SitesBLAST
Comparing WP_028320271.1 NCBI__GCF_000422285.1:WP_028320271.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
8a6tB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from thermoanaerobacter kivui in the reduced state (see paper)
53% identity, 55% coverage: 1:570/1043 of query aligns to 1:595/630 of 8a6tB
- binding fe2/s2 (inorganic) cluster: C31 (= C31), G33 (vs. gap), C36 (= C35), C82 (= C67), F85 (= F70), C86 (= C71)
- binding flavin mononucleotide: G201 (= G187), N227 (= N213), E230 (= E216), N355 (= N341), G535 (= G521), L536 (= L522)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: S320 (≠ E306), R337 (= R323), R340 (≠ F326), T341 (≠ P327), N342 (≠ A328), S433 (≠ A419)
- binding iron/sulfur cluster: S487 (= S473), C488 (= C474), G489 (= G475), C491 (= C477), C494 (= C480), C534 (= C520), L536 (= L522), G537 (= G523), Y575 (vs. gap), I577 (vs. gap), C582 (vs. gap), I583 (vs. gap), C585 (≠ I560), C588 (= C563), C592 (= C567)
- binding zinc ion: C471 (= C457), H558 (= H544), C564 (= C550)
Sites not aligning to the query:
7q4vB Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
53% identity, 52% coverage: 25:569/1043 of query aligns to 5:563/599 of 7q4vB
- binding fe2/s2 (inorganic) cluster: C11 (= C31), C16 (= C35), C48 (= C67), F49 (≠ H68), L51 (≠ F70), C52 (= C71)
- binding flavin mononucleotide: G166 (= G185), G168 (= G187), N196 (= N213), D198 (= D215), F284 (= F301), G287 (= G304), E288 (= E305), E289 (= E306), N324 (= N341)
- binding iron/sulfur cluster: C457 (= C474), G458 (= G475), K459 (= K476), C460 (= C477), C463 (= C480), C503 (= C520), G506 (= G523), F544 (vs. gap), C551 (vs. gap), K552 (vs. gap), G553 (vs. gap), C554 (vs. gap), G555 (vs. gap), I556 (vs. gap), C557 (= C563), C561 (= C567), P562 (= P568)
- binding zinc ion: C440 (= C457), H527 (= H544), C533 (= C550)
Sites not aligning to the query:
7p8nB Tmhydabc- t. Maritima hydrogenase with bridge closed (see paper)
50% identity, 53% coverage: 16:568/1043 of query aligns to 16:578/613 of 7p8nB
- binding fe2/s2 (inorganic) cluster: C31 (= C31), G33 (vs. gap), T34 (= T33), C36 (= C35), C67 (= C67), C68 (≠ H68), G69 (= G69), R70 (≠ F70), C71 (= C71)
- binding flavin mononucleotide: G185 (= G185), R186 (= R186), G187 (= G187), N213 (= N213), D215 (= D215), E216 (= E216), G217 (= G217), F301 (= F301), G304 (= G304), E305 (= E305), E306 (= E306), N340 (= N340), N341 (= N341), G521 (= G521), L522 (= L522)
- binding iron/sulfur cluster: P320 (= P320), S473 (= S473), C474 (= C474), G475 (= G475), K476 (= K476), C477 (= C477), C480 (= C480), L519 (= L519), C520 (= C520), L522 (= L522), G523 (= G523), Y560 (vs. gap), C567 (vs. gap), C570 (vs. gap), G571 (vs. gap), C573 (= C563), C577 (= C567)
- binding zinc ion: C457 (= C457), H544 (= H544), C549 (= C550), C554 (= C555)
Sites not aligning to the query:
8oh5B Cryo-em structure of the electron bifurcating transhydrogenase stnabc complex from sporomusa ovata (state 2) (see paper)
52% identity, 51% coverage: 37:568/1043 of query aligns to 13:547/584 of 8oh5B
- binding fe2/s2 (inorganic) cluster: C41 (= C67), C45 (= C71)
- binding flavin mononucleotide: R154 (= R186), K164 (= K196), N181 (= N213), F269 (= F301), E273 (= E305), E274 (= E306), I307 (= I339), N308 (= N340), N309 (= N341), G489 (= G521), L490 (= L522)
- binding nicotinamide-adenine-dinucleotide: G155 (= G187), G156 (= G188), F159 (= F191), F163 (≠ L195), E273 (= E305), E274 (= E306), K291 (≠ R323), F294 (= F326), G413 (= G445)
- binding iron/sulfur cluster: P288 (= P320), C442 (= C474), G443 (= G475), C445 (= C477), C448 (= C480), C488 (= C520), L490 (= L522), G491 (= G523), I531 (vs. gap), C536 (vs. gap), T540 (≠ S561), C542 (= C563), C546 (= C567), P547 (= P568)
- binding zinc ion: C425 (= C457), H512 (= H544), C518 (= C550), C523 (= C555)
Sites not aligning to the query:
7t30B Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
62% identity, 41% coverage: 132:555/1043 of query aligns to 1:424/425 of 7t30B
- binding fe2/s2 (inorganic) cluster: C326 (= C457), C364 (≠ T495), H413 (= H544), C419 (= C550), A421 (≠ G552), C424 (= C555)
- binding flavin mononucleotide: G54 (= G185), G56 (= G187), K65 (= K196), N82 (= N213), D84 (= D215), E85 (= E216), G173 (= G304), E175 (= E306), N210 (= N341), G390 (= G521), L391 (= L522)
- binding nicotinamide-adenine-dinucleotide: G56 (= G187), G57 (= G188), A58 (= A189), F60 (= F191), K65 (= K196), F68 (≠ L199), E85 (= E216), E175 (= E306), R192 (= R323), F195 (= F326), I312 (= I443), M313 (= M444), S315 (= S446)
- binding iron/sulfur cluster: S342 (= S473), C343 (= C474), G344 (= G475), C346 (= C477), C349 (= C480), S387 (= S518), C389 (= C520), L391 (= L522), G392 (= G523)
7t2rB Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn-free apo state (see paper)
62% identity, 41% coverage: 132:555/1043 of query aligns to 1:424/425 of 7t2rB
- binding fe2/s2 (inorganic) cluster: C326 (= C457), D329 (≠ E460), C364 (≠ T495), H413 (= H544), C419 (= C550), A421 (≠ G552), C424 (= C555)
- binding iron/sulfur cluster: P189 (= P320), C343 (= C474), G344 (= G475), C346 (= C477), C349 (= C480), C389 (= C520), G392 (= G523)
7q4vF Electron bifurcating hydrogenase - hydabc from a. Woodii (see paper)
57% identity, 40% coverage: 149:569/1043 of query aligns to 1:434/470 of 7q4vF
- binding flavin mononucleotide: G37 (= G185), G39 (= G187), N67 (= N213), G158 (= G304), E159 (= E305), E160 (= E306), G375 (= G521)
- binding nicotinamide-adenine-dinucleotide: G40 (= G188), F43 (= F191), K48 (= K196), R177 (= R323), F180 (= F326), M297 (≠ I443)
- binding iron/sulfur cluster: S327 (= S473), C328 (= C474), G329 (= G475), K330 (= K476), C331 (= C477), C334 (= C480), L373 (= L519), C374 (= C520), F415 (vs. gap), I417 (= I560), C422 (vs. gap), G424 (vs. gap), C425 (vs. gap), G426 (vs. gap), I427 (vs. gap), C428 (= C563), C432 (= C567), P433 (= P568)
- binding zinc ion: C311 (= C457), H398 (= H544), C404 (= C550), C409 (= C555)
Sites not aligning to the query:
- binding iron/sulfur cluster: 437, 445, 452, 454, 455, 456, 457, 458, 462, 463, 467
8a5eB Cryo-em structure of the electron bifurcating fe-fe hydrogenase hydabc complex from acetobacterium woodii in the reduced state (see paper)
58% identity, 38% coverage: 174:569/1043 of query aligns to 3:411/447 of 8a5eB
- binding flavin mononucleotide: G14 (= G185), G16 (= G187), N44 (= N213), G135 (= G304), E137 (= E306), N171 (= N340), N172 (= N341), G352 (= G521)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G16 (= G187), G17 (= G188), F20 (= F191), K25 (= K196), F28 (≠ L199), D49 (= D218), R154 (= R323), F157 (= F326), S250 (≠ A419)
- binding iron/sulfur cluster: P151 (= P320), C305 (= C474), G306 (= G475), K307 (= K476), C308 (= C477), C311 (= C480), C351 (= C520), G354 (= G523), F392 (vs. gap), C399 (vs. gap), G401 (vs. gap), C402 (vs. gap), G403 (vs. gap), C405 (= C563), C409 (= C567), P410 (= P568)
- binding zinc ion: C288 (= C457), H375 (= H544), C381 (= C550), C386 (= C555)
Sites not aligning to the query:
6vw7D Formate dehydrogenase fdsabg subcomplex fdsbg from c. Necator - nadh bound (see paper)
42% identity, 47% coverage: 57:541/1043 of query aligns to 35:510/514 of 6vw7D
- binding flavin mononucleotide: G154 (= G185), G156 (= G187), K165 (= K196), N182 (= N213), E185 (= E216), G273 (= G304), E274 (= E305), E275 (= E306), N309 (= N340), N310 (= N341), S313 (≠ T344), A490 (≠ G521), M491 (≠ L522)
- binding 1,4-dihydronicotinamide adenine dinucleotide: A158 (= A189), F160 (= F191), K165 (= K196), T168 (≠ L199), E275 (= E306), L295 (≠ F326)
- binding iron/sulfur cluster: V271 (= V302), V289 (≠ P320), S442 (= S473), C443 (= C474), G444 (= G475), K445 (= K476), C446 (= C477), C449 (= C480), L488 (= L519), C489 (= C520), M491 (≠ L522), G492 (= G523)
6tg9B Cryo-em structure of nadh reduced form of NAD+-dependent formate dehydrogenase from rhodobacter capsulatus (see paper)
42% identity, 46% coverage: 60:541/1043 of query aligns to 34:492/493 of 6tg9B
- binding flavin mononucleotide: G146 (= G185), R147 (= R186), G148 (= G187), N174 (= N213), D176 (= D215), E177 (= E216), Y254 (≠ F301), G257 (= G304), E258 (= E305), N293 (= N340), N294 (= N341), S297 (≠ T344)
- binding 1,4-dihydronicotinamide adenine dinucleotide: F152 (= F191), K157 (= K196), E258 (= E305), E259 (= E306), L279 (≠ F326), K466 (≠ T515), L470 (= L519)
- binding iron/sulfur cluster: S426 (= S473), C427 (= C474), G428 (= G475), T429 (≠ K476), C430 (= C477), C433 (= C480), L470 (= L519), C471 (= C520), G474 (= G523)
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
42% identity, 40% coverage: 136:549/1043 of query aligns to 14:428/437 of 4hea1
- binding flavin mononucleotide: G63 (= G185), K74 (= K196), N91 (= N213), D93 (= D215), Y179 (≠ F301), G182 (= G304), E183 (= E305), N218 (= N340), N219 (= N341), L401 (= L522)
- binding iron/sulfur cluster: I180 (≠ V302), P198 (= P320), S351 (= S473), C352 (= C474), G353 (= G475), K354 (= K476), C355 (= C477), C358 (= C480), F398 (≠ L519), C399 (= C520), L401 (= L522)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
42% identity, 40% coverage: 136:549/1043 of query aligns to 14:428/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G185), G65 (= G187), N91 (= N213), D93 (= D215), G182 (= G304), E183 (= E305), E184 (= E306), N218 (= N340), N219 (= N341), T222 (= T344), P400 (≠ G521)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G187), G66 (= G188), F69 (= F191), K74 (= K196), F77 (≠ L199), E96 (≠ D218), Y179 (≠ F301), E184 (= E306), K201 (≠ R323), F204 (= F326), T324 (≠ S446)
- binding iron/sulfur cluster: S351 (= S473), C352 (= C474), K354 (= K476), C355 (= C477), C358 (= C480), F398 (≠ L519), C399 (= C520), L401 (= L522), A402 (≠ G523)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
42% identity, 40% coverage: 136:549/1043 of query aligns to 15:429/438 of Q56222
- K75 (= K196) binding FMN
- NADES 92:96 (≠ NADEG 213:217) binding FMN
- YICGEE 180:185 (≠ FVCGEE 301:306) binding FMN
- INN 218:220 (= INN 339:341) binding FMN
- C353 (= C474) binding [4Fe-4S] cluster
- C356 (= C477) binding [4Fe-4S] cluster
- C359 (= C480) binding [4Fe-4S] cluster
- C400 (= C520) binding [4Fe-4S] cluster
6q9cB Crystal structure of aquifex aeolicus nadh-quinone oxidoreductase subunits nuoe and nuof bound to nadh under anaerobic conditions (see paper)
41% identity, 41% coverage: 122:544/1043 of query aligns to 9:416/418 of 6q9cB
- binding flavin mononucleotide: G64 (= G185), G66 (= G187), K75 (= K196), N91 (= N213), D93 (= D215), E94 (= E216), G182 (= G304), E183 (= E305), E184 (= E306), V217 (≠ I339), N218 (= N340), N219 (= N341), T222 (= T344), G393 (= G521)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G66 (= G187), G67 (= G188), A68 (= A189), F70 (= F191), K75 (= K196), E94 (= E216), E96 (≠ D218), Y179 (≠ F301), E184 (= E306), Y204 (≠ F326)
- binding iron/sulfur cluster: P198 (= P320), T345 (≠ S473), C346 (= C474), G347 (= G475), Q348 (≠ K476), C349 (= C477), C352 (= C480), I391 (≠ L519), C392 (= C520), L394 (= L522), G395 (= G523)
8qh7B Crystal structure of respiratory complex i subunits nuoef from aquifex aeolicus bound to reduced 3-acetylpyridine adenine dinucleotide (without reducing agent) (see paper)
41% identity, 41% coverage: 122:544/1043 of query aligns to 8:415/417 of 8qh7B
- binding acetyl pyridine adenine dinucleotide, reduced: G65 (= G187), G66 (= G188), A67 (= A189), F69 (= F191), K74 (= K196), E93 (= E216), E95 (≠ D218), Y178 (≠ F301), E183 (= E306), Y203 (≠ F326)
- binding 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2h-benzo[g]pteridin-1-id-10(5h)-yl)-5-o-phosphonato-d-ribitol: G63 (= G185), G65 (= G187), K74 (= K196), N90 (= N213), D92 (= D215), E93 (= E216), G181 (= G304), E182 (= E305), V216 (≠ I339), N217 (= N340), N218 (= N341), T221 (= T344)
- binding iron/sulfur cluster: P197 (= P320), T344 (≠ S473), C345 (= C474), G346 (= G475), Q347 (≠ K476), C348 (= C477), C351 (= C480), S389 (= S518), I390 (≠ L519), C391 (= C520), L393 (= L522), G394 (= G523)
8qg1B Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to adp-ribose (see paper)
41% identity, 41% coverage: 122:544/1043 of query aligns to 8:415/417 of 8qg1B
- binding adenosine-5-diphosphoribose: G66 (= G188), A67 (= A189), F69 (= F191), K74 (= K196), E183 (= E306), Y203 (≠ F326)
- binding flavin mononucleotide: G63 (= G185), G65 (= G187), K74 (= K196), N90 (= N213), D92 (= D215), E93 (= E216), Y178 (≠ F301), G181 (= G304), E182 (= E305), V216 (≠ I339), N217 (= N340), N218 (= N341), T221 (= T344)
- binding iron/sulfur cluster: P197 (= P320), T344 (≠ S473), C345 (= C474), G346 (= G475), Q347 (≠ K476), C348 (= C477), C351 (= C480), I390 (≠ L519), C391 (= C520), L393 (= L522), G394 (= G523)
6hl3B Wild-type nuoef from aquifex aeolicus - oxidized form bound to NAD+ (see paper)
41% identity, 41% coverage: 122:544/1043 of query aligns to 8:415/416 of 6hl3B
- binding flavin mononucleotide: G63 (= G185), G65 (= G187), K74 (= K196), N90 (= N213), D92 (= D215), E93 (= E216), G181 (= G304), E182 (= E305), E183 (= E306), V216 (≠ I339), N217 (= N340), N218 (= N341), T221 (= T344)
- binding nicotinamide-adenine-dinucleotide: G65 (= G187), G66 (= G188), A67 (= A189), F69 (= F191), K74 (= K196), E95 (≠ D218), Y178 (≠ F301), E183 (= E306), K200 (≠ R323), Y203 (≠ F326)
- binding iron/sulfur cluster: I179 (≠ V302), P197 (= P320), T344 (≠ S473), C345 (= C474), G346 (= G475), Q347 (≠ K476), C348 (= C477), C351 (= C480), S389 (= S518), I390 (≠ L519), C391 (= C520), L393 (= L522), G394 (= G523)
6hl2B Wild-type nuoef from aquifex aeolicus - oxidized form (see paper)
41% identity, 41% coverage: 122:544/1043 of query aligns to 8:415/416 of 6hl2B
- binding flavin mononucleotide: G63 (= G185), G65 (= G187), K74 (= K196), N90 (= N213), E93 (= E216), G181 (= G304), E182 (= E305), E183 (= E306), V216 (≠ I339), N217 (= N340), N218 (= N341), T221 (= T344)
- binding iron/sulfur cluster: P197 (= P320), T344 (≠ S473), C345 (= C474), G346 (= G475), Q347 (≠ K476), C348 (= C477), C351 (= C480), S389 (= S518), I390 (≠ L519), C391 (= C520), G394 (= G523)
8qgwB Crystal structure of oxidized respiratory complex i subunits nuoef from aquifex aeolicus bound to oxidized 3-acetylpyridine adenine dinucleotide (see paper)
41% identity, 41% coverage: 122:544/1043 of query aligns to 8:415/418 of 8qgwB
- binding 3-acetylpyridine adenine dinucleotide: G66 (= G188), A67 (= A189), F69 (= F191), K74 (= K196), E183 (= E306), Y203 (≠ F326)
- binding flavin mononucleotide: G63 (= G185), G65 (= G187), K74 (= K196), N90 (= N213), E93 (= E216), Y178 (≠ F301), G181 (= G304), E182 (= E305), E183 (= E306), V216 (≠ I339), N217 (= N340), N218 (= N341), T221 (= T344)
- binding iron/sulfur cluster: P197 (= P320), T344 (≠ S473), C345 (= C474), G346 (= G475), Q347 (≠ K476), C348 (= C477), C351 (= C480), I390 (≠ L519), C391 (= C520), L393 (= L522), G394 (= G523)
6saqB Wild-type nuoef from aquifex aeolicus bound to nadh-oh (see paper)
41% identity, 41% coverage: 122:544/1043 of query aligns to 9:416/419 of 6saqB
- binding flavin mononucleotide: G64 (= G185), G66 (= G187), K75 (= K196), N91 (= N213), D93 (= D215), E94 (= E216), Y179 (≠ F301), G182 (= G304), E183 (= E305), N218 (= N340), N219 (= N341), T222 (= T344)
- binding [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[[(1~{E},3~{Z})-5-azanyl-4-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-methanoyl-amino]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate: G66 (= G187), G67 (= G188), A68 (= A189), F70 (= F191), K75 (= K196), E94 (= E216), E96 (≠ D218), T99 (≠ A221), E184 (= E306), Y204 (≠ F326), T318 (≠ S446)
- binding iron/sulfur cluster: P198 (= P320), T345 (≠ S473), C346 (= C474), G347 (= G475), Q348 (≠ K476), C349 (= C477), C352 (= C480), I391 (≠ L519), C392 (= C520), G395 (= G523)
Query Sequence
>WP_028320271.1 NCBI__GCF_000422285.1:WP_028320271.1
MQKLASIGQLEWLRNKILAEAGAGRTEVHVCMTGCRAYGAAAVRDALQEEVARAGLDRQV
EVRSTGCHGFCAKAPVVAIEPLGVQYQEVDPQDAPEIVRSTLKEGRLIDRLAYRDPKSGQ
PIYHRNQIPFYQKQVRRVLAHCGRIDPTRIEHYIAAGGYKALVKALTKMTPESVIEEVVQ
SKLRGRGGAGFPTGLKWRLARQSQATPKYLVCNADEGDPGAFMDRALLEGDPHAVIEGMM
IGGYAMGAEYGIIYVREEYPIAVEHLNLAIEQCLELGLAGENILGTGYDFHLSLKKGAGA
FVCGEETALMASIEGRRGMPRPRPPFPAQAGVDGKPTNINNVETLANIPLIVAHGAAWYA
EMGTEASRGTKIFSLAGKVNNTGLVEVPIGTTIKEVVFDIGGGIPKGRSFKAVQMGGPAG
GCVPARFLNLPIDYDTIQRIGAIMGSGGMVVLDENNCMVEIARFFLNFTQSESCGKCAPC
RLGTTQLLETLSRITDGRGRAEDIAAIQSIGRTMTEASLCGLGQASPKPALSTLMYFEDE
YREHIQEHRCAGAVCDAMVISACQHACPAGIDVPNYVAAIAQKDYRAAVDIIRERNPFPA
VCGRVCIHPCEYKCRRGELDEPVAIRALKRFAADWYYQRFGAAHAPFPVTRPQKVAVVGA
GPAGLTCAYFLAKMGYAATVFEAQPVPGGMLGIAVPEFRLPRAVIDLEIQSISNAGVRIV
CNHPIDANHTINDLLKEGFSAVFIAAGAQASKRIGIPGEEEGLAGLHYGLTFLRDVRMGL
GGRLSGKTVVIGGGNVAMDVARTALRAGAEDVQLFCLEKRDEMPAWEKDVEETIEEGIVI
NPAWSPVQIEHTNGAVSGIQFMHCLSVFDQNGRFSPECDADDTQFIKADHIIIAIGQAPD
MSFLPEDSQLERALWGTLAVNENTLATNIPGVFAGGDFTTGPTFVIRAIASGRRAALAID
KYLQGDSSGIRMVDEKTPLAQDTGLALEEESTEDRPRILVEMEDPSERVQDFREVERGFS
AEQAHVEARRCLRCDLEKERSRA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory