SitesBLAST
Comparing WP_026608213.1 NCBI__GCF_000427445.1:WP_026608213.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
47% identity, 96% coverage: 7:566/586 of query aligns to 99:661/670 of P17597
- A122 (= A30) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L32) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E52) binding
- S186 (= S94) binding
- P197 (= P105) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ H107) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q115) binding
- K220 (= K128) binding
- R246 (= R154) binding ; binding
- K256 (= K164) binding
- G308 (= G214) binding
- TL 331:332 (= TL 241:242) binding
- C340 (≠ A250) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 259:262) binding
- GVRFD 371:375 (≠ GARFD 281:285) binding
- DR 376:377 (= DR 286:287) binding
- DI 395:396 (= DI 305:306) binding
- DV 414:415 (≠ DC 324:325) binding
- QH 487:488 (= QH 399:400) binding
- GG 508:509 (= GG 420:421) binding
- GAM 511:513 (≠ GTM 423:425) binding
- D538 (≠ E450) binding
- DGS 538:540 (≠ EAS 450:452) binding
- N565 (= N477) binding
- NQHLGM 565:570 (≠ NEYMGM 477:482) binding
- H567 (≠ Y479) binding
- W574 (= W486) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (= S558) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/583 of 5k3sA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R287), M485 (= M482), W489 (= W486), G569 (= G559)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), M266 (= M261), G286 (= G281), R288 (= R283), D290 (= D285), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), D453 (≠ E450), G454 (≠ A451), S455 (= S452), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), G484 (= G481), M485 (= M482), V486 (= V483)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/585 of 5k2oA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M261), R292 (= R287), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), G286 (= G281), R288 (= R283), D290 (= D285), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), Q404 (= Q401), M405 (= M402), G423 (= G420)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), M428 (= M425), D453 (≠ E450), G454 (≠ A451), S455 (= S452), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), G484 (= G481), M485 (= M482), V486 (= V483)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), D453 (≠ E450), G454 (≠ A451), S455 (= S452), M458 (= M455), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), G484 (= G481), M485 (= M482), V486 (= V483)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420)
- binding magnesium ion: F370 (≠ Y366), D453 (≠ E450), M458 (= M455), Q461 (= Q458), N480 (= N477), H482 (≠ Y479), K533 (≠ P523)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M261), R292 (= R287), M485 (= M482), W489 (= W486), S568 (= S558)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 5wj1A
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), M263 (= M258), L264 (= L259), G286 (= G281), R288 (= R283), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420), G424 (= G421)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M261), D291 (= D286), R292 (= R287), M485 (= M482), W489 (= W486), S568 (= S558)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), M428 (= M425), D453 (≠ E450), G454 (≠ A451), S455 (= S452), M458 (= M455), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), G484 (= G481), M485 (= M482), V486 (= V483)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 5k6tA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H262), R292 (= R287), M485 (= M482), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), G286 (= G281), R288 (= R283), D290 (= D285), R292 (= R287), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), Q404 (= Q401), M405 (= M402), G423 (= G420)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), G454 (≠ A451), S455 (= S452), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), G484 (= G481)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 5k6rA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R287), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), M266 (= M261), G286 (= G281), R288 (= R283), R292 (= R287), V293 (≠ I288), D310 (= D305), I311 (= I306), G328 (= G323), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), D453 (≠ E450), G454 (≠ A451), S455 (= S452), M458 (= M455), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), G484 (= G481), M485 (= M482), V486 (= V483)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 1z8nA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K128), R161 (= R154), Y191 (= Y184), R194 (= R187), D291 (= D286), R292 (= R287), D312 (= D307), W489 (= W486), G569 (= G559)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), G265 (= G260), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420), G424 (= G421)
- binding magnesium ion: D453 (≠ E450), N480 (= N477)
- binding thiamine diphosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), G454 (≠ A451), S455 (= S452), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), G484 (= G481), M485 (= M482), V486 (= V483)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 1yi1A
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D286), R292 (= R287), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), M263 (= M258), L264 (= L259), G265 (= G260), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420), G424 (= G421)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 1yi0A
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D286), R292 (= R287), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), G265 (= G260), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (≠ I288), D310 (= D305), I311 (= I306), G328 (= G323), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420), G424 (= G421)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 1yhzA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D286), R292 (= R287), M485 (= M482), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), Q404 (= Q401), M405 (= M402), G423 (= G420), G424 (= G421)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 1yhyA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D286), R292 (= R287), V486 (= V483), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), G265 (= G260), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), Q404 (= Q401), M405 (= M402), G423 (= G420), G424 (= G421)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
47% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 1ybhA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M261), V293 (≠ I288), V400 (= V397), G426 (= G423), M428 (= M425), D453 (≠ E450), N480 (= N477), H482 (≠ Y479), L483 (≠ M480), M485 (= M482), V486 (= V483), W489 (= W486), H558 (≠ K548)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M261), D291 (= D286), R292 (= R287), M485 (= M482), W489 (= W486), S568 (= S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), V287 (≠ A282), R288 (= R283), D290 (= D285), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), Q404 (= Q401), M405 (= M402), G423 (= G420), G424 (= G421)
- binding magnesium ion: D453 (≠ E450), N480 (= N477), H482 (≠ Y479)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
46% identity, 96% coverage: 7:566/586 of query aligns to 13:575/582 of 3ea4A
- active site: Y32 (= Y26), G34 (= G28), G35 (= G29), A36 (= A30), S37 (≠ V31), E58 (= E52), T81 (= T75), F120 (= F114), Q121 (= Q115), E122 (= E116), K170 (= K164), M265 (= M261), V292 (≠ I288), V399 (= V397), G425 (= G423), M427 (= M425), D452 (≠ E450), N479 (= N477), H481 (≠ Y479), L482 (≠ M480), M484 (= M482), V485 (= V483), W488 (= W486), H557 (≠ K548)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D286), R291 (= R287), W488 (= W486), S567 (= S558)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G213), G222 (= G214), G223 (= G215), T245 (= T241), L246 (= L242), M247 (= M243), L263 (= L259), G264 (= G260), M265 (= M261), H266 (= H262), G285 (= G281), R287 (= R283), D289 (= D285), R291 (= R287), D309 (= D305), I310 (= I306), G327 (= G323), D328 (= D324), V329 (≠ C325), M404 (= M402), G422 (= G420)
- binding magnesium ion: D452 (≠ E450), N479 (= N477), H481 (≠ Y479)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V397), G400 (= G398), Q401 (= Q399), H402 (= H400), M427 (= M425), G451 (= G449), D452 (≠ E450), G453 (≠ A451), S454 (= S452), N479 (= N477), H481 (≠ Y479), L482 (≠ M480), G483 (= G481), M484 (= M482), V485 (= V483)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
46% identity, 96% coverage: 7:566/586 of query aligns to 13:575/582 of 3e9yA
- active site: Y32 (= Y26), G34 (= G28), G35 (= G29), A36 (= A30), S37 (≠ V31), E58 (= E52), T81 (= T75), F120 (= F114), Q121 (= Q115), E122 (= E116), K170 (= K164), M265 (= M261), V292 (≠ I288), V399 (= V397), G425 (= G423), M427 (= M425), D452 (≠ E450), N479 (= N477), H481 (≠ Y479), L482 (≠ M480), M484 (= M482), V485 (= V483), W488 (= W486), H557 (≠ K548)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D286), R291 (= R287), W488 (= W486), S567 (= S558)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G213), G222 (= G214), G223 (= G215), T245 (= T241), L246 (= L242), M247 (= M243), L263 (= L259), G285 (= G281), R287 (= R283), D289 (= D285), R291 (= R287), D309 (= D305), I310 (= I306), G327 (= G323), D328 (= D324), V329 (≠ C325), M404 (= M402), G422 (= G420)
- binding magnesium ion: D452 (≠ E450), N479 (= N477), H481 (≠ Y479)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V397), G400 (= G398), Q401 (= Q399), H402 (= H400), M427 (= M425), G451 (= G449), G453 (≠ A451), S454 (= S452), N479 (= N477), H481 (≠ Y479), L482 (≠ M480), G483 (= G481), M484 (= M482), V485 (= V483)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
46% identity, 96% coverage: 7:566/586 of query aligns to 14:576/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M261), R292 (= R287), W489 (= W486), S568 (= S558)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V397), G401 (= G398), Q402 (= Q399), H403 (= H400), G426 (= G423), M428 (= M425), G452 (= G449), D453 (≠ E450), G454 (≠ A451), S455 (= S452), L483 (≠ M480), G484 (= G481), M485 (= M482), V486 (= V483)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G213), G223 (= G214), G224 (= G215), T246 (= T241), L247 (= L242), M248 (= M243), M263 (= M258), L264 (= L259), M266 (= M261), H267 (= H262), G286 (= G281), R288 (= R283), V293 (≠ I288), D310 (= D305), I311 (= I306), D329 (= D324), V330 (≠ C325), M405 (= M402), G423 (= G420)
- binding magnesium ion: A37 (= A30), T82 (= T75), S83 (= S76), Q122 (= Q115), Y381 (≠ F377), D453 (≠ E450), M458 (= M455), Q461 (= Q458), N480 (= N477), H482 (≠ Y479), K533 (≠ P523)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
46% identity, 97% coverage: 5:573/586 of query aligns to 12:582/597 of 6demA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K228 (≠ H225), M264 (= M261), V291 (≠ I288), V407 (= V397), L432 (= L422), G433 (= G423), M435 (= M425), D460 (≠ E450), N487 (= N477), E489 (≠ Y479), Q490 (≠ M480), M492 (= M482), V493 (= V483), W496 (= W486), L518 (= L509), N523 (≠ G514), V524 (≠ A515)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M261), D289 (= D286), R290 (= R287), M492 (= M482), W496 (= W486), A567 (≠ S558)
- binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G213), A218 (≠ G214), G219 (= G215), N222 (= N218), T244 (= T241), L245 (= L242), Q246 (≠ M243), L262 (= L259), G284 (= G281), A285 (= A282), R286 (= R283), D288 (= D285), R290 (= R287), V291 (≠ I288), E317 (≠ D305), I318 (= I306), N322 (≠ S310), D336 (= D324), V337 (≠ C325), M412 (= M402), G430 (= G420)
- binding magnesium ion: D460 (≠ E450), N487 (= N477), E489 (≠ Y479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (= Q399), H410 (= H400), M435 (= M425), G459 (= G449), D460 (≠ E450), A461 (= A451), S462 (= S452), M465 (= M455), N487 (= N477), E489 (≠ Y479), Q490 (≠ M480), G491 (= G481), M492 (= M482), V493 (= V483)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
46% identity, 97% coverage: 5:573/586 of query aligns to 12:582/597 of 6delA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K228 (≠ H225), M264 (= M261), V291 (≠ I288), V407 (= V397), L432 (= L422), G433 (= G423), M435 (= M425), D460 (≠ E450), N487 (= N477), E489 (≠ Y479), Q490 (≠ M480), M492 (= M482), V493 (= V483), W496 (= W486), L518 (= L509), N523 (≠ G514), V524 (≠ A515)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D286), R290 (= R287), W496 (= W486)
- binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G213), A218 (≠ G214), G219 (= G215), N222 (= N218), T244 (= T241), L245 (= L242), Q246 (≠ M243), L262 (= L259), G284 (= G281), A285 (= A282), R286 (= R283), D288 (= D285), R290 (= R287), V291 (≠ I288), E317 (≠ D305), I318 (= I306), N322 (≠ S310), D336 (= D324), V337 (≠ C325), M412 (= M402), G430 (= G420)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (= Q399), H410 (= H400), G433 (= G423), M435 (= M425), G459 (= G449), D460 (≠ E450), A461 (= A451), S462 (= S452), M465 (= M455), N487 (= N477), E489 (≠ Y479), Q490 (≠ M480), G491 (= G481), M492 (= M482), V493 (= V483)
- binding magnesium ion: D460 (≠ E450), N487 (= N477), E489 (≠ Y479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V397), G408 (= G398), Q409 (= Q399), H410 (= H400), G433 (= G423), M435 (= M425), G459 (= G449), D460 (≠ E450), A461 (= A451), S462 (= S452), M465 (= M455), N487 (= N477), E489 (≠ Y479), Q490 (≠ M480), G491 (= G481), M492 (= M482), V493 (= V483)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
46% identity, 97% coverage: 5:573/586 of query aligns to 14:584/599 of 6denA
- active site: Y35 (= Y26), G37 (= G28), G38 (= G29), A39 (= A30), I40 (≠ V31), E61 (= E52), T84 (= T75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (= K164), K230 (≠ H225), M266 (= M261), V293 (≠ I288), V409 (= V397), L434 (= L422), G435 (= G423), M437 (= M425), D462 (≠ E450), N489 (= N477), E491 (≠ Y479), Q492 (≠ M480), M494 (= M482), V495 (= V483), W498 (= W486), L520 (= L509), N525 (≠ G514), V526 (≠ A515)
- binding flavin-adenine dinucleotide: R163 (= R154), G219 (= G213), A220 (≠ G214), G221 (= G215), N224 (= N218), T246 (= T241), L247 (= L242), Q248 (≠ M243), L264 (= L259), G286 (= G281), A287 (= A282), R288 (= R283), D290 (= D285), R292 (= R287), V293 (≠ I288), E319 (≠ D305), I320 (= I306), N324 (≠ S310), D338 (= D324), V339 (≠ C325), M414 (= M402), G432 (= G420)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M261), D291 (= D286), R292 (= R287), W498 (= W486)
- binding magnesium ion: D462 (≠ E450), N489 (= N477), E491 (≠ Y479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V397), G410 (= G398), Q411 (= Q399), H412 (= H400), G435 (= G423), M437 (= M425), G461 (= G449), D462 (≠ E450), A463 (= A451), S464 (= S452), N489 (= N477), E491 (≠ Y479), Q492 (≠ M480), G493 (= G481), M494 (= M482), V495 (= V483)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
46% identity, 97% coverage: 5:573/586 of query aligns to 10:578/593 of 6deoA
- active site: Y31 (= Y26), G33 (= G28), G34 (= G29), A35 (= A30), I36 (≠ V31), E57 (= E52), T80 (= T75), F119 (= F114), Q120 (= Q115), E121 (= E116), K169 (= K164), K224 (≠ H225), M260 (= M261), V287 (≠ I288), V403 (= V397), L428 (= L422), G429 (= G423), M431 (= M425), D456 (≠ E450), N483 (= N477), E485 (≠ Y479), Q486 (≠ M480), M488 (= M482), V489 (= V483), W492 (= W486), L514 (= L509), N519 (≠ G514), V520 (≠ A515)
- binding flavin-adenine dinucleotide: R159 (= R154), G213 (= G213), A214 (≠ G214), G215 (= G215), N218 (= N218), T240 (= T241), L241 (= L242), Q242 (≠ M243), L258 (= L259), G280 (= G281), A281 (= A282), R282 (= R283), D284 (= D285), R286 (= R287), V287 (≠ I288), E313 (≠ D305), I314 (= I306), N318 (≠ S310), D332 (= D324), V333 (≠ C325), M408 (= M402), G426 (= G420)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M261), D285 (= D286), R286 (= R287), M488 (= M482), W492 (= W486)
- binding magnesium ion: D456 (≠ E450), N483 (= N477), E485 (≠ Y479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V397), G404 (= G398), Q405 (= Q399), H406 (= H400), G429 (= G423), M431 (= M425), G455 (= G449), D456 (≠ E450), A457 (= A451), S458 (= S452), M461 (= M455), N483 (= N477), E485 (≠ Y479), Q486 (≠ M480), G487 (= G481), M488 (= M482), V489 (= V483)
Query Sequence
>WP_026608213.1 NCBI__GCF_000427445.1:WP_026608213.1
MSNLLTGAEMVVRALQDQGVETIFGYPGGAVLPIYDALFHQKHIKHVLVRHEQGAAHAAE
GYARSSGKAGVLLVTSGPGATNAITGLTDALMDSIPLVCITGQVPTHLIGSDAFQECDTV
GITRHCTKHNYLVRHVDDLARVLHEAFYVAQNGRPGPVVIDIPKDVQFAVGAYFGPHKVE
HKTYKPRLEGDPDKIAQAVEMMAAAKRPIFYTGGGVINSGVEASHLLRELVGLTGFPITS
TLMGLGSYPASGEKWLGMLGMHGTFEANNAMHDCDLMVAVGARFDDRITGRLDAFSPGSK
KIHVDIDPSSINKNVKIDLGIIGDCAHVLRKMVELWRARRHVASAEPLAKWWAQIDQWRA
RKSLSYKASKEVIKPQFAVQRLYELTKARDVYITTEVGQHQMWAAQHYHFEEPNRWMTSG
GLGTMGYGLPAAIGAQLAHPDALVVDIAGEASILMNIQELSTAAQYRLPVKVFILNNEYM
GMVRQWQELLHDGRYSESYSEALPDFVKLAEAYGAHGIRCSDPAQLDAAILEMIDTPRTV
IFDCIVDKTENCLPMIPSGKAHNEMILPDHDAEIGSVIDAPGKMLV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory