SitesBLAST
Comparing WP_024487810.1 NCBI__GCF_002893965.1:WP_024487810.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P07872 Peroxisomal acyl-coenzyme A oxidase 1; ACO; AOX; Palmitoyl-CoA oxidase; Peroxisomal fatty acyl-CoA oxidase; Straight-chain acyl-CoA oxidase; EC 1.3.3.6 from Rattus norvegicus (Rat) (see 3 papers)
34% identity, 84% coverage: 95:631/643 of query aligns to 100:621/661 of P07872
- T139 (= T134) binding FAD
- G178 (= G173) binding FAD
- E421 (= E419) active site, Proton acceptor
- VA 468:469 (vs. gap) Cleavage
5y9dA Crystal structure of acyl-coa oxidase1 from yarrowia lipolytica (see paper)
32% identity, 86% coverage: 82:631/643 of query aligns to 94:637/687 of 5y9dA
- binding flavin-adenine dinucleotide: F145 (= F131), M147 (= M133), T148 (= T134), G153 (= G139), S154 (= S140), W185 (≠ Y171), R316 (= R306), F319 (= F309), I330 (= I320), Y333 (= Y323), R339 (= R329), A417 (= A393), G420 (= G396), Y423 (= Y399), V438 (= V414), T441 (= T417), W442 (≠ F418), D445 (= D421)
5ys9A Crystal structure of acyl-coa oxidase3 from yarrowia lipolytica (see paper)
32% identity, 86% coverage: 77:631/643 of query aligns to 97:641/692 of 5ys9A
- binding flavin-adenine dinucleotide: F153 (= F131), M155 (= M133), T156 (= T134), G161 (= G139), S162 (= S140), W193 (≠ Y171), R324 (= R306), Q326 (= Q308), F327 (= F309), Y341 (= Y323), R347 (= R329), Q421 (≠ E392), A422 (= A393), G425 (= G396), Y428 (= Y399), V443 (= V414), T446 (= T417), W447 (≠ F418), D450 (= D421), V453 (= V424)
1is2A Crystal structure of peroxisomal acyl-coa oxidase-ii from rat liver (see paper)
33% identity, 83% coverage: 100:631/643 of query aligns to 105:603/637 of 1is2A
- binding flavin-adenine dinucleotide: T139 (= T134), G144 (= G139), T145 (≠ S140), W176 (≠ Y171), P177 (≠ I172), R303 (= R306), S306 (≠ F309), F320 (≠ Y323), Q323 (≠ H326), K326 (≠ R329), A391 (= A393), G393 (= G395), G394 (= G396), Y397 (= Y399), T415 (= T417), F416 (= F418), E419 (≠ D421), V422 (= V424)
2fonB X-ray crystal structure of leacx1, an acyl-coa oxidase from lycopersicon esculentum (tomato) (see paper)
31% identity, 83% coverage: 97:631/643 of query aligns to 99:616/656 of 2fonB
- binding flavin-adenine dinucleotide: Y133 (≠ F131), Q135 (≠ M133), T136 (= T134), G141 (= G139), S142 (= S140), W173 (≠ Y171), P174 (≠ I172), G175 (= G173), R308 (= R306), F311 (= F309), V322 (≠ I320), Y325 (= Y323), Q328 (≠ H326), R331 (= R329), L396 (≠ A393), G399 (= G396), P417 (≠ V414), T420 (= T417), Y421 (≠ F418), D424 (= D421), V427 (= V424)
O65202 Peroxisomal acyl-coenzyme A oxidase 1; AOX 1; Long-chain acyl-CoA oxidase; AtCX1; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
31% identity, 83% coverage: 97:631/643 of query aligns to 101:618/664 of O65202
- Y135 (≠ F131) binding FAD
- Q137 (≠ M133) binding FAD
- T138 (= T134) binding FAD
- S144 (= S140) binding FAD
- G177 (= G173) binding FAD
- R310 (= R306) binding FAD
- Q330 (≠ H326) binding FAD
- R333 (= R329) binding FAD
- G401 (= G396) binding FAD
- T422 (= T417) binding FAD
- D426 (= D421) binding FAD
- C467 (≠ T477) modified: Disulfide link with 576
- C576 (≠ H589) modified: Disulfide link with 467
2ddhA Crystal structure of acyl-coa oxidase complexed with 3-oh-dodecanoate (see paper)
32% identity, 81% coverage: 110:631/643 of query aligns to 114:588/622 of 2ddhA
Sites not aligning to the query:
1w07B Arabidopsis thaliana acyl-coa oxidase 1 (see paper)
31% identity, 83% coverage: 97:631/643 of query aligns to 100:617/658 of 1w07B
- binding flavin-adenine dinucleotide: Y134 (≠ F131), Q136 (≠ M133), T137 (= T134), G142 (= G139), S143 (= S140), W174 (≠ Y171), P175 (≠ I172), R309 (= R306), F312 (= F309), V323 (≠ I320), Y326 (= Y323), Q329 (≠ H326), R332 (= R329), L397 (≠ A393), G400 (= G396), P418 (≠ V414), T421 (= T417), Y422 (≠ F418), D425 (= D421), V428 (= V424), L431 (≠ Q427)
7q86A Crystal structure of human peroxisomal acyl-co-a oxidase 1a, fad- bound-form (see paper)
31% identity, 83% coverage: 100:631/643 of query aligns to 105:586/612 of 7q86A