E

G
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G

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x
D

V
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V

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A

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N

L

L

A

Q

A

S

L

F

I

I

E

P

R

L

L

V

K

D

S

S

T

I

G

E

K

N

R

R

P

P

N

E

P

-

D

-

A

-

L

-

A

-

W

W

W

F

E

N

Q

K

I

I

E

N

N

E

W

W

R

K

A

K

I

K

D

Y

C

P

L

Y

R

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Y

Y

E

Q

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L

D

E

S

T

P

P

-

G

-

S

L

L

I

I

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K

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P

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Q

Y

T

V

L

I

I

E

K

Q

E

L

I

W

S

E

D

A

Q

T

A

R

Q

-

T

-

Y

-

N

G

K

K

E

A

V

Y

I

V

V

T

T

S

T

D

G

V
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V

G
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G

Q
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Q

H
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H

Q
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Q

M
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M

W

W

V

A

A

A

Q

Q

Y

H

Y

F

K

T

F

W

D

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R

Q

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P

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R

H

T

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M

I

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G

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L

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G

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M
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M

G

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F

Y

G

G

M

L

P

P

A

A

I

I

G

G

V

A

K

Q

L

V

G

A

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P

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E

A

D

I

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V

I

C

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V

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G

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x
D

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A

S
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S

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M
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M

C

T

I

L

Q

T

E

E

L

L

S

S

T

S

A

A

L

V

Q

Q

Y

A

K

G

A

A

P

P

I

I

K

K

I

V

V

C

N

V

L

L

N

N

N
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N

R

E

Y
x
E

M
x
Q

G
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G

M
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M

V
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V

R

T

Q

Q

W
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W

Q

Q

E

S

F

L

S

F

Y

Y

E

E

S

H

R

R

Y

Y

S

S

H

H

S

T

Y

H

M

Q

D

S

T

N

L

-

P

P

D

D

F

F

V

M

K

K

L
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L

A

A

E

E

A

S

Y

M

G
x
N

H
x
V

V

K

G

G

M

I

R

R

I

I

E

T

K

N

P

Q

E

Q

D

E

V

L

R

K

P

S

A

G

L

V

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K

E

E

A

-

F

F

Q

L

M

D

K

A

D

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R

E

L

P

V

V

F

L

L

L

D

E

C

V

I

I

T

V

D

E

R

K

T

K

E

V

N

P

V

V

Y

L

P

P

M

M

V

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E

P

A
|
A

G

G

K

K

A

A

active site: Y35 (= Y24), G37 (= G26), G38 (= G27), A39 (= A28), I40 (≠ V29), E61 (= E50), T84 (= T73), F123 (= F112), Q124 (= Q113), E125 (= E114), K173 (= K162), K231 (≠ E224), M267 (= M259), V294 (= V286), V410 (= V394), L435 (= L419), G436 (= G420), M438 (= M422), D463 (≠ E447), N490 (= N474), E492 (≠ Y476), Q493 (≠ M477), M495 (= M479), V496 (= V480), W499 (= W483), L521 (= L506), N526 (≠ G511), V527 (≠ H512)
binding flavin-adenine dinucleotide: R163 (= R152), G220 (= G213), A221 (≠ G214), G222 (= G215), N225 (≠ L218), T247 (= T239), L248 (= L240), Q249 (≠ M241), L265 (= L257), H268 (= H260), G287 (= G279), A288 (= A280), R289 (= R281), D291 (= D283), R293 (= R285), V294 (= V286), E320 (≠ D303), I321 (≠ V304), N325 (≠ S308), G338 (= G321), D339 (≠ Q322), V340 (= V323), Q414 (= Q398), M415 (= M399), G433 (= G417)
binding Metosulam: R293 (= R285), M495 (= M479), W499 (= W483), A570 (= A556)
binding magnesium ion: D463 (≠ E447), N490 (= N474), E492 (≠ Y476)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V394), G411 (= G395), Q412 (= Q396), H413 (= H397), G436 (= G420), M438 (= M422), G462 (= G446), D463 (≠ E447), A464 (= A448), S465 (= S449), N490 (= N474), E492 (≠ Y476), Q493 (≠ M477), G494 (= G478), M495 (= M479), V496 (= V480)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V394), G411 (= G395), Q412 (= Q396), H413 (= H397), G436 (= G420), M438 (= M422), G462 (= G446), D463 (≠ E447), A464 (= A448), S465 (= S449), M468 (= M452), N490 (= N474), E492 (≠ Y476), Q493 (≠ M477), G494 (= G478), V496 (= V480)

6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
45% identity, 97% coverage: 3:559/576 of query aligns to 12:570/597 of 6demA

query
sites
6demA

L

L

S

T

G

G

A

G

E

E

I

I

V

F

I

H

Q

E

A

M

L

M

K

L

D

R

E

H

G

K

V

V

E

D

F

T

I

V

F

F

G

G

Y
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Y

P

A

G
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G

A
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A

V
x
I

L

L

H

P

I

V

Y

F

D

D

A

A

L

I

F

Y

G

N

Q

S

E

D

D

K

V

F

K

K

H

F

V

V

L

L

V

P

R

R

H

H

E
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E

Q

Q

G

G

A

A

A

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

P

P

G

G

V

V

L

L

A

V

T
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T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

H

L

M

M

D

D

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G

I

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P

L

L

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V

L

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G

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A

I

I

G

G

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F

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E

C

A

D

D

T

I

V

V

G

G

I

I

T

S

L

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S

C

C

V

T

K

K

H

W

N

N

F

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L

M

V

V

K

K

D

N

R

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R

A

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L

L

A

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R

I

I

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K

E

A

A

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Y

E

I

I

A

A

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G

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R

P

P

G

G

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P

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V

L

V

V

D

D

I

L

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K
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K

D

D

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A

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N

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L

K

R

I

-

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I

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I

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N

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L

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L

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L

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A

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Y

T

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G
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G

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x
A

G
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G

V

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I

L

L
x
N

G

N

E

E

A

Q

A

G

A

P

E
x
K

-

L

L

L

T

K

E

E

L

L

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W

K

L

A

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N

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L
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L

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Q

G

G

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L

G

G

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A

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D

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F

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M

L
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L

G

G

M
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M

H

H

G

G

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F

A

E

A

A

A

N

N

M

T

A

A

M

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L

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R

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D

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V

T

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G

G

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L

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F

C

A

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Y

E

A

A

K

K

-

L

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A

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-

G

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G

I

I

I

L

H

H

I

F

D
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E

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x
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N

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L

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I

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L

L

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D

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E

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L

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W

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W

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G

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L

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M

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A

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M

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E

L

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A

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G

A

A

P

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K

I

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V

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L

N

N

N
|
N

R

E

Y
x
E

M
x
Q

G
|
G

M
|
M

V
|
V

R

T

Q

Q

W
|
W

Q

Q

E

S

F

L

S

F

Y

Y

E

E

S

H

R

R

Y

Y

S

S

H

H

S

T

Y

H

M

Q

D

S

T

N

L

-

P

P

D

D

F

F

V

M

K

K

L
|
L

A

A

E

E

A

S

Y

M

G
x
N

H
x
V

V

K

G

G

M

I

R

R

I

I

E

T

K

N

P

Q

E

Q

D

E

V

L

R

K

P

S

A

G

L

V

E

K

E

E

A

-

F

F

Q

L

M

D

K

A

D

T

R

E

L

P

V

V

F

L

L

L

D

E

C

V

I

I

T

V

D

E

R

K

T

K

E

V

N

P

V

V

Y

L

P

P

M

M

V

V

E

P

A
|
A

G

G

K

K

A

A

active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), I38 (≠ V29), E59 (= E50), T82 (= T73), F121 (= F112), Q122 (= Q113), E123 (= E114), K171 (= K162), K228 (≠ E224), M264 (= M259), V291 (= V286), V407 (= V394), L432 (= L419), G433 (= G420), M435 (= M422), D460 (≠ E447), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), M492 (= M479), V493 (= V480), W496 (= W483), L518 (= L506), N523 (≠ G511), V524 (≠ H512)
binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M259), D289 (= D284), R290 (= R285), M492 (= M479), W496 (= W483), A567 (= A556)
binding flavin-adenine dinucleotide: R161 (= R152), G217 (= G213), A218 (≠ G214), G219 (= G215), N222 (≠ L218), T244 (= T239), L245 (= L240), Q246 (≠ M241), L262 (= L257), G284 (= G279), A285 (= A280), R286 (= R281), D288 (= D283), R290 (= R285), V291 (= V286), E317 (≠ D303), I318 (≠ V304), N322 (≠ S308), D336 (≠ Q322), V337 (= V323), M412 (= M399), G430 (= G417)
binding magnesium ion: D460 (≠ E447), N487 (= N474), E489 (≠ Y476)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V394), G408 (= G395), Q409 (= Q396), H410 (= H397), M435 (= M422), G459 (= G446), D460 (≠ E447), A461 (= A448), S462 (= S449), M465 (= M452), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), G491 (= G478), M492 (= M479), V493 (= V480)

6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
45% identity, 97% coverage: 3:559/576 of query aligns to 12:570/597 of 6delA

query
sites
6delA

L

L

S

T

G

G

A

G

E

E

I

I

V

F

I

H

Q

E

A

M

L

M

K

L

D

R

E

H

G

K

V

V

E

D

F

T

I

V

F

F

G

G

Y
|
Y

P

A

G
|
G

A
|
A

V
x
I

L

L

H

P

I

V

Y

F

D

D

A

A

L

I

F

Y

G

N

Q

S

E

D

D

K

V

F

K

K

H

F

V

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

G

G

A

A

A

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

P

P

G

G

V

V

L

L

A

V

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

H

L

M

M

D

D

S

G

I

V

P

P

L

L

V

V

L

F

T

S

G

G

Q

Q

V

V

A

P

T

T

P

T

V

A

I

I

G

G

S

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

C

A

D

D

T

I

V

V

G

G

I

I

T

S

L

R

P

S

C

C

V

T

K

K

H

W

N

N

F

V

L

M

V

V

K

K

D

N

R

V

R

A

Q

E

L

L

A

P

E

R

T

R

I

I

K

N

K

E

A

A

F

F

Y

E

I

I

A

A

T

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
|
K

D

D

V

V

T

T

D

A

P

S

N

I

V

L

K

R

I

-

P

-

Y

E

H

S

Y

I

P

P

D

I

N

N

V

T

S

T

L

L

R

P

S

S

Y

V

R

S

P

-

K

-

I

-

Q

E

G

F

N

T

P

S

R

E

Q

A

I

I

R

K

K

R

A

A

E

N

L

I

I

L

L

N

E

K

A

A

R

K

P

P

M

I

L

I

Y

Y

T

A

G
|
G

G
x
A

G
|
G

V

I

I

L

L
x
N

G

N

E

E

A

Q

A

G

A

P

E
x
K

-

L

L

L

T

K

E

E

L

L

T

A

R

D

W

K

L

A

G

N

F

I

P

P

I

V

T

T

N

T

T
|
T

L
|
L

M
x
Q

G

G

L

L

G

G

A

A

Y

F

P

D

G

Q

A

R

D

D

R

P

Q

K

F

S

L

L

G

D

M

M

L
|
L

G

G

M
|
M

H

H

G

G

T

S

F

A

E

A

A

A

N

N

M

T

A

A

M

I

H

Q

E

N

C

A

D

D

V

C

L

I

I

I

A

A

V

L

G
|
G

A
|
A

R
|
R

F

F

D
|
D

R
|
R

V
|
V

T

T

G

G

K

N

L

I

D

S

E

K

F

F

C

A

P

P

Y

E

A

A

K

K

-

L

-

A

-

S

-

E

-

G

-

R

-

G

I

I

I

L

H

H

I

F

D
x
E

V
x
I

D

S

P

P

A

K

S
x
N

I

I

A

N

K

K

T

V

V

V

P

E

V

A

D

T

I

E

P

A

I

I

V

E

G

G

Q
x
D

V
|
V

K

T

P

A

V

N

L

L

A

Q

A

S

L

F

I

I

E

P

R

L

L

V

K

D

S

S

T

I

G

E

K

N

R

R

P

P

N

E

P

-

D

-

A

-

L

-

A

-

W

W

W

F

E

N

Q

K

I

I

E

N

N

E

W

W

R

K

A

K

I

K

D

Y

C

P

L

Y

R

S

Y

Y

E

Q

Q

L

D

E

S

T

P

P

-

G

-

S

L

L

I

I

K

K

P

P

Q

Q

Y

T

V

L

I

I

E

K

Q

E

L

I

W

S

E

D

A

Q

T

A

R

Q

-

T

-

Y

-

N

G

K

K

E

A

V

Y

I

V

V

T

T

S

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

V

A

A

A

Q

Q

Y

H

Y

F

K

T

F

W

D

T

R

Q

P

P

R

R

H

T

W

M

I

I

N

T

S

S

G
|
G

G

G

L
|
L

G
|
G

T

T

M
|
M

G

G

F

Y

G

G

M

L

P

P

A

A

I

I

G

G

V

A

K

Q

L

V

G

A

F

K

P

P

E

D

E

A

D

I

V

V

V

I

C

D

V

I

T

D

G
|
G

E
x
D

A
|
A

S
|
S

I

F

Q

N

M
|
M

C

T

I

L

Q

T

E

E

L

L

S

S

T

S

A

A

L

V

Q

Q

Y

A

K

G

A

A

P

P

I

I

K

K

I

V

V

C

N

V

L

L

N

N

N
|
N

R

E

Y
x
E

M
x
Q

G
|
G

M
|
M

V
|
V

R

T

Q

Q

W
|
W

Q

Q

E

S

F

L

S

F

Y

Y

E

E

S

H

R

R

Y

Y

S

S

H

H

S

T

Y

H

M

Q

D

S

T

N

L

-

P

P

D

D

F

F

V

M

K

K

L
|
L

A

A

E

E

A

S

Y

M

G
x
N

H
x
V

V

K

G

G

M

I

R

R

I

I

E

T

K

N

P

Q

E

Q

D

E

V

L

R

K

P

S

A

G

L

V

E

K

E

E

A

-

F

F

Q

L

M

D

K

A

D

T

R

E

L

P

V

V

F

L

L

L

D

E

C

V

I

I

T

V

D

E

R

K

T

K

E

V

N

P

V

V

Y

L

P

P

M

M

V

V

E

P

A

A

G

G

K

K

A

A

active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (= A28), I38 (≠ V29), E59 (= E50), T82 (= T73), F121 (= F112), Q122 (= Q113), E123 (= E114), K171 (= K162), K228 (≠ E224), M264 (= M259), V291 (= V286), V407 (= V394), L432 (= L419), G433 (= G420), M435 (= M422), D460 (≠ E447), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), M492 (= M479), V493 (= V480), W496 (= W483), L518 (= L506), N523 (≠ G511), V524 (≠ H512)
binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D284), R290 (= R285), W496 (= W483)
binding flavin-adenine dinucleotide: R161 (= R152), G217 (= G213), A218 (≠ G214), G219 (= G215), N222 (≠ L218), T244 (= T239), L245 (= L240), Q246 (≠ M241), L262 (= L257), G284 (= G279), A285 (= A280), R286 (= R281), D288 (= D283), R290 (= R285), V291 (= V286), E317 (≠ D303), I318 (≠ V304), N322 (≠ S308), D336 (≠ Q322), V337 (= V323), M412 (= M399), G430 (= G417)
binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V394), G408 (= G395), Q409 (= Q396), H410 (= H397), G433 (= G420), M435 (= M422), G459 (= G446), D460 (≠ E447), A461 (= A448), S462 (= S449), M465 (= M452), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), G491 (= G478), M492 (= M479), V493 (= V480)
binding magnesium ion: D460 (≠ E447), N487 (= N474), E489 (≠ Y476)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V394), G408 (= G395), Q409 (= Q396), H410 (= H397), G433 (= G420), M435 (= M422), G459 (= G446), D460 (≠ E447), A461 (= A448), S462 (= S449), M465 (= M452), N487 (= N474), E489 (≠ Y476), Q490 (≠ M477), G491 (= G478), M492 (= M479), V493 (= V480)

6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
45% identity, 97% coverage: 3:559/576 of query aligns to 10:566/593 of 6deoA

query
sites
6deoA

L

L

S

T

G

G

A

G

E

E

I

I

V

F

I

H

Q

E

A

M

L

M

K

L

D

R

E

H

G

K

V

V

E

D

F

T

I

V

F

F

G

G

Y
|
Y

P

A

G
|
G

A
|
A

V
x
I

L

L

H

P

I

V

Y

F

D

D

A

A

L

I

F

Y

G

N

Q

S

E

D

D

K

V

F

K

K

H

F

V

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

G

G

A

A

A

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

P

P

G

G

V

V

L

L

A

V

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

H

L

M

M

D

D

S

G

I

V

P

P

L

L

V

V

L

F

T

S

G

G

Q

Q

V

V

A

P

T

T

P

T

V

A

I

I

G

G

S

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

C

A

D

D

T

I

V

V

G

G

I

I

T

S

L

R

P

S

C

C

V

T

K

K

H

W

N

N

F

V

L

M

V

V

K

K

D

N

R

V

R

A

Q

E

L

L

A

P

E

R

T

R

I

I

K

N

K

E

A

A

F

F

Y

E

I

I

A

A

T

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
|
K

D

D

V

V

T

T

D

A

P

S

N

I

V

L

K

R

I

-

P

-

Y

E

H

S

Y

I

P

P

D

I

N

N

V

T

S

T

L

L

R

P

S

S

Y

-

R

-

P

-

K

-

I

-

Q

E

G

F

N

T

P

S

R

E

Q

A

I

I

R

K

K

R

A

A

E

N

L

I

I

L

L

N

E

K

A

A

R

K

P

P

M

I

L

I

Y

Y

T

A

G
|
G

G
x
A

G
|
G

V

I

I

L

L
x
N

G

N

E

E

A

Q

A

G

A

P

E
x
K

-

L

L

L

T

K

E

E

L

L

T

A

R

D

W

K

L

A

G

N

F

I

P

P

I

V

T

T

N

T

T
|
T

L
|
L

M
x
Q

G

G

L

L

G

G

A

A

Y

F

P

D

G

Q

A

R

D

D

R

P

Q

K

F

S

L

L

G

D

M

M

L
|
L

G

G

M
|
M

H

H

G

G

T

S

F

A

E

A

A

A

N

N

M

T

A

A

M

I

H

Q

E

N

C

A

D

D

V

C

L

I

I

I

A

A

V

L

G
|
G

A
|
A

R
|
R

F

F

D
|
D

R
|
R

V
|
V

T

T

G

G

K

N

L

I

D

S

E

K

F

F

C

A

P

P

Y

E

A

A

K

K

-

L

-

A

-

S

-

E

-

G

-

R

-

G

I

I

I

L

H

H

I

F

D
x
E

V
x
I

D

S

P

P

A

K

S
x
N

I

I

A

N

K

K

T

V

V

V

P

E

V

A

D

T

I

E

P

A

I

I

V

E

G

G

Q
x
D

V
|
V

K

T

P

A

V

N

L

L

A

Q

A

S

L

F

I

I

E

P

R

L

L

V

K

D

S

S

T

I

G

E

K

N

R

R

P

P

N

E

P

-

D

-

A

-

L

-

A

-

W

W

W

F

E

N

Q

K

I

I

E

N

N

E

W

W

R

K

A

K

I

K

D

Y

C

P

L

Y

R

S

Y

Y

E

Q

Q

L

D

E

S

T

P

P

-

G

-

S

L

L

I

I

K

K

P

P

Q

Q

Y

T

V

L

I

I

E

K

Q

E

L

I

W

S

E

D

A

Q

T

A

R

Q

-

T

-

Y

-

N

G

K

K

E

A

V

Y

I

V

V

T

T

S

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

V

A

A

A

Q

Q

Y

H

Y

F

K

T

F

W

D

T

R

Q

P

P

R

R

H

T

W

M

I

I

N

T

S

S

G
|
G

G

G

L
|
L

G
|
G

T

T

M
|
M

G

G

F

Y

G

G

M

L

P

P

A

A

I

I

G

G

V

A

K

Q

L

V

G

A

F

K

P

P

E

D

E

A

D

I

V

V

V

I

C

D

V

I

T

D

G
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G

E
x
D

A
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A

S
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S

I

F

Q

N

M
|
M

C

T

I

L

Q

T

E

E

L

L

S

S

T

S

A

A

L

V

Q

Q

Y

A

K

G

A

A

P

P

I

I

K

K

I

V

V

C

N

V

L

L

N

N

N
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N

R

E

Y
x
E

M
x
Q

G
|
G

M
|
M

V
|
V

R

T

Q

Q

W
|
W

Q

Q

E

S

F

L

S

F

Y

Y

E

E

S

H

R

R

Y

Y

S

S

H

H

S

T

Y

H

M

Q

D

S

T

N

L

-

P

P

D

D

F

F

V

M

K

K

L
|
L

A

A

E

E

A

S

Y

M

G
x
N

H
x
V

V

K

G

G

M

I

R

R

I

I

E

T

K

N

P

Q

E

Q

D

E

V

L

R

K

P

S

A

G

L

V

E

K

E

E

A

-

F

F

Q

L

M

D

K

A

D

T

R

E

L

P

V

V

F

L

L

L

D

E

C

V

I

I

T

V

D

E

R

K

T

K

E

V

N

P

V

V

Y

L

P

P

M

M

V

V

E

P

A

A

G

G

K

K

A

A

active site: Y31 (= Y24), G33 (= G26), G34 (= G27), A35 (= A28), I36 (≠ V29), E57 (= E50), T80 (= T73), F119 (= F112), Q120 (= Q113), E121 (= E114), K169 (= K162), K224 (≠ E224), M260 (= M259), V287 (= V286), V403 (= V394), L428 (= L419), G429 (= G420), M431 (= M422), D456 (≠ E447), N483 (= N474), E485 (≠ Y476), Q486 (≠ M477), M488 (= M479), V489 (= V480), W492 (= W483), L514 (= L506), N519 (≠ G511), V520 (≠ H512)
binding flavin-adenine dinucleotide: R159 (= R152), G213 (= G213), A214 (≠ G214), G215 (= G215), N218 (≠ L218), T240 (= T239), L241 (= L240), Q242 (≠ M241), L258 (= L257), G280 (= G279), A281 (= A280), R282 (= R281), D284 (= D283), R286 (= R285), V287 (= V286), E313 (≠ D303), I314 (≠ V304), N318 (≠ S308), D332 (≠ Q322), V333 (= V323), M408 (= M399), G426 (= G417)
binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M259), D285 (= D284), R286 (= R285), M488 (= M479), W492 (= W483)
binding magnesium ion: D456 (≠ E447), N483 (= N474), E485 (≠ Y476)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V394), G404 (= G395), Q405 (= Q396), H406 (= H397), G429 (= G420), M431 (= M422), G455 (= G446), D456 (≠ E447), A457 (= A448), S458 (= S449), M461 (= M452), N483 (= N474), E485 (≠ Y476), Q486 (≠ M477), G487 (= G478), M488 (= M479), V489 (= V480)

6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
45% identity, 97% coverage: 3:559/576 of query aligns to 14:574/601 of 6deqA

query
sites
6deqA

L

L

S

T

G

G

A

G

E

E

I

I

V

F

I

H

Q

E

A

M

L

M

K

L

D

R

E

H

G

K

V

V

E

D

F

T

I

V

F

F

G

G

Y
|
Y

P

A

G
|
G

A
|
A

V
x
I

L

L

H

P

I

V

Y

F

D

D

A

A

L

I

F

Y

G

N

Q

S

E

D

D

K

V

F

K

K

H

F

V

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

G

G

A

A

A

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

P

P

G

G

V

V

L

L

A

V

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

L

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

H

L

M

M

D

D

S

G

I

V

P

P

L

L

V

V

L

F

T

S

G

G

Q

Q

V

V

A

P

T

T

P

T

V

A

I

I

G

G

S

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

C

A

D

D

T

I

V

V

G

G

I

I

T

S

L

R

P

S

C

C

V

T

K

K

H

W

N

N

F

V

L

M

V

V

K

K

D

N

R

V

R

A

Q

E

L

L

A

P

E

R

T

R

I

I

K

N

K

E

A

A

F

F

Y

E

I

I

A

A

T

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
|
K

D

D

V

V

T

T

D

A

P

S

N

I

V

L

K

R

I

-

P

-

Y

E

H

S

Y

I

P

P

D

I

N

N

V

T

S

T

L

L

R

P

S

S

Y

N

R

A

P

V

K

S

I

-

Q

E

G

F

N

T

P

S

R

E

Q

A

I

I

R

K

K

R

A

A

E

N

L

I

I

L

L

N

E

K

A

A

R

K

P

P

M

I

L

I

Y

Y

T

A

G
|
G

G
x
A

G
|
G

V

I

I

L

L
x
N

G

N

E

E

A

Q

A

G

A

P

E
x
K

-

L

L

L

T

K

E

E

L

L

T

A

R

D

W

K

L

A

G

N

F

I

P

P

I

V

T

T

N

T

T
|
T