SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_028485829.1 NCBI__GCF_000483485.1:WP_028485829.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6rl5G The first crystal structure of the daba aminotransferase ectb in the ectoine biosynthesis pathway of the model organism chromohalobacter salexigens dsm 3034 (see paper)
46% identity, 98% coverage: 8:418/418 of query aligns to 9:422/422 of 6rl5G

query
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6rl5G

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active site: S16 (= S15), F137 (= F136), D237 (= D235), K266 (= K264)
binding pyridoxal-5'-phosphate: G110 (= G109), T111 (= T110), F137 (= F136), H138 (= H137), D237 (= D235), I239 (= I237), Q240 (= Q238), K266 (= K264), G294 (= G293), T295 (= T294)

Q5SHH5 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
34% identity, 96% coverage: 2:401/418 of query aligns to 8:384/395 of Q5SHH5

query
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Q5SHH5

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GT 113:114 (= GT 109:110) binding pyridoxal 5'-phosphate
K254 (= K264) modified: N6-(pyridoxal phosphate)lysine
T283 (= T294) binding pyridoxal 5'-phosphate

1sffA Structure of gamma-aminobutyrate aminotransferase complex with aminooxyacetate (see paper)
32% identity, 96% coverage: 12:412/418 of query aligns to 16:421/425 of 1sffA

query
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1sffA

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active site: V18 (≠ Y14), Y137 (≠ F136), E205 (= E202), D238 (= D235), Q241 (= Q238), K267 (= K264), T296 (= T294), R397 (≠ K388)
binding 4'-deoxy-4'-acetylyamino-pyridoxal-5'-phosphate: Q78 (≠ M77), G110 (= G109), S111 (≠ T110), Y137 (≠ F136), H138 (= H137), R140 (≠ M139), E205 (= E202), D238 (= D235), V240 (≠ I237), Q241 (= Q238), K267 (= K264), T296 (= T294)
binding sulfate ion: N152 (= N149), Y393 (≠ G384)

1sf2A Structure of e. Coli gamma-aminobutyrate aminotransferase (see paper)
32% identity, 96% coverage: 12:412/418 of query aligns to 16:421/425 of 1sf2A

query
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1sf2A

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A

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Y

H

P

P

A

I

V

F

F

A

V

D

K

R

G

A

D

E

N

N

A

C

R

R

Q

V

V

W

D

D

E

V

D

E

G

G

K

R

V

E

Y

Y

I

L

D

D

F

F

Y

A

A

G

G

G

A

I

G

A

V

V

L

L

N

N

F

T

G

G

H

H

N

L

N

H

A

P

K

K

M

V

T

V

N

A

A

A

M

V

V

E

D

A

Y

Q

L

L

Q

K

S

K

G

-

V

L

I

S

H

H

T

T

L

C

D

-

M

F

M

Q

T

V

P

L

P

A

K

Y

R

E

N

P

F

Y

I

L

Q

E

A

-

F

L

V

C

E

E

T

I

I

M

L

N

Q

Q

P

K

R

V

N

P

M

G

D

D

Y

F

-

A

K

K

L

K

Q

T

F

L

M

L

G

V

P

T

T

T

G
|
G

T
x
S

N

E

A

A

V

V

E

E

A

N

A

A

L

V

K

K

L

I

A

A

R

R

K

A

V

A

T

T

G

K

R

R

E

S

Q

G

V

T

V

I

S

A

F

F

T

S

Q

G

G

A

F
x
Y

H
|
H

G

G

M

R

T

T

L

H

G

Y

A

T

L

L

A

A

C

L

T

T

-

G

-

K

A

V

N
|
N

S

P

Y

Y

F

-

R

-

N

-

A

S

A

A

G

G

V

M

S

G

L

L

-

M

-

P

N

G

N

H

V

V

I

Y

R

R

-

A

-

L

W

Y

P

P

F

C

E

P

T

L

H

H

E

G

G

I

G

S

G

E

L

D

D

D

S

A

L

I

N

A

T

S

L

I

R

H

A

R

L

I

F

F

K

K

N

N

S

D

S

A

G

A

G

-

T

P

E

E

P

D

P

I

A

A

F

I

M

V

V

I

E
|
E

V

P

V

V

Q

Q

A

G

E

E

G

G

V

F

N

Y

V

A

A

S

S

S

T

P

E

A

W

F

M

M

Q

Q

A

R

L

L

Q

R

K

A

L

L

A

C

K

D

D

E

L

H

G

G

A

I

L

M

L

L

I

I

V

A

D
|
D

D

E

I
x
V

Q
|
Q

A

S

G

G

C

A

G

G

R

R

T

T

G

G

H

T

Y

L

F

F

S

A

F

M

E

E

E

Q

M

M

G

G

I

V

Q

A

P

P

D

D

I

L

I

T

T

T

L

F

A

A

K
|
K

G

S

I

I

G

A

G

G

I

-

G

G

T

F

P

P

M

L

A

A

M

G

N

V

L

T

V

G

K

R

P

A

E

E

H

V

D

M

K

D

H

A

W

V

Q

A

P

P

G

G

E

G

H

L

T

G

G

G

T
|
T

F

Y

R

A

G

G

Q

N

N

P

L

I

S

A

F

C

V

V

A

A

G

A

R

L

E

E

A

V

L

L

R

K

Y

V

F

F

E

E

D

Q

N

E

R

N

F

L

M

L

E

Q

E

K

T

A

R

N

T

D

K

L

G

G

E

Q

I

K

M

L

R

K

T

D

A

G

L

L

Q

L

D

A

I

I

A

A

D

E

Q

K

Y

H

P

P

E

E

K

I

N

G

F

-

K

D

V

V

R

R

G

G

K

L

G

G

M

A

M

M

Q

I

A

A

L

I

D

E

I

L

-

F

-

E

-

D

-

G

-

D

-

H

-

N

-

K

G

P

D

D

G

A

T

K

L

L

S

T

K

A

A

E

I

I

A

V

R

A

D

R

C

A

F

R

E

D

H

K

G

G

M

L

L

I

F

L

G

L

P

S

C

C

G

G

I

P

G

Y

G
x
Y

E

N

V

V

M

L

K
x
R

L

I

I

L

P

V

P

P

L

L

T

T

I

I

P

E

E

D

A

A

D

Q

L

I

Q

R

S

Q

G

G

L

L

A

E

I

I

F

I

K

S

E

Q

S

C

I

F

D

D

active site: V18 (≠ Y14), Y137 (≠ F136), E205 (= E202), D238 (= D235), Q241 (= Q238), K267 (= K264), T296 (= T294), R397 (≠ K388)
binding pyridoxal-5'-phosphate: G110 (= G109), S111 (≠ T110), Y137 (≠ F136), H138 (= H137), E205 (= E202), D238 (= D235), V240 (≠ I237), Q241 (= Q238), K267 (= K264)
binding sulfate ion: N152 (= N149), Y393 (≠ G384)

P22256 4-aminobutyrate aminotransferase GabT; 5-aminovalerate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT; EC 2.6.1.19; EC 2.6.1.48 from Escherichia coli (strain K12) (see 2 papers)
32% identity, 96% coverage: 12:412/418 of query aligns to 17:422/426 of P22256

query
sites
P22256

R

R

A

G

Y

V

S

G

R

Q

A

I

Y

H

P

P

A

I

V

F

F

A

V

D

K

R

G

A

D

E

N

N

A

C

R

R

Q

V

V

W

D

D

E

V

D

E

G

G

K

R

V

E

Y

Y

I

L

D

D

F

F

Y

A

A

G

G

G

A
x
I

G

A

V

V

L

L

N

N

F

T

G

G

H

H

N

L

N

H

A

P

K

K

M

V

T

V

N

A

A

A

M

V

V

E

D

A

Y

Q

L

L

Q

K

S

K

G

-

V

L

I

S

H

H

T

T

L

C

D

-

M

F

M

Q

T

V

P

L

P

A

K

Y

R

E

N

P

F

Y

I

L

Q

E

A

-

F

L

V

C

E

E

T

I

I

M

L

N

Q

Q

P

K

R

V

N

P

M

G

D

D

Y

F

-

A

K

K

L

K

Q

T

F

L

M

L

G

V

P

T

T

T

G
|
G

T
x
S

N

E

A

A

V

V

E

E

A

N

A

A

L

V

K

K

L

I

A

A

R

R

K

A

V

A

T

T

G

K

R

R

E

S

Q

G

V

T

V

I

S

A

F

F

T

S

Q

G

G

A

F

Y

H

H

G

G

M

R

T

T

L

H

G

Y

A

T

L

L

A

A

C

L

T

T

-

G

-

K

A

V

N

N

S

P

Y

Y

F

-

R

-

N

-

A

S

A

A

G

G

V

M

S

G

L

L

-

M

-

P

N

G

N

H

V

V

I

Y

R

R

-

A

-

L

W

Y

P

P

F

C

E

P

T

L

H

H

E

G

G

I

G

S

G

E

L

D

D

D

S

A

L

I

N

A

T

S

L

I

R

H

A

R

L

I

F

F

K

K

N

N

S

D

S

A

G

A

G

-

T

P

E

E

P

D

P

I

A

A

F

I

M

V

V

I

E

E

V

P

V

V

Q

Q

A

G

E
|
E

G

G

V

F

N

Y

V

A

A

S

S

S

T

P

E

A

W

F

M

M

Q

Q

A

R

L

L

Q

R

K

A

L

L

A

C

K

D

D

E

L

H

G

G

A

I

L

M

L

L

I

I

V

A

D

D

D

E

I
x
V

Q
|
Q

A

S

G

G

C

A

G

G

R

R

T

T

G

G

H

T

Y

L

F

F

S

A

F

M

E

E

E

Q

M

M

G

G

I

V

Q

A

P

P

D

D

I

L

I

T

T

T

L

F

A

A

K
|
K

G

S

I

I

G

A

G

G

I

-

G

G

T

F

P

P

M

L

A

A

M

G

N

V

L

T

V

G

K

R

P

A

E

E

H

V

D

M

K

D

H

A

W

V

Q

A

P

P

G

G

E

G

H

L

T

G

G

G

T
|
T

F

Y

R

A

G

G

Q

N

N

P

L

I

S

A

F

C

V

V

A

A

G

A

R

L

E

E

A

V

L

L

R

K

Y

V

F

F

E

E

D

Q

N

E

R

N

F

L

M

L

E

Q

E

K

T

A

R

N

T

D

K

L

G

G

E

Q

I

K

M

L

R

K

T

D

A

G

L

L

Q

L

D

A

I

I

A

A

D

E

Q

K

Y

H

P

P

E

E

K

I

N

G

F

-

K

D

V

V

R

R

G

G

K

L

G

G

M

A

M

M

Q

I

A

A

L

I

D

E

I

L

-

F

-

E

-

D

-

G

-

D

-

H

-

N

-

K

G

P

D

D

G

A

T

K

L

L

S

T

K

A

A

E

I

I

A

V

R

A

D

R

C

A

F

R

E

D

H

K

G

G

M

L

L

I

F

L

G

L

P

S

C

C

G

G

I

P

G

Y

E

N

V

V

M

L

K

R

L

I

I

L

P

V

P

P

L

L

T

T

I

I

P

E

E

D

A

A

D

Q

L

I

Q

R

S

Q

G

G

L

L

A

E

I

I

F

I

K

S

E

Q

S

C

I

F

D

D

I50 (≠ A45) mutation to Q: 3-fold decrease in catalytic activity and 12-fold decrease in affinity for GABA.
GS 111:112 (≠ GT 109:110) binding pyridoxal 5'-phosphate
E211 (= E207) mutation to S: 100-fold decrease in catalytic activity and 15-fold decrease in affinity for GABA.
V241 (≠ I237) mutation to A: 25-fold decrease in catalytic activity and 5-fold decrease in affinity for GABA.
Q242 (= Q238) binding pyridoxal 5'-phosphate
K268 (= K264) modified: N6-(pyridoxal phosphate)lysine
T297 (= T294) binding pyridoxal 5'-phosphate

1wkhA Acetylornithine aminotransferase from thermus thermophilus hb8
35% identity, 91% coverage: 21:401/418 of query aligns to 22:376/387 of 1wkhA

query
sites
1wkhA

V

L

F

I

V

V

K

R

G

G

D

Q

N

G

A

A

R

R

Q

V

V

W

D

D

E

A

D

E

G

G

K

N

V

E

Y

Y

I

I

D

D

F

C

Y

V

A

G

G

G

A
x
Y

G

G

V

V

L

A

N

N

F

L

G

G

H

H

N

G

N

N

A

P

K

E

M

V

T

V

N

E

A

A

M

V

V

K

D

R

Y

-

L

-

Q

Q

S

A

G

E

G

T

V

L

I

M

H

A

T

M

L

P

D

Q

M

T

M

L

T

P

P

T

P

P

K

M

R

R

N

G

F

E

I

F

Q

Y

A

R

F

T

V

L

E

T

T

A

I

I

L

L

Q

P

P

P

R

-

N

-

M

-

D

E

Y

L

K

N

L

R

Q

V

F

F

M

P

G

V

P

N

T
x
S

G
|
G

T
|
T

N

E

A

A

V

N

E

E

A

A

L

L

K

K

L

F

A

A

R

R

K

A

V

H

T

T

G

G

R

R

E

K

Q

K

V

F

V

V

S

A

F

A

T

M

Q

R

G

G

F
|
F

H
x
S

G

G

M

R

T

T

L

M

G

G

A

S

L

L

A

S

C

V

T

T

A

W

N

E

S

P

Y

K

F

Y

R

R

N

E

A

P

A

F

G

L

V

P

S

L

L

V

N

E

N

P

V

V

I

E

R

F

W

I

P

P

F

Y

E

-

T

-

H

-

E

-

G

-

L

-

D

-

S

-

L

-

N

N

T

D

L

V

R

E

A

A

L

L

F

K

K

R

N

A

S

V

S

D

G

E

T

T

E

-

P

-

A

A

F

V

M

I

V

L

E
|
E

V

P

V

V

Q

Q

A

G

E
|
E

G

G

V

V

N

R

V

P

A

A

S

T

T

P

E

E

W

F

M

L

Q

R

A

A

L

A

Q

R

K

E

L

I

A

T

K

Q

D

E

L

K

G

G

A

A

L

L

I

I

V

L

D
|
D

D

E

I
|
I

Q
|
Q

A

T

G

G

C

M

G

G

R

R

T

T

G

G

H

K

Y

R

F

F

S

A

F

F

E

E

E

H

M

F

G

G

I

I

Q

V

P

P

D

D

I

I

I

L

T

T

L

L

A

A

K
|
K

G

A

I

L

G

G

I

-

G

G

T

V

P

P

M

L

A

G

M

V

N

A

L

V

V

M

K

R

P

E

E

E

H

V

D

A

K

R

H

S

W

M

Q

P

P

K

G

G

E

G

H

H

T

G

G

T

T
|
T

F

F

R

G

G

G

Q

N

N

P

L

L

S

A

F

M

V

A

A

A

G

G

R

V

E

A

A

A

L

I

R

R

Y

Y

F

L

E

E

D

R

N

T

R

R

F

L

M

W

E

E

E

R

T

A

R

A

T

E

K

L

G

G

E

P

I

W

M

F

R

M

T

E

A

K

L

L

Q

R

D

A

I

I

A

P

D

S

Q

P

Y

-

P

-

E

-

K

K

N

I

F

R

K

E

V

V

R

R

G

G

K

M

G

G

M

L

M

M

Q

V

A

G

L

L

D

E

I

L

G

K

D

E

G

K

T

A

L

-

S

A

K

P

A

Y

I

I

A

A

R

R

D

L

C

E

F

K

E

E

H

H

G

R

M

V

L

L

F

A

G

-

P

-

C

L

G

Q

I

A

G

G

G

P

E

T

V

V

M

I

K
x
R

L

F

I

L

P

P

L

L

T

V

I

I

P

E

E

K

A

E

D

D

L

L

Q

E

active site: F132 (= F136), E184 (= E202), D217 (= D235), Q220 (= Q238), K246 (= K264), T275 (= T294), R363 (≠ K388)
binding 4-[(1,3-dicarboxy-propylamino)-methyl]-3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridinium: Y46 (≠ A45), S104 (≠ T108), G105 (= G109), T106 (= T110), F132 (= F136), S133 (≠ H137), E184 (= E202), E189 (= E207), D217 (= D235), I219 (= I237), K246 (= K264), R363 (≠ K388)

Sites not aligning to the query:

active site: 13

1wkgA Acetylornithine aminotransferase from thermus thermophilus hb8
35% identity, 91% coverage: 21:401/418 of query aligns to 22:376/387 of 1wkgA

query
sites
1wkgA

V

L

F

I

V

V

K

R

G

G

D

Q

N

G

A

A

R

R

Q

V

V

W

D

D

E

A

D

E

G

G

K

N

V

E

Y

Y

I

I

D

D

F

C

Y

V

A

G

G

G

A
x
Y

G

G

V

V

L

A

N

N

F

L

G

G

H

H

N

G

N

N

A

P

K

E

M

V

T

V

N

E

A

A

M

V

V

K

D

R

Y

-

L

-

Q

Q

S

A

G

E

G

T

V

L

I

M

H

A

T

M

L

P

D

Q

M

T

M

L

T

P

P

T

P

P

K

M

R

R

N

G

F

E

I

F

Q

Y

A

R

F

T

V

L

E

T

T

A

I

I

L

L

Q

P

P

P

R

-

N

-

M

-

D

E

Y

L

K

N

L

R

Q

V

F

F

M

P

G

V

P

N

T

S

G
|
G

T
|
T

N

E

A

A

V

N

E

E

A

A

L

L

K

K

L

F

A

A

R

R

K

A

V

H

T

T

G

G

R

R

E

K

Q

K

V

F

V

V

S

A

F

A

T

M

Q

R

G

G

F
|
F

H
x
S

G

G

M
x
R

T

T

L

M

G

G

A

S

L

L

A

S

C

V

T

T

A

W

N

E

S

P

Y

K

F

Y

R

R

N

E

A

P

A

F

G

L

V

P

S

L

L

V

N

E

N

P

V

V

I

E

R

F

W

I

P

P

F

Y

E

-

T

-

H

-

E

-

G

-

L

-

D

-

S

-

L

-

N

N

T

D

L

V

R

E

A

A

L

L

F

K

K

R

N

A

S

V

S

D

G

E

T

T

E

-

P

-

A

A

F

V

M

I

V

L

E
|
E

V

P

V

V

Q

Q

A

G

E

E

G

G

V

V

N

R

V

P

A

A

S

T

T

P

E

E

W

F

M

L

Q

R

A

A

L

A

Q

R

K

E

L

I

A

T

K

Q

D

E

L

K

G

G

A

A

L

L

I

I

V

L

D
|
D

D

E

I
|
I

Q
|
Q

A

T

G

G

C

M

G

G

R

R

T

T

G

G

H

K

Y

R

F

F

S

A

F

F

E

E

E

H

M

F

G

G

I

I

Q

V

P

P

D

D

I

I

I

L

T

T

L

L

A

A

K
|
K

G

A

I

L

G

G

I

-

G

G

T

V

P

P

M

L

A

G

M

V

N

A

L

V

V

M

K

R

P

E

E

E

H

V

D

A

K

R

H

S

W

M

Q

P

P

K

G

G

E

G

H

H

T
x
G

G
x
T

T
|
T

F

F

R

G

G

G

Q

N

N

P

L

L

S

A

F

M

V

A

A

A

G

G

R

V

E

A

A

A

L

I

R

R

Y

Y

F

L

E

E

D

R

N

T

R

R

F

L

M

W

E

E

E

R

T

A

R

A

T

E

K

L

G

G

E

P

I

W

M

F

R

M

T

E

A

K

L

L

Q

R

D

A

I

I

A

P

D

S

Q

P

Y

-

P

-

E

-

K

K

N

I

F

R

K

E

V

V

R

R

G

G

K

M

G

G

M

L

M

M

Q

V

A

G

L

L

D

E

I

L

G

K

D

E

G

K

T

A

L

-

S

A

K

P

A

Y

I

I

A

A

R

R

D

L

C

E

F

K

E

E

H

H

G

R

M

V

L

L

F

A

G

-

P

-

C

L

G

Q

I

A

G

G

G

P

E

T

V

V

M

I

K
x
R

L

F

I

L

P

P

L

L

T

V

I

I

P

E

E

K

A

E

D

D

L

L

Q

E

active site: F132 (= F136), E184 (= E202), D217 (= D235), Q220 (= Q238), K246 (= K264), T275 (= T294), R363 (≠ K388)
binding n~2~-acetyl-n~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-l-ornithine: Y46 (≠ A45), G105 (= G109), T106 (= T110), F132 (= F136), S133 (≠ H137), R135 (≠ M139), E184 (= E202), D217 (= D235), I219 (= I237), Q220 (= Q238), K246 (= K264), G273 (≠ T292), T274 (≠ G293), T275 (= T294)

Sites not aligning to the query:

1vefA Acetylornithine aminotransferase from thermus thermophilus hb8
35% identity, 91% coverage: 21:401/418 of query aligns to 22:376/387 of 1vefA

query
sites
1vefA

V

L

F

I

V

V

K

R

G

G

D

Q

N

G

A

A

R

R

Q

V

V

W

D

D

E

A

D

E

G

G

K

N

V

E

Y

Y

I

I

D

D

F

C

Y

V

A

G

G

G

A

Y

G

G

V

V

L

A

N

N

F

L

G

G

H

H

N

G

N

N

A

P

K

E

M

V

T

V

N

E

A

A

M

V

V

K

D

R

Y

-

L

-

Q

Q

S

A

G

E

G

T

V

L

I

M

H

A

T

M

L

P

D

Q

M

T

M

L

T

P

P

T

P

P

K

M

R

R

N

G

F

E

I

F

Q

Y

A

R

F

T

V

L

E

T

T

A

I

I

L

L

Q

P

P

P

R

-

N

-

M

-

D

E

Y

L

K

N

L

R

Q

V

F

F

M

P

G

V

P

N

T

S

G
|
G

T
|
T

N

E

A

A

V

N

E

E

A

A

L

L

K

K

L

F

A

A

R

R

K

A

V

H

T

T

G

G

R

R

E

K

Q

K

V

F

V

V

S

A

F

A

T

M

Q

R

G

G

F
|
F

H
x
S

G

G

M

R

T

T

L

M

G

G

A

S

L

L

A

S

C

V

T

T

A

W

N

E

S

P

Y

K

F

Y

R

R

N

E

A

P

A

F

G

L

V

P

S

L

L

V

N

E

N

P

V

V

I

E

R

F

W

I

P

P

F

Y

E

-

T

-

H

-

E

-

G

-

L

-

D

-

S

-

L

-

N

N

T

D

L

V

R

E

A

A

L

L

F

K

K

R

N

A

S

V

S

D

G

E

T

T

E

-

P

-

A

A

F

V

M

I

V

L

E
|
E

V

P

V

V

Q

Q

A

G

E

E

G

G

V

V

N

R

V

P

A

A

S

T

T

P

E

E

W

F

M

L

Q

R

A

A

L

A

Q

R

K

E

L

I

A

T

K

Q

D

E

L

K

G

G

A

A

L

L

I

I

V

L

D
|
D

D

E

I
|
I

Q

Q

A

T

G

G

C

M

G

G

R

R

T

T

G

G

H

K

Y

R

F

F

S

A

F

F

E

E

E

H

M

F

G

G

I

I

Q

V

P

P

D

D

I

I

I

L

T

T

L

L

A

A

K
|
K

G

A

I

L

G

G

I

-

G

G

T

V

P

P

M

L

A

G

M

V

N

A

L

V

V

M

K

R

P

E

E

E

H

V

D

A

K

R

H

S

W

M

Q

P

P

K

G

G

E

G

H

H

T

G

G

T

T
|
T

F

F

R

G

G

G

Q

N

N

P

L

L

S

A

F

M

V

A

A

A

G

G

R

V

E

A

A

A

L

I

R

R

Y

Y

F

L

E

E

D

R

N

T

R

R

F

L

M

W

E

E

E

R

T

A

R

A

T

E

K

L

G

G

E

P

I

W

M

F

R

M

T

E

A

K

L

L

Q

R

D

A

I

I

A

P

D

S

Q

P

Y

-

P

-

E

-

K

K

N

I

F

R

K

E

V

V

R

R

G

G

K

M

G

G

M

L

M

M

Q

V

A

G

L

L

D

E

I

L

G

K

D

E

G

K

T

A

L

-

S

A

K

P

A

Y

I

I

A

A

R

R

D

L

C

E

F

K

E

E

H

H

G

R

M

V

L

L

F

A

G

-

P

-

C

L

G

Q

I

A

G

G

G

P

E

T

V

V

M

I

K
x
R

L

F

I

L

P

P

L

L

T

V

I

I

P

E

E

K

A

E

D

D

L

L

Q

E

active site: F132 (= F136), D217 (= D235), K246 (= K264), T275 (= T294), R363 (≠ K388)
binding pyridoxal-5'-phosphate: G105 (= G109), T106 (= T110), F132 (= F136), S133 (≠ H137), E184 (= E202), D217 (= D235), I219 (= I237), K246 (= K264)

Sites not aligning to the query:

active site: 13

1szkA The structure of gamma-aminobutyrate aminotransferase mutant: e211s (see paper)
32% identity, 96% coverage: 12:412/418 of query aligns to 16:421/425 of 1szkA

query
sites
1szkA

R

R

A

G

Y
x
V

S

G

R

Q

A

I

Y

H

P

P

A

I

V

F

F

A

V

D

K

R

G

A

D

E

N

N

A

C

R

R

Q

V

V

W

D

D

E

V

D

E

G

G

K

R

V

E

Y

Y

I

L

D

D

F

F

Y

A

A

G

G

G

A

I

G

A

V

V

L

L

N

N

F

T

G

G

H

H

N

L

N

H

A

P

K

K

M

V

T

V

N

A

A

A

M

V

V

E

D

A

Y

Q

L

L

Q

K

S

K

G

-

V

L

I

S

H

H

T

T

L

C

D

-

M

F

M

Q

T

V

P

L

P

A

K

Y

R

E

N

P

F

Y

I

L

Q

E

A

-

F

L

V

C

E

E

T

I

I

M

L

N

Q

Q

P

K

R

V

N

P

M

G

D

D

Y

F

-

A

K

K

L

K

Q

T

F

L

M

L

G

V

P

T

T

T

G
|
G

T
x
S

N

E

A

A

V

V

E

E

A

N

A

A

L

V

K

K

L

I

A

A

R

R

K

A

V

A

T

T

G

K

R

R

E

S

Q

G

V

T

V

I

S

A

F

F

T

S

Q

G

G

A

F
x
Y

H
|
H

G

G

M

R

T

T

L

H

G

Y

A

T

L

L

A

A

C

L

T

T

-

G

-

K

A

V

N

N

S

P

Y

Y

F

-

R

-

N

-

A

S

A

A

G

G

V

M

S

G

L

L

-

M

-

P

N

G

N

H

V

V

I

Y

R

R

-

A

-

L

W

Y

P

P

F

C

E

P

T

L

H

H

E

G

G

I

G

S

G

E

L

D

D

D

S

A

L

I

N

A

T

S

L

I

R

H

A

R

L

I

F

F

K

K

N

N

S

D

S

A

G

A

G

-

T

P

E

E

P

D

P

I

A

A

F

I

M

V

V

I

E
|
E

V

P

V

V

Q

Q

A

G

E

S

G

G

V

F

N

Y

V

A

A

S

S

S

T

P

E

A

W

F

M

M

Q

Q

A

R

L

L

Q

R

K

A

L

L

A

C

K

D

D

E

L

H

G

G

A

I

L

M

L

L

I

I

V

A

D
|
D

D

E

I
x
V

Q
|
Q

A

S

G

G

C

A

G

G

R

R

T

T

G

G

H

T

Y

L

F

F

S

A

F

M

E

E

E

Q

M

M

G

G

I

V

Q

A

P

P

D

D

I

L

I

T

T

T

L

F

A

A

K
|
K

G

S

I

I

G

A

G

G

I

-

G

G

T

F

P

P

M

L

A

A

M

G

N

V

L

T

V

G

K

R

P

A

E

E

H

V

D

M

K

D

H

A

W

V

Q

A

P

P

G

G

E

G

H

L

T

G

G

G

T
|
T

F

Y

R

A

G

G

Q

N

N

P

L

I

S

A

F

C

V

V

A

A

G

A

R

L

E

E

A

V

L

L

R

K

Y

V

F

F

E

E

D

Q

N

E

R

N

F

L

M

L

E

Q

E

K

T

A

R

N

T

D

K

L

G

G

E

Q

I

K

M

L

R

K

T

D

A

G

L

L

Q

L

D

A

I

I

A

A

D

E

Q

K

Y

H

P

P

E

E

K

I

N

G

F

-

K

D

V

V

R

R

G

G

K

L

G

G

M

A

M

M

Q

I

A

A

L

I

D

E

I

L

-

F

-

E

-

D

-

G

-

D

-

H

-

N

-

K

G

P

D

D

G

A

T

K

L

L

S

T

K

A

A

E

I

I

A

V

R

A

D

R

C

A

F

R

E

D

H

K

G

G

M

L

L

I

F

L

G

L

P

S

C

C

G

G

I

P

G

Y

E

N

V

V

M

L

K
x
R

L

I

I

L

P

V

P

P

L

L

T

T

I

I

P

E

E

D

A

A

D

Q

L

I

Q

R

S

Q

G

G

L

L

A

E

I

I

F

I

K

S

E

Q

S

C

I

F

D

D

active site: V18 (≠ Y14), Y137 (≠ F136), E205 (= E202), D238 (= D235), Q241 (= Q238), K267 (= K264), T296 (= T294), R397 (≠ K388)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G110 (= G109), S111 (≠ T110), Y137 (≠ F136), H138 (= H137), E205 (= E202), D238 (= D235), V240 (≠ I237), Q241 (= Q238), K267 (= K264)

2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
30% identity, 95% coverage: 14:409/418 of query aligns to 7:373/375 of 2eh6A

query
sites
2eh6A

Y

Y

S

A

R

R

A

L

Y

-

P

P

A

V

V

K

F

F

V

V

K

R

G

G

D

K

N

G

A

V

R

Y

Q

L

V

Y

D

D

E

E

D

E

G

G

K

K

V

E

Y

Y

I

L

D

D

F

F

Y

V

A

S

G

G

A

I

G

G

V

V

L

N

N

S

F

L

G

G

H

H

N

A

N

Y

A

P

K

K

M

L

T

T

N

E

A

A

M

L

V

K

D

E

Y

Q

L

V

Q

E

S

K

G

-

V

L

I

L

H

H

T

V

L

S

D

N

M

L

M

Y

T

E

P

N

P

P

K

-

R

-

N

-

F

W

I

Q

Q

E

A

E

F

L

V

A

E

H

T

K

I

L

L

V

Q

K

P

H

R

F

N

W

M

T

D

E

Y

G

K

K

L

V

Q

-

F

F

M

F

G

A

P

N

T

S

G
|
G

T
|
T

N

E

A

S

V

V

E

E

A

A

L

I

K

K

L

L

A

A

R

R

K

K

V

Y

-

W

-

R

-

D

-

K

-

G

T

K

G

N

R

K

E

W

Q

K

V

F

V

I

S

S

F

F

T

E

Q

N

G

S

F
|
F

H
|
H

G

G

M

R

T

T

L

Y

G

G

A

S

L

L

A

S

C

A

T

T

A

G

N

Q

S

P

Y

K

F

F

R

H

N

K

A

G

A

-

G

-

V

-

S

-

L

-

N

-

V

-

I

-

R

-

W

-

P

-

F

F

E

E

T

P

H

L

-

V

E

P

G

G

G

F

G

S

L

Y

D

A

S

K

L

L

N

N

T

D

L

I

R

D

A

S

L

V

F

Y

K

K

N

L

S

L

S

D

G

-

T

-

E

E

P

E

P

T

A

A

A

G

F

I

M

I

V

I

E
|
E

V

V

V

I

Q

Q

A

G

E

E

G

G

V

V

N

N

V

E

A

A

S

S

T

E

E

D

W

F

M

L

Q

S

A

K

L

L

Q

Q

K

E

L

I

A

C

K

K

D

E

L

K

G

D

A

V

L

L

I

I

V

I

D
|
D

D

E

I
x
V

Q
|
Q

A

T

G

G

C

I

G

G

R

R

T

T

G

G

H

E

Y

F

F

Y

S

A

F

Y

E

Q

E

H

M

F

G

N

I

L

Q

K

P

P

D

D

I

V

I

I

T

A

L

L

A

A

K
|
K

G

G

I

L

G

G

I

-

G

G

T

V

P

P

M

I

A

G

M

A

N

I

L

L

V

A

K

R

P

E

E

E

H

V

D

A

K

Q

H

S

W

F

Q

T

P

P

G

G

E

S

H

H

T

G

G

S

T
|
T

F

F

R

G

G

G

Q

N

N

P

L

L

S

A

F

C

V

R

A

A

G

G

R

T

E

V

A

V

L

V

R

D

Y

-

F

-

E

E

D

V

N

E

R

K

F

L

M

L

E

P

E

H

T

V

R

R

T

E

K

V

G

G

E

N

I

Y

M

F

R

K

T

E

A

K

L

L

Q

K

D

E

I

L

A

G

D

K

Q

G

Y

-

P

-

E

-

K

-

N

-

F

-

K

K

V

V

R

K

G

G

K

R

G

G

M

L

M

M

Q

L

A

G

L

L

D

E

I

L

G

E

D

R

G

E

T

C

L

-

S

-

K

K

A

D

I

Y

A

V

R

L

D

K

C

A

F

L

E

E

H

K

G

G

M

L

L

L

F

I

G

N

P

-

C

C

G

-

I

T

G

A

G

G

E

K

V

V

M

L

K
x
R

L

F

I

L

P

P

L

L

T

I

I

I

P

Q

E

K

A

E

D

H

L

I

Q

D

S

R

G

A

L

I

A

S

I

V

F

L

K

R

E

E

active site: F127 (= F136), E179 (= E202), D212 (= D235), Q215 (= Q238), K241 (= K264), T270 (= T294), R352 (≠ K388)
binding pyridoxal-5'-phosphate: G95 (= G109), T96 (= T110), F127 (= F136), H128 (= H137), E179 (= E202), D212 (= D235), V214 (≠ I237), K241 (= K264)

O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
30% identity, 95% coverage: 14:409/418 of query aligns to 8:374/376 of O66442

query
sites
O66442

Y

Y

S

A

R

R

A

L

Y

-

P

P

A

V

V

K

F

F

V

V

K

R

G

G

D

K

N

G

A

V

R

Y

Q

L

V

Y

D

D

E

E

D

E

G

G

K

K

V

E

Y

Y

I

L

D

D

F

F

Y

V

A

S

G

G

A

I

G

G

V

V

L

N

N

S

F

L

G

G

H

H

N

A

N

Y

A

P

K

K

M

L

T

T

N

E

A

A

M

L

V

K

D

E

Y

Q

L

V

Q

E

S

K

G

-

V

L

I

L

H

H

T

V

L

S

D

N

M

L

M

Y

T

E

P

N

P

P

K

-

R

-

N

-

F

W

I

Q

Q

E

A

E

F

L

V

A

E

H

T

K

I

L

L

V

Q

K

P

H

R

F

N

W

M

T

D

E

Y

G

K

K

L

V

Q

-

F

F

M

F

G

A

P

N

T

S

G
|
G

T
|
T

N

E

A

S

V

V

E

E

A

A

L

I

K

K

L

L

A

A

R

R

K

K

V

Y

-

W

-

R

-

D

-

K

-

G

T

K

G

N

R

K

E

W

Q

K

V

F

V

I

S

S

F

F

T

E

Q

N

G

S

F

F

H

H

G

G

M

R

T

T

L

Y

G

G

A

S

L

L

A

S

C

A

T

T

A

G

N

Q

S

P

Y

K

F

F

R

H

N

K

A

G

A

-

G

-

V

-

S

-

L

-

N

-

V

-

I

-

R

-

W

-

P

-

F

F

E

E

T

P

H

L

-

V

E

P

G

G

G

F

G

S

L

Y

D

A

S

K

L

L

N

N

T

D

L

I

R

D

A

S

L

V

F

Y

K

K

N

L

S

L

S

D

G

-

T

-

E

E

P

E

P

T

A

A

A

G

F

I

M

I

V

I

E

E

V

V

V

I

Q

Q

A

G

E

E

G

G

V

V

N

N

V

E

A

A

S

S

T

E

E

D

W

F

M

L

Q

S

A

K

L

L

Q

Q

K

E

L

I

A

C

K

K

D

E

L

K

G

D

A

V

L

L

I

I

V

I

D

D

D

E

I

V

Q

Q

A

T

G

G

C

I

G

G

R

R

T

T

G

G

H

E

Y

F

F

Y

S

A

F

Y

E

Q

E

H

M

F

G

N

I

L

Q

K

P

P

D

D

I

V

I

I

T

A

L

L

A

A

K
|
K

G

G

I

L

G

G

I

-

G

G

T

V

P

P

M

I

A

G

M

A

N

I

L

L

V

A

K

R

P

E

E

E

H

V

D

A

K

Q

H

S

W

F

Q

T

P

P

G

G

E

S

H

H

T

G

G

S

T
|
T

F

F

R

G

G

G

Q

N

N

P

L

L

S

A

F

C

V

R

A

A

G

G

R

T

E

V

A

V

L

V

R

D

Y

-

F

-

E

E

D

V

N

E

R

K

F

L

M

L

E

P

E

H

T

V

R

R

T

E

K

V

G

G

E

N

I

Y

M

F

R

K

T

E

A

K

L

L

Q

K

D

E

I

L

A

G

D

K

Q

G

Y

-

P

-

E

-

K

-

N

-

F

-

K

K

V

V

R

K

G

G

K

R

G

G

M

L

M

M

Q

L

A

G

L

L

D

E

I

L

G

E

D

R

G

E

T

C

L

-

S

-

K

K

A

D

I

Y

A

V

R

L

D

K

C

A

F

L

E

E

H

K

G

G

M

L

L

L

F

I

G

N

P

-

C

C

G

-

I

T

G

A

G

G

E

K

V

V

M

L

K

R

L

F

I

L

P

P

L

L

T

I

I

I

P

Q

E

K

A

E

D

H

L

I

Q

D

S

R

G

A

L

I

A

S

I

V

F

L

K

R

E

E

GT 96:97 (= GT 109:110) binding pyridoxal 5'-phosphate
K242 (= K264) modified: N6-(pyridoxal phosphate)lysine
T271 (= T294) binding pyridoxal 5'-phosphate

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
30% identity, 96% coverage: 11:411/418 of query aligns to 4:382/385 of Q9X2A5

query
sites
Q9X2A5

I

M

R

N

A

T

Y

Y

S

S

R

R

A

-

Y

F

P

P

A

A

V

T

F

F

V

V

K

Y

G

G

D

K

N

G

A

S

R

W

Q

I

V

Y

D

D

E

E

D

K

G

G

K

N

V

A

Y

Y

I

L

D

D

F

F

Y

T

A

S

G

G

A

I

G

A

V

V

L

N

N

V

F

L

G

G

H

H

N

S

N

H

A

P

K

R

M

L

T

V

N

E

A

A

M

I

V

K

D

D

Y

-

L

-

Q

Q

S

A

G

E

G

K

V

L

I

I

H

H

T

C

L

S

D

N

M

L

M

F

T

W

P

-

K

-

R

-

N

N

F

R

I

P

Q

Q

A

M

F

E

V

L

E

A

T

E

I

L

L

L

Q

S

P

K

R

N

N

T

M

F

D

G

Y

G

K

K

L

V

Q

-

F

F

M

F

G

A

P

N

T

T

G
|
G

T
|
T

N

E

A

A