Comparing WP_022947788.1 NCBI__GCF_000421465.1:WP_022947788.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1i5rA Type 1 17-beta hydroxysteroid dehydrogenase em1745 complex (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:262/285 of 1i5rA
1a27A Human 17-beta-hydroxysteroid-dehydrogenase type 1 c-terminal deletion mutant complexed with estradiol and NADP+
32% identity, 94% coverage: 7:268/278 of query aligns to 3:262/285 of 1a27A
Sites not aligning to the query:
3hb4X 17beta-hydroxysteroid dehydrogenase type1 complexed with e2b (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:262/284 of 3hb4X
3dheA Estrogenic 17-beta hydroxysteroid dehydrogenase complexed dehydroepiandrosterone (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:262/284 of 3dheA
1equA Type 1 17-beta hydroxysteroid dehydrogenase equilin complexed with NADP+ (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:262/284 of 1equA
1dhtA Estrogenic 17-beta hydroxysteroid dehydrogenase complexed dihydrotestosterone (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:262/284 of 1dhtA
Sites not aligning to the query:
P14061 17-beta-hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 1; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1; EC 1.1.1.51; EC 1.1.1.62 from Homo sapiens (Human) (see 12 papers)
32% identity, 94% coverage: 7:268/278 of query aligns to 4:263/328 of P14061
Sites not aligning to the query:
1fdvA Human 17-beta-hydroxysteroid-dehydrogenase type 1 mutant h221l complexed with NAD+ (see paper)
32% identity, 89% coverage: 7:253/278 of query aligns to 3:256/285 of 1fdvA
6mncB Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone (see paper)
32% identity, 89% coverage: 7:253/278 of query aligns to 3:248/276 of 6mncB
Sites not aligning to the query:
1qywA Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstanedione and NADP (see paper)
32% identity, 89% coverage: 7:253/278 of query aligns to 3:248/276 of 1qywA
3klpX 17beta-hsd1 in complex with a-diol
32% identity, 89% coverage: 7:253/278 of query aligns to 3:247/276 of 3klpX
Sites not aligning to the query:
1qyxA Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstenedione and NADP (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:254/277 of 1qyxA
Sites not aligning to the query:
6cgcA Crystal structure of human 17beta-hsd type 1 in ternary complex with 2-meo-cc-156 and NADP+ (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:255/278 of 6cgcA
Sites not aligning to the query:
1jtvA Crystal structure of 17beta-hydroxysteroid dehydrogenase type 1 complexed with testosterone (see paper)
32% identity, 94% coverage: 7:268/278 of query aligns to 3:255/278 of 1jtvA
Sites not aligning to the query:
6dtpA Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with em139
31% identity, 94% coverage: 7:268/278 of query aligns to 3:256/279 of 6dtpA
6cgeA Crystal structure of human 17beta-hsd type 1 in ternary complex with pbrm and NADP+ (see paper)
31% identity, 94% coverage: 7:268/278 of query aligns to 3:256/279 of 6cgeA
Sites not aligning to the query:
3km0A 17betahsd1 in complex with 3beta-diol
32% identity, 89% coverage: 7:253/278 of query aligns to 3:250/278 of 3km0A
Sites not aligning to the query:
P29147 D-beta-hydroxybutyrate dehydrogenase, mitochondrial; 3-hydroxybutyrate dehydrogenase; BDH; EC 1.1.1.30 from Rattus norvegicus (Rat) (see paper)
28% identity, 87% coverage: 9:251/278 of query aligns to 58:316/343 of P29147
O75452 Retinol dehydrogenase 16; Human epidermal retinol dehydrogenase; hRDH-E; Microsomal NAD(+)-dependent retinol dehydrogenase 4; RoDH-4; Short chain dehydrogenase/reductase family 9C member 8; Sterol/retinol dehydrogenase; EC 1.1.1.105; EC 1.1.1.209; EC 1.1.1.315; EC 1.1.1.53 from Homo sapiens (Human) (see paper)
29% identity, 87% coverage: 9:250/278 of query aligns to 32:281/317 of O75452
Q9BPW9 Dehydrogenase/reductase SDR family member 9; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; RDHL; Retinol dehydrogenase 15; Short chain dehydrogenase/reductase family 9C member 4; Short-chain dehydrogenase/reductase retSDR8; Tracheobronchial epithelial cell-specific retinol dehydrogenase; RDH-TBE; EC 1.1.1.209; EC 1.1.1.53; EC 1.1.1.105 from Homo sapiens (Human) (see paper)
29% identity, 97% coverage: 9:277/278 of query aligns to 32:308/319 of Q9BPW9
>WP_022947788.1 NCBI__GCF_000421465.1:WP_022947788.1
MSNPPVNTILITGCSSGIGYVTALGLKERGYQVFASARKPEDMERLKAEGFEAVQLDLDD
SASIQAAVTEVLERTGGTLDALFNNGAWGQVGAVEDLSRDVLRAEFETNLFGTHELTNTV
LPIMRRQGHGRILYNSSVLGLIALPYRGAYNASKFALEGLVDTLRLELSGTRIYPVLIEP
GPILTKFRDNAYRKFKENIDPEPSPYREVYRKMEEKLTADGPVVPFTLPPEAVLQKVIYA
LESPRPKIRYYVTVPTYLFGFLKRVLPLRALDWVLRRV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory