SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_024771205.1 NCBI__GCF_000520995.1:WP_024771205.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
35% identity, 92% coverage: 26:391/396 of query aligns to 27:393/393 of 2ordA

query
sites
2ordA

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active site: F134 (≠ Y132), E186 (= E183), D219 (= D216), Q222 (= Q219), K248 (= K245), T276 (= T277), R367 (= R365)
binding pyridoxal-5'-phosphate: G102 (= G105), T103 (= T106), F134 (≠ Y132), H135 (= H133), E186 (= E183), D219 (= D216), V221 (≠ I218), Q222 (= Q219), K248 (= K245)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
35% identity, 92% coverage: 26:391/396 of query aligns to 19:385/385 of Q9X2A5

query
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Q9X2A5

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GT 94:95 (= GT 105:106) binding pyridoxal 5'-phosphate
T268 (= T277) binding pyridoxal 5'-phosphate

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
37% identity, 92% coverage: 26:389/396 of query aligns to 27:384/390 of A0QYS9

query
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A0QYS9

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K304 (≠ E308) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

8ht4B Crystal structure of acetylornithine aminotransferase complex with plp from corynebacterium glutamicum (see paper)
35% identity, 92% coverage: 19:384/396 of query aligns to 19:385/390 of 8ht4B

query
sites
8ht4B

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P

P

L

M

I

P

P

S

D

G

T

V

A

E

F

F

I

Y

T

P

F

Y

N

G

D

D

E

T

K

D

D

Y

I

L

K

R

Q

K

I

M

T

V

R

E

K

T

T

N

-

P

-

T

-

D

-

V

G

A

A

A

V

I

I

F

L

L

E
|
E

T

P

I

I

Q

Q

G

G

G

E

A

T

G

G

F

V

I

V

E

P

P

A

K

P

Y

E

E

G

Y

F

L

L

K

K

K

A

V

V

K

R

K

E

Q

L

C

C

E

D

E

E

V

Y

G

G

A

I

L

L

L

M

I

I

L

T

D
|
D

E

E

I
x
V

Q
|
Q

P

T

G

G

F

V

G

G

R

R

T

T

G

G

K

D

L

F

F

F

G

A

F

H

Q

Q

N

H

Y

D

D

G

I

V

P

P

D

D

I

V

V

V

V

T

M

M

G

A

K
|
K

G

G

M

L

G

G

L

L

P

P

V

I

G

G

A

A

F

C

T

L

A

A

S

T

T

G

T

R

M

A

D

E

Q

L

L

M

Q

T

D

P

N

G

P

K

K

-

L

-

G

-

H

H

I

G

T

T

F

F

G

G

N

N

P

P

V

V

I

A

A

C

A

A

L

K

A

A

T

V

L

L

Q

S

E

-

I

V

T

V

E

D

S

D

D

A

V

F

M

C

A

A

A

E

T

V

L

A

E

R

K

K

E

G

K

E

L

L

F

F

R

K

S

E

L

L

I

A

H

K

-

V

P

D

L

G

I

V

K

V

E

D

V

V

R

R

G

G

L

R

G

G

L

L

M

M

L

L

A

G

F

V

I

V

T

L

P

-

S

E

A

R

E

D

I

V

T

A

N

K

Q

Q

V

A

I

V

L

L

K

D

C

G

Q

F

D

K

H

H

G

G

L

V

I

I

L

L

F

N

W

A

L

P

L

A

F

D

E

N

P

-

L

-

A

I

I

I

R

R

I

L

T

T

P

P

L

L

T

V

I

I

S

T

E

D

S

E

E

E

I

I

R

A

E

D

G

A

C

V

Q

K

I

A

I

I

binding pyridoxal-5'-phosphate: S108 (= S104), G109 (= G105), A110 (≠ T106), F135 (≠ Y132), H136 (= H133), E190 (= E183), D223 (= D216), V225 (≠ I218), Q226 (= Q219), K252 (= K245)

Q5SHH5 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
36% identity, 92% coverage: 26:388/396 of query aligns to 36:394/395 of Q5SHH5

query
sites
Q5SHH5

G

G

S

A

Y

R

I

V

Y

W

D

D

T

A

N

E

N

G

K

N

K

E

Y

Y

L

I

D

D

F

C

V

V

A

G

G

G

V

Y

S

G

A

V

C

A

S

N

L

L

G

G

H

H

K

G

H

N

P

P

R

E

I

V

R

E

A

A

V

V

K

K

D

R

Q

Q

L

A

D

E

K

T

Y

-

L

-

H

-

V

L

M

M

V

A

Y

M

G

P

E

Q

Y

T

I

L

Q

P

Q

T

P

P

A

M

V

R

-

G

E

E

L

F

T

Y

K

R

L

T

L

L

A

T

S

A

H

I

L

L

P

P

H

P

P

E

L

L

E

N

K

R

T

V

Y

F

L

P

T

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

I

N

E

E

G

A

S

A

L

L

K

K

L

F

A

A

R

R

R

A

V

H

T

T

G

G

R

R

S

K

Q

K

I

F

I

V

A

A

K

M

L

R

A

G

Y

F

H

S

G

G

N

R

T

T

M

M

G

G

S

S

M

L

S

S

V

V

M

T

G

W

Y

E

E

P

E

K

R

Y

K

R

Q

E

A

P

F

F

R

L

P

P

L

L

I

V

P

E

D

P

T

V

A

E

F

F

I

I

T

P

F

Y

N

N

D

D

E

V

K

E

D

A

I

L

K

K

Q

R

-

A

I

V

T

D

R

E

K

E

T

T

G

A

A

A

V

V

I

I

L

L

E

E

T

P

I

V

Q

Q

G

G

G

E

A

G

G

G

F

V

I

R

E

P

P

A

K

T

Y

P

E

E

Y

F

L

L

K

R

K

A

V

A

K

R

K

E

Q

I

C

T

E

Q

E

E

V

K

G

G

A

A

L

L

I

I

L

L

D

D

E

E

I

I

Q

Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

R

F

F

G

A

F

F

Q

E

N

H

Y

F

D

G

I

I

I

V

P

P

D

D

I

I

V

L

V

T

M

L

G

A

K
|
K

G

A

M

L

G

G

L

V

P

P

V

L

G

G

A

A

F

-

T

-

A

-

S

-

T

A

T

V

M

M

M

R

D

E

Q

E

L

V

-

A

Q

R

D

S

N

M

P

P

K

K

L

G

G

G

H

H

I

G

T

T

T
|
T

F

F

G

G

N

N

P

P

V

L

I

A

A

M

A

A

A

G

L

V

A

A

T

A

L

I

Q

R

E

Y

I

L

T

E

E

R

S

T

D

R

V

L

M

W

A

E

A

R

T

A

L

A

E

E

K

L

E

G

K

P

L

W

F

F

R

M

S

E

L

K

L

L

-

R

-

A

-

I

I

P

H

S

P

P

L

K

I

I

K

R

E

E

V

V

R

R

G

G

L

M

G

G

L

L

M

M

L

V

A

G

F

L

I

E

T

L

P

-

S

-

A

K

E

E

I

K

T

A

N

A

Q

P

V

Y

I

I

L

A

K

R

C

L

Q

E

D

K

H

E

G

H

L

R

I

V

L

L

F

A

W

-

L

L

L

Q

F

A

E

G

P

P

L

T

A

V

I

I

R

R

I

F

T

L

P

P

L

L

T

V

I

I

S

E

E

K

S

E

E

D

I

L

R

E

E

R

G

V

C

V

Q

E

I

A

I

V

L

R

T

A

V

V

L

L

GT 113:114 (= GT 105:106) binding pyridoxal 5'-phosphate
K254 (= K245) modified: N6-(pyridoxal phosphate)lysine
T283 (= T277) binding pyridoxal 5'-phosphate

1wkhA Acetylornithine aminotransferase from thermus thermophilus hb8
36% identity, 92% coverage: 26:388/396 of query aligns to 28:386/387 of 1wkhA

query
sites
1wkhA

G

G

S

A

Y

R

I

V

Y

W

D

D

T

A

N

E

N

G

K

N

K

E

Y

Y

L

I

D

D

F

C

V

V

A

G

G

G

V
x
Y

S

G

A

V

C

A

S

N

L

L

G

G

H

H

K

G

H

N

P

P

R

E

I

V

R

E

A

A

V

V

K

K

D

R

Q

Q

L

A

D

E

K

T

Y

-

L

-

H

-

V

L

M

M

V

A

Y

M

G

P

E

Q

Y

T

I

L

Q

P

Q

T

P

P

A

M

V

R

-

G

E

E

L

F

T

Y

K

R

L

T

L

L

A

T

S

A

H

I

L

L

P

P

H

P

P

E

L

L

E

N

K

R

T

V

Y

F

L

P

T

V

N

N

S
|
S

G
|
G

T
|
T

E

E

A

A

I

N

E

E

G

A

S

A

L

L

K

K

L

F

A

A

R

R

R

A

V

H

T

T

G

G

R

R

S

K

Q

K

I

F

I

V

A

A

K

M

L

R

A

G

Y
x
F

H
x
S

G

G

N

R

T

T

M

M

G

G

S

S

M

L

S

S

V

V

M

T

G

W

Y

E

E

P

E

K

R

Y

K

R

Q

E

A

P

F

F

R

L

P

P

L

L

I

V

P

E

D

P

T

V

A

E

F

F

I

I

T

P

F

Y

N

N

D

D

E

V

K

E

D

A

I

L

K

K

Q

R

-

A

I

V

T

D

R

E

K

E

T

T

G

A

A

A

V

V

I

I

L

L

E
|
E

T

P

I

V

Q

Q

G

G

G
x
E

A

G

G

G

F

V

I

R

E

P

P

A

K

T

Y

P

E

E

Y

F

L

L

K

R

K

A

V

A

K

R

K

E

Q

I

C

T

E

Q

E

E

V

K

G

G

A

A

L

L

I

I

L

L

D
|
D

E

E

I
|
I

Q
|
Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

R

F

F

G

A

F

F

Q

E

N

H

Y

F

D

G

I

I

I

V

P

P

D

D

I

I

V

L

V

T

M

L

G

A

K
|
K

G

A

M

L

G

G

L

V

P

P

V

L

G

G

A

V

F

-

T

-

A

-

S

-

T

A

T

V

M

M

M

R

D

E

Q

E

L

V

-

A

Q

R

D

S

N

M

P

P

K

K

L

G

G

G

H

H

I

G

T

T

T
|
T

F

F

G

G

N

N

P

P

V

L

I

A

A

M

A

A

A

G

L

V

A

A

T

A

L

I

Q

R

E

Y

I

L

T

E

E

R

S

T

D

R

V

L

M

W

A

E

A

R

T

A

L

A

E

E

K

L

E

G

K

P

L

W

F

F

R

M

S

E

L

K

L

L

-

R

-

A

-

I

I

P

H

S

P

P

L

K

I

I

K

R

E

E

V

V

R

R

G

G

L

M

G

G

L

L

M

M

L

V

A

G

F

L

I

E

T

L

P

-

S

-

A

K

E

E

I

K

T

A

N

A

Q

P

V

Y

I

I

L

A

K

R

C

L

Q

E

D

K

H

E

G

H

L

R

I

V

L

L

F

A

W

-

L

L

L

Q

F

A

E

G

P

P

L

T

A

V

I

I

R
|
R

I

F

T

L

P

P

L

L

T

V

I

I

S

E

E

K

S

E

E

D

I

L

R

E

E

R

G

V

C

V

Q

E

I

A

I

V

L

R

T

A

V

V

L

L

active site: F132 (≠ Y132), E184 (= E183), D217 (= D216), Q220 (= Q219), K246 (= K245), T275 (= T277), R363 (= R365)
binding 4-[(1,3-dicarboxy-propylamino)-methyl]-3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridinium: Y46 (≠ V44), S104 (= S104), G105 (= G105), T106 (= T106), F132 (≠ Y132), S133 (≠ H133), E184 (= E183), E189 (≠ G188), D217 (= D216), I219 (= I218), K246 (= K245), R363 (= R365)

Sites not aligning to the query:

active site: 13

1wkgA Acetylornithine aminotransferase from thermus thermophilus hb8
36% identity, 92% coverage: 26:388/396 of query aligns to 28:386/387 of 1wkgA

query
sites
1wkgA

G

G

S

A

Y

R

I

V

Y

W

D

D

T

A

N

E

N

G

K

N

K

E

Y

Y

L

I

D

D

F

C

V

V

A

G

G

G

V
x
Y

S

G

A

V

C

A

S

N

L

L

G

G

H

H

K

G

H

N

P

P

R

E

I

V

R

E

A

A

V

V

K

K

D

R

Q

Q

L

A

D

E

K

T

Y

-

L

-

H

-

V

L

M

M

V

A

Y

M

G

P

E

Q

Y

T

I

L

Q

P

Q

T

P

P

A

M

V

R

-

G

E

E

L

F

T

Y

K

R

L

T

L

L

A

T

S

A

H

I

L

L

P

P

H

P

P

E

L

L

E

N

K

R

T

V

Y

F

L

P

T

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

I

N

E

E

G

A

S

A

L

L

K

K

L

F

A

A

R

R

R

A

V

H

T

T

G

G

R

R

S

K

Q

K

I

F

I

V

A

A

K

M

L

R

A

G

Y
x
F

H
x
S

G

G

N
x
R

T

T

M

M

G

G

S

S

M

L

S

S

V

V

M

T

G

W

Y

E

E

P

E

K

R

Y

K

R

Q

E

A

P

F

F

R

L

P

P

L

L

I

V

P

E

D

P

T

V

A

E

F

F

I

I

T

P

F

Y

N

N

D

D

E

V

K

E

D

A

I

L

K

K

Q

R

-

A

I

V

T

D

R

E

K

E

T

T

G

A

A

A

V

V

I

I

L

L

E
|
E

T

P

I

V

Q

Q

G

G

G

E

A

G

G

G

F

V

I

R

E

P

P

A

K

T

Y

P

E

E

Y

F

L

L

K

R

K

A

V

A

K

R

K

E

Q

I

C

T

E

Q

E

E

V

K

G

G

A

A

L

L

I

I

L

L

D
|
D

E

E

I
|
I

Q
|
Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

R

F

F

G

A

F

F

Q

E

N

H

Y

F

D

G

I

I

I

V

P

P

D

D

I

I

V

L

V

T

M

L

G

A

K
|
K

G

A

M

L

G

G

L

V

P

P

V

L

G

G

A

V

F

-

T

-

A

-

S

-

T

A

T

V

M

M

M

R

D

E

Q

E

L

V

-

A

Q

R

D

S

N

M

P

P

K

K

L

G

G

G

H

H

I
x
G

T
|
T

F

F

G

G

N

N

P

P

V

L

I

A

A

M

A

A

A

G

L

V

A

A

T

A

L

I

Q

R

E

Y

I

L

T

E

E

R

S

T

D

R

V

L

M

W

A

E

A

R

T

A

L

A

E

E

K

L

E

G

K

P

L

W

F

F

R

M

S

E

L

K

L

L

-

R

-

A

-

I

I

P

H

S

P

P

L

K

I

I

K

R

E

E

V

V

R

R

G

G

L

M

G

G

L

L

M

M

L

V

A

G

F

L

I

E

T

L

P

-

S

-

A

K

E

E

I

K

T

A

N

A

Q

P

V

Y

I

I

L

A

K

R

C

L

Q

E

D

K

H

E

G

H

L

R

I

V

L

L

F

A

W

-

L

L

L

Q

F

A

E

G

P

P

L

T

A

V

I

I

R
|
R

I

F

T

L

P

P

L

L

T

V

I

I

S

E

E

K

S

E

E

D

I

L

R

E

E

R

G

V

C

V

Q

E

I

A

I

V

L

R

T

A

V

V

L

L

active site: F132 (≠ Y132), E184 (= E183), D217 (= D216), Q220 (= Q219), K246 (= K245), T275 (= T277), R363 (= R365)
binding n~2~-acetyl-n~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-l-ornithine: Y46 (≠ V44), G105 (= G105), T106 (= T106), F132 (≠ Y132), S133 (≠ H133), R135 (≠ N135), E184 (= E183), D217 (= D216), I219 (= I218), Q220 (= Q219), K246 (= K245), G273 (≠ I275), T274 (= T276), T275 (= T277)

Sites not aligning to the query:

1vefA Acetylornithine aminotransferase from thermus thermophilus hb8
36% identity, 92% coverage: 26:388/396 of query aligns to 28:386/387 of 1vefA

query
sites
1vefA

G

G

S

A

Y

R

I

V

Y

W

D

D

T

A

N

E

N

G

K

N

K

E

Y

Y

L

I

D

D

F

C

V

V

A

G

G

G

V

Y

S

G

A

V

C

A

S

N

L

L

G

G

H

H

K

G

H

N

P

P

R

E

I

V

R

E

A

A

V

V

K

K

D

R

Q

Q

L

A

D

E

K

T

Y

-

L

-

H

-

V

L

M

M

V

A

Y

M

G

P

E

Q

Y

T

I

L

Q

P

Q

T

P

P

A

M

V

R

-

G

E

E

L

F

T

Y

K

R

L

T

L

L

A

T

S

A

H

I

L

L

P

P

H

P

P

E

L

L

E

N

K

R

T

V

Y

F

L

P

T

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

I

N

E

E

G

A

S

A

L

L

K

K

L

F

A

A

R

R

R

A

V

H

T

T

G

G

R

R

S

K

Q

K

I

F

I

V

A

A

K

M

L

R

A

G

Y
x
F

H
x
S

G

G

N

R

T

T

M

M

G

G

S

S

M

L

S

S

V

V

M

T

G

W

Y

E

E

P

E

K

R

Y

K

R

Q

E

A

P

F

F

R

L

P

P

L

L

I

V

P

E

D

P

T

V

A

E

F

F

I

I

T

P

F

Y

N

N

D

D

E

V

K

E

D

A

I

L

K

K

Q

R

-

A

I

V

T

D

R

E

K

E

T

T

G

A

A

A

V

V

I

I

L

L

E
|
E

T

P

I

V

Q

Q

G

G

G

E

A

G

G

G

F

V

I

R

E

P

P

A

K

T

Y

P

E

E

Y

F

L

L

K

R

K

A

V

A

K

R

K

E

Q

I

C

T

E

Q

E

E

V

K

G

G

A

A

L

L

I

I

L

L

D
|
D

E

E

I
|
I

Q

Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

R

F

F

G

A

F

F

Q

E

N

H

Y

F

D

G

I

I

I

V

P

P

D

D

I

I

V

L

V

T

M

L

G

A

K
|
K

G

A

M

L

G

G

L

V

P

P

V

L

G

G

A

V

F

-

T

-

A

-

S

-

T

A

T

V

M

M

M

R

D

E

Q

E

L

V

-

A

Q

R

D

S

N

M

P

P

K

K

L

G

G

G

H

H

I

G

T

T

T
|
T

F

F

G

G

N

N

P

P

V

L

I

A

A

M

A

A

A

G

L

V

A

A

T

A

L

I

Q

R

E

Y

I

L

T

E

E

R

S

T

D

R

V

L

M

W

A

E

A

R

T

A

L

A

E

E

K

L

E

G

K

P

L

W

F

F

R

M

S

E

L

K

L

L

-

R

-

A

-

I

I

P

H

S

P

P

L

K

I

I

K

R

E

E

V

V

R

R

G

G

L

M

G

G

L

L

M

M

L

V

A

G

F

L

I

E

T

L

P

-

S

-

A

K

E

E

I

K

T

A

N

A

Q

P

V

Y

I

I

L

A

K

R

C

L

Q

E

D

K

H

E

G

H

L

R

I

V

L

L

F

A

W

-

L

L

L

Q

F

A

E

G

P

P

L

T

A

V

I

I

R
|
R

I

F

T

L

P

P

L

L

T

V

I

I

S

E

E

K

S

E

E

D

I

L

R

E

E

R

G

V

C

V

Q

E

I

A

I

V

L

R

T

A

V

V

L

L

active site: F132 (≠ Y132), D217 (= D216), K246 (= K245), T275 (= T277), R363 (= R365)
binding pyridoxal-5'-phosphate: G105 (= G105), T106 (= T106), F132 (≠ Y132), S133 (≠ H133), E184 (= E183), D217 (= D216), I219 (= I218), K246 (= K245)

Sites not aligning to the query:

active site: 13

8cplC Yzw2 a scaffold for cryo-em of small proteins of interest
35% identity, 93% coverage: 18:385/396 of query aligns to 57:434/499 of 8cplC

query
sites
8cplC

A

A

I

V

E

E

V

W

S

Q

H

A

A

G

I

S

G

L

S

N

Y

T

I

L

Y

V

D

D

T

T

N

Q

N

G

K

Q

K

E

Y

F

L

I

D

D

F

C

V

L

A

G

G

G

V

F

S

G

A

I

C

F

S

N

L

V

G

G

H

H

K

R

H

N

P

P

R

V

I

V

R

S

A

A

V

V

K

Q

D

N

Q

Q

L

L

D

A

K

K

Y

Q

-

P

L

L

H

H

V

S

M

Q

V

-

Y

-

G

-

E

E

Y

L

I

L

Q

D

Q

P

P

L

A

R

V

A

E

M

L

L

T

A

K

K

L

T

L

L

A

A

S

A

H

L

L

T

P

P

H

G

P

K

L

L

E

K

K

Y

T

S

Y

F

L

F

T

C

N

N

S
|
S

G
|
G

T
|
T

E

E

A

S

I

V

E

E

G

A

S

A

L

L

K

K

L

L

A

A

R

K

R

A

V

Y

T

Q

-

S

-

P

-

R

G

G

R

K

S

F

Q

T

I

F

I

I

A

A

A

T

K

S

L

G

A

A

Y
x
F

H
|
H

G

G

N

K

T

S

M

L

G

G

S

A

M

L

S

S

V

A

M

T

G

A

Y

K

E

S

E

T

R

F

K

R

Q

K

A

P

F

F

R

M

P

P

L

L

I

L

P

P

D

G

T

F

A

R

F

H

I

V

T

P

F

F

N

G

D

N

E

I

K

E

D

A

I

M

K

R

Q

T

I

A

-

L

-

N

-

E

T

C

R

K

K

K

T

T

G

G

-

D

-

V

-

A

A

A

V

V

I

I

L

L

E
|
E

T

P

I

I

Q

Q

G

G

G

E

A

G

G

G

F

V

I

I

E

L

P

P

K

P

Y

P

E

G

Y

Y

L

L

K

T

K

A

V

V

K

R

K

K

Q

L

C

C

E

D

E

E

V

F

G

G

A

A

L

L

L

M

I

I

L

L

D
|
D

E

E

I
x
V

Q
|
Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

M

F

F

G

A

F

C

Q

E

N

H

Y

E

D

N

I

V

I

Q

P

P

D

D

I

I

V

L

V

C

M

L

G

A

K
|
K

G

A

M

L

G

G

-

V

L

M

P

P

V

I

G

G

A

A

F

T

T

I

A

A

S

T

T

E

M

V

M

F

D

S

Q

V

L

L

Q

F

D

D

N

N

P

P

K

F

L

L

G

-

H

H

I

T

T

T

F

F

G

G

N

N

P

P

V

L

I

A

A

C

A

A

L

L

A

A

T

T

L

I

Q

N

E

V

I

L

T

L

E

E

S

Q

D

N

V

L

M

P

A

A

A

Q

T

A

L

E

E

Q

K

K

E

G

K

D

L

M

-

L

-

D

-

G

F

F

R

R

S

Q

L

L

L

A

I

R

-

E

H

Y

P

P

-

D

L

L

I

V

K

Q

E

E

V

A

R

R

G

G

L

K

G

G

L

M

M

L

L

M

A

A

F

I

I

E

T

F

P

V

S

D

A

N

E

E

I

I

T

G

N

Y

Q

N

V

F

I

A

L

S

K

E

C

M

Q

F

D

R

H

Q

G

R

L

V

I

L

L

V

F

A

W

G

L

T

L

L

F

N

E

N

P

A

L

K

A

T

I

I

R

R

I

I

T

E

P

P

L

L

T

T

I

L

S

T

E

-

S

-

E

-

I

-

R

I

E

E

G

Q

C

C

Q

E

I

L

I

V

L

I

binding pyridoxal-5'-phosphate: S141 (= S104), G142 (= G105), T143 (= T106), F172 (≠ Y132), H173 (= H133), E230 (= E183), D263 (= D216), V265 (≠ I218), Q266 (= Q219), K292 (= K245)

4uoxA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate and putrescine (see paper)
35% identity, 93% coverage: 18:385/396 of query aligns to 59:436/453 of 4uoxA

query
sites
4uoxA

A

A

I

V

E

E

V

W

S

Q

H

A

A

G

I

S

G

L

S

N

Y

T

I

L

Y

V

D

D

T

T

N

Q

N

G

K

Q

K

E

Y

F

L

I

D

D

F

C

V

L

A

G

G

G

V

F

S

G

A

I

C

F

S

N

L

V

G

G

H

H

K

R

H

N

P

P

R

V

I

V

R

S

A

A

V

V

K

Q

D

N

Q

Q

L

L

D

A

K

K

Y

Q

-

P

L

L

H

H

V

S

M

Q

V

-

Y

-

G

-

E

E

Y

L

I

L

Q

D

Q

P

P

L

A

R

V

A

E

M

L

L

T

A

K

K

L

T

L

L

A

A

S

A

H

L

L

T

P

P

H

G

P

K

L

L

E

K

K

Y

T

S

Y

F

L

F

T

C

N

N

S
|
S

G
|
G

T
|
T

E

E

A

S

I

V

E

E

G

A

S

A

L

L

K

K

L

L

A

A

R

K

R

A

V

Y

T

Q

-

S

-

P

-

R

G

G

R

K

S

F

Q

T

I

F

I

I

A

A

A

T

K

S

L

G

A

A

Y
x
F

H
|
H

G
|
G

N

K

T

S

M

L

G

G

S

A

M

L

S

S

V

A

M

T

G

A

Y

K

E

S

E

T

R

F

K

R

Q

K

A

P

F

F

R

M

P

P

L

L

I

L

P

P

D

G

T

F

A

R

F

H

I

V

T

P

F

F

N

G

D

N

E

I

K

E

D

A

I

M

K

R

Q

T

I

A

-

L

-

N

-

E

T

C

R

K

K

K

T

T

G

G

-

D

-

V

-

A

A

A

V

V

I

I

L

L

E
|
E

T

P

I

I

Q

Q

G

G

G
x
E

A

G

G

G

F

V

I

I

E

L

P

P

K

P

Y

P

E

G

Y

Y

L

L

K

T

K

A

V

V

K

R

K

K

Q

L

C

C

E

D

E

E

V

F

G

G

A

A

L

L

L

M

I

I

L

L

D
|
D

E

E

I
x
V

Q
|
Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

M

F

F

G

A

F

C

Q

E

N

H

Y

E

D

N

I

V

I

Q

P

P

D

D

I

I

V

L

V

C

M

L

G

A

K
|
K

G

A

M

L

G

G

-

V

L

M

P

P

V

I

G

G

A

A

F

T

T

I

A

A

S

T

T

E

M

V

M

F

D

S

Q

V

L

L

Q

F

D

D

N

N

P

P

K

F

L

L

G

-

H

H

I

T

T
|
T

F

F

G

G

N

N

P

P

V

L

I

A

A

C

A

A

L

L

A

A

T

T

L

I

Q

N

E

V

I

L

T

L

E

E

S

Q

D

N

V

L

M

P

A

A

A

Q

T

A

L

E

E

Q

K

K

E

G

K

D

L

M

-

L

-

D

-

G

F

F

R

R

S

Q

L

L

L

A

I

R

-

E

H

Y

P

P

-

D

L

L

I

V

K

Q

E

E

V

A

R

R

G

G

L

K

G

G

L

M

M

L

L

M

A

A

F

I

I

E

T

F

P

V

S

D

A

N

E

E

I

I

T

G

N

Y

Q

N

V

F

I

A

L

S

K

E

C

M

Q

F

D

R

H

Q

G

R

L

V

I

L

L

V

F

A

W

G

L

T

L

L

F

N

E

N

P

A

L

K

A

T

I

I

R
|
R

I

I

T

E

P

P

L

L

T

T

I

L

S

T

E

-

S

-

E

-

I

-

R

I

E

E

G

Q

C

C

Q

E

I

L

I

V

L

I

active site: F174 (≠ Y132), E232 (= E183), D265 (= D216), Q268 (= Q219), K294 (= K245), T326 (= T277), R420 (= R365)
binding pyridoxal-5'-phosphate: S143 (= S104), G144 (= G105), T145 (= T106), F174 (≠ Y132), H175 (= H133), G176 (= G134), D265 (= D216), V267 (≠ I218), Q268 (= Q219), T325 (= T276), T326 (= T277)
binding 1,4-diaminobutane: E237 (≠ G188), K294 (= K245)

Sites not aligning to the query:

active site: 44

4uoyA Crystal structure of ygjg in complex with pyridoxal-5'-phosphate (see paper)
35% identity, 93% coverage: 18:385/396 of query aligns to 59:436/454 of 4uoyA

query
sites
4uoyA

A

A

I

V

E

E

V

W

S

Q

H

A

A

G

I

S

G

L

S

N

Y

T

I

L

Y

V

D

D

T

T

N

Q

N

G

K

Q

K

E

Y

F

L

I

D

D

F

C

V

L

A

G

G

G

V

F

S

G

A

I

C

F

S

N

L

V

G

G

H

H

K

R

H

N

P

P

R

V

I

V

R

S

A

A

V

V

K

Q

D

N

Q

Q

L

L

D

A

K

K

Y

Q

-

P

L

L

H

H

V

S

M

Q

V

-

Y

-

G

-

E

E

Y

L

I

L

Q

D

Q

P

P

L

A

R

V

A

E

M

L

L

T

A

K

K

L

T

L

L

A

A

S

A

H

L

L

T

P

P

H

G

P

K

L

L

E

K

K

Y

T

S

Y

F

L

F

T

C

N

N

S

S

G
|
G

T
|
T

E

E

A

S

I

V

E

E

G

A

S

A

L

L

K

K

L

L

A

A

R

K

R

A

V

Y

-

Q

-

S

-

P

T

R

G

G

R

K

S

F

Q

T

I

F

I

I

A

A

A

T

K

S

L

G

A

A

Y
x
F

H
|
H

G
|
G

N

K

T

S

M

L

G

G

S

A

M

L

S

S

V

A

M

T

G

A

Y

K

E

S

E

T

R

F

K

R

Q

K

A

P

F

F

R

M

P

P

L

L

I

L

P

P

D

G

T

F

A

R

F

H

I

V

T

P

F

F

N

G

D

N

E

I

K

E

D

A

I

M

K

R

Q

T

I

A

-

L

-

N

-

E

T

C

R

K

K

K

T

T

G

G

-

D

-

V

-

A

A

A

V

V

I

I

L

L

E
|
E

T

P

I

I

Q

Q

G

G

G

E

A

G

G

G

F

V

I

I

E

L

P

P

K

P

Y

P

E

G

Y

Y

L

L

K

T

K

A

V

V

K

R

K

K

Q

L

C

C

E

D

E

E

V

F

G

G

A

A

L

L

L

M

I

I

L

L

D
|
D

E

E

I
x
V

Q
|
Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

M

F

F

G

A

F

C

Q

E

N

H

Y

E

D

N

I

V

I

Q

P

P

D

D

I

I

V

L

V

C

M

L

G

A

K
|
K

G

A

M

L

G

G

-

V

L

M

P

P

V

I

G

G

A

A

F

T

T

I

A

A

S

T

T

E

M

V

M

F

D

S

Q

V

L

L

Q

F

D

D

N

N

P

P

K

F

L

L

G

-

H

H

I

T

T

T

T
|
T

F

F

G

G

N

N

P

P

V

L

I

A

A

C

A

A

L

L

A

A

T

T

L

I

Q

N

E

V

I

L

T

L

E

E

S

Q

D

N

V

L

M

P

A

A

A

Q

T

A

L

E

E

Q

K

K

E

G

K

D

L

M

-

L

-

D

-

G

F

F

R

R

S

Q

L

L

L

A

I

R

-

E

H

Y

P

P

-

D

L

L

I

V

K

Q

E

E

V

A

R

R

G

G

L

K

G

G

L

M

M

L

L

M

A

A

F

I

I

E

T

F

P

V

S

D

A

N

E

E

I

I

T

G

N

Y

Q

N

V

F

I

A

L

S

K

E

C

M

Q

F

D

R

H

Q

G

R

L

V

I

L

L

V

F

A

W

G

L

T

L

L

F

N

E

N

P

A

L

K

A

T

I

I

R
|
R

I

I

T

E

P

P

L

L

T

T

I

L

S

T

E

-

S

-

E

-

I

-

R

I

E

E

G

Q

C

C

Q

E

I

L

I

V

L

I

active site: F174 (≠ Y132), E232 (= E183), D265 (= D216), Q268 (= Q219), K294 (= K245), T326 (= T277), R420 (= R365)
binding pyridoxal-5'-phosphate: G144 (= G105), T145 (= T106), F174 (≠ Y132), H175 (= H133), G176 (= G134), E232 (= E183), D265 (= D216), V267 (≠ I218), Q268 (= Q219), K294 (= K245)

Sites not aligning to the query:

active site: 44

P42588 Putrescine aminotransferase; PAT; PATase; Cadaverine transaminase; Diamine transaminase; Putrescine transaminase; Putrescine--2-oxoglutaric acid transaminase; Putrescine:2-OG aminotransferase; EC 2.6.1.82; EC 2.6.1.29 from Escherichia coli (strain K12) (see paper)
35% identity, 93% coverage: 18:385/396 of query aligns to 65:442/459 of P42588

query
sites
P42588

A

A

I

V

E

E

V

W

S

Q

H

A

A

G

I

S

G

L

S

N

Y

T

I

L

Y

V

D

D

T

T

N

Q

N

G

K

Q

K

E

Y

F

L

I

D

D

F

C

V

L

A

G

G

G

V

F

S

G

A

I

C

F

S

N

L

V

G

G

H

H

K

R

H

N

P

P

R

V

I

V

R

S

A

A

V

V

K

Q

D

N

Q

Q

L

L

D

A

K

K

Y

Q

-

P

L

L

H

H

V

S

M

Q

V

-

Y

-

G

-

E

E

Y

L

I

L

Q

D

Q

P

P

L

A

R

V

A

E

M

L

L

T

A

K

K

L

T

L

L

A

A

S

A

H

L

L

T

P

P

H

G

P

K

L

L

E

K

K

Y

T

S

Y

F

L

F

T

C

N

N

S

S

G
|
G

T
|
T

E

E

A

S

I

V

E

E

G

A

S

A

L

L

K

K

L

L

A

A

R

K

R

A

V

Y

-

Q

-

S

-

P

T

R

G

G

R

K

S

F

Q

T

I

F

I

I

A

A

A

T

K

S

L

G

A

A

Y

F

H

H

G

G

N

K

T

S

M

L

G

G

S

A

M

L

S

S

V

A

M

T

G

A

Y

K

E

S

E

T

R

F

K

R

Q

K

A

P

F

F

R

M

P

P

L

L

I

L

P

P

D

G

T

F

A

R

F

H

I

V

T

P

F

F

N

G

D

N

E

I

K

E

D

A

I

M

K

R

Q

T

I

A

-

L

-

N

-

E

T

C

R

K

K

K

T

T

G

G

-

D

-

V

-

A

A

A

V

V

I

I

L

L

E

E

T

P

I

I

Q

Q

G

G

G

E

A

G

G

G

F

V

I

I

E

L

P

P

K

P

Y

P

E

G

Y

Y

L

L

K

T

K

A

V

V

K

R

K

K

Q

L

C

C

E

D

E

E

V

F

G

G

A

A

L

L

L

M

I

I

L

L

D

D

E

E

I

V

Q
|
Q

P

T

G

G

F

M

G

G

R

R

T

T

G

G

K

K

L

M

F

F

G

A

F

C

Q

E

N

H

Y

E

D

N

I

V

I

Q

P

P

D

D

I

I

V

L

V

C

M

L

G

A

K
|
K

G

A

M

L

G

G

-

V

L

M

P

P

V

I

G

G

A

A

F

T

T

I

A

A

S

T

T

E

M

V

M

F

D

S

Q

V

L

L

Q

F

D

D

N

N

P

P

K

F

L

L

G

-

H

H

I

T

T

T

T
|
T

F

F

G

G

N

N

P

P

V

L

I

A

A

C

A

A

L

L

A

A

T

T

L

I

Q

N

E

V

I

L

T

L

E

E

S

Q

D

N

V

L

M

P

A

A

A

Q

T

A

L

E

E

Q

K

K

E

G

K

D

L

M

-

L

-

D

-

G

F

F

R

R

S

Q

L

L

L

A

I

R

-

E

H

Y

P

P

-

D

L

L

I

V

K

Q

E

E

V

A

R

R

G

G

L

K

G

G

L

M

M

L

L

M

A

A

F

I

I

E

T

F

P

V

S

D

A

N

E

E

I

I

T

G

N

Y

Q

N

V

F

I

A

L

S

K

E

C

M

Q

F

D

R

H

Q

G

R

L

V

I

L

L

V

F

A

W

G

L

T

L

L

F

N

E

N

P

A

L

K

A

T

I

I

R

R

I

I

T

E

P

P

L

L

T

T

I

L

S

T

E

-

S

-

E

-

I

-

R

I

E

E

G

Q

C

C

Q

E

I

L

I

V

L

I

GT 150:151 (= GT 105:106) binding in other chain
Q274 (= Q219) binding in other chain
K300 (= K245) modified: N6-(pyridoxal phosphate)lysine
T332 (= T277) binding pyridoxal 5'-phosphate

3nx3A Crystal structure of acetylornithine aminotransferase (argd) from campylobacter jejuni
36% identity, 89% coverage: 26:379/396 of query aligns to 20:376/388 of 3nx3A

query
sites
3nx3A

G

G

S

V

Y

Y

I

L

Y

F

D

D

T

D

N

K

N

A

K

K

Y

Y

L

L

D

D

F

F

V

S

A

S

G

G

V

I

S

G

A

V

C

C

S

A