SitesBLAST
Comparing WP_025763370.1 NCBI__GCF_000566685.1:WP_025763370.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4wecA Crystal structure of a short chain dehydrogenase from mycobacterium smegmatis
49% identity, 100% coverage: 2:257/257 of query aligns to 7:258/258 of 4wecA
- active site: G21 (= G16), S143 (= S143), Q154 (= Q154), Y157 (= Y157), K161 (= K161)
- binding nicotinamide-adenine-dinucleotide: G17 (= G12), A19 (≠ S14), S20 (≠ G15), G21 (= G16), I22 (= I17), D41 (= D36), I42 (≠ V37), V61 (≠ S61), D62 (= D62), V63 (= V63), N89 (= N89), T141 (= T141), Y157 (= Y157), K161 (= K161), P187 (= P187), P189 (= P189), V190 (≠ L190)
8y83A Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
43% identity, 97% coverage: 3:251/257 of query aligns to 4:248/249 of 8y83A
- binding nicotinamide-adenine-dinucleotide: G13 (= G12), S16 (≠ G15), G17 (= G16), I18 (= I17), D37 (= D36), I38 (≠ V37), A62 (≠ S61), D63 (= D62), S64 (≠ V63), N90 (= N89), M141 (≠ T141), Y156 (= Y157), K160 (= K161), P186 (= P187), G187 (= G188), Y188 (≠ P189), I189 (≠ L190), L193 (= L194)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
41% identity, 97% coverage: 3:251/257 of query aligns to 3:247/248 of 6ixmC
- active site: G16 (= G16), S142 (= S143), Y155 (= Y157), K159 (= K161)
- binding nicotinamide-adenine-dinucleotide: G12 (= G12), S15 (≠ G15), G16 (= G16), I17 (= I17), D36 (= D36), I37 (≠ V37), A61 (≠ S61), D62 (= D62), T63 (≠ V63), N89 (= N89), A90 (= A90), M140 (≠ T141), S142 (= S143), Y155 (= Y157), K159 (= K161), P185 (= P187), A186 (≠ G188), Y187 (≠ P189), I188 (≠ L190), L192 (= L194)
7djsD Crystal structure of isopiperitenol dehydrogenase from pseudomonas aeruginosa complexed with NAD
42% identity, 97% coverage: 3:251/257 of query aligns to 3:250/251 of 7djsD
- binding nicotinamide-adenine-dinucleotide: G12 (= G12), G16 (= G16), I17 (= I17), D36 (= D36), L37 (≠ V37), C61 (≠ S61), D62 (= D62), V63 (= V63), N89 (= N89), A90 (= A90), T140 (= T141), S142 (= S143), Y155 (= Y157), K159 (= K161), A186 (≠ G188), V187 (≠ P189)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
40% identity, 97% coverage: 1:249/257 of query aligns to 1:245/247 of 4jroC
- active site: G16 (= G16), S142 (= S143), Q152 (= Q154), Y155 (= Y157), K159 (= K161)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), R15 (≠ G15), G16 (= G16), I17 (= I17), N35 (≠ S35), Y36 (vs. gap), N37 (≠ D36), G38 (≠ V37), S39 (≠ N38), N63 (≠ D62), V64 (= V63), N90 (= N89), A91 (= A90), I93 (= I92), I113 (= I114), S142 (= S143), Y155 (= Y157), K159 (= K161), P185 (= P187), I188 (≠ L190), T190 (= T192)
4urfB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
38% identity, 98% coverage: 1:251/257 of query aligns to 1:247/248 of 4urfB
- active site: G16 (= G16), S142 (= S143), I152 (≠ A151), Y155 (= Y157), K159 (= K161)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: L210 (≠ M214), R211 (≠ G215), R212 (= R216)
- binding bicarbonate ion: I92 (= I92), G94 (≠ H94), R109 (≠ L110), R179 (= R181), S228 (= S232)
- binding nicotinamide-adenine-dinucleotide: G12 (= G12), G14 (≠ S14), N15 (≠ G15), G16 (= G16), I17 (= I17), D36 (= D36), I37 (≠ V37), D62 (= D62), T63 (≠ V63), N89 (= N89), A90 (= A90), G91 (= G91), I140 (≠ T141), Y155 (= Y157), K159 (= K161), P185 (= P187), A186 (≠ G188), I188 (≠ L190), T190 (= T192)
4urfA Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
38% identity, 98% coverage: 1:251/257 of query aligns to 1:247/248 of 4urfA
- active site: G16 (= G16), S142 (= S143), I152 (≠ A151), Y155 (= Y157), K159 (= K161)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: I92 (= I92), S93 (≠ M93), G94 (≠ H94), E95 (≠ S95), T97 (≠ D97), E101 (≠ M101), T103 (= T103), Q106 (≠ S106), R109 (≠ L110), S175 (≠ R177), G177 (≠ N179)
- binding magnesium ion: S237 (≠ T241), Y238 (≠ D242)
- binding nicotinamide-adenine-dinucleotide: G12 (= G12), G14 (≠ S14), N15 (≠ G15), G16 (= G16), I17 (= I17), D36 (= D36), I37 (≠ V37), W41 (≠ M41), D62 (= D62), T63 (≠ V63), N89 (= N89), A90 (= A90), G91 (= G91), I140 (≠ T141), Y155 (= Y157), K159 (= K161), P185 (= P187), I188 (≠ L190), T190 (= T192)
4ureB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
38% identity, 98% coverage: 1:251/257 of query aligns to 1:247/248 of 4ureB
- active site: G16 (= G16), S142 (= S143), I152 (≠ A151), Y155 (= Y157), K159 (= K161)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: N15 (≠ G15), G16 (= G16), I17 (= I17), N89 (= N89), G91 (= G91), Y155 (= Y157), P185 (= P187), A186 (≠ G188)
5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
39% identity, 98% coverage: 1:251/257 of query aligns to 3:254/255 of 5itvA
- active site: G18 (= G16), S141 (= S143), Y154 (= Y157), K158 (= K161)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G12), S17 (≠ G15), G18 (= G16), I19 (= I17), D38 (= D36), I39 (≠ V37), T61 (≠ S61), I63 (≠ V63), N89 (= N89), G91 (= G91), T139 (= T141), S141 (= S143), Y154 (= Y157), K158 (= K161), P184 (= P187), G185 (= G188), I186 (≠ P189), I187 (≠ L190)
Q9LBG2 Levodione reductase; (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase; EC 1.1.1.- from Leifsonia aquatica (Corynebacterium aquaticum) (see paper)
38% identity, 98% coverage: 2:253/257 of query aligns to 10:267/267 of Q9LBG2
- 17:42 (vs. 9:34, 54% identical) binding NAD(+)
- E103 (≠ M93) mutation E->A,D,N,Q: 26-fold increase in Km and a much lower enantiomeric excess of the reaction products.
1iy8A Crystal structure of levodione reductase (see paper)
38% identity, 98% coverage: 2:253/257 of query aligns to 1:258/258 of 1iy8A
- active site: G15 (= G16), S143 (= S143), Q153 (= Q154), Y156 (= Y157), K160 (= K161)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), S14 (≠ G15), G15 (= G16), L16 (≠ I17), D35 (= D36), V36 (= V37), A62 (≠ S61), D63 (= D62), V64 (= V63), N90 (= N89), G92 (= G91), I93 (= I92), T141 (= T141), S143 (= S143), Y156 (= Y157), K160 (= K161), P186 (= P187), G187 (= G188), T191 (= T192), P192 (≠ E193), M193 (≠ L194)
7ejhA Crystal structure of kred mutant-f147l/l153q/y190p/l199a/m205f/m206f and 2-hydroxyisoindoline-1,3-dione complex
40% identity, 97% coverage: 2:251/257 of query aligns to 5:252/253 of 7ejhA
- binding 2-oxidanylisoindole-1,3-dione: S144 (= S143), I145 (≠ F144), E146 (≠ V145), Y157 (= Y157), V197 (≠ L195), F207 (≠ K205)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G12), T17 (≠ S14), I20 (= I17), R40 (≠ V37), H41 (≠ N38), D64 (= D62), A65 (≠ V63), N91 (= N89), A92 (= A90), V114 (≠ I114), M142 (≠ T141), S144 (= S143), Y157 (= Y157), K161 (= K161), P189 (= P187), G190 (= G188), P191 (= P189), I192 (≠ L190), T194 (= T192), P195 (≠ E193), L196 (= L194)
7ejiB Crystal structure of kred f147l/l153q/y190p/l199a/m205f/m206f variant and methyl methacrylate complex
40% identity, 97% coverage: 2:251/257 of query aligns to 3:250/251 of 7ejiB
- binding methyl 2-methylprop-2-enoate: S142 (= S143), I143 (≠ F144), Y155 (= Y157), F205 (≠ K205)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G12), T15 (≠ S14), L16 (≠ G15), G17 (= G16), I18 (= I17), R38 (≠ V37), H39 (≠ N38), D62 (= D62), A63 (≠ V63), N89 (= N89), A90 (= A90), V112 (≠ I114), M140 (≠ T141), S142 (= S143), Y155 (= Y157), K159 (= K161), P187 (= P187), P189 (= P189), I190 (≠ L190), T192 (= T192), P193 (≠ E193), L194 (= L194)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
38% identity, 96% coverage: 2:249/257 of query aligns to 4:242/244 of 4nbuB
- active site: G18 (= G16), N111 (= N115), S139 (= S143), Q149 (= Q154), Y152 (= Y157), K156 (= K161)
- binding acetoacetyl-coenzyme a: D93 (≠ S95), K98 (≠ A100), S139 (= S143), N146 (≠ A151), V147 (≠ T152), Q149 (= Q154), Y152 (= Y157), F184 (≠ P189), M189 (≠ L194), K200 (≠ R207)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G12), N17 (≠ G15), G18 (= G16), I19 (= I17), D38 (= D36), F39 (≠ V37), V59 (≠ S61), D60 (= D62), V61 (= V63), N87 (= N89), A88 (= A90), G89 (= G91), I90 (= I92), T137 (= T141), S139 (= S143), Y152 (= Y157), K156 (= K161), P182 (= P187), F184 (≠ P189), T185 (≠ L190), T187 (= T192), M189 (≠ L194)
5jc8D Crystal structure of a putative short-chain dehydrogenase/reductase from burkholderia xenovorans
35% identity, 97% coverage: 2:251/257 of query aligns to 3:259/262 of 5jc8D
8y46A SDR family oxidoreductase (see paper)
35% identity, 96% coverage: 2:248/257 of query aligns to 4:248/251 of 8y46A