SitesBLAST
Comparing WP_026050167.1 NCBI__GCF_000691145.1:WP_026050167.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1kl2A Crystal structure of serine hydroxymethyltransferase complexed with glycine and 5-formyl tetrahydrofolate (see paper)
78% identity, 97% coverage: 1:404/415 of query aligns to 1:404/405 of 1kl2A
- active site: Y51 (= Y51), E53 (= E53), D197 (= D197), T223 (= T223), K226 (= K226), R232 (= R232)
- binding N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid: E53 (= E53), Y60 (= Y60), G121 (= G121), H122 (= H122), S172 (= S172), F251 (= F251), N341 (= N341)
- binding glycine: S31 (= S31), Y51 (= Y51), Y61 (= Y61), H200 (= H200), R357 (= R357)
- binding pyridoxal-5'-phosphate: S93 (= S93), G94 (= G94), A95 (= A95), H122 (= H122), S172 (= S172), D197 (= D197), A199 (= A199), H200 (= H200), T223 (= T223), H225 (= H225), K226 (= K226)
1kl1A Crystal structure of serine hydroxymethyltransferase complexed with glycine (see paper)
78% identity, 97% coverage: 1:404/415 of query aligns to 1:404/405 of 1kl1A
- active site: Y51 (= Y51), E53 (= E53), D197 (= D197), T223 (= T223), K226 (= K226), R232 (= R232)
- binding glycine: S31 (= S31), H122 (= H122), R357 (= R357)
- binding pyridoxal-5'-phosphate: S93 (= S93), G94 (= G94), A95 (= A95), H122 (= H122), A171 (= A171), S172 (= S172), D197 (= D197), A199 (= A199), H200 (= H200), T223 (= T223), H225 (= H225), K226 (= K226)
1kkpA Crystal structure of serine hydroxymethyltransferase complexed with serine (see paper)
78% identity, 97% coverage: 1:404/415 of query aligns to 1:404/405 of 1kkpA
- active site: Y51 (= Y51), E53 (= E53), D197 (= D197), T223 (= T223), K226 (= K226), R232 (= R232)
- binding pyridoxal-5'-phosphate: S93 (= S93), G94 (= G94), A95 (= A95), H122 (= H122), S172 (= S172), D197 (= D197), A199 (= A199), H200 (= H200), K226 (= K226)
- binding serine: S31 (= S31), H122 (= H122), R357 (= R357)
1kkjA Crystal structure of serine hydroxymethyltransferase from b.Stearothermophilus (see paper)
78% identity, 97% coverage: 1:404/415 of query aligns to 1:404/405 of 1kkjA
- active site: Y51 (= Y51), E53 (= E53), D197 (= D197), T223 (= T223), K226 (= K226), R232 (= R232)
- binding pyridoxal-5'-phosphate: S93 (= S93), G94 (= G94), A95 (= A95), H122 (= H122), S172 (= S172), D197 (= D197), A199 (= A199), H200 (= H200), T223 (= T223), H225 (= H225), K226 (= K226)
2vmyA Crystal structure of f351gbsshmt in complex with gly and fthf (see paper)
78% identity, 97% coverage: 1:404/415 of query aligns to 1:404/405 of 2vmyA
- active site: Y51 (= Y51), E53 (= E53), D197 (= D197), T223 (= T223), K226 (= K226), R232 (= R232)
- binding N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid: E53 (= E53), Y60 (= Y60), Y61 (= Y61), L117 (= L117), G121 (= G121), H122 (= H122), L123 (= L123), S172 (= S172), K248 (= K248), F251 (= F251), N341 (= N341), S349 (≠ K349), P350 (= P350), G351 (≠ F351), R357 (= R357)
- binding glycine: S31 (= S31), Y51 (= Y51), Y61 (= Y61), H200 (= H200), K226 (= K226), R357 (= R357)
- binding pyridoxal-5'-phosphate: Y51 (= Y51), S93 (= S93), G94 (= G94), A95 (= A95), H122 (= H122), S172 (= S172), D197 (= D197), A199 (= A199), H200 (= H200), T223 (= T223), K226 (= K226), G257 (= G257)
2vmxA Crystal structure of f351gbsshmt in complex with l-allo-thr (see paper)
78% identity, 97% coverage: 1:404/415 of query aligns to 1:404/405 of 2vmxA
- active site: Y51 (= Y51), E53 (= E53), D197 (= D197), T223 (= T223), K226 (= K226), R232 (= R232)
- binding allo-threonine: S31 (= S31), H122 (= H122), H200 (= H200), R357 (= R357)
- binding pyridoxal-5'-phosphate: S93 (= S93), G94 (= G94), A95 (= A95), H122 (= H122), S172 (= S172), D197 (= D197), A199 (= A199), H200 (= H200), T223 (= T223), K226 (= K226)
3pgyB Serine hydroxymethyltransferase from staphylococcus aureus, s95p mutant.
71% identity, 99% coverage: 1:410/415 of query aligns to 1:404/404 of 3pgyB
9j4gA Serine hydroxymethyltransferase (see paper)
63% identity, 97% coverage: 8:410/415 of query aligns to 7:411/411 of 9j4gA
- binding (+)-shin-2: E52 (= E53), Y59 (= Y60), L116 (= L117), G120 (= G121), H121 (= H122), L122 (= L123), K341 (= K340), N342 (= N341), S343 (≠ A342), P351 (= P350)
- binding [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine: S30 (= S31), Y50 (= Y51), E52 (= E53), S92 (= S93), G93 (= G94), S94 (≠ A95), H121 (= H122), S171 (= S172), D196 (= D197), A198 (= A199), H199 (= H200), K225 (= K226), G256 (= G256), R358 (= R357)
7x5oB Crystal structure of e. Faecium shmt in complex with me-thf and plp- gly (see paper)
63% identity, 97% coverage: 8:410/415 of query aligns to 7:411/412 of 7x5oB
- binding n-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]: S30 (= S31), Y50 (= Y51), Y60 (= Y61), S92 (= S93), G93 (= G94), S94 (≠ A95), H121 (= H122), S171 (= S172), D196 (= D197), A198 (= A199), H199 (= H200), K225 (= K226), R358 (= R357)
- binding n-[4-({[(6s)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid: E52 (= E53), Y59 (= Y60), L116 (= L117), G119 (= G120), G120 (= G121), H121 (= H122), S171 (= S172), P252 (= P252), N342 (= N341), P351 (= P350)
7x5nA Crystal structure of e. Faecium shmt in complex with (+)-shin-1 and plp-ser (see paper)
64% identity, 97% coverage: 8:409/415 of query aligns to 6:409/409 of 7x5nA
- binding (4R)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1H-pyrano[2,3-c]pyrazole-5-carbonitrile: E51 (= E53), Y58 (= Y60), Y59 (= Y61), L115 (= L117), G119 (= G121), H120 (= H122), L121 (= L123), K340 (= K340), N341 (= N341), S342 (≠ A342), P350 (= P350), F351 (= F351), R357 (= R357)
- binding [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine: S29 (= S31), Y49 (= Y51), E51 (= E53), Y59 (= Y61), S91 (= S93), G92 (= G94), S93 (≠ A95), H120 (= H122), S170 (= S172), D195 (= D197), A197 (= A199), H198 (= H200), K224 (= K226), R357 (= R357)
7v3dA Complex structure of serine hydroxymethyltransferase from enterococcus faecium and its inhibitor (see paper)
64% identity, 97% coverage: 8:409/415 of query aligns to 6:409/409 of 7v3dA