SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_024770448.1 NCBI__GCF_000520995.1:WP_024770448.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
74% identity, 100% coverage: 1:468/468 of query aligns to 4:470/470 of 6uziC

query
sites
6uziC

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active site: C45 (= C42), C50 (= C47), S53 (= S50), V187 (= V185), E191 (= E189), H448 (= H446), E453 (= E451)
binding flavin-adenine dinucleotide: I12 (= I9), G13 (= G10), G15 (= G12), P16 (= P13), G17 (= G14), E36 (= E33), K37 (= K34), G43 (= G40), T44 (= T41), C45 (= C42), G49 (= G46), C50 (= C47), S53 (= S50), K54 (= K51), V117 (= V115), G118 (= G116), T147 (= T145), G148 (= G146), I188 (= I186), R276 (= R274), D316 (= D314), M322 (= M320), L323 (= L321), A324 (= A322)
binding zinc ion: H448 (= H446), E453 (= E451)

3urhB Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
54% identity, 97% coverage: 4:459/468 of query aligns to 1:458/465 of 3urhB

query
sites
3urhB

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active site: Y35 (≠ L38), C39 (= C42), C44 (= C47), S47 (= S50), V183 (= V185), E187 (= E189), H443 (= H444), H445 (= H446), E450 (= E451)
binding flavin-adenine dinucleotide: I6 (= I9), G7 (= G10), G9 (= G12), P10 (= P13), G11 (= G14), E30 (= E33), K31 (= K34), G37 (= G40), T38 (= T41), C39 (= C42), G43 (= G46), C44 (= C47), K48 (= K51), T111 (≠ V115), G112 (= G116), A140 (= A144), T141 (= T145), G142 (= G146), I184 (= I186), R273 (= R274), G312 (= G313), D313 (= D314), M319 (= M320), L320 (= L321), A321 (= A322), H322 (= H323)

6aonA 1.72 angstrom resolution crystal structure of 2-oxoglutarate dehydrogenase complex subunit dihydrolipoamide dehydrogenase from bordetella pertussis in complex with fad
51% identity, 99% coverage: 4:468/468 of query aligns to 3:473/473 of 6aonA

query
sites
6aonA

Y

F

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V

D

D

K

A

K

K

G

G

N

A

P

E

V

Q

E

K

L

L

K

V

G

V

D

D

Y

K

C

L

L

I

V

V

S

S

V

I

G

G

R
|
R

R

V

P

P

Y
|
Y

T

T

D

G

G

G

L

L

N

N

A

A

E

E

A

A

A

V

G

G

V

L

K

K

L

L

N

D

D

E

R

R

G

G

Q

F

V

V

E

A

V

V

N

D

D

E

H

D

L

C

Q

K

T

T

S

N

A

L

S

P

N

N

I

V

Y

W

A

A

I

V

G
|
G

D
|
D

V

V

I

V

K

R

G

G

A

P

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

E

E

E

E

E

E

G

G

T

V

F

A

V

V

A

A

E

E

T

R

L

I

A

A

G

G

Q

Q

K

H

P

G

H

H

I

V

D

N

Y

F

N

A

L

T

I

V

P

P

G

W

V

V

V

I

Y

Y

T

T

W

S

P

P

E

E

V

I

A

A

A

W

V

V

G

G

K

K

T

T

E

E

E

Q

E

Q

L

L

T

K

E

A

A

E

G

G

I

R

K

E

Y

Y

K

K

S

A

G

G

Q

S

F

F

P

P

F

F

R

M

A

A

L

N

G

G

R

R

S

A

R

R

A

A

S

L

G

G

D

D

L

T

D

T

G

G

F

F

V

A

K

K

I

V

L

I

A

A

D

D

E

A

T

K

T

T

D

D

E

E

V

V

L

L

G

G

V

V

H

H

M

I

I

I

G

G

A

P

R

M

C

A

A

S

D

E

L

L

I

I

A

S

E

E

A

A

V

V

T

T

A

I

M

M

E

E

F

F

R

R

A

G

S

A

A

A

E

E

D

D

I

I

S

A

R

R

M

I

S

C

H
|
H

A

A

H
|
H

P

P

T

T

F

L

T

S

E
|
E

A

A

V

V

K

K

E

E

A

A

A

A

L

L

A

-

A

A

T

V

D

D

N

K

R

R

A

T

L

L

H

N

M

F

active site: P43 (≠ L38), C47 (= C42), C52 (= C47), S55 (= S50), V191 (= V185), E195 (= E189), H450 (= H444), H452 (= H446), E457 (= E451)
binding calcium ion: A218 (≠ P212), A220 (≠ M214), Q222 (≠ K216)
binding flavin-adenine dinucleotide: I8 (= I9), G11 (= G12), P12 (= P13), G13 (= G14), D32 (≠ E33), A33 (≠ K34), W34 (≠ Y35), G45 (= G40), T46 (= T41), C47 (= C42), G51 (= G46), C52 (= C47), K56 (= K51), K119 (≠ V115), G120 (= G116), T151 (= T145), G152 (= G146), N171 (≠ S165), I192 (= I186), R280 (= R274), Y283 (= Y277), G319 (= G313), D320 (= D314), M326 (= M320), L327 (= L321), A328 (= A322), H329 (= H323)

2yquB Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
51% identity, 99% coverage: 4:468/468 of query aligns to 2:455/455 of 2yquB

query
sites
2yquB

Y

Y

D

D

V

L

A

L

V

V

I

I

G
|
G

S

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

V

V

A

A

A

A

I

I

R

R

C

A

A

A

Q

Q

L

L

G

G

M

M

K

K

T

V

A

G

I

V

I

V

E
|
E

K
|
K

Y

E

S

K

T

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

N
x
R

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

D

E

S

T

S

T

H

E

H

R

Y

I

E

Y

H

E

A

A

V

K

K

K

H

G

F

L

A

L

D

-

H

-

G

G

I

A

E

K

I

V

P

K

G
|
G

D

-

V
|
V

K

E

I

L

N

D

L

L

E

P

K

A

M

L

I

M

A

A

R

H

K

K

Q

D

S

K

V

V

V

V

D

Q

Q

A

T

N

C

T

D

Q

G

G

V

V

S

E

F

F

L

L

M

F

K

K

K

K

N

N

K

G

I

I

D

A

V

R

F

H

E

Q

G

G

V
x
T

G
x
A

S

R

F

F

K

L

D

S

A

E

T

R

H

K

V

V

N

L

I

V

T

E

K

E

A

-

D

-

G

-

T

T

V

G

E

E

T

E

I

L

E

E

A

A

K

R

N

Y

T

I

I

L

I

I

A

A

T
|
T

G
|
G

S

S

K

A

P

P

S

L

T

I

L

P

P

P

F

W

I

A

K

Q

I

V

D

D

K

Y

K

E

R

R

V

V

I

V

T

T

S

S

T

T

E

E

A

A

L

L

K

S

L

F

K

P

E

E

V

V

P

P

K

K

H

R

L

L

I

I

I

V

I

V

G

G

G

G

G

G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

Q

V

V

V

Y

W

R

H

R

R

L

L

G

G

A

A

E

E

V

V

S

I

V

V

V

L

E

E

Y

Y

M

M

D

D

R

R

I

I

I

L

P

P

G

T

M

M

D

D

K

L

A

E

L

V

S

S

K

R

E

A

L

A

Q

E

K

R

V

V

M

F

K

K

K

K

Q

Q

K

G

S

L

K

T

I

I

Y

R

T

T

S

G

H

V

K

R

V

V

T

T

G

A

V

V

S

-

V

-

S

-

G

-

D

-

E

-

V

-

T

-

V

-

T

-

A

V

D

P

D

E

K

A

K

K

G

G

N

A

P

R

V

V

E

E

L

L

K

E

G

G

-

G

-

E

-

V

-

L

-

E

-

A

D

D

Y

R

C

V

L

L

V

V

S

A

V

V

G

G

R

R

R

R

P

P

Y
|
Y

T

T

D

E

G

G

L

L

N

S

A

L

E

E

A

N

A

A

G

G

V

L

K

S

L

T

N

D

D

E

R

R

G

G

Q

R

V

I

E

P

V

V

N

D

D

E

H

H

L

L

Q

R

T

T

S

R

A

V

S

P

N

H

I

I

Y

Y

A

A

I

I

G
|
G

D
|
D

V

V

I

V

K

R

G

G

A

P

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

E
x
S

E

E

E

E

G

G

T

I

F

A

V

A

A

V

E

E

T

H

L

M

A

V

G

R

Q

G

K

F

P

G

H

H

I

V

D

D

Y

Y

N

Q

L

A

I

I

P

P

G

S

V

V

V

V

Y

Y

T

T

W

H

P

P

E

E

V

I

A

A

A

A

V

V

G

G

K

Y

T

T

E

E

E

E

E

E

L

L

T

K

E

A

A

Q

G

G

I

I

K

P

Y

Y

K

K

S

V

G

G

Q

K

F

F

P

P

F

Y

R

S

A

A

L

S

G

G

R

R

S

A

R

R

A

A

S

M

G

G

D

E

L

T

D

E

G

G

F

F

V

I

K

K

I

V

L

L

A

A

D

H

E

A

T

K

T

T

D

D

E

R

V

I

L

L

G

G

V

V

H

H

M

G

I

I

G

G

A

A

R

R

C

V

A

G

D

D

L

V

I

L

A

A

E

E

A

A

V

A

T

L

A

A

M

L

E

F

F

F

R

K

A

A

S
|
S

A

A

E

E

D
|
D

I

L

S

G

R

R

M

A

S

P

H
|
H

A

A

H
|
H

P

P

T

S

F

L

T

S

E
|
E

A

I

V

L

K

K

E

E

A

A

A

A

L

L

A

A

A

A

T

W

D

E

N

-

R

R

A

P

L

I

H

H

M

L

active site: P11 (= P13), L36 (= L38), C40 (= C42), C45 (= C47), S48 (= S50), G72 (= G76), V73 (= V78), V177 (= V185), E181 (= E189), S314 (≠ E326), H432 (= H444), H434 (= H446), E439 (= E451)
binding carbonate ion: A310 (= A322), S314 (≠ E326), S423 (= S435), D426 (= D438)
binding flavin-adenine dinucleotide: G8 (= G10), G10 (= G12), P11 (= P13), G12 (= G14), E31 (= E33), K32 (= K34), G38 (= G40), T39 (= T41), C40 (= C42), R42 (≠ N44), G44 (= G46), C45 (= C47), K49 (= K51), T110 (≠ V115), A111 (≠ G116), T137 (= T145), G138 (= G146), I178 (= I186), Y265 (= Y277), G301 (= G313), D302 (= D314), M308 (= M320), L309 (= L321), A310 (= A322), H311 (= H323)

2yquA Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
51% identity, 99% coverage: 4:468/468 of query aligns to 2:455/455 of 2yquA

query
sites
2yquA

Y

Y

D

D

V

L

A

L

V

V

I

I

G
|
G

S

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

V

V

A

A

A

A

I

I

R

R

C

A

A

A

Q

Q

L

L

G

G

M

M

K

K

T

V

A

G

I

V

I

V

E
|
E

K
|
K

Y

E

S

K

T

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

N
x
R

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

D

E

S

T

S

T

H

E

H

R

Y

I

E

Y

H

E

A

A

V

K

K

K

H

G

F

L

A

L

D

-

H

-

G

G

I

A

E

K

I

V

P

K

G
|
G

D

-

V
|
V

K

E

I

L

N

D

L

L

E

P

K

A

M

L

I

M

A

A

R

H

K

K

Q

D

S

K

V

V

V

V

D

Q

Q

A

T

N

C

T

D

Q

G

G

V

V

S

E

F

F

L

L

M

F

K

K

K

K

N

N

K

G

I

I

D

A

V

R

F

H

E

Q

G

G

V
x
T

G
x
A

S

R

F

F

K

L

D

S

A

E

T

R

H

K

V

V

N

L

I

V

T

E

K

E

A

-

D

-

G

-

T

T

V

G

E

E

T

E

I

L

E

E

A

A

K

R

N

Y

T

I

I

L

I

I

A

A

T
|
T

G
|
G

S

S

K

A

P

P

S

L

T

I

L

P

P

P

F

W

I

A

K

Q

I

V

D

D

K

Y

K

E

R

R

V

V

I

V

T

T

S
|
S

T

T

E

E

A

A

L

L

K

S

L

F

K

P

E

E

V

V

P

P

K

K

H

R

L

L

I

I

I

V

I

V

G

G

G

G

G

G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

Q

V

V

V

Y

W

R

H

R

R

L

L

G

G

A

A

E

E

V

V

S

I

V

V

V

L

E

E

Y

Y

M

M

D

D

R

R

I

I

I

L

P

P

G

T

M

M

D

D

K

L

A

E

L

V

S

S

K

R

E

A

L

A

Q

E

K

R

V

V

M

F

K

K

K

K

Q

Q

K

G

S

L

K

T

I

I

Y

R

T

T

S

G

H

V

K

R

V

V

T

T

G

A

V

V

S

-

V

-

S

-

G

-

D

-

E

-

V

-

T

-

V

-

T

-

A

V

D

P

D

E

K

A

K

K

G

G

N

A

P

R

V

V

E

E

L

L

K

E

G

G

-

G

-

E

-

V

-

L

-

E

-

A

D

D

Y

R

C

V

L

L

V

V

S

A

V

V

G

G

R

R

R

R

P

P

Y
|
Y

T

T

D

E

G

G

L

L

N

S

A

L

E

E

A

N

A

A

G

G

V

L

K

S

L

T

N

D

D

E

R

R

G

G

Q

R

V

I

E

P

V

V

N

D

D

E

H

H

L

L

Q

R

T

T

S

R

A

V

S

P

N

H

I

I

Y

Y

A

A

I

I

G
|
G

D
|
D

V

V

I

V

K

R

G

G

A

P

M
|
M

L
|
L

A
|
A

H

H

K

K

A

A

E
x
S

E

E

E

E

G

G

T

I

F

A

V

A

A

V

E

E

T

H

L

M

A

V

G

R

Q

G

K

F

P

G

H

H

I

V

D

D

Y

Y

N

Q

L

A

I

I

P

P

G

S

V

V

V

V

Y

Y

T

T

W

H

P

P

E

E

V

I

A

A

A

A

V

V

G

G

K

Y

T

T

E

E

E

E

E

E

L

L

T

K

E

A

A

Q

G

G

I

I

K

P

Y

Y

K

K

S

V

G

G

Q

K

F

F

P

P

F

Y

R

S

A

A

L

S

G

G

R

R

S

A

R

R

A

A

S

M

G

G

D

E

L

T

D

E

G

G

F

F

V

I

K

K

I

V

L

L

A

A

D

H

E

A

T

K

T

T

D

D

E

R

V

I

L

L

G

G

V

V

H

H

M

G

I

I

G

G

A

A

R

R

C

V

A

G

D

D

L

V

I

L

A

A

E

E

A

A

V

A

T

L

A

A

M

L

E

F

F

F

R

K

A

A

S

S

A

A

E

E

D

D

I

L

S

G

R

R

M

A

S

P

H
|
H

A

A

H
|
H

P

P

T

S

F

L

T

S

E
|
E

A

I

V

L

K

K

E

E

A

A

A

A

L

L

A

A

A

A

T

W

D

E

N

-

R

R

A

P

L

I

H

H

M

L

active site: P11 (= P13), L36 (= L38), C40 (= C42), C45 (= C47), S48 (= S50), G72 (= G76), V73 (= V78), V177 (= V185), E181 (= E189), S314 (≠ E326), H432 (= H444), H434 (= H446), E439 (= E451)
binding flavin-adenine dinucleotide: G8 (= G10), G10 (= G12), P11 (= P13), G12 (= G14), E31 (= E33), K32 (= K34), G38 (= G40), T39 (= T41), C40 (= C42), R42 (≠ N44), G44 (= G46), C45 (= C47), K49 (= K51), T110 (≠ V115), A111 (≠ G116), T137 (= T145), G138 (= G146), S157 (= S165), I178 (= I186), Y265 (= Y277), G301 (= G313), D302 (= D314), M308 (= M320), L309 (= L321), A310 (= A322)

2eq7A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8 with psbdo
52% identity, 98% coverage: 4:463/468 of query aligns to 2:451/452 of 2eq7A

query
sites
2eq7A

Y

Y

D

D

V

L

A

L

V

V

I

I

G

G

S

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

V

V

A

A

A

A

I

I

R

R

C

A

A

A

Q

Q

L

L

G

G

M

M

K

K

T

V

A

G

I

V

I

V

E
|
E

K
|
K

Y

E

S

K

T

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

N
x
R

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

D

E

S

T

S

T

H

E

H

R

Y

I

E

Y

H

E

A

A

V

K

K

K

H

G

F

L

A

L

D

-

H

-

G

G

I

A

E

K

I

V

P

K

G
|
G

D

-

V
|
V

K

E

I

L

N

D

L

L

E

P

K

A

M

L

I

M

A

A

R

H

K

K

Q

D

S

K

V

V

V

V

D

Q

Q

A

T

N

C

T

D

Q

G

G

V

V

S

E

F

F

L

L

M

F

K

K

K

K

N

N

K

G

I

I

D

A

V

R

F

H

E

Q

G

G

V
x
T

G
x
A

S

R

F

F

K

L

D

S

A

E

T

R

H

K

V

V

N

L

I

V

T

E

K

E

A

-

D

-

G

-

T

T

V

G

E

E

T

E

I

L

E

E

A

A

K

R

N

Y

T

I

I

L

I

I

A

A

T
|
T

G
|
G

S

S

K

A

P

P

S

L

T

I

L

P

P

P

F
x
W

I

A

K

Q

I

V

D

D

K

Y

K

E

R

R

V

V

I

V

T

T

S
|
S

T

T

E

E

A

A

L

L

K

S

L

F

K

P

E

E

V

V

P

P

K

K

H

R

L

L

I

I

I

V

I

V

G
|
G

G

G

G
|
G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

Q

V

V

V

Y

W

R

H

R

R

L

L

G

G

A

A

E

E

V

V

S

I

V

V

V

L

E
|
E

Y
|
Y

M

M

D

D

R

R

I

I

I

L

P

P

G

T

M

M

D

D

K

L

A

E

L

V

S

S

K

R

E

A

L

A

Q

E

K

R

V

V

M

F

K

K

K

K

Q

Q

K

G

S

L

K

T

I

I

Y

R

T

T

S

G

H

V

K

R

V
|
V

T

T

G

A

V

V

S

-

V

-

S

-

G

-

D

-

E

-

V

-

T

-

V

-

T

-

A

V

D

P

D

E

K

A

K

K

G

G

N

A

P

R

V

V

E

E

L

L

K

E

G

G

-

G

-

E

-

V

-

L

-

E

-

A

D

D

Y

R

C

V

L

L

V

V

S

A

V
|
V

G
|
G

R
|
R

R

R

P

P

Y
|
Y

T

T

D

E

G

G

L

L

N

S

A

L

E

E

A

N

A

A

G

G

V

L

K

S

L

T

N

D

D

E

R

R

G

G

Q

R

V

I

E

P

V

V

N

D

D

E

H

H

L

L

Q

R

T

T

S

R

A

V

S

P

N

H

I

I

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

V

K

R

G

G

A

P

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

E
x
S

E

E

E

E

G

G

T

I

F

A

V

A

A

V

E

E

T

H

L

M

A

V

G

R

Q

G

K

F

P

G

H

H

I

V

D

D

Y

Y

N

Q

L

A

I

I

P

P

G

S

V
|
V

V

V

Y
|
Y

T

T

W

H

P

P

E

E

V

I

A

A

A

A

V

V

G

G

K

Y

T

T

E

E

E

E

E

E

L

L

T

K

E

A

A

Q

G

G

I

I

K

P

Y

Y

K

K

S

V

G

G

Q

K

F

F

P

P

F

Y

R

S

A

A

L

S

G

G

R

R

S

A

R

R

A

A

S

M

G

G

D

E

L

T

D

E

G

G

F

F

V

I

K

K

I

V

L

L

A

A

D

H

E

A

T

K

T

T

D

D

E

R

V

I

L

L

G

G

V

V

H

H

M

G

I

I

G

G

A

A

R

R

C

V

A

G

D

D

L

V

I

L

A

A

E

E

A

A

V

A

T

L

A

A

M

L

E

F

F

F

R

K

A

A

S

S

A

A

E

E

D

D

I

L

S

G

R

R

M

A

S

P

H
|
H

A

A

H
|
H

P

P

T

S

F

L

T

S

E
|
E

A

I

V

L

K

K

E

E

A

A

A

A

L

L

A

A

A

A

T

W

D

E

N

R

active site: P11 (= P13), L36 (= L38), C40 (= C42), C45 (= C47), S48 (= S50), G72 (= G76), V73 (= V78), V177 (= V185), E181 (= E189), S314 (≠ E326), H432 (= H444), H434 (= H446), E439 (= E451)
binding flavin-adenine dinucleotide: G10 (= G12), P11 (= P13), G12 (= G14), E31 (= E33), K32 (= K34), G38 (= G40), T39 (= T41), C40 (= C42), R42 (≠ N44), G44 (= G46), C45 (= C47), K49 (= K51), T110 (≠ V115), A111 (≠ G116), T137 (= T145), G138 (= G146), S157 (= S165), I178 (= I186), R262 (= R274), Y265 (= Y277), D302 (= D314), M308 (= M320), L309 (= L321), A310 (= A322), H311 (= H323), Y341 (= Y353)
binding nicotinamide-adenine-dinucleotide: W146 (≠ F154), G174 (= G182), G176 (= G184), V177 (= V185), I178 (= I186), E197 (= E205), Y198 (= Y206), V231 (= V239), V260 (= V272), G261 (= G273), R262 (= R274), M308 (= M320), L309 (= L321), V339 (= V351)

3ladA Refined crystal structure of lipoamide dehydrogenase from azotobacter vinelandii at 2.2 angstroms resolution. A comparison with the structure of glutathione reductase (see paper)
50% identity, 99% coverage: 4:468/468 of query aligns to 4:471/472 of 3ladA

query
sites
3ladA

Y

F

D

D

V

V

A

I

V

V

I
|
I

G
|
G

S

A

G
|
G

P
|
P

G

G

G

G

Y

Y

V

V

A

A

A

A

I

I

R

K

C

S

A

A

Q

Q

L

L

G

G

M

L

K

K

T

T

A

A

I

L

I

I

E
|
E

K
|
K

Y

Y

-

K

-

G

-

K

-

E

-

G

-

K

S

T

T

A

L
|
L

G

G

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K

K

A

A

L

L

L

L

D

D

S

S

S

S

H

Y

H

K

Y

F

E

H

H

E

A

A

V

H

K

E

H

S

F

F

A

K

D

L

H

H

G

G

I

I

E

S

I

T

P

-

G

G

D

E

V

V

K

A

I

I

N

D

L

V

E

P

K

T

M

M

I

I

A

A

R

R

K

K

Q

D

S

Q

V

I

V

V

D

R

Q

N

T

L

C

T

D

G

G

G

V

V

S

A

F

S

L

L

M

I

K

K

K

A

N

N

K

G

I

V

D

T

V

L

F

F

E

E

G

G

V
x
H

G
|
G

S

K

F

L

K

L

D

A

A

G

T

K

H

K

V

V

N

E

I

V

T

T

K

A

A

A

D

D

G

G

T

S

V

S

E

Q

T

V

I

L

E

D

A

T

K

E

N

N

T

V

I

I

I

L

A
|
A

T
x
S

G
|
G

S

S

K

K

P

P

S

V

T

E

L

I

P

P

F

P

I

A

K

P

I

V

D

D

K

Q

K

D

R

V

V

I

I

V

T

D

S

S

T

T

E

G

A

A

L

L

K

D

L

F

K

Q

E

N

V

V

P

P

K

G

H

K

L

L

I

G

I

V

I

I

G

G

G

A

G

G

V
|
V

I
|
I

G

G

L

L

E
|
E

L

L

G

G

Q

S

V

V

Y

W

R

A

R

R

L

L

G

G

A

A

E

E

V

V

S

T

V

V

V

L

E

E

Y

A

M

M

D

D

R

K

I

F

I

L

P

P

G

A

M

V

D

D

K

E

A

Q

L

V

S

A

K

K

E

E

L

A

Q

Q

K

K

V

I

M

L

K

T

K

K

Q

Q

K

G

S

L

K

K

I

I

Y

L

T

L

S

G

H

A

K

R

V

V

T

T

G

G

V

T

S

E

V

V

S

K

G

N

D

K

E

Q

V

V

T

T

V

V

T

K

A

F

D

V

D

D

K

A

K

E

G

G

N

E

P

K

V

S

E

Q

L

-

K

A

G

F

D

D

Y

K

C

L

L

I

V

V

S

A

V

V

G

G

R
|
R

R

R

P

P

Y

V

T

T

D

T

G

D

L

L

N

L

A

A

E

A

A

D

A

S

G

G

V

V

K

T

L

L

N

D

D

E

R

R

G

G

Q

F

V

I

E

Y

V

V

N

D

D

D

H

Y

L

C

Q

A

T

T

S

S

A

V

S

P

N

G

I

V

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

V

K

R

G

G

A

A

M

M

L
|
L

A
|
A

H

H

K

K

A

A

E

S

E

E

E

E

G

G

T

V

F

V

V

V

A

A

E

E

T

R

L

I

A

A

G

G

Q

H

K

K

P

A

H

Q

I

M

D

N

Y

Y

N

D

L

L

I

I

P

P

G

A

V

V

V

I

Y

Y

T

T

W

H

P

P

E

E

V

I

A

A

A

G

V

V

G

G

K

K

T

T

E

E

E

Q

E

A

L

L

T

K

E

A

A

E

G

G

I

V

K

A

Y

I

K

N

S

V

G

G

Q

V

F

F

P

P

F

F

R

A

A

A

L

S

G

G

R

R

S

A

R

M

A

A

S

A

G

N

D

D

L

T

D

A

G

G

F

F

V

V

K

K

I

V

L

I

A

A

D

D

E

A

T

K

T

T

D

D

E

R

V

V

L

L

G

G

V

V

H

H

M

V

I

I

G

G

A

P

R

S

C

A

A

A

D

E

L

L

I

V

A

Q

E

Q

A

G

V

A

T

I

A

A

M

M

E

E

F

F

R

G

A

T

S

S

A

A

E

E

D

D

I

L

S

G

R

M

M

M

S

V

H
x
F

A

A

H
|
H

P

P

T

A

F

L

T

S

E
|
E

A

A

V

L

K

H

E

E

A

A

A

A

L

L

A

A

A

V

T

S

D

-

N

G

R

H

A

A

L

I

H

H

M

V

active site: L44 (= L38), C48 (= C42), C53 (= C47), S56 (= S50), V190 (= V185), E194 (= E189), F448 (≠ H444), H450 (= H446), E455 (= E451)
binding flavin-adenine dinucleotide: I9 (= I9), G10 (= G10), G12 (= G12), P13 (= P13), E33 (= E33), K34 (= K34), G46 (= G40), T47 (= T41), C48 (= C42), G52 (= G46), C53 (= C47), H120 (≠ V115), G121 (= G116), A149 (= A144), S150 (≠ T145), G151 (= G146), I191 (= I186), R278 (= R274), D318 (= D314), L325 (= L321), A326 (= A322)

P18925 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Azotobacter vinelandii (see 2 papers)
50% identity, 99% coverage: 4:468/468 of query aligns to 5:472/477 of P18925

query
sites
P18925

Y

F

D

D

V

V

A

I

V

V

I

I

G

G

S

A

G

G

P

P

G

G

G

G

Y

Y

V

V

A

A

A

A

I

I

R

K

C

S

A

A

Q

Q

L

L

G

G

M

L

K

K

T

T

A

A

I

L

I

I

E
|
E

K
|
K

Y
|
Y

-
x
K

-
x
G

-
x
K

-
x
E

-
x
G

-
x
K

S
x
T

T
x
A

L
|
L

G
|
G

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G

G

C
|
C

I

I

P

P

S

S

K
|
K

A

A

L

L

L

L

D

D

S

S

S

S

H

Y

H

K

Y

F

E

H

H

E

A

A

V

H

K

E

H

S

F

F

A

K

D

L

H

H

G

G

I

I

E

S

I

T

P

-

G

G

D

E

V

V

K

A

I

I

N

D

L

V

E

P

K

T

M

M

I

I

A

A

R

R

K

K

Q

D

S

Q

V

I

V

V

D

R

Q

N

T

L

C

T

D

G

G

G

V

V

S

A

F

S

L

L

M

I

K

K

K

A

N

N

K

G

I

V

D

T

V

L

F

F

E

E

G

G

V

H

G

G

S

K

F

L

K

L

D

A

A

G

T

K

H

K

V

V

N

E

I

V

T

T

K

A

A

A

D

D

G

G

T

S

V

S

E

Q

T

V

I

L

E

D

A

T

K

E

N

N

T

V

I

I

I

L

A

A

T

S

G

G

S

S

K

K

P

P

S

V

T

E

L

I

P

P

F

P

I

A

K

P

I

V

D

D

K

Q

K

D

R

V

V

I

I

V

T

D

S

S

T

T

E

G

A

A

L

L

K

D

L

F

K

Q

E

N

V

V

P

P

K

G

H

K

L

L

I

G

I

V

I

I

G

G

G

A

G

G

V

V

I

I

G

G

L

L

E

E

L

L

G

G

Q

S

V

V

Y

W

R

A

R

R

L

L

G

G

A

A

E

E

V

V

S

T

V

V

V

L

E

E

Y

A

M

M

D

D

R

K

I

F

I

L

P

P

G

A

M

V

D

D

K

E

A

Q

L

V

S

A

K

K

E

E

L

A

Q

Q

K

K

V

I

M

L

K

T

K

K

Q

Q

K

G

S

L

K

K

I

I

Y

L

T

L

S

G

H

A

K

R

V

V

T

T

G

G

V

T

S

E

V

V

S

K

G

N

D

K

E

Q

V

V

T

T

V

V

T

K

A

F

D

V

D

D

K

A

K

E

G

G

N

E

P

K

V

S

E

Q

L

-

K

A

G

F

D

D

Y

K

C

L

L

I

V

V

S

A

V

V

G

G

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R

R

R

P

P

Y

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T

T

D

T

G

D

L

L

N

L

A

A

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A

A

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A

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G

G

V

V

K

T

L

L

N

D

D

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R

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G

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F

V

I

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Y

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V

N

D

D

D

H

Y

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C

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A

T

T

S

S

A

V

S

P

N

G

I

V

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

V

K

R

G

G

A

A

M

M

L

L

A
|
A

H

H

K

K

A

A

E

S

E

E

E

E

G

G

T

V

F

V

V

V

A

A

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T

R

L

I

A

A

G

G

Q

H

K

K

P

A

H

Q

I

M

D

N

Y

Y

N

D

L

L

I

I

P

P

G

A

V

V

V

I

Y

Y

T

T

W

H

P

P

E

E

V

I

A

A

A

G

V

V

G

G

K

K

T

T

E

E

E

Q

E

A

L

L

T

K

E

A

A

E

G

G

I

V

K

A

Y

I

K

N

S

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G

G

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V

F

F

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P

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F

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A

A

A

L

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G

G

R

R

S

A

R

M

A

A

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A

G

N

D

D

L

T

D

A

G

G

F

F

V

V

K

K

I

V

L

I

A

A

D

D

E

A

T

K

T

T

D

D

E

R

V

V

L

L

G

G

V

V

H

H

M

V

I

I

G

G

A

P

R

S

C

A

A

A

D

E

L

L

I

V

A

Q

E

Q

A

G

V

A

T

I

A

A

M

M

E

E

F

F

R

G

A

T

S

S

A

A

E

E

D

D

I

L

S

G

R

M

M

M

S

V

H

F

A

A

H

H

P

P

T

A

F

L

T

S

E

E

A

A

V

L

K

H

E

E

A

A

A

A

L

L

A

A

A

V

T

S

D

-

N

G

R

H

A

A

L

I

H

H

M

V

34:49 (vs. 33:42, 50% identical) binding FAD
C49 (= C42) modified: Disulfide link with 54, Redox-active
C54 (= C47) modified: Disulfide link with 49, Redox-active
K58 (= K51) binding FAD
D319 (= D314) binding FAD
A327 (= A322) binding FAD

P09622 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; EC 1.8.1.4 from Homo sapiens (Human) (see 14 papers)
49% identity, 99% coverage: 5:468/468 of query aligns to 43:509/509 of P09622

query
sites
P09622

D

D

V

V

A

T

V

V

I

I

G

G

S

S

G

G

P

P

G

G

G

G

Y

Y

V

V

A

A

A

A

I

I

R

K

C

A

A

A

Q

Q

L

L

G

G

M

F

K

K

T

T

A

V

I

C

I

I

E
|
E

K
|
K

Y
x
N

S
x
E

T
|
T

L
|
L

G
|
G

G
|
G

T
|
T

C
|
C

L

L

N

N

V

V

G

G

C

C

I

I

P

P

S

S

K
|
K

A

A

L

L

L

L

D

N

S

N

S

S

H

H

H

Y

Y

Y

E

H

H

M

A

A

-

H

V

G

K
|
K

H

D

F

F

A

A

D

S

H

R

G

G

I

I

E

E

I

M

P

S

G

-

D

E

V

V

K

R

I

L

N

N

L

L

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D

K

K

M

M

I

M

A

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R

Q

K

K

Q

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S

T

V

A

V

V

D

K

Q

A

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L

C

T

D

G

G

G

V

I

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A

F

H

L

L

M

F

K

K

K

Q

N

N

K

K

I

V

D

V

V

H

F

V

E

N

G

G

V

Y

G
|
G

S

K

F

I

K

T

D

G

A

K

T

N

H

Q

V

V

N

T

I

A

T

T

K

K

A

A

D

D

G

G

T

G

V

T

E

Q

T

V

I

I

E

D

A

T

K

K

N

N

T

I

I

L

I

I

A

A

T
|
T

G
|
G

S
|
S

K

E

P

V

S

T

T

P

L

F

P

P

F

G

I

I

K

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I

I

D

D

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T

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A

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L

K

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L

L

K

K

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K

V

V

P

P

K

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H

K

L

M

I

V

I

V

I

I

G
|
G

G
x
A

G
|
G

V
|
V

I
|
I

G
|
G

L
x
V

E
|
E

L

L

G

G

Q

S

V

V

Y

W

R

Q

R

R

L

L

G

G

A

A

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D

V

V

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T

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A

V

V

E
|
E

Y

F

M

L

D

G

R

H

I

V

I

G

P

G

-

V

G

G

M

I

D

D

K

M

A

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L

I

S

S

K

K

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N

L

F

Q

Q

K

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V

I

M

L

K

Q

K

K

Q

Q

K

G

S

F

K

K

I

F

Y

K

T

L

S

N

H

T

K

K

V
|
V

T

T

G

G

V

A

S

T

V

K

S

K

G

S

D

D

-

G

E

K

V

I

T

D

V

V

T

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A

I

D

E

D

A

K

A

K

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G

G

N

G

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K

V

A

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-

V

L

I

K

T

G

C

D

D

Y

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C

L

L

L

V

V

S

C

V

I

G
|
G

R

R

R

R

P

P

Y

F

T

T

D

K

G

N

L

L

N

G

A

L

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A

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G

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I

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L

N

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D

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N

D

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L

F

Q

Q

T

T

S

K

A

I

S

P

N

N

I

I

Y

Y

A

A

I

I

G

G

D
|
D

V

V

I

V

K

A

G

G

A

P

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

E

E

E

D

E

E

G

G

T

I

F

I

V

C

A

V

E
|
E

T

G

L

M

A

A

G

G

Q

G

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A

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V

H
|
H

I

I

D

D

Y

Y

N

N

L

C

I

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P

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V

V

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Y

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V

A

A

A

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V

G

G

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K

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L

L

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A

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G

I

I

K

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Y

Y

K

K

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G

G

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A

A

A

L

N

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R

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A

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A

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N

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A

D

D

L

T

D

D

G

G

F

M

V

V

K

K

I

I

L

L

A

G

D

Q

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T

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T

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D
|
D

E

R

V

V

L

L

G

G

V

A