SitesBLAST
Comparing WP_026167600.1 NCBI__GCF_000375485.1:WP_026167600.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7e1sC Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
41% identity, 94% coverage: 3:359/379 of query aligns to 8:365/366 of 7e1sC
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M89), A129 (= A114), G130 (= G115), L131 (= L116), I150 (= I142), I151 (≠ V143), S152 (= S144), E178 (= E170), H185 (= H177), Y280 (≠ L278), I324 (= I318), L328 (= L322)
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), E178 (= E170), S182 (≠ A174), G183 (= G175), G223 (= G220), G224 (= G221), M244 (= M241), A245 (≠ G242), T246 (= T243), L249 (≠ V246), F342 (= F336), T343 (≠ A337)
- binding iron/sulfur cluster: C303 (= C301), N306 (≠ K304), C307 (= C305), V308 (≠ L306), C311 (= C309), G314 (≠ A310), A317 (≠ N313), C323 (= C317), I324 (= I318)
- binding : L131 (= L116), T133 (≠ L118), N134 (≠ D119), K155 (≠ R147), I159 (= I151), K162 (= K154), R163 (≠ K155), R167 (≠ K159)
7e1sA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
41% identity, 94% coverage: 3:359/379 of query aligns to 8:365/366 of 7e1sA
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M89), A129 (= A114), G130 (= G115), I150 (= I142), I151 (≠ V143), S152 (= S144), E178 (= E170), H185 (= H177), G187 (= G179), Y280 (≠ L278), L328 (= L322)
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), L104 (≠ M89), E178 (= E170), G183 (= G175), G223 (= G220), G224 (= G221), Q243 (= Q240), M244 (= M241), A245 (≠ G242), T246 (= T243)
- binding iron/sulfur cluster: C303 (= C301), N306 (≠ K304), C307 (= C305), V308 (≠ L306), C311 (= C309), G314 (≠ A310), A317 (≠ N313), C323 (= C317), I324 (= I318)
7e1rA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with holo-acp (see paper)
41% identity, 94% coverage: 3:359/379 of query aligns to 8:365/366 of 7e1rA
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), L104 (≠ M89), E178 (= E170), G183 (= G175), G224 (= G221), Q243 (= Q240), M244 (= M241), A245 (≠ G242), T246 (= T243), F342 (= F336)
- binding N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide: G128 (= G113), A129 (= A114), G130 (= G115), E178 (= E170), H185 (= H177), G187 (= G179)
- binding iron/sulfur cluster: C303 (= C301), N306 (≠ K304), C307 (= C305), V308 (≠ L306), C311 (= C309), G314 (≠ A310), A317 (≠ N313), C323 (= C317), I324 (= I318)
7e1qA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori (see paper)
41% identity, 94% coverage: 3:359/379 of query aligns to 8:365/366 of 7e1qA
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), L104 (≠ M89), E178 (= E170), S182 (≠ A174), G183 (= G175), G223 (= G220), G224 (= G221), M244 (= M241), A245 (≠ G242), T246 (= T243), F342 (= F336)
- binding iron/sulfur cluster: P277 (= P275), C303 (= C301), N306 (≠ K304), C307 (= C305), V308 (≠ L306), C311 (= C309), G314 (≠ A310), A317 (≠ N313), C323 (= C317), I324 (= I318)
7l00C Crystal structure of c. Difficile enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor
29% identity, 95% coverage: 11:369/379 of query aligns to 14:314/315 of 7l00C
- binding flavin mononucleotide: G23 (= G20), G24 (= G21), M25 (= M22), A26 (≠ G23), N74 (= N87), E142 (= E170), G146 (≠ A174), G147 (= G175), G174 (= G220), G175 (= G221), Q194 (= Q240), G196 (= G242), T197 (= T243), M281 (≠ F336), S285 (≠ N340)
- binding N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-2-[2-(1H-pyrrol-1-yl)-1,3-thiazol-4-yl]acetamide: A26 (≠ G23), M76 (= M89), G100 (= G113), A101 (= A114), G102 (= G115), V121 (≠ I142), P123 (≠ S144), H149 (= H177), L266 (≠ A321), M281 (≠ F336)
5gvhA Structure of fabk from thermotoga maritima (see paper)
30% identity, 93% coverage: 11:361/379 of query aligns to 10:300/311 of 5gvhA
- binding flavin mononucleotide: G19 (= G20), G20 (= G21), M21 (= M22), A22 (≠ G23), N70 (= N87), I72 (≠ M89), E138 (= E170), S142 (≠ A174), G143 (= G175), G170 (= G220), G171 (= G221), Q190 (= Q240), G192 (= G242), T193 (= T243), M275 (≠ F336), S279 (≠ N340)
2z6iB Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) (see paper)
29% identity, 77% coverage: 79:368/379 of query aligns to 61:320/321 of 2z6iB
- binding calcium ion: E137 (= E170), H144 (= H177), A158 (≠ V200), I161 (≠ V203)
- binding flavin mononucleotide: N69 (= N87), E137 (= E170), A141 (= A174), G142 (= G175), G169 (= G220), G170 (= G221), G191 (= G242), T192 (= T243), M281 (≠ F336)
Sites not aligning to the query:
2z6jA Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor (see paper)
28% identity, 77% coverage: 79:368/379 of query aligns to 61:307/307 of 2z6jA
- binding calcium ion: A158 (≠ V200), I161 (≠ V203)
- binding flavin mononucleotide: N69 (= N87), E137 (= E170), A141 (= A174), G142 (= G175), G169 (= G220), G170 (= G221), G191 (= G242), T192 (= T243)
- binding 2-(4-(2-((3-(5-(pyridin-2-ylthio)thiazol-2-yl)ureido)methyl)-1h-imidazol-4-yl)phenoxy)acetic acid: M71 (= M89), L73 (≠ A91), A96 (= A114), G97 (= G115), V116 (≠ I142), P118 (≠ S144), L122 (≠ S153), E137 (= E170), H144 (= H177)
Sites not aligning to the query:
5lsmA Crystal structure of nitronate monooxygenase (so_0471) from shewanella oneidensis mr-1
25% identity, 73% coverage: 14:288/379 of query aligns to 10:275/339 of 5lsmA
- binding flavin mononucleotide: A16 (≠ G20), P17 (≠ G21), M18 (= M22), A19 (≠ G23), N67 (= N87), H123 (vs. gap), A170 (= A174), G171 (= G175), G207 (= G220), G208 (= G221), G229 (= G242), T230 (= T243)
Sites not aligning to the query:
4iqlA Crystal structure of porphyromonas gingivalis enoyl-acp reductase ii (fabk) with cofactors NADPH and fmn (see paper)
27% identity, 93% coverage: 11:363/379 of query aligns to 8:304/313 of 4iqlA
- binding flavin mononucleotide: G18 (= G21), M19 (= M22), V20 (= V24), N68 (= N87), S94 (≠ G113), E136 (= E170), A140 (= A174), G141 (= G175), G170 (= G220), G171 (= G221), Q190 (= Q240), G192 (= G242), T193 (= T243), E277 (≠ F336)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: W21 (≠ G25), W21 (≠ G25), W25 (≠ S29), S44 (≠ M51), M45 (≠ R52), M45 (≠ R52), H46 (≠ D53), N49 (≠ R56), H52 (≠ E70), H53 (≠ E71), Y73 (≠ L92), P74 (≠ T93), E75 (≠ N94), S202 (≠ D252), K263 (≠ L322), F267 (≠ Y326)
4q4kA Crystal structure of nitronate monooxygenase from pseudomonas aeruginosa pao1 (see paper)
26% identity, 75% coverage: 11:295/379 of query aligns to 9:293/351 of 4q4kA
- binding flavin mononucleotide: A18 (≠ G20), P19 (≠ G21), M20 (= M22), L21 (≠ V24), N69 (= N87), F71 (≠ M89), H133 (vs. gap), Q176 (≠ E170), A180 (= A174), G181 (= G175), G182 (= G176), G217 (= G220), G218 (= G221), G239 (= G242), T240 (= T243)
Sites not aligning to the query:
Q9HWH9 Nitronate monooxygenase; NMO; Propionate 3-nitronate monooxygenase; P3N monooxygenase; EC 1.13.12.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
26% identity, 75% coverage: 11:295/379 of query aligns to 9:293/351 of Q9HWH9
- L21 (≠ V24) binding FMN
- N69 (= N87) binding FMN
- Q176 (≠ E170) binding FMN
- G181 (= G175) binding FMN
- G218 (= G221) binding FMN
- QMGT 237:240 (= QMGT 240:243) binding FMN
4qitA Crystal structure of nitroalkane oxidase from pseudomonas aeruginosa in mutant complex form
25% identity, 75% coverage: 11:295/379 of query aligns to 9:293/350 of 4qitA
- binding flavin mononucleotide: A18 (≠ G20), P19 (≠ G21), M20 (= M22), L21 (≠ V24), N69 (= N87), F71 (≠ M89), H133 (vs. gap), Q176 (≠ E170), A180 (= A174), G181 (= G175), G217 (= G220), G218 (= G221), M238 (= M241), G239 (= G242), T240 (= T243)
- binding nitroethane: F71 (≠ M89), G182 (= G176), S183 (≠ H177)
Sites not aligning to the query:
4qiuB Crystal structure of nitroalkane oxidase from pseudomonas aeruginosa in mutant complex form
25% identity, 75% coverage: 11:295/379 of query aligns to 8:292/350 of 4qiuB
- binding flavin mononucleotide: A17 (≠ G20), P18 (≠ G21), M19 (= M22), L20 (≠ V24), N68 (= N87), F70 (≠ M89), H132 (vs. gap), Q175 (≠ E170), A179 (= A174), G180 (= G175), G181 (= G176), G216 (= G220), G217 (= G221), G238 (= G242), T239 (= T243)
- binding 1-nitropropane: L20 (≠ V24)
Sites not aligning to the query:
3bw2A Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes (see paper)
33% identity, 33% coverage: 165:289/379 of query aligns to 162:279/347 of 3bw2A
Sites not aligning to the query:
6bkaA Crystal structure of nitronate monooxygenase from cyberlindnera saturnus (see paper)
29% identity, 47% coverage: 165:342/379 of query aligns to 185:354/374 of 6bkaA
Sites not aligning to the query:
- binding 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane-1,38-diol: 34, 37, 67, 69
- binding flavin mononucleotide: 21, 22, 23, 24, 77, 79, 147
3bw3A Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes (see paper)
32% identity, 33% coverage: 165:289/379 of query aligns to 162:279/346 of 3bw3A
Sites not aligning to the query:
- binding flavin mononucleotide: 14, 15, 16, 17, 66, 68, 124, 315
- binding nitroethane: 18, 42, 293, 300
6e2aA Crystal structure of nadh:quinone reductase pa1024 from pseudomonas aeruginosa pao1 in complex with NAD+ (see paper)
26% identity, 39% coverage: 214:360/379 of query aligns to 172:311/326 of 6e2aA
Sites not aligning to the query:
- binding flavin mononucleotide: 21, 22, 23, 74, 123, 148, 149
- binding nicotinamide-adenine-dinucleotide: 23, 76, 77, 79, 150, 151
2gjnA Crystal structure of 2-nitropropane dioxygenase complexed with fmn and substrate (see paper)
35% identity, 21% coverage: 214:291/379 of query aligns to 171:248/324 of 2gjnA
Sites not aligning to the query:
Q9I4V0 NADH:quinone reductase; EC 1.6.5.9 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
26% identity, 39% coverage: 214:360/379 of query aligns to 173:312/328 of Q9I4V0
Sites not aligning to the query:
- 22:24 binding FMN
- 75 binding FMN
- 124 binding FMN
- 150 binding FMN
Query Sequence
>WP_026167600.1 NCBI__GCF_000375485.1:WP_026167600.1
MKLPTLKFGDLAAKMPIIQGGMGVGISLSGLASAVANQGGVGVIATSMIGMRDPQRAKDP
HAADIRALTEEIRTAREKMNDGLLGVNIMCALTNFADMVSTSIKENVDIVFSGAGLPLDL
PKYAREASDNLKQEVRTKLVPIVSSGRAAKIISKKWLSKYGYLPDGFVVEGPKAGGHLGF
KPEEIDNPDYQLEKIVSDVVETVKPFEDQHGRAIPVIAAGGVYSGEDIGKYLALGASGVQ
MGTRFVATEECDADIEFKQAYVNAKQEDVGIIKSPVGLPGRAIMNNFLNSVSDGLRKPKK
CVHKCLHSCAEENSPYCIAQALVNAYKGKLKHGFAFAGANAYLVDKIVTVQELMTSLSEE
FDRRWSSVEEFGRDLAKKK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory