SitesBLAST
Comparing WP_027699414.1 NCBI__GCF_000691805.2:WP_027699414.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7omlA Bacillus subtilis phosphoglucomutase glmm (metal bound) (see paper)
65% identity, 98% coverage: 6:450/452 of query aligns to 3:445/445 of 7omlA
7ojrA Bacillus subtilis phosphoglucomutase glmm (phosphate bound) (see paper)
65% identity, 98% coverage: 6:450/452 of query aligns to 3:445/445 of 7ojrA
P31120 Phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli (strain K12) (see 3 papers)
43% identity, 98% coverage: 1:445/452 of query aligns to 1:442/445 of P31120
- M1 (= M1) modified: Initiator methionine, Removed
- S100 (≠ T102) mutation to A: 2% of wild-type activity.; mutation to T: 20-fold increase in the non-specific phosphoglucomutase activity towards glucose-phosphate substrates (non aminated).
- S102 (= S104) active site, Phosphoserine intermediate; modified: Phosphoserine; by autocatalysis; mutation to A: Loss of activity in the absence or presence of glucosamine-1,6-diP.
3i3wA Structure of a phosphoglucosamine mutase from francisella tularensis
40% identity, 98% coverage: 6:449/452 of query aligns to 2:440/441 of 3i3wA
- active site: R9 (= R13), S99 (= S104), H100 (= H105), K109 (= K114), D237 (= D244), D239 (= D246), D241 (= D248), R242 (= R249), H324 (= H333)
- binding zinc ion: S99 (= S104), D237 (= D244), D239 (= D246), D241 (= D248)
1wqaA Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
34% identity, 96% coverage: 7:439/452 of query aligns to 5:444/455 of 1wqaA
- active site: R11 (= R13), S101 (= S104), H102 (= H105), K111 (= K114), D243 (= D244), D245 (= D246), D247 (= D248), R248 (= R249), G330 (≠ H333), R340 (≠ G343)
- binding magnesium ion: S101 (= S104), D243 (= D244), D245 (= D246), D247 (= D248)
2h5aX Complex of the enzyme pmm/pgm with xylose 1-phosphate (see paper)
29% identity, 93% coverage: 12:432/452 of query aligns to 11:431/455 of 2h5aX
- active site: H101 (= H105), D234 (= D244), D236 (= D246), D238 (= D248), R239 (= R249), D332 (≠ G343)
- binding 1-O-phosphono-alpha-D-xylopyranose: T298 (≠ V310), G299 (= G311), H300 (≠ D312), E317 (= E329), S319 (= S331), H321 (= H333), R413 (= R414), S415 (= S416), N416 (≠ G417), T417 (= T418)
- binding zinc ion: S100 (= S104), D234 (= D244), D236 (= D246), D238 (= D248)
Sites not aligning to the query:
2h4lX Complex of pmm/pgm with ribose 1-phosphate (see paper)
29% identity, 93% coverage: 12:432/452 of query aligns to 11:431/455 of 2h4lX
- active site: H101 (= H105), D234 (= D244), D236 (= D246), D238 (= D248), R239 (= R249), D332 (≠ G343)
- binding 1-O-phosphono-alpha-D-ribofuranose: R12 (= R13), S100 (= S104), T298 (≠ V310), E317 (= E329), R413 (= R414), S415 (= S416), N416 (≠ G417), T417 (= T418)
- binding zinc ion: S100 (= S104), D234 (= D244), D236 (= D246), D238 (= D248)
Sites not aligning to the query:
2fkfA Phosphomannomutase/phosphoglucomutase from pseudomonas aeruginosa with alpha-d-glucose 1,6-bisphosphate bound (see paper)
29% identity, 93% coverage: 12:432/452 of query aligns to 11:431/455 of 2fkfA
- active site: R12 (= R13), S100 (= S104), H101 (= H105), K110 (= K114), D234 (= D244), D236 (= D246), D238 (= D248), R239 (= R249), H321 (= H333), D332 (≠ G343)
- binding 1,6-di-O-phosphono-alpha-D-glucopyranose: H101 (= H105), S319 (= S331), R413 (= R414), S415 (= S416), N416 (≠ G417), T417 (= T418)
- binding zinc ion: S100 (= S104), D234 (= D244), D236 (= D246), D238 (= D248)
Sites not aligning to the query:
1pcmX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
29% identity, 93% coverage: 12:432/452 of query aligns to 11:431/455 of 1pcmX
- active site: R12 (= R13), S100 (= S104), H101 (= H105), K110 (= K114), D234 (= D244), D236 (= D246), D238 (= D248), R239 (= R249), H321 (= H333), D332 (≠ G343)
- binding 6-O-phosphono-alpha-D-mannopyranose: S100 (= S104), T298 (≠ V310), G299 (= G311), H300 (≠ D312), E317 (= E329), S319 (= S331), H321 (= H333), R413 (= R414), S415 (= S416)
- binding zinc ion: S100 (= S104), D234 (= D244), D236 (= D246), D238 (= D248)
Sites not aligning to the query:
1p5gX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
29% identity, 93% coverage: 12:432/452 of query aligns to 11:431/455 of 1p5gX
- active site: R12 (= R13), S100 (= S104), H101 (= H105), K110 (= K114), D234 (= D244), D236 (= D246), D238 (= D248), R239 (= R249), H321 (= H333), D332 (≠ G343)
- binding 6-O-phosphono-alpha-D-glucopyranose: S100 (= S104), K277 (≠ M289), G299 (= G311), H300 (≠ D312), E317 (= E329), S319 (= S331), H321 (= H333), R413 (= R414), S415 (= S416), N416 (≠ G417), T417 (= T418)
- binding zinc ion: S100 (= S104), D234 (= D244), D236 (= D246), D238 (= D248)
Sites not aligning to the query:
1p5dX Enzyme-ligand complex of p. Aeruginosa pmm/pgm (see paper)
29% identity, 93% coverage: 12:432/452 of query aligns to 11:431/455 of 1p5dX