SitesBLAST

C154 (≠ A150) modified: Disulfide link with 163, Reversible; mutation to S: Severe reduction in catalytic activity. Does not affect TRX1-mediated activation. Severe reduction in catalytic activity and loss of TRX1-mediated activation; when associated with S-163.
C163 (≠ F159) modified: Disulfide link with 154, Reversible; mutation to S: No effect on catalytic activity. Requires higher concentrations of TRX1 for activation. Severe reduction in catalytic activity and loss of TRX1-mediated activation; when associated with S-154.
C316 (≠ I316) mutation to S: About 70% reduction in catalytic activity. Does not affect TRX1-mediated activation.
C350 (≠ I350) mutation to S: About 70% reduction in catalytic activity. Does not affect TRX1-mediated activation.

Sites not aligning to the query:

390 C→S: About 70% reduction in catalytic activity. Does not affect TRX1-mediated activation.

P42588 Putrescine aminotransferase; PAT; PATase; Cadaverine transaminase; Diamine transaminase; Putrescine transaminase; Putrescine--2-oxoglutaric acid transaminase; Putrescine:2-OG aminotransferase; EC 2.6.1.82; EC 2.6.1.29 from Escherichia coli (strain K12) (see paper)
38% identity, 77% coverage: 3:354/455 of query aligns to 34:395/459 of P42588

query
sites
P42588

V

L

E

N

R

R

E

E

A

V

E

I

R

E

Y

Y

S

-

L

-

H

F

T

K

Q

E

H

H

L

V

N

N

E

P

-

G

-

F

M

L

M

E

V

Y

R

R

V

K

L

S

Q

V

T

T

I

A

G

G

F

G

D

D

V

Y

G

G

-

A

-

V

-

E

F

W

K

Q

S

A

G

G

R

S

G

L

Q

N

Y

T

L

L

W

V

D

D

R

T

K

Q

G

G

D

Q

R

E

Y

F

L

I

D

D

L

C

L

L

S

G

G

G

W

F

G

G

V

I

F

F

G

N

L

V

G

G

R

H

N

R

H

N

P

P

T

V

V

V

R

V

D

S

A

A

L

V

K

Q

T

N

V

Q

L

L

D

-

A

A

D

K

L

Q

P

P

G

L

L

H

V

S

Q

Q

M

E

D

L

L

L

P

D

L

P

L

L

A

R

G

A

L

M

L

L

A

A

E

K

R

T

L

L

L

A

R

A

Y

L

V

T

P

P

-

G

Y

K

L

L

D

K

K

Y

V

S

F

F

A

C

N

N

S

S

G
|
G

S
x
T

E

E

A

S

V

V

E

E

S

A

A

A

I

L

K

K

F

L

A

A

R

K

-

A

-

Y

-

Q

R

S

A

P

T

R

G

G

R

K

S

F

G

T

I

F

V

I

Y

A

C

T

D

S

H

G

A

A

F

F

H

H

G

G

L

K

S

S

Y

L

G

G

A

A

L

L

A

S

L

A

N

T

G

A

D

K

N

S

T

T

F

F

R

R

E

K

G

P

F

F

G

M

P

P

L

L

P

P

D

G

C

F

H

R

E

H

I

V

P

P

F

F

N

G

D

N

L

I

A

E

A

A

L

M

E

R

K

T

A

A

L

L

R

N

T

E

R

C

Q

K

-

K

-

T

-

G

-

D

I

V

A

A

G

A

F

V

I

I

V

L

E

E

P

P

I

I

Q

Q

G

G

K

E

G

G

-

G

V

V

N

I

M

L

P

P

D

P

L

G

Y

Y

L

L

R

T

G

A

A

V

Q

R

A

K

L

L

C

C

R

D

K

E

Y

F

G

G

T

A

L

L

F

M

I

I

A

L

D

D

E

E

I

V

Q
|
Q

T

T

G

G

M

M

G

G

R

R

T

T

G

G

R

K

F

M

L

F

A

A

V

C

E

E

H

H

W

E

N

N

V

V

E

Q

P

P

D

D

M

I

V

L

L

C

L

L

A

A

K
|
K

T

A

L

L

S

G

G

G

H

V

V

M

P

P

V

I

G

G

A

A

V

T

L

I

T

A

R

T

K

E

A

E

V

V

F

F

D

S

K

V

V

L

F

F

T

-

R

-

M

-

D

D

K

N

A

P

V

F

V

L

H

H

G

T

S

T

T
|
T

F

F

A

G

K

G

N

N

D

P

L

L

A

A

M

C

A

A

G

A

L

L

A

A

T

T

L

I

E

N

V

V

I

L

E

L

Q

E

E

Q

R

N

L

L

I

P

Q

A

N

Q

A

A

A

E

K

Q

T

K

G

G

A

D

R

M

L

L

A

D

A

G

F

F

E

R

A

Q

M

L

V

A

P

R

R

E

Y

Y

-

P

E

D

L

L

L

V

K

Q

A

E

V

A

R

R

G

G

K

K

G

G

L

M

M

L

I

M

G

A

I

I

E

E

F

F

GT 150:151 (≠ GS 116:117) binding in other chain
Q274 (= Q231) binding in other chain
K300 (= K257) modified: N6-(pyridoxal phosphate)lysine
T332 (= T292) binding pyridoxal 5'-phosphate

P04181 Ornithine aminotransferase, mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Homo sapiens (Human) (see 8 papers)
39% identity, 77% coverage: 2:352/455 of query aligns to 43:380/439 of P04181

query
sites
P04181

L

I

V

F

E

E

R

R

E

E

A

Y

E

-

R

K

Y

Y

S
x
G

L

A

H

H

T

N

Q
x
Y

H

H

L

-

N

-

E

-

M

-

V

-

R

-

V

-

L

-

Q

-

T

-

I

-

G

P

F

L

D

P

V

V

G

A

F

L

K

E

S

R

G

G

R

K

G

G

Q

I

Y

Y

L

L

W

W

D

D

R

V

K

E

G

G

D

R

R

K

Y

Y

L

F

D

D

L

F

L

L

S

S

G

S

W

Y

G

S

V

A

F

V

G
x
N

L
x
Q

G

G

R

H

N
x
C

H

H

P

P

T

K

V

I

R

V

D

N

A

A

L

L

K

K

T

S

V
x
Q

L

V

D

D

A

K

D

-

L

-

P

-

G

-

L

L

V

T

Q

L

M

T

D

S

L

R

P

A

L

F

L

Y

A

N

G

N

L

V

L

L

A

G

E

E

R

-

L

-

R

-

Y

Y

V

E

P

E

Y

Y

L

I

D

T

K

K

V

L

F

F

F

N

-

Y

-

H

-

K

-

V

-

L

-

P

A

M

N

N

S

T

G

G

S

V

E

E

A

A

V

G

E

E

S

T

A

A

I

C

K

K

F

L

A

A

R
|
R

R

K

-

W

-

G

-

Y

-

T

-

V

-

K

-

G

-

I

A

Q

T

K

G

Y

R

K

S

A

G

K

I

I

V

V

Y

F

C

A

D

A

H

G

A

N

F

F

H

W

G

G

L
x
R

S

T

Y

L

G

S

A
|
A

L

I

A

S

L

S

N

S

G

T

D

D

N

P

T

T

F

S

R

Y

E

D

G

G

F

F

G

G

P
|
P

L

F

L

M

P

P

D

G

C

F

H

D

E

I

I

I

P

P

F

Y

N

N

D

D

L

L

A

P

A

A

L

L

E

E

K

R

A

A

L

L

R

Q

T

D

R

P

Q

N

I

V

A

A

G
x
A

F

F

I

M

V

V

E

E

P

P

I

I

Q

Q

G

G

K

E

-

A

G

G

V

V

N

V

M

V

P
|
P

D

D

D

P

L

G

Y
|
Y

L

L

R

M

G

G

A

V

Q
x
R

A

E

L

L

C

C

R

T

K

R

Y

H

G

Q

T

V

L

L

F

F

I

I

A

A

D

D

E

E

I

I

Q

Q

T
|
T

G

G

M

L

G
x
A

R
|
R

T

T

G

G

R

R

F

W

L

L

A

A

V

V

E

D

H

Y

W

E

N

N

V

V

E

R

P

P

D

D

M

I

V

V

L

L

A

G

K
|
K

T

A

L

L

S

S

G

G

H

L

V

Y

P

P

V

V

G

S

A

A

V

V

L

L

T

C

R

D

K

D

A

D

V

I

F

M

D

L

K

T

V

I

F

-

T

-

R

-

M

-

D

-

K

K

A

P

V

G

V
x
E

H

H

G

G

S

S

T

T

F

Y

A

G

K

G

N

N

D

P

L

L

A

G

M

C

A

R

A
x
V

G

A

L

I

A

A

T

A

L

L

E

E

V

V

I

L

E

E

Q

E

E

E

R

N

L

L

I

A

Q

E

N

N

A

A

A

D

K

K

T

L

G
|
G

A

-

R

-

L

I

A

L

A

R

F

N

E

E

A

L

M

M

V

K

P

L

R

P

Y

S

E

D

L

V

K

T

A

A

V

V

R

R

G

G

K

K

G
|
G

L

L

M

L

I

N

G

A

I

I

G51 (≠ S11) to D: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs11553554
Y55 (≠ Q15) to H: in HOGA; decreased protein abundance; dbSNP:rs121965037
N89 (≠ G61) to K: in HOGA; no effect on protein abundance; dbSNP:rs386833602
Q90 (≠ L62) to E: in HOGA; mistargeted, accumulates in cytoplasm; dbSNP:rs121965060
C93 (≠ N65) to F: in HOGA; no effect on protein abundance; dbSNP:rs121965038
Q104 (≠ V76) to R: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833604
R154 (= R128) to L: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965039
R180 (≠ L146) to T: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965040
A184 (= A150) natural variant: Missing (in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965035)
P199 (= P165) to Q: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs267606925
A226 (≠ G192) to V: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965059
P241 (= P206) to L: in HOGA; no effect on protein abundance; dbSNP:rs121965051
Y245 (= Y210) to C: in HOGA; no effect on protein abundance; dbSNP:rs121965046
R250 (≠ Q215) to P: in HOGA; no effect on protein abundance; dbSNP:rs121965052
T267 (= T232) to I: in HOGA; decreased protein abundance; dbSNP:rs386833618
A270 (≠ G235) to P: decreased protein abundance; dbSNP:rs121965041
R271 (= R236) to K: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965042
K292 (= K257) modified: N6-(pyridoxal phosphate)lysine
E318 (≠ V288) to K: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833621
V332 (≠ A302) to M: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965047
G353 (= G323) to D: in HOGA; decreased protein abundance; dbSNP:rs121965053
G375 (= G347) to A: in HOGA; decreased protein abundance; dbSNP:rs121965045

Sites not aligning to the query:

1:35 modified: transit peptide, Mitochondrion; in renal form
394 C → R: in HOGA; no effect on protein abundance; dbSNP:rs121965054; C → Y: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833597
402 L → P: in HOGA; may affect protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965043
417 P → L: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965044
436 I → N: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833598
437 L → F: in HOGA; likely benign; no effect on protein stability; no effect on ornithine aminotransferase activity; dbSNP:rs1800456

8ez1B Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid (see paper)
39% identity, 77% coverage: 2:352/455 of query aligns to 6:343/402 of 8ez1B

query
sites
8ez1B

L

I

V

F

E

E

R

R

E

E

A

Y

E

-

R

K

Y

Y

S

G

L

A

H

H

T

N

Q

Y

H

H

L

-

N

-

E

-

M

-

V

-

R

-

V

-

L

-

Q

-

T

-

I

-

G

P

F

L

D

P

V

V

G

A

F

L

K

E

S

R

G

G

R

K

G

G

Q

I

Y

Y

L

L

W

W

D

D

R

V

K

E

G

G

D

R

R

K

Y

Y

L

F

D

D

L

F

L

L

S

S

G

S

W
x
Y

G

S

V

A

F

V

G

N

L

Q

G

G

R

H

N

C

H

H

P

P

T

K

V

I

R

V

D

N

A

A

L

L

K

K

T

S

V

Q

L

V

D

D

A

K

D

-

L

-

P

-

G

-

L

L

V

T

Q

L

M

T

D

S

L

R

P

A

L

F

L

Y

A

N

G

N

L

V

L

L

A

G

E

E

R

-

L

-

R

-

Y

Y

V

E

P

E

Y

Y

L

I

D

T

K

K

V

L

F

F

F

N

-

Y

-

H

-

K

-

V

-

L

-

P

A

M

N

N

S
x
T

G
|
G

S
x
V

E

E

A

A

V

G

E

E

S

T

A

A

I

C

K

K

F

L

A

A

R

R

R

K

-

W

-

G

-

Y

-

T

-

V

-

K

-

G

-

I

A

Q

T

K

G

Y

R

K

S

A

G

K

I

I

V

V

Y

F

C

A

D

A

H

G

A

N

F
|
F

H
x
W

G

G

L

R

S

T

Y

L

G

S

A

A

L

I

A

S

L

S

N

S

G

T

D

D

N

P

T

T

F

S

R

Y

E

D

G

G

F

F

G

G

P

P

L

F

L

M

P

P

D

G

C

F

H

D

E

I

I

I

P

P

F

Y

N

N

D

D

L

L

A

P

A

A

L

L

E

E

K

R

A

A

L

L

R

Q

T

D

R

P

Q

N

I

V

A

A

G

A

F

F

I

M

V

V

E

E

P

P

I

I

Q

Q

G

G

K
x
E

-

A

G

G

V

V

N

V

M

V

P

P

D

D

D

P

L

G

Y

Y

L

L

R

M

G

G

A

V

Q

R

A

E

L

L

C

C

R

T

K

R

Y

H

G

Q

T

V

L

L

F

F

I

I

A

A

D
|
D

E

E

I
|
I

Q
|
Q

T

T

G

G

M

L

G

A

R

R

T

T

G

G

R

R

F

W

L

L

A

A

V

V

E

D

H

Y

W

E

N

N

V

V

E

R

P

P

D

D

M

I

V

V

L

L

A

G

K
|
K

T

A

L

L

S

S

G

G

H

L

V

Y

P

P

V

V

G

S

A

A

V

V

L

L

T

C

R

D

K

D

A

D

V

I

F

M

D

L

K

T

V

I

F

-

T

-

R

-

M

-

D

-

K

K

A

P

V

G

V

E

H

H

G

G

S

S

T

T

F

Y

A

G

K

G

N

N

D

P

L

L

A

G

M

C

A

R

A

V

G

A

L

I

A

A

T

A

L

L

E

E

V

V

I

L

E

E

Q

E

E

E

R

N

L

L

I

A

Q

E

N

N

A

A

A

D

K

K

T

L

G

G

A

-

R

-

L

I

A

L

A

R

F

N

E

E

A

L

M

M

V

K

P

L

R

P

Y

S

E

D

L

V

K

T

A

A

V

V

R

R

G

G

K

K

G

G

L

L

M

L

I

N

G

A

I

I

binding (1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid: Y48 (≠ W57), T104 (≠ S115), G105 (= G116), V106 (≠ S117), F140 (= F143), W141 (≠ H144), E198 (≠ K201), D226 (= D228), I228 (= I230), Q229 (= Q231), K255 (= K257)

Sites not aligning to the query:

binding (1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid: 376

8ez1A Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid (see paper)
39% identity, 77% coverage: 2:352/455 of query aligns to 6:343/402 of 8ez1A

query
sites
8ez1A

L

I

V

F

E

E

R

R

E

E

A

Y

E

-

R

K

Y

Y

S

G

L

A

H

H

T

N

Q

Y

H

H

L

-

N

-

E

-

M

-

V

-

R

-

V

-

L

-

Q

-

T

-

I

-

G

P

F

L

D

P

V

V

G

A

F

L

K

E

S

R

G

G

R

K

G

G

Q

I

Y

Y

L

L

W

W

D

D

R

V

K

E

G

G

D

R

R

K

Y

Y

L

F

D

D

L

F

L

L

S

S

G

S

W
x
Y

G

S

V

A

F

V

G

N

L

Q

G

G

R

H

N

C

H

H

P

P

T

K

V

I

R

V

D

N

A

A

L

L

K

K

T

S

V

Q

L

V

D

D

A

K

D

-

L

-

P

-

G

-

L

L

V

T

Q

L

M

T

D

S

L

R

P

A

L

F

L

Y

A

N

G

N

L

V

L

L

A

G

E

E

R

-

L

-

R

-

Y

Y

V

E

P

E

Y

Y

L

I

D

T

K

K

V

L

F

F

F

N

-

Y

-

H

-

K

-

V

-

L

-

P

A

M

N

N

S

T

G
|
G

S
x
V

E

E

A

A

V

G

E

E

S

T

A

A

I

C

K

K

F

L

A

A

R

R

R

K

-

W

-

G

-

Y

-

T

-

V

-

K

-

G

-

I

A

Q

T

K

G

Y

R

K

S

A

G

K

I

I

V

V

Y

F

C

A

D

A

H

G

A

N

F
|
F

H
x
W

G

G

L

R

S

T

Y

L

G

S

A

A

L

I

A

S

L

S

N

S

G

T

D

D

N

P

T

T

F

S

R

Y

E

D

G

G

F

F

G

G

P

P

L

F

L

M

P

P

D

G

C

F

H

D

E

I

I

I

P

P

F

Y

N

N

D

D

L

L

A

P

A

A

L

L

E

E

K

R

A

A

L

L

R

Q

T

D

R

P

Q

N

I

V

A

A

G

A

F

F

I

M

V

V

E

E

P

P

I

I

Q

Q

G

G

K
x
E

-

A

G

G

V

V

N

V

M

V

P

P

D

D

D

P

L

G

Y

Y

L

L

R

M

G

G

A

V

Q

R

A

E

L

L

C

C

R

T

K

R

Y

H

G

Q

T

V

L

L

F

F

I

I

A

A

D
|
D

E

E

I
|
I

Q
|
Q

T

T

G

G

M

L

G

A

R

R

T

T

G

G

R

R

F

W

L

L

A

A

V

V

E

D

H

Y

W

E

N

N

V

V

E

R

P

P

D

D

M

I

V

V

L

L

A

G

K
|
K

T

A

L

L

S

S

G

G

H

L

V

Y

P

P

V

V

G

S

A

A

V

V

L

L

T

C

R

D

K

D

A

D

V

I

F

M

D

L

K

T

V

I

F

-

T

-

R

-

M

-

D

-

K

K

A

P

V

G

V

E

H

H

G

G

S

S

T

T

F

Y

A

G

K

G

N

N

D

P

L

L

A

G

M

C

A

R

A

V

G

A

L

I

A

A

T

A

L

L

E

E

V

V

I

L

E

E

Q

E

E

E

R

N

L

L

I

A

Q

E

N

N

A

A

A

D

K

K

T

L

G

G

A

-

R

-

L

I

A

L

A

R

F

N

E

E

A

L

M

M

V

K

P

L

R

P

Y

S

E

D

L

V

K

T

A

A

V

V

R

R

G

G

K

K

G

G

L

L

M

L

I

N

G

A

I

I

binding (3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic acid: Y48 (≠ W57), G105 (= G116), V106 (≠ S117), F140 (= F143), W141 (≠ H144), E198 (≠ K201), D226 (= D228), I228 (= I230), Q229 (= Q231), K255 (= K257)

Sites not aligning to the query:

binding (3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic acid: 376

7tfpC Human ornithine aminotransferase cocrystallized with its inhibitor, (1s,3s)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid. (see paper)
39% identity, 77% coverage: 2:352/455 of query aligns to 6:343/402 of 7tfpC

query
sites
7tfpC

L

I

V

F

E

E

R

R

E

E

A

Y

E

-

R

K

Y

Y

S

G

L

A

H

H

T

N

Q
x
Y

H

H

L

-

N

-

E

-

M

-

V

-

R

-

V

-

L

-

Q

-

T

-

I

-

G

P

F

L

D

P

V

V

G

A

F

L

K

E

S

R

G

G

R

K

G

G

Q

I

Y

Y

L

L

W

W

D

D

R

V

K

E

G

G

D

R

R

K

Y

Y

L

F

D

D

L

F

L

L

S

S

G

S

W
x
Y

G

S

V

A

F

V

G

N

L

Q

G

G

R

H

N

C

H

H

P

P

T

K

V

I

R

V

D

N

A

A

L

L

K

K

T

S

V

Q

L

V

D

D

A

K

D

-

L

-

P

-

G

-

L

L

V

T

Q

L

M

T

D

S

L

R

P

A

L

F

L

Y

A

N

G

N

L

V

L

L

A

G

E

E

R

-

L

-

R

-

Y

Y

V

E

P

E

Y

Y

L

I

D

T

K

K

V

L

F

F

F

N

-

Y

-

H

-

K

-

V

-

L

-

P

A

M

N

N

S

T

G
|
G

S
x
V

E

E

A

A

V

G

E

E

S

T

A

A

I

C

K

K

F

L

A

A

R

R

R

K

-

W

-

G

-

Y

-

T

-

V

-

K

-

G

-

I

A

Q

T

K

G

Y

R

K

S

A

G

K

I

I

V

V

Y

F

C

A

D

A

H

G

A

N

F
|
F

H
x
W

G

G

L

R

S

T

Y

L

G

S

A

A

L

I

A

S

L

S

N

S

G

T

D

D

N

P

T

T

F

S

R

Y

E

D

G

G

F

F

G

G

P

P

L

F

L

M

P

P

D

G

C

F

H

D

E

I

I

I

P

P

F

Y

N

N

D

D

L

L

A

P

A

A

L

L

E

E

K

R

A

A

L

L

R

Q

T

D

R

P

Q

N

I

V

A

A

G

A

F

F

I

M

V

V

E

E

P

P

I

I

Q

Q

G

G

K
x
E

-

A

G

G

V

V

N

V

M

V

P

P

D

D

D

P

L

G

Y

Y

L

L

R

M

G

G

A

V

Q

R

A

E

L

L

C

C

R

T

K

R

Y

H

G

Q

T

V

L

L

F

F

I

I

A

A

D
|
D

E

E

I
|
I

Q
|
Q

T

T

G

G

M

L

G

A

R

R

T

T

G

G

R

R

F

W

L

L

A

A

V

V

E

D

H

Y

W

E

N

N

V

V

E

R

P

P

D

D

M

I

V

V

L

L

A

G

K
|
K

T

A

L

L

S

S

G

G

H

L

V

Y

P

P

V

V

G

S

A

A

V

V

L

L

T

C

R

D

K

D

A

D

V

I

F

M

D

L

K

T

V

I

F

-

T

-

R

-

M

-

D

-

K

K

A

P

V

G

V

E

H

H

G

G

S

S

T

T

F

Y

A

G

K

G

N

N

D

P

L

L

A

G

M

C

A

R

A

V

G

A

L

I

A

A

T

A

L

L

E

E

V

V

I

L

E

E

Q

E

E

E

R

N

L

L

I

A

Q

E

N

N

A

A

A

D

K

K

T

L

G

G

A

-

R

-

L

I

A

L

A

R

F

N

E

E

A

L

M

M

V

K

P

L

R

P

Y

S

E

D

L

V

K

T

A

A

V

V

R

R

G

G

K

K

G

G

L

L

M

L

I

N

G

A

I

I

binding (1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic acid: Y18 (≠ Q15), Y48 (≠ W57), F140 (= F143), E198 (≠ K201), K255 (= K257)
binding pyridoxal-5'-phosphate: G105 (= G116), V106 (≠ S117), F140 (= F143), W141 (≠ H144), D226 (= D228), I228 (= I230), Q229 (= Q231), K255 (= K257)

Sites not aligning to the query:

binding (1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic acid: 376

7lk0A Ornithine aminotransferase (oat) cocrystallized with its potent inhibitor - (s)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (ss-1-148) (see paper)
39% identity, 77% coverage: 2:352/455 of query aligns to 6:343/402 of 7lk0A

query
sites
7lk0A

L

I

V

F

E

E

R

R

E

E

A

Y

E

-

R

K

Y

Y

S

G

L

A

H

H

T

N

Q
x
Y

H

H

L

-

N

-

E

-

M

-

V

-

R

-

V

-

L

-

Q

-

T

-

I

-

G

P

F

L

D

P

V

V

G

A

F

L

K

E

S

R

G

G

R

K

G

G

Q

I

Y

Y

L

L

W

W

D

D

R

V

K

E

G

G

D

R

R

K

Y

Y

L

F

D

D

L

F

L

L

S

S

G

S

W
x
Y

G

S

V

A

F

V

G

N

L

Q

G

G

R

H

N

C

H

H

P

P

T

K

V

I

R

V

D

N

A

A

L

L

K

K

T

S

V

Q

L

V

D

D

A

K

D

-

L

-

P

-

G

-

L

L

V

T

Q

L

M

T

D

S

L

R

P

A

L

F

L

Y

A

N

G

N

L

V

L

L

A

G

E

E

R

-

L

-

R

-

Y

Y

V

E

P

E

Y

Y

L

I

D

T

K

K

V

L

F

F

F

N

-

Y

-

H

-

K

-

V

-

L

-

P

A

M

N

N

S

T

G
|
G

S
x
V

E

E

A

A

V

G

E

E

S

T

A

A

I

C

K

K

F

L

A

A

R

R

R

K

-

W

-

G

-

Y

-

T

-

V

-

K

-

G

-

I

A

Q

T

K

G

Y

R

K

S

A

G

K

I

I

V

V

Y

F

C

A

D

A

H

G

A

N

F
|
F

H
x
W

G

G

L

R

S

T

Y

L

G

S

A

A

L

I

A

S

L

S

N

S

G

T

D

D

N

P

T

T

F

S

R

Y

E

D

G

G

F

F

G

G

P

P

L

F

L

M

P

P

D

G

C

F

H

D

E

I

I

I

P

P

F

Y

N

N

D

D

L

L

A

P

A

A

L

L

E

E

K

R

A

A

L

L

R

Q

T

D

R

P

Q

N

I

V

A

A

G

A

F

F

I

M

V

V

E

E

P

P

I

I

Q

Q

G

G

K
x
E

-

A

G

G

V

V

N

V

M

V

P

P

D

D

D

P

L

G

Y

Y

L

L

R

M

G

G

A

V

Q

R

A

E

L

L

C

C

R

T

K

R

Y

H

G

Q

T

V

L

L

F

F

I

I

A

A

D
|
D

E

E

I
|
I

Q
|
Q

T

T

G

G

M

L

G

A

R

R

T

T

G

G

R

R

F

W

L

L

A

A

V

V

E

D

H

Y

W

E

N

N

V

V

E

R

P

P

D

D

M

I

V

V

L

L

A

G

K
|
K

T

A

L

L

S

S

G

G

H

L

V

Y

P

P

V

V

G

S

A

A

V

V

L

L

T

C

R

D

K

D

A

D

V

I

F

M

D

L

K

T

V

I

F

-

T

-

R

-

M

-

D

-

K

K

A

P

V

G

V

E

H

H

G

G

S

S

T

T

F

Y

A

G

K

G

N

N

D

P

L

L

A

G

M

C

A

R

A

V

G

A

L

I

A

A

T

A

L

L

E

E

V

V

I

L

E

E

Q

E

E

E

R

N

L

L

I

A

Q

E

N

N

A

A

A

D

K

K

T

L

G

G

A

-

R

-

L

I

A

L

A

R

F

N

E

E

A

L

M

M

V

K

P

L

R

P

Y

S

E

D

L

V

K

T

A

A

V

V

R

R

G

G

K

K

G

G

L

L

M

L

I

N

G

A

I

I

binding (1R,3S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxocyclopentane-1-carboxylic acid: Y18 (≠ Q15),