SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_026606401.1 NCBI__GCF_000427445.1:WP_026606401.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0A9C5 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Escherichia coli (strain K12) (see 3 papers)
63% identity, 99% coverage: 3:468/469 of query aligns to 2:468/469 of P0A9C5

query
sites
P0A9C5

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Y398 (= Y398) modified: O-AMP-tyrosine

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

P0A1P6 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
63% identity, 99% coverage: 3:468/469 of query aligns to 2:468/469 of P0A1P6

query
sites
P0A1P6

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E130 (= E131) binding Mn(2+)
E132 (= E133) binding Mn(2+)
E208 (= E209) binding ATP
E213 (= E214) binding Mn(2+)
E221 (= E221) binding Mn(2+)
NG 265:266 (= NG 265:266) binding L-glutamate
H270 (= H270) binding Mn(2+)
HMS 272:274 (≠ HQS 272:274) binding ATP
R322 (= R322) binding L-glutamate
E358 (= E358) binding Mn(2+)
R360 (= R360) binding L-glutamate

1fpyA Crystal structure of glutamine synthetase from salmonella typhimurium with inhibitor phosphinothricin (see paper)
63% identity, 99% coverage: 3:468/469 of query aligns to 1:467/468 of 1fpyA

query
sites
1fpyA

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N

N

S

S

Y

Y

K

K

R
|
R

L

L

V

V

P

P

G

G

Y

Y

E
|
E

A

A

P

P

V

V

L

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R

R

S

S

A

A

S

S

C

I

R

R

I

I

P

P

F

V

A

V

T

A

N

S

P

P

K

K

A

A

K

R

R
|
R

V

I

E
|
E

V

V

R
|
R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

A

C

F

F

A

A

A

A

M

L

L

L

L

M

A

A

G

G

I

L

D

D

G

G

I

I

L

K

N

N

K

K

I

I

D

H

P

P

G

G

A

E

A

P

M

M

D

D

K

K

D

N

L

L

Y

Y

D

D

L

L

P

P

P

P

K

E

E

E

L

A

K

K

K

E

I

I

P

P

T

Q

V

V

C

A

G

G

S

S

L

L

R

E

E

E

A

A

L

L

S

N

N

A

L

L

D

D

K

L

D

D

R

R

A

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

D

T

D

D

D

E

F

A

I

I

D

D

S

A

Y

Y

I

I

D

A

L

L

K

R

M

R

Q

E

D

E

V

D

L

D

R

R

F

V

E

R

T

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

D

E

M

L

Y

Y

Y

Y

S

S

binding adenosine-5'-diphosphate: G127 (= G129), E129 (= E131), E207 (= E209), T223 (≠ L224), F225 (= F226), H271 (= H272), S273 (= S274), R355 (= R356), E357 (= E358)
binding manganese (ii) ion: E129 (= E131), E131 (= E133), E212 (= E214), E220 (= E221), H269 (= H270), E357 (= E358)
binding phosphinothricin: E131 (= E133), E212 (= E214), G265 (= G266), H269 (= H270), R321 (= R322), E327 (= E328), R359 (= R360)

1f1hA Crystal structure of glutamine synthetase from salmonella typhimurium with thallium ions (see paper)
63% identity, 99% coverage: 3:468/469 of query aligns to 1:467/468 of 1f1hA

query
sites
1f1hA

T

S

A

A

K

E

D

H

V

V

L

L

K

T

S

M

I

L

K

N

D

E

N

H

D

E

I

V

K

K

Y

F

V

V

D

D

F

L

R

R

F

F

T

T

D

D

P

T

R

K

G

G

K

K

W

E

Q

Q

H

H

V

V

T

T

F

I

D

P

V

A

S

H

L

Q

I

V

E

N

D

A

E

E

T

F

F

F

T

E

E

E

G

G

V

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

A

G

G

G

W

W

K

K

A

G

I

I

N

N

E

E

S

S

D

D

M

M

T

V

L

L

L

M

P

P

D

D

P

A

K

S

T

T

A

A

F

V

I

I

D

D

P

P

F

F

F

F

A

A

A

D

P

S

T

T

L

L

V

I

I

I

V

R

C

C

D

D

I

I

L

L

D

E

P

P

A

G

S

T

G

L

E

Q

P

G

Y

Y

S

D

R

R

D

D

P

P

R

R

G

S

I

I

A

A

K

K

K

R

A

A

E

E

A

D

F

Y

A

L

A

R

S

A

S

T

G

G

I

I

A

A

D

D

A

T

A

V

Y

L

F

F

G

G

P

P

E
|
E

A

P

E
|
E

F

F

F

F

V

L

F

F

D

D

D

D

V

I

R

R

F

F

N

G

T

A

D

S

P

I

Y

S

N

G

M

S

G

H

F

V

I

A

L

I

D

D

S

D

S

I

E

E

L

G

P

A

S

W

N

N

T

S

G

S

T

T

P

K

Y

Y

E

E

G

G

G

G

N

N

L

K

G

G

H

H

R

R

I

P

R

G

T

V

K

K

G

G

G

G

Y

Y

F

F

P

P

V

V

P

P

P

P

Q

V

D

D

S

S

A

A

Q

Q

D

D

M

I

R

R

G

S

E

E

M

M

L

C

A

L

A

V

M

M

A

E

Q

Q

M

M

G

G

A

L

K

V

V

V

E
|
E

K

A

H

H

H
|
H

H

H

E
|
E

V

V

A

A

S

T

A

A

-

G

Q

Q

H

N

E
|
E

L

V

G

A

L
x
T

K

R

F
|
F

G

N

P

T

L

M

T

T

T

K

M

K

A

A

D

D

H

E

L

I

Q

Q

I

I

Y

Y

K

K

Y

Y

A

V

I

V

H

H

Q

N

V

V

A

A

H

H

S

R

Y

F

G

G

K

K

S

T

A

A

T

T

F

F

M

M

P

P

K

K

P

P

I

M

F

F

G

G

D

D

N

N

G

G

S

S

G

G

M

M

H
|
H

V

C

H
|
H

Q

M

S
|
S

L

L

W

A

K

K

G

N

G

G

K

T

P

N

L

L

F

F

A

S

G

G

N

D

K

K

Y

Y

A

A

D

G

L

L

S

S

E

E

E

Q

C

A

L

L

F

Y

Y

Y

I

I

G

G

G

G

I

V

I

I

R

K

H

H

A

A

R

K

A

A

L

I

N

N

A

A

F

L

T

A

N

N

P

P

S

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

G

Y

Y

E

E

A

A

P

P

V

V

L

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R

R

S

S

A

A

S

S

C

I

R

R

I

I

P

P

F

V

A

V

T

A

N

S

P

P

K

K

A

A

K

R

R
|
R

V

I

E
|
E

V

V

R

R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

A

C

F

F

A

A

A

A

M

L

L

L

L

M

A

A

G

G

I

L

D

D

G

G

I

I

L

K

N

N

K

K

I

I

D

H

P

P

G

G

A

E

A

P

M

M

D

D

K

K

D

N

L

L

Y

Y

D

D

L

L

P

P

P

P

K

E

E

E

L

A

K

K

K

E

I

I

P

P

T

Q

V

V

C

A

G

G

S

S

L

L

R

E

E

E

A

A

L

L

S

N

N

A

L

L

D

D

K

L

D

D

R

R

A

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

D

T

D

D

D

E

F

A

I

I

D

D

S

A

Y

Y

I

I

D

A

L

L

K

R

M

R

Q

E

D

E

V

D

L

D

R

R

F

V

E

R

T

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

D

E

M

L

Y

Y

Y

Y

S

S

binding adenosine-5'-diphosphate: E129 (= E131), E207 (= E209), H210 (= H212), E220 (= E221), T223 (≠ L224), F225 (= F226), H271 (= H272), S273 (= S274), R355 (= R356)
binding manganese (ii) ion: E129 (= E131), E131 (= E133), E212 (= E214), E220 (= E221), H269 (= H270), E357 (= E358)

P77961 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Synechocystis sp. (strain PCC 6803 / Kazusa)
60% identity, 99% coverage: 3:467/469 of query aligns to 4:471/473 of P77961

query
sites
P77961

T

T

A

P

K

Q

D

E

V

V

L

L

K

K

S

W

I

I

K

Q

D

D

N

E

D

N

I

I

K

K

Y

I

V

I

D

D

F

L

R

K

F

F

T

I

D

D

P

T

R

P

G

G

K

I

W

W

Q

Q

H

H

V

C

T

S

F

F

D

Y

V

Y

S

D

L

Q

I

L

E

D

D

E

E

N

T

S

F

F

T

T

E

E

G

G

V

I

M

P

F

F

D

D

G

G

S

S

S

S

I

I

A

R

G

G

W

W

K

K

A

A

I

I

N

N

E

E

S

S

D

D

M

M

T

C

L

M

L

V

P

P

D

D

P

P

K

N

T

T

A

A

F

T

I

I

D

D

P

P

F

F

F

C

A

K

A

E

P

P

T

T

L

L

V

S

I

M

V

I

C

C

D

S

I

I

L

K

D

E

P

P

A

R

S

T

G

G

E

E

P

W

Y

Y

S

N

R

R

D

D

P

P

R

R

G

T

I

I

A

A

K

A

K

K

A

A

E

V

A

E

F

Y

A

L

A

R

S

G

S

T

G

G

I

I

A

A

D

D

A

T

A

V

Y

Y

F

F

G

G

P

P

E

E

A

A

E
|
E

F

F

F

F

V

L

F

F

D

D

D

D

V

I

R

R

F

F

N

G

T

Q

D

T

P

E

Y

N

N

S

M

S

G

Y

F

Y

I

F

L

A

D

D

S

S

S

V

E

E

L

G

P

R

S

W

N

N

T

T

G

G

T

R

P

E

Y

E

E

E

G

G

G

G

N

N

L

L

G

G

H

Y

R

K

I

P

R

G

T

Y

K

K

G

Q

G

G

Y

Y

F

F

P

P

V

V

P

A

P

P

Q

T

D

D

S

T

A

A

Q

Q

D

D

M

I

R

R

G

T

E

E

M

M

L

L

A

L

A

T

M

M

A

A

Q

G

M

L

G

C

A

V

K

P

V

I

E

E

K

K

H

H

H

H

H

H

E
|
E

V

V

A

A

S

S

-

G

A

G

Q

Q

H

N

E
|
E

L

L

G

G

L

I

K

K

F

F

G

D

P

K

L

L

T

V

T

N

M

S

A

A

D

D

H

N

L

L

Q

M

I

I

Y

Y

K

K

Y

Y

A

V

I

I

H

K

Q

N

V

V

A

A

H

K

S

K

Y

Y

G

G

K

K

S

T

A

V

T

T

F

F

M

M

P

P

K

K

P

P

I

I

F

F

G

N

D

D

N

N

G

G

S

S

G

G

M

M

H

H

V

V

H

H

Q

Q

S

S

L

L

W

W

K

K

G

D

G

G

K

Q

P

P

L

L

F

F

A

A

G

G

N

D

K

K

Y

Y

A

A

D

G

L

F

S

S

E

Q

E

M

C

G

L

L

F

W

Y

Y

I

I

G

G

G

G

I

I

I

L

R

K

H

H

A

A

R

P

A

A

L

L

N

L

A

A

F

F

T

T

N

N

P

P

S

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

G

Y

F

E

E

A

A

P

P

V

V

L

N

L

L

A

A

Y

Y

S

S

A

Q

R

G

N

N

R

R

S

S

A

A

S

S

C

V

R

R

I

I

P

P

F

L

A

S

-

G

T

G

N

N

P

P

K

K

A

A

K

K

R

R

V

L

E
|
E

V

F

R

R

F

C

P

P

D

D

P

A

A

T

A

S

N

N

P

P

Y

Y

L

L

A

A

F

F

A

A

A

A

M

M

L

L

L

C

A

A

G

G

I

I

D

D

G

G

I

I

L

K

N

N

K

Q

I

I

D

D

P

P

G

G

A

E

A

P

M

L

D

D

K

V

D

D

L

I

Y

Y

D

D

L

L

P

S

P

P

K

E

E

E

L

L

K

A

K

K

I

I

P

P

T

S

V

T

C

P

G

G

S

S

L

L

R

E

E

A

A

A

L

L

S

E

N

A

L

L

D

E

K

K

D

D

R

H

A

E

F

F

L

L

K

T

A

G

G

T

G

G

V

V

F

F

D

S

D

P

D

D

F

F

I

V

D

E

S

S

Y

W

I

I

D

E

L

Y

K

K

M

L

-

D

Q

N

D

E

V

V

L

N

R

P

F

M

E

R

T

L

T

R

P

P

H

H

P

P

V

Y

E

E

F

F

D

S

M

L

Y

Y

Y

Y

E134 (= E133) binding Mg(2+)
E215 (= E214) binding Mg(2+)
E223 (= E221) binding Mg(2+)
E361 (= E358) binding Mn(2+)

2lgsA Feedback inhibition of fully unadenylylated glutamine synthetase from salmonella typhimurium by glycine, alanine, and serine (see paper)
59% identity, 99% coverage: 3:468/469 of query aligns to 1:444/445 of 2lgsA

query
sites
2lgsA

T

S

A

A

K

E

D

H

V

V

L

L

K

T

S

M

I

L

K

N

D

E

N

H

D

E

I

V

K

K

Y

F

V

V

D

D

F

L

R

R

F

F

T

T

D

D

P

T

R

K

G

G

K

K

W

E

Q

Q

H

H

V

V

T

T

F

I

D

P

V

A

S

H

L

Q

I

V

E

N

D

A

E

E

T

F

F

F

T

E

E

E

G

G

V

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

A

G

G

G

W

W

K

-

A

-

I

-

N

-

E

-

S

-

D

D

M

M

T

V

L

L

L

M

P

P

D

D

P

A

K

S

T

T

A

A

F

V

I

I

D

D

P

P

F

F

F

F

A

A

A

D

P

S

T

T

L

L

V

I

I

I

V

R

C

C

D

D

I

I

L

L

D

E

P

P

A

G

S

T

G

L

E

Q

P

G

Y

Y

S

D

R

R

D

D

P

P

R

R

G

S

I

I

A

A

K

K

K

R

A

A

E

E

A

D

F

Y

A

L

A

R

S

A

S

T

G

G

I

I

A

A

D

D

A

T

A

V

Y

L

F

F

G

G

P

P

E
|
E

A

P

E
|
E

F

F

F

F

V

L

F

F

D

D

D

D

V

I

R

R

F

F

N

G

T

A

D

S

P

I

Y

S

N

G

M

S

G

H

F

V

I

A

L

I

D

D

S

D

S

I

E

E

L

G

P

A

S

W

N

N

T

S

G

S

T

T

P

K

Y

Y

E

E

G

G

G

G

N

N

L

K

G

G

H

H

R

R

I

P

R

G

T

V

K

K

G

G

G

G

Y

Y

F

F

P

P

V

V

P

P

P

P

Q

V

D

D

S

S

A

A

Q

Q

D

D

M

I

R

R

G

S

E

E

M

M

L

C

A

L

A

V

M

M

A

E

Q

Q

M

M

G

G

A

L

K

V

V

V

E

E

K

A

H

H

H

H

H

H

E
|
E

V

V

A

A

S

T

A

A

-

G

Q

Q

H

N

E
|
E

L

V

G

A

L

T

K

R

F

F

G

N

P

T

L

M

T

T

T

K

M

K

A

A

D

D

H

E

L

I

Q

Q

I

I

Y

Y

K

K

Y

Y

A

V

I

V

H

H

Q

N

V

V

A

A

H

H

S

R

Y

F

G

G

K

K

S

T

A

A

T

T

F

F

M

M

P

P

K

K

P

P

I

M

F

F

G

G

D

D

N
|
N

G
|
G

S

S

G
|
G

M

M

H
|
H

V

C

H

H

Q

M

S

S

L

L

W

A

K

K

G

N

G

G

K

T

P

N

L

L

F

F

A

S

G

G

N

D

K

K

Y

Y

A

A

D

G

L

L

S

S

E

E

E

Q

C

A

L

L

F

Y

Y

Y

I

I

G

G

G

G

I

V

I

I

R

K

H

H

A

A

R

K

A

A

L

I

N

N

A

A

F

L

T

A

N

N

P

P

S

T

T

T

N

N

S

S

Y

Y

K

K

R
|
R

L

L

V

V

P

P

G

-

Y

-

E

-

A

-

P

P

V

V

L

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R

R

S

S

A

A

S

S

C

I

R

R

I

I

P

P

F

V

A

V

T

A

N

S

P

P

K

K

A

A

K

R

R

R

V

I

E
|
E

V

V

R
|
R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

A

C

F

F

A

A

A

A

M

L

L

L

L

M

A

A

G

G

I

L

D

D

G

G

I

I

L

K

N

N

K

K

I

I

D

H

P

P

G

G

A

E

A

P

M

M

D

D

K

-

D

-

L

-

Y

-

D

-

L

-

P

-

P

-

K

-

E

-

L

-

K

-

K

-

I

I

P

P

T

Q

V

V

C

A

G

G

S

S

L

L

R

E

E

E

A

A

L

L

S

N

N

A

L

L

D

D

K

L

D

D

R

R

A

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

D

T

D

D

D

E

F

A

I

I

D

D

S

A

Y

Y

I

I

D

A

L

L

K

R

M

R

Q

E

D

E

V

D

L

D

R

R

F

V

E

R

T

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

D

E

M

L

Y

Y

Y

Y

S

S

binding glutamic acid: E125 (= E133), N258 (= N265), G259 (= G266), G261 (= G268), H263 (= H270), R315 (= R322), R349 (= R360)
binding manganese (ii) ion: E123 (= E131), E125 (= E133), E206 (= E214), E214 (= E221), H263 (= H270), E347 (= E358)

1lgrA Interactions of nucleotides with fully unadenylylated glutamine synthetase from salmonella typhimurium (see paper)
59% identity, 99% coverage: 3:468/469 of query aligns to 1:444/445 of 1lgrA

query
sites
1lgrA

T

S

A

A

K

E

D

H

V

V

L

L

K

T

S

M

I

L

K

N

D

E

N

H

D

E

I

V

K

K

Y

F

V

V

D

D

F

L

R

R

F

F

T

T

D

D

P

T

R

K

G

G

K

K

W

E

Q

Q

H

H

V

V

T

T

F

I

D

P

V

A

S

H

L

Q

I

V

E

N

D

A

E

E

T

F

F

F

T

E

E

E

G

G

V

K

M

M

F

F

D

D

G

G

S

S

S

S

I

I

A

G

G

G

W

W

K

-

A

-

I

-

N

-

E

-

S

-

D

D

M

M

T

V

L

L

L

M

P

P

D

D

P

A

K

S

T

T

A

A

F

V

I

I

D

D

P

P

F

F

F

F

A

A

A

D

P

S

T

T

L

L

V

I

I

I

V

R

C

C

D

D

I

I

L

L

D

E

P

P

A

G

S

T

G

L

E

Q

P

G

Y

Y

S

D

R

R

D

D

P

P

R

R

G

S

I

I

A

A

K

K

K

R

A

A

E

E

A

D

F

Y

A

L

A

R

S

A

S

T

G

G

I

I

A

A

D

D

A

T

A

V

Y

L

F

F

G

G

P

P

E
|
E

A

P

E
|
E

F

F

F

F

V

L

F

F

D

D

D

D

V

I

R

R

F

F

N

G

T

A

D

S

P

I

Y

S

N

G

M

S

G

H

F

V

I

A

L

I

D

D

S

D

S

I

E

E

L

G

P

A

S

W

N

N

T

S

G

S

T

T

P

K

Y

Y

E

E

G

G

G

G

N

N

L

K

G

G

H

H

R

R

I

P

R

G

T

V

K

K

G

G

G

G

Y

Y

F

F

P

P

V

V

P

P

P

P

Q

V

D

D

S

S

A

A

Q

Q

D

D

M

I

R

R

G

S

E

E

M

M

L

C

A

L

A

V

M

M

A

E

Q

Q

M

M

G

G

A

L

K

V

V

V

E
|
E

K

A

H

H

H

H

H

H

E
|
E

V

V

A

A

S

T

A

A

-

G

Q

Q

H

N

E
|
E

L

V

G

A

L
x
T

K

R

F
|
F

G

N

P

T

L

M

T

T

T

K

M

K

A

A

D

D

H

E

L

I

Q

Q

I

I

Y

Y

K

K

Y

Y

A

V

I

V

H

H

Q

N

V

V

A

A

H

H

S

R

Y

F

G

G

K

K

S

T

A

A

T

T

F

F

M

M

P

P

K

K

P

P

I

M

F

F

G

G

D

D

N

N

G

G

S

S

G

G

M

M

H
|
H

V

C

H
|
H

Q

M

S
|
S

L

L

W

A

K

K

G

N

G

G

K

T

P

N

L

L

F

F

A

S

G

G

N

D

K

K

Y

Y

A

A

D

G

L

L

S

S

E

E

E

Q

C

A

L

L

F

Y

Y

Y

I

I

G

G

G

G

I

V

I

I

R

K

H

H

A

A

R

K

A

A

L

I

N

N

A

A

F

L

T

A

N

N

P

P

S

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

-

Y

-

E

-

A

-

P

P

V

V

L

M

L

L

A

A

Y

Y

S

S

A

A

R

R

N

N

R

R

S

S

A

A

S

S

C

I

R

R

I

I

P

P

F

V

A

V

T

A

N

S

P

P

K

K

A

A

K

R

R
|
R

V

I

E
|
E

V

V

R

R

F

F

P

P

D

D

P

P

A

A

A

A

N

N

P

P

Y

Y

L

L

A

C

F

F

A

A

A

A

M

L

L

L

L

M

A

A

G

G

I

L

D

D

G

G

I

I

L

K

N

N

K

K

I

I

D

H

P

P

G

G

A

E

A

P

M

M

D

D

K

-

D

-

L

-

Y

-

D

-

L

-

P

-

P

-

K

-

E

-

L

-

K

-

K

-

I

I

P

P

T

Q

V

V

C

A

G

G

S

S

L

L

R

E

E

E

A

A

L

L

S

N

N

A

L

L

D

D

K

L

D

D

R

R

A

E

F

F

L

L

K

K

A

A

G

G

G

G

V

V

F

F

D

T

D

D

D

E

F

A

I

I

D

D

S

A

Y

Y

I

I

D

A

L

L

K

R

M

R

Q

E

D

E

V

D

L

D

R

R

F

V

E

R

T

M

T

T

P

P

H

H

P

P

V

V

E

E

F

F

D

E

M

L

Y

Y

Y

Y

S

S

binding adenosine monophosphate: E201 (= E209), T217 (≠ L224), F219 (= F226), H265 (= H272), S267 (= S274), R345 (= R356)
binding manganese (ii) ion: E123 (= E131), E125 (= E133), E206 (= E214), E214 (= E221), H263 (= H270), E347 (= E358)

3ng0A Crystal structure of glutamine synthetase from synechocystis sp. Pcc 6803
59% identity, 99% coverage: 3:467/469 of query aligns to 2:463/465 of 3ng0A

query
sites
3ng0A

T

T

A

P

K

Q

D

E

V

V

L

L

K

K

S

W

I

I

K

Q

D

D

N

E

D

N

I

I

K

K

Y

I

V

I

D

D

F

L

R

K

F

F

T

I

D

D

P

T

R

P

G

G

K

I

W

W

Q

Q

H

H

V

C

T

S

F

F

D

Y

V

Y

S

D

L

Q

I

L

E

D

D

E

E

N

T

S

F

F

T

T

E

E

G

G

V

I

M

P

F

F

D
|
D

G

G

S

S

S

S

I

I

A

R

G

G

W

W

K

K

A

A

I

I

N

N

E

E

S

S

D

D

M

M

T

C

L

M

L

V

P

P

D

D

P

P

K

N

T

T

A

A

F

T

I

I

D

D

P

P

F

F

F

C

A

K

A

E

P

P

T

T

L

L

V

S

I

M

V

I

C

C

D

S

I

I

L

K

D

E

P

P

A

R

S

T

G

G

E

E

P

W

Y

Y

S

N

R

R

D

D

P

P

R

R

G

T

I

I

A

A

K

A

K

K

A

A

E

A

A

E

F

Y

A

L

A

R

S

G

S

T

G

G

I

I

A

A

D

D

A

T

A

V

Y
|
Y

F

F

G

G

P

P

E
|
E

A

A

E
|
E

F

F

F

F

V

L

F

F

D

D

D

D

V

I

R

R

F

F

N

G

T

Q

D

T

P

E

Y

N

N

S

M

S

G

Y

F

Y

I

F

L

A

D

D

S

S

S

V

E

E

L

G

P

R

S

W

N

N

T

T

G

G

T

R

P

E

Y

E

E

E

G

G

G

G

N

N

L

L

G

G

H

Y

R

K

I

P

R

G

T

Y

K

K

G

Q

G

G

Y

Y

F

F

P

P

V

V

P

A

P

P

Q

T

D

D

S

T

A

A

Q

Q

D

D

M

I

R

R

G

T

E

E

M

M

L

L

A

L

A

T

M

M

A

A

Q

A

M

F

G

G

A

V

K

P

V

I

E

E

K
|
K

H

H

H

H

H

H

E
|
E

V

V

A

A

S

S

-

G

A

G

Q

Q

H

N

E
|
E

L

L

G

G

L
x
I

K

K

F
|
F

G

D

P

K

L

L

T

V

T

N

M

S

A

A

D

D

H

N

L

L

Q

M

I

I

Y

Y

K

K

Y

Y

A

V

I

I

H

K

Q

N

V

V

A

A

H

K

S

K

Y

Y

G

G

K

K

S

T

A

V

T

T

F

F

M

M

P

P

K

K

P

P

I

I

F

F

G

N

D

D

N

N

G

G

S

S

G

G

M

M

H
|
H

V

V

H
|
H

Q

Q

S
|
S

L

L

W

W

K

K

G

D

G

G

K

Q

P

P

L

L

F

F

A

A

G

G

N

D

K

K

Y

Y

A

A

D

G

L

F

S

S

E

Q

E

M

C

G

L

L

F

W

Y

Y

I

I

G

G

G

G

I

I

I

L

R

K

H

H

A

A

R

P

A

A

L

L

N

L

A

A

F

F

T

T

N

N

P

P

S

T

T

T

N

N

S

S

Y

Y

K

K

R

R

L

L

V

V

P

P

G

G

Y

F

E

E

A

A

P

P

V

V

L

N

L

L

A

A

Y

Y

S

S

A

Q

R

G

N

N

R
|
R

S

S

A

A

S

S

C

V

R
|
R

I

I

P

P

F

L

A

S

-

G

T

G

N

N

P

P

K

K

A

A

K

K

R
|
R

V

L

E
|
E

V

F

R
|
R

F

C

P

P

D

D

P

A

A

T

A

S

N

N

P

P

Y

Y

L

L

A

A

F

F

A

A

A

A

M

M

L

L

L

C

A

A

G

G

I

I

D

D

G

G

I

I

L

K

N

N

K

Q

I

I

D

D

P

P

G

G

A

E

A

P

M

L

D

D

K

V

D

D

L

I

Y

-

D

-

L

-

P

-

P

-

K

-

E

E

L

L

K

A

K

K

I

I

P

P

T

S

V

T

C

P

G

G

S

S

L

L

R

E

E

A

A

A

L

L

S

E

N

A

L

L

D

E

K

K

D

D

R

H

A

E

F

F

L

L

K

T

A

G

G

T

G

G

V

V

F

F

D

S

D

P

D

D

F

F

I

V

D

E

S

S

Y

W

I

I

D

E

L

Y

K

K

M

L

-

D

Q

N

D

E

V

V

L

N

R

P

F

M

E

R

T

L

T

R

P

P

H

H

P

P

V

Y

E

E

F

F

D

S

M

L

Y

Y

Y

Y

active site: D51 (= D52), E130 (= E131), E132 (= E133), E213 (= E214), E221 (= E221), H270 (= H270), R340 (= R340), E359 (= E358), R361 (= R360)
binding phosphoaminophosphonic acid-adenylate ester: Y126 (= Y127), E130 (= E131), K209 (= K210), I224 (≠ L224), F226 (= F226), H272 (= H272), S274 (= S274), R340 (= R340), R345 (= R345), R357 (= R356)
binding manganese (ii) ion: E130 (= E131), E132 (= E133), E213 (= E214), E221 (= E221), H270 (= H270), E359 (= E358), R361 (= R360)

A0R079 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
51% identity, 99% coverage: 3:467/469 of query aligns to 5:476/478 of A0R079

query
sites
A0R079

T

T

A

S

K

D

D

D

V

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K14 (= K12) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

P9WN39 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
52% identity, 99% coverage: 3:467/469 of query aligns to 5:476/478 of P9WN39

query
sites
P9WN39

T

T

A

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K

D

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|
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|
E

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|
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|
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|
H

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