SitesBLAST

Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
32% identity, 85% coverage: 3:208/243 of query aligns to 2:232/234 of Q7WTT9

query
sites
Q7WTT9

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C12 (= C13) binding [4Fe-4S] cluster
C15 (= C16) binding [4Fe-4S] cluster
C18 (= C19) binding [4Fe-4S] cluster
C22 (= C23) binding [4Fe-4S] cluster
C57 (= C74) binding [4Fe-4S] cluster
C60 (= C77) binding [4Fe-4S] cluster
C65 (= C82) binding [4Fe-4S] cluster
C69 (= C86) binding [4Fe-4S] cluster
C89 (= C107) binding [4Fe-4S] cluster
C92 (= C110) binding [4Fe-4S] cluster
C95 (= C113) binding [4Fe-4S] cluster
C99 (= C117) binding [4Fe-4S] cluster
C164 (= C134) binding [4Fe-4S] cluster
C167 (= C137) binding [4Fe-4S] cluster
C179 (= C155) binding [4Fe-4S] cluster
C183 (= C159) binding [4Fe-4S] cluster

6f0kB Alternative complex iii (see paper)
32% identity, 83% coverage: 3:203/243 of query aligns to 723:950/961 of 6f0kB

query
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6f0kB

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binding fe3-s4 cluster: C803 (= C86), V805 (≠ T88), M818 (≠ V102), C823 (= C107), I824 (= I108), G825 (= G109), C829 (= C113), M869 (= M131)
binding heme c: N821 (≠ D105), R822 (≠ K106), R884 (vs. gap), N887 (vs. gap)
binding iron/sulfur cluster: C733 (= C13), T734 (≠ V14), G735 (= G15), C736 (= C16), N737 (≠ S17), A738 (= A18), C739 (= C19), C743 (= C23), W765 (≠ F50), I768 (≠ V54), C791 (= C74), M792 (≠ L75), H793 (= H76), C794 (= C77), P798 (= P81), C799 (= C82), N816 (≠ V100), C833 (= C117), C872 (= C134), Y874 (≠ L136), C875 (= C137), A901 (= A154), C902 (= C155), C906 (= C159)

Sites not aligning to the query:

binding heme c: 719

P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
38% identity, 69% coverage: 2:169/243 of query aligns to 3:155/205 of P18776

query
sites
P18776

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C102 (= C110) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

8k9fB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 2.9 angstrom (see paper)
31% identity, 86% coverage: 5:213/243 of query aligns to 711:951/951 of 8k9fB

query
sites
8k9fB

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binding fe3-s4 cluster: C787 (= C86), P788 (= P87), M802 (≠ V102), C807 (= C107), G809 (= G109), T810 (≠ C110), K811 (= K111), Y812 (= Y112), C813 (= C113)
binding heme c: N805 (≠ D105), R806 (≠ K106), R867 (≠ T145), K871 (≠ D149)
binding iron/sulfur cluster: C719 (= C13), G721 (= G15), C722 (= C16), N723 (≠ S17), C725 (= C19), C729 (= C23), N733 (= N27), W751 (≠ F51), I752 (≠ N52), P772 (= P71), C775 (= C74), M776 (≠ L75), Q777 (≠ H76), C778 (= C77), C783 (= C82), N800 (≠ V100), C817 (= C117), Y819 (= Y119), V821 (≠ A121), C856 (= C134), Y858 (≠ L136), C859 (= C137), T891 (≠ P153), C893 (= C155), C897 (= C159), P898 (= P160), T899 (= T161)

Sites not aligning to the query:

8k9eB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 3.3 angstrom (see paper)
31% identity, 86% coverage: 5:213/243 of query aligns to 711:951/951 of 8k9eB

query
sites
8k9eB

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-

D

-

G

-

A

-

I

K

Q

P
x
T

A

A

C
|
C

V

E

L

Q

A

A

C
|
C

P

P

T
|
T

S

G

A

A

R

I

L

V

F

F

G

G

D

D

V

I

H

N

D

D

P

S

A

N

S

S

E

R

V

V

S

A

I

K

A

W

I

K

N

A

E

E

R

G

G

H

G

N

Y

Y

Q

G

L

L

M

L

P

G

E

F

W

L

G

N

T

T

R

V

P

P

A

R

N

T

H

T

Y

Y

L

L

P

A

R

R

H

V

K

R

V

N

K

P

S

S

Q

E

V

E

T

L

E

E

E

K

binding fe3-s4 cluster: C787 (= C86), M802 (≠ V102), C807 (= C107), V808 (≠ I108), G809 (= G109), T810 (≠ C110), K811 (= K111), Y812 (= Y112), C813 (= C113), M853 (= M131)
binding heme c: N805 (≠ D105), R867 (≠ T145), K871 (≠ D149)
binding iron/sulfur cluster: C719 (= C13), I720 (≠ V14), G721 (= G15), C722 (= C16), N723 (≠ S17), C725 (= C19), C729 (= C23), N733 (= N27), I754 (≠ V54), C775 (= C74), M776 (≠ L75), C778 (= C77), P782 (= P81), C783 (= C82), N800 (≠ V100), C817 (= C117), Y819 (= Y119), V821 (≠ A121), R822 (= R122), C856 (= C134), Y858 (≠ L136), C859 (= C137), T891 (≠ P153), C893 (= C155), C897 (= C159), T899 (= T161)

Sites not aligning to the query:

binding heme c: 3

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
35% identity, 68% coverage: 2:167/243 of query aligns to 28:187/294 of P0AAJ3

query
sites
P0AAJ3

T

A

Q

E

L

V

A

A

L

K

V

L

I

I

D

D

L

V

N

S

V

T

C
|
C

V

I

G

G

C
|
C

S

K

A

A

C
|
C

V

Q

T

V

S

A

C
|
C

K

S

E

E

W

W

N

N

-

D

T

I

S

R

S

D

E

E

G

V

G

G

K

H

-

C

-

V

G

G

M

V

V

Y

D

D

K

-

N

N

P

P

Y

-

G

-

K

A

D

D

P

L

T

S

G

A

T

K

F

S

F

W

N

T

R

V

V

M

Q

R

T

F

F

S

E

E

V

T

G

E

E

Q

Y

N

P

G

N

K

V

L

E

E

T

W

V

L

H

I

F

R

P

K

K

D

S

G

C
|
C

L

M

H

H

C
|
C

E

E

D

D

P

P

P

G

C
|
C

V

L

P

K

V

A

C
|
C

P

P

T

S

G

A

A

G

S

A

Y

I

K

I

R

Q

K

Y

E

A

D

N

G

G

I

I

V

V

L

D

V

F

D

Q

Y

S

D

E

K

N

C
|
C

I

I

G

G

C
|
C

K

G

Y

Y

C
|
C

S

I

W

A

A

G

C
|
C

P

P

Y

F

G

N

A

I

R

P

E

R

I

L

D

N

E

K

Q

E

Q

D

K

N

V

R

M

V

K

Y

K

K

C
|
C

T

T

L

L

C
|
C

V

V

D

D

R

R

I

V

Y

-

D

-

T

-

L

-

R

-

E

S

D

V

R

G

R

Q

K

E

P

P

A

A

C
|
C

V

V

L

K

A

T

C
|
C

P

P

T

T

S

G

A

A

R

I

L

H

F

F

G

G

C39 (= C13) binding [4Fe-4S] cluster
C42 (= C16) binding [4Fe-4S] cluster
C45 (= C19) binding [4Fe-4S] cluster
C49 (= C23) binding [4Fe-4S] cluster
C100 (= C74) binding [4Fe-4S] cluster
C103 (= C77) binding [4Fe-4S] cluster
C108 (= C82) binding [4Fe-4S] cluster
C112 (= C86) binding [4Fe-4S] cluster
C133 (= C107) binding [4Fe-4S] cluster
C136 (= C110) binding [4Fe-4S] cluster
C139 (= C113) binding [4Fe-4S] cluster
C143 (= C117) binding [4Fe-4S] cluster
C160 (= C134) binding [4Fe-4S] cluster
C163 (= C137) binding [4Fe-4S] cluster
C175 (= C155) binding [4Fe-4S] cluster
C179 (= C159) binding [4Fe-4S] cluster

1kqfB Formate dehydrogenase n from e. Coli (see paper)
35% identity, 68% coverage: 2:167/243 of query aligns to 27:186/289 of 1kqfB

query
sites
1kqfB

T

A

Q

E

L

V

A

A

L
x
K

V

L

I

I

D

D

L

V

N

S

V

T

C
|
C

V
x
I

G
|
G

C
|
C

S
x
K

A

A

C
|
C

V

Q

T

V

S

A

C
|
C

K

S

E

E

W

W

N
|
N

-

D

T

I

S

R

S

D

E

E

G

V

G

G

K

H

-

C

-

V

G

G

M

V

V

Y

D

D

K

-

N

N

P

P

Y

-

G

-

K

A

D

D

P

L

T

S

G

A

T

K

F

S

F

W

N
x
T

R

V

V
x
M

Q

R

T

F

F

S

E

E

V

T

G

E

E

Q

Y

N

P

G

N

K

V

L

E

E

T

W

V

L

H

I

F

R

P

K

K

D

S

G

C
|
C

L
x
M

H
|
H

C
|
C

E

E

D

D

P
|
P

P

G

C
|
C

V

L

P

K

V

A

C
|
C

P
|
P

T

S

G

A

A

G

S

A

Y
x
I

K

I

R

Q

K

Y

E

A

D

N

G

G

I

I

V
|
V

L

D

V

F

D

Q

Y

S

D

E

K

N

C
|
C

I
|
I

G
|
G

C
|
C

K
x
G

Y
|
Y

C
|
C

S

I

W

A

A

G

C
|
C

P

P

Y

F

G

N

A
x
I

R
x
P

E

R

I

L

D

N

E

K

Q

E

Q

D

K

N

V

R

M
x
V

K

Y

K
|
K

C
|
C

T

T

L
|
L

C
|
C

V

V

D

D

R

R

I

V

Y

-

D

-

T

-

L

-

R

-

E

S

D

V

R

G

R

Q

K

E

P
|
P

A

A

C
|
C

V

V

L

K

A

T

C
|
C

P
|
P

T

T

S

G

A

A

R
x
I

L

H

F

F

G

G

binding protoporphyrin ix containing fe: Y137 (= Y112)
binding iron/sulfur cluster: K31 (≠ L6), C38 (= C13), I39 (≠ V14), G40 (= G15), C41 (= C16), K42 (≠ S17), C44 (= C19), C48 (= C23), N52 (= N27), T77 (≠ N52), M79 (≠ V54), C99 (= C74), M100 (≠ L75), H101 (= H76), C102 (= C77), P105 (= P80), C107 (= C82), C111 (= C86), P112 (= P87), I117 (≠ Y92), V125 (= V100), C132 (= C107), I133 (= I108), G134 (= G109), C135 (= C110), G136 (≠ K111), Y137 (= Y112), C138 (= C113), C142 (= C117), I146 (≠ A121), P147 (≠ R122), V156 (≠ M131), K158 (= K133), C159 (= C134), L161 (= L136), C162 (= C137), P172 (= P153), C174 (= C155), C178 (= C159), P179 (= P160), I183 (≠ R164)

Sites not aligning to the query:

binding protoporphyrin ix containing fe: 252

5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
30% identity, 82% coverage: 3:202/243 of query aligns to 7:256/329 of 5ch7B

query
sites
5ch7B

Q

Q

L

L

A

T

L

Y

V

V

I

T

D

D

L

L

N

N

V

K

C
|
C

V
x
I

G
|
G

C
|
C

S
x
Q

A

T

C
|
C

V

T

T

V

S

A

C
|
C

K

K

E

K

-

L

-
x
W

-

T

-

G

-

P

-

G

-

Q

-

D

-

F

-

M

-

Y

-

W

-
x
R

-

N

-
x
V

-

E

-

T

-

A

-

P

-

G

-

L

-

G

-

Y

-

P

-

R

-

N

W

W

N

Q

T

T

S

K

S

G

E

G

G

G

G

Y

K

K

G

N

-

G

-

E

-

L

-

Q

-

K

-

G

-

K

-

I

-

P

M

M

V

I

D

D

K

Y

N

G

-

I

P

P

Y

F

G

E

K

F

D

D

P

Y

T

A

G

G

T

R

F

L

F

F

-

E

-

G

-

K

-

P

-

G

-

R

-

V

-

R

-

P

-

S

-

P

-

T

-

P

-

R

-

S

-

A

-

P

N

N

R

W

V

D

Q

E

T

D

F

Q

E

G

V

A

G

G

E

E

Y

Y

P

P

N

N

V

N

E

S

T

F

V

F

H

Y

F

L

P
|
P

K

R

S

M

C
|
C

L
x
N

H

H

C
|
C

E

T

D

K

P
|
P

P

A

C
|
C

V

L

P

E

V

A

C
|
C

P

P

T

N

G

E

A

A

S
x
I

Y

Y

K

K

R

R

K

E

E

Q

D

D

G

G

I

I

V

V

L

V

V

I

D

H

Y

Q

D

D

K

K

C
|
C

I
x
K

G
|
G

C
x
A

K
x
Q

Y
x
A

C
|
C

S

V

W

Q

A

S

C
|
C

P

P

Y

Y

G

A

A

K

R

P

E

Y

I

F

D

N

E

P

Q

L

Q

T

K

N

V

K

M
x
A

K

N

K

K

C
|
C

T

I

L
x
G

C
|
C

V

F

D

P

R

R

I

I

Y

-

D

-

T

-

L

-

R

-

E

E

D

Q

R

G

R

V

K

A

P

P

A

A

C
|
C

V

V

L

A

A

Q

C
|
C

P
x
V

T
x
G

S

R

A

A

R

M

L

H

F

V

G

G

D

F

V

V

H

D

D

D

P

V

A

N

S

S

E

S

V

V

S

Y

I

K

A

L

I

I

N

K

E

Q

-

Y

R

K

G

V

G

A

Y

L

Q

P

L

L

M

H

P

P

E

E

W

F

G

G

T

T

R

E

P

P

A

N

N

V

H

F

Y

Y

L

V

P

P

binding fe3-s4 cluster: C145 (= C86), I150 (≠ S91), C166 (= C107), K167 (≠ I108), G168 (= G109), A169 (≠ C110), Q170 (≠ K111), A171 (≠ Y112), C172 (= C113), A190 (≠ M131)
binding iron/sulfur cluster: C17 (= C13), I18 (≠ V14), G19 (= G15), C20 (= C16), Q21 (≠ S17), C23 (= C19), C27 (= C23), W31 (vs. gap), R43 (vs. gap), V45 (vs. gap), P130 (= P71), C133 (= C74), N134 (≠ L75), C136 (= C77), P139 (= P80), C141 (= C82), C176 (= C117), C193 (= C134), G195 (≠ L136), C196 (= C137), C208 (= C155), C212 (= C159), V213 (≠ P160), G214 (≠ T161)

2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
37% identity, 66% coverage: 43:202/243 of query aligns to 106:259/337 of 2ivfB

query
sites
2ivfB

G

G

K

K

D

D

P

P

T

A

G

W

T

G

F

Y

F

-

N

N

R

W

V

D

Q

E

T

D

F

Q

E

G

V

G

G

G

E

K

Y

W

P

P

N

N

V

P

E

F

T

F

V

F

H

Y

F

L

P

A

K

R

S
x
M

C
|
C

L
x
N

H
|
H

C
|
C

E

T

D

N

P
|
P

P

A

C
|
C

V

L

P

A

V

A

C
|
C

P

P

T
|
T

G

G

A

A

S
x
I

Y

Y

K

K

R

R

K

E

E

D

D

N

G

G

I

I

V
|
V

L

L

V

V

D

D

Y

Q

D

E

K

R

C
|
C

I
x
K

G
|
G

C
x
H

K
x
R

Y
x
H

C
|
C

S

V

W

E

A

A

C
|
C

P

P

Y

Y

G

K

A
|
A

R
x
I

E

Y

I

F

D

N

E

P

Q

V

Q

S

K

Q

V

T

M
x
S

K

E

K
|
K

C
|
C

T
x
I

L
|
L

C
|
C

V

Y

D

P

R

R

I

I

Y

-

D

-

T

-

L

-

R

-

E

E

D

K

R

G

R

I

K

A

P
x
N

A

A

C
|
C

V

N

L

R

A

Q

C
|
C

P

P

T

G

S

R

A
x
V

R
|
R

L

A

F

F

G

G

D

Y

V

L

H

D

D

D

P

T

A

T

S

S

E

H

V

V

S

H

I

K

A

L

I

V

N

K

E

K

-

W

R

K

G

V

G

A

Y

L

Q

P

L

L

M

H

P

A

E

E

W

Y

G

G

T

T

R

G

P

P

A

N

N

I

H

Y

Y

Y

L

V

P

P

binding fe3-s4 cluster: C148 (= C86), T150 (= T88), I153 (≠ S91), C169 (= C107), K170 (≠ I108), G171 (= G109), H172 (≠ C110), R173 (≠ K111), H174 (≠ Y112), C175 (= C113), S193 (≠ M131)
binding protoporphyrin ix containing fe: T150 (= T88), K170 (≠ I108), H172 (≠ C110)
binding iron/sulfur cluster: M135 (≠ S73), C136 (= C74), N137 (≠ L75), H138 (= H76), C139 (= C77), P142 (= P80), C144 (= C82), V162 (= V100), C179 (= C117), A183 (= A121), I184 (≠ R122), K195 (= K133), C196 (= C134), I197 (≠ T135), L198 (= L136), C199 (= C137), N209 (≠ P153), C211 (= C155), C215 (= C159), V219 (≠ A163), R220 (= R164)

Sites not aligning to the query:

binding iron/sulfur cluster: 13, 14, 15, 16, 17, 19, 23, 27, 38, 39, 41

6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
29% identity, 83% coverage: 5:205/243 of query aligns to 684:921/929 of 6lodB

query
sites
6lodB

A

G

L

M

V

S

I

I

D

D

L

L

N

N

V

V

C
|
C

V
x
N

G
x
S

C
|
C

S
x
N

A
|
A

C
|
C

V

V

T

V

S

A

C
|
C

K

Q

E

S

W

E

N
|
N

T

N

S

I

S

P

E

V

G

V

G

G

K

K

G

-

M

-

V

-

D

D

K

E

N

V

P

W

Y

L

G

G

K

R

D

E

P

-

T

-

G

-

T

M

F

H

F
x
W

N

I

R

R

V
x
I

Q

D

T

Q

F

Y

E

Y

V

V

G

G

E

D

Y

E

P

H

N

T

V

P

E

N

T

V

V

Y

H

N

F

M

P

V

K

M

S
x
L

C
|
C

L
x
Q

H
x
Q

C
|
C

E

E

D

H

P

A

P
|
P

C
|
C

V

E

P

I

V
|
V

C
|
C

P
|
P

T

V

G

A

A

A

S

T

Y

V

K

H

R

D

K

A

E

E

D

-

G

G

I

L

V
x
N

L

N

V

M

D

V

Y

Y

D
x
N

K
x
R

C
|
C

I
x
V

G
|
G

C
x
T

K

K

Y

Y

C
|
C

S

S

W

N

A

N

C
|
C

P

P

Y
|
Y

G

K

A
x
V

R
|
R

E

R

I

F

D

N

E

F

Q

L

Q

Q

-

Y

-

Q

-

D

-

V

-

P

-

Y

-

R

-

S

-

P

-

I

-

D

-

A

-

S

-

T

-

E

-

N

-

D

-

S

-

I

-

P

-

V

-

L

-

K

-

M

-

R

-

N

-

P

-

D

-

V

-

T

-

V

-

R

-

A

-

R

K

G

V

V

M
|
M

K

E

K
|
K

C
|
C

T

T

L
x
F

C
|
C

V

V

D

Q

R

R

I

I

Y

N

D

E

T

A

T
x
R

L
x
I

R

Q

-

A

-
x
R

-

T

E

E

D

N

R

R

-

I

-

A

-

D

-

G

-

E

-

I

K

M

P
x
T

A

A

C
|
C

V

Q

L

Q

A

V

C
|
C

P

P

T

T

S

Q

A

A

R
x
I

L

V

F

F

G

G

D

D

V

L

H

N

D

D

P

P

A

Q

S

A

E

R

V

V

S

V

I

D

A

L

I

K

N

E

E

Q

R

P

G

L

G

K

Y

Y

Q

T

L

S

M

L

P

D

E

K

W

L

G

N

T

T

R

K

P

P

A

R

N

V

H

S

Y

Y

L

L

P

A

R

K

H

I

K

K

binding fe3-s4 cluster: V758 (= V85), C759 (= C86), P760 (= P87), C779 (= C107), V780 (≠ I108), G781 (= G109), T782 (≠ C110), C785 (= C113), M838 (= M131)
binding heme c: N777 (≠ D105), R778 (≠ K106), R852 (≠ T145), I853 (≠ L146), R856 (vs. gap)
binding iron/sulfur cluster: C692 (= C13), N693 (≠ V14), S694 (≠ G15), C695 (= C16), N696 (≠ S17), A697 (= A18), C698 (= C19), C702 (= C23), N706 (= N27), W724 (≠ F51), I727 (≠ V54), L746 (≠ S73), C747 (= C74), Q748 (≠ L75), Q749 (≠ H76), C750 (= C77), P754 (= P81), C755 (= C82), N772 (≠ V100), C789 (= C117), Y791 (= Y119), V793 (≠ A121), R794 (= R122), K840 (= K133), C841 (= C134), F843 (≠ L136), C844 (= C137), T869 (≠ P153), C871 (= C155), C875 (= C159), I880 (≠ R164)

4v4cB Pyrogallol hydroxytransferase small subunit (see paper)
30% identity, 82% coverage: 1:200/243 of query aligns to 1:188/274 of 4v4cB

query
sites
4v4cB

M

M

T

E

Q

Q

L

Y

A

Y

L

M

V

V

I

I

D

D

L

V

N

A

V

K

C
|
C

V
x
Q

G
x
D

C
|
C

S
x
N

A
x
N

C
|
C

V

F

T

M

S

G

C
|
C

K

M

E

D

W

E

N

H

T

E

S

L

S

N

E

E

-

W

-

P

G

G

G

Y

K

T

G

A

M

S

V

M

D

Q

K

R

N

-

P

-

Y

-

G

-

K

-

D

-

P

-

T

-

G

G

T

H

F

R

F

W

N

M

R

N

V

I

Q

E

T

R

F

R

E

E

V

R

G

G

E

T

Y

Y

P

P

N

R

V

N

E

D

T
x
I

V
x
N

H

Y

F

R

P

P

K

T

S

P

C
|
C

L
x
M

H
|
H

C
|
C

E

E

D

N

P

A

P

P

C
|
C

V

V

P

A

V

K

C

-

P

G

T

N

G

G

A

A

S

V

Y

Y

K

Q

R

R

K

-

E

E

D

D

G

G

I

I

V
|
V

L

L

V

I

D

D

Y

P

D

E

K

K

C

A

I

K

G

G

C

K

K

K

Y

E

C

L

S

L

W

D

A

T

C
|
C

P

P

Y

Y

G

G

A
x
V

R

M

E

Y

I

W

D

N

E

E

Q

E

K

N

V

V

M

A

K

Q

K

K

C
|
C

T

T

L
x
M

C
|
C

V

A

D

H

R

L

I

L

Y

D

D

D

T

E

T

S

L

W

R

A

E

P

D

-

R

-

R

K

K

M

P
|
P

A

R

C
|
C

V

A

L

H

A

N

C
|
C

P

G

T
x
S

S

F

A
x
V

R
x
Y

L

E

F

F

G

-

D

-

V

L

H

K

D

T

P

T

A

P

S

E

E

A

V

M

S

A

I

K

A

K

I

V

N

E

E

E

R

E

G

G

G

L

Y

E

Q

V

L

I

M

K

P

P

E

E

W

L

G

G

T

T

R

K

P

P

A

R

N

V

H

Y

Y

Y

binding calcium ion: I61 (≠ T67), N62 (≠ V68)
binding iron/sulfur cluster: C13 (= C13), Q14 (≠ V14), D15 (≠ G15), C16 (= C16), N17 (≠ S17), N18 (≠ A18), C19 (= C19), C23 (= C23), C68 (= C74), M69 (≠ L75), H70 (= H76), C71 (= C77), C76 (= C82), V92 (= V100), C109 (= C117), V113 (≠ A121), C126 (= C134), M128 (≠ L136), C129 (= C137), P143 (= P153), C145 (= C155), C149 (= C159), S151 (≠ T161), V153 (≠ A163), Y154 (≠ R164)

3egwB The crystal structure of the narghi mutant narh - c16a
34% identity, 56% coverage: 51:187/243 of query aligns to 161:294/509 of 3egwB

query
sites
3egwB

F

F

N

D

R

N

V

I

Q

Q

T

K

F

A

E

M

V

Y

G

S

E

Q

Y

F

P

E

N

N

V

T

E

F

T

M

V

M

H

Y

F

L

P
|
P

K

R

S

L

C
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C

L
x
E

H
|
H

C
|
C

E

L

D

N

P
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P

P

A

C
|
C

V

V

P

A

V

T

C
|
C

P

P

T
x
S

G

G

A

A

S
x
I

Y

Y

K

K

R

R

K

E

E

E

D

D

G

G

I

I

V

V

L

L

V

I

D

D

Y

Q

D

D

K

K

C
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C

I
x
R

G
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G

C
x
W

K
x
R

Y

M

C
|
C

S

I

W

T

A

G

C
|
C

P

P

Y

Y

G

K

A

K

R
x
I

E

Y

I

F

D

N

E

W

Q

K

Q

S

K

G

V

K

M
x
S

K

E

K
|
K

C
|
C

T

I

L
x
F

C
|
C

V

Y

D

P

R

R

I

I

Y

-

D

-

T

-

L

-

R

-

E

E

D

A

R

G

R

Q

K

P

P
x
T

A

V

C
|
C

V

S

L

E

A

T

C
|
C

P

V

T
x
G

S

R

A

I

R
|
R

L

Y

F

L

G

G

D

V

V

L

H

L

D

Y

P

D

A

A

S

D

E

A

V

I

S

E

I

R

A

A

I

A

-

S

-

T

-

E

N

N

E

E

R

K

G

D

G

L

Y

Y

Q

Q

binding fe3-s4 cluster: P181 (= P71), C196 (= C86), S198 (≠ T88), I201 (≠ S91), C217 (= C107), R218 (≠ I108), G219 (= G109), W220 (≠ C110), R221 (≠ K111), C223 (= C113), S241 (≠ M131), C263 (= C159), G265 (≠ T161), R268 (= R164)
binding protoporphyrin ix containing fe: W220 (≠ C110), R221 (≠ K111)
binding iron/sulfur cluster: C184 (= C74), E185 (≠ L75), H186 (= H76), C187 (= C77), P190 (= P80), C192 (= C82), C227 (= C117), I232 (≠ R122), K243 (= K133), C244 (= C134), F246 (≠ L136), C247 (= C137), T257 (≠ P153), C259 (= C155)

Sites not aligning to the query:

binding fe3-s4 cluster: 17, 18, 19, 20, 22
binding protoporphyrin ix containing fe: 88, 89
binding iron/sulfur cluster: 26, 30, 41, 42

P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
34% identity, 56% coverage: 51:187/243 of query aligns to 161:294/512 of P11349

query
sites
P11349

F

F

N

D

R

N

V

I

Q

Q

T

K

F

A

E

M

V

Y

G

S

E

Q

Y

F

P

E

N

N

V

T

E

F

T

M

V

M

H

Y

F

L

P

P

K

R

S

L

C
|
C

L

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H

H

C
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C

E

L

D

N

P

P

P

A

C
|
C

V

V

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A

V

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C
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C

P

P

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S

G

G

A

A

S

I

Y

Y

K

K

R

R

K

E

E

E

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D

G

G

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I

V

V

L

L

V

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D

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Y

Q

D

D

K

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C

I

R

G

G

C

W

K

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Y

M

C
|
C

S

I

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A

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C
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C

P

P

Y

Y

G

K

A

K

R

I

E

Y

I

F

D

N

E

W

Q

K

Q

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K

G

V

K

M

S

K

E

K

K

C
|
C

T

I

L

F

C
|
C

V

Y

D

P

R

R

I

I

Y

-

D

-

T

-

L

-

R

-

E

E

D

A

R

G

R

Q

K

P

P

T

A

V

C
|
C

V

S

L

E

A

T

C
|
C

P

V

T

G

S

R

A

I

R

R

L

Y

F

L

G

G

D

V

V

L

H

L

D

Y

P

D

A

A

S

D

E

A

V

I

S

E

I

R

A

A

I

A

-

S

-

T

-

E

N

N

E

E

R

K

G

D

G

L

Y

Y

Q

Q

C184 (= C74) binding [4Fe-4S] cluster
C187 (= C77) binding [4Fe-4S] cluster
C192 (= C82) binding [4Fe-4S] cluster
C196 (= C86) binding [3Fe-4S] cluster
C217 (= C107) binding [3Fe-4S] cluster
C223 (= C113) binding [3Fe-4S] cluster
C227 (= C117) binding [4Fe-4S] cluster
C244 (= C134) binding [4Fe-4S] cluster
C247 (= C137) binding [4Fe-4S] cluster
C259 (= C155) binding [4Fe-4S] cluster
C263 (= C159) binding [4Fe-4S] cluster

Sites not aligning to the query:

16 binding [4Fe-4S] cluster
19 binding [4Fe-4S] cluster
22 binding [4Fe-4S] cluster
26 binding [4Fe-4S] cluster

7b04A of Nitrite oxidoreductase (Nxr) from the anammox bacterium Kuenenia stuttgartiensis.
35% identity, 56% coverage: 68:202/243 of query aligns to 168:306/409 of 7b04A

query
sites
7b04A

V

F

H

Y

F

L

P
x
Q

K

R

S
x
I

C
|
C

L
x
N

H
|
H

C
|
C

E

T

D

Y

P
|
P

P

G

C
|
C

V

L

P

A

V

A

C
|
C

P

P

T
x
R

G

K

A

A

S
x
I

Y

Y

K

K

R

R

K

K

E

E

D

D

G

G

I

I

V

V

L

L

V

I

D

D

Y

Q

D

K

K

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C
|
C

I
x
R

G
|
G

C
x
Y

K
x
R

Y
x
K

C
|
C

S

V

W

E

A

Q

C
|
C

P

P

Y

Y

G

K

A

K

R
x
P

E

M

I

Y

D

R

E

G

Q

L

Q

T

K

R

V

V

M
x
S

K

E

K
|
K

C
|
C

T

I

L
x
A

C
|
C

V

Y

D

P

R

R

I

I

Y

E

D

G

T

R

T

D

L

S

R

L

E

T

D

D

R

G

R

R

-

P

-

M

K

E

P
x
T

A
x
R

C
|
C

V

M

L

S

A

A

C
|
C

P
x
V

T

G

S

Q

A
x
I

R
|
R

L

L

F

Q

G

G

D

F

V

L

H

D

D

D

-

N

P

P

A

K

S

N

E

P

V

I

S

T

I

W

A

L

I

I

-

R

N

H

E

Q

R

K

G

I

G

A

Y

L

Q

P

L

L

M

Y

P

P

E

Q

W

F

G

G

T

T

R

E

P

P

A

N

N

I

H

Y

Y

Y

L

I

P

P

binding fe3-s4 cluster: C186 (= C86), I191 (≠ S91), C207 (= C107), R208 (≠ I108), G209 (= G109), Y210 (≠ C110), R211 (≠ K111), K212 (≠ Y112), C213 (= C113), S231 (≠ M131)
binding protoporphyrin ix containing fe: R188 (≠ T88), R208 (≠ I108), Y210 (≠ C110)
binding iron/sulfur cluster: Q171 (≠ P71), I173 (≠ S73), C174 (= C74), N175 (≠ L75), H176 (= H76), C177 (= C77), P180 (= P80), C182 (= C82), C217 (= C117), P222 (≠ R122), K233 (= K133), C234 (= C134), A236 (≠ L136), C237 (= C137), T255 (≠ P153), R256 (≠ A154), C257 (= C155), C261 (= C159), V262 (≠ P160), I265 (≠ A163), R266 (= R164)

Sites not aligning to the query:

binding iron/sulfur cluster: 34, 35, 36, 37, 38, 40, 44, 48, 59, 60, 62

6btmB Structure of alternative complex iii from flavobacterium johnsoniae (wild type) (see paper)
26% identity, 80% coverage: 6:200/243 of query aligns to 686:942/948 of 6btmB

query
sites
6btmB

L

L

V

S

I

I

D

D

L

L

N

N

V

A

C

C

V

T

G

G

C

C

S

G

A

A

C

C

V

V

T

I

S

A

C

C

K

H

E

A

W

E

N

N

T

N

S

V

S

P

E

V

G

V

G

G

K

K

G

A

M

E

V

V

D

R

K

R

N

S

P

R

-

D

-

M

-

H

-

W

-

L

-

R

-

I

-

D

-

R

-

Y

Y

Y

G

S

K

S

D

E

P

S

T

T

-

F

-

E

-

G

-

D

-

N

-

E

-

R

-

K

-

E

-

G

-

I

G

A

T

G

F

L

F

S

N

S

R

S

V

L

Q

S

T

T

F

F

E

N

V

E

G

M

E

E

Y

K

P

P

-

G

-

D

N

N

V

P

E

Q

T

V

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A

H

F

F

Q

P

P

K

V

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M

C
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C

L
x
Q

H

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C

E

N

D

H

P

A

P

P

C
|
C

V

E

P

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V

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C
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C

P

P

T

V

G

A

A

A

S

T

Y

S

K

H

R

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K

R

E

Q

D

-

G

G

I

Q

V
x
N

L

H

V

M

D

A

Y

Y

D

N

K

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C
|
C

I
x
V

G

G

C
x
T

K

R

Y

Y

C
|
C

S

A

W

N

A

N

C
|
C

P

P

Y

Y

G

K

A

V

R
|
R

E

R

I

F

D

N

-

W

-

F

-

L

-

Y

-

N

-

K

-

N

-

S

-

E

-

F

-

D

-

Y

-

H

-

M

-

N

-

D

-

L

-

G

-

R

-

M

-

V

-

L

-

N

-

P

-

D

-

V

-

N

-

V

E

R

Q

S

Q

R

K

G

V

V

M
|
M

K

E

K

K

C

C

T

S

L

F

C

C

V

I

D

Q

R

S

I

T

Y

Q

D

A

T

V

T

I

L

L

R

E

E

A

D

K

R

R

R

Q

K

G

P

R

A

V

C

V

-

G

-

K

-

D

-

E

-

F

-

N

-

A

-

C

-

A

-

C

V

S

L

A

A

A

C

C

P

S

T

S

S

G

A

A

R

M

L

V

F

F

G

G

D

D

V

V

H

N

D

D

P

K

A

E

S

S

E

E

V

V

S

A

I

K

A

L

I

A

N

E

E

S

R

E

G

R

G

M

Y

Y

Q

H

L

L

M

L

P

E

E

H

W

V

G

G

T

T

R

K

P

P

A

N

N

V

H

F

Y

Y

binding fe3-s4 cluster: C789 (= C86), C809 (= C107), V810 (≠ I108), T812 (≠ C110), C815 (= C113), M862 (= M131)
binding iron/sulfur cluster: C777 (= C74), Q778 (≠ L75), C780 (= C77), C785 (= C82), N802 (≠ V100), C819 (= C117), R824 (= R122)

Sites not aligning to the query:

binding (2R)-3-{[(2R)-2-(decanoylamino)-3-hydroxypropyl]sulfanyl}propane-1,2-diyl ditetradecanoate: 1, 2

8cm6D W-formate dehydrogenase c872a from desulfovibrio vulgaris - with formamide (see paper)
30% identity, 67% coverage: 6:168/243 of query aligns to 4:165/214 of 8cm6D

query
sites
8cm6D

L
x
F

V

F

I

V

D

D

L

L

N

S

V

R

C
|
C

V
x
T

G
x
A

C
|
C

S
x
R

A

G

C
|
C

V

Q

T

I

S

A

C
|
C

K

K

E

Q

W

W

-
x
K

N

N

T

L

S

P

S

A

E

E

G

E

G

T

K

R

G

N

M

T

V

G

D

S

K

H

N

-

P

-

Y

-

G

-

K

Q

D

N

P

P

T

P

G

D

T

L

F

S

F

Y

N

V

R

T

V

L

Q
x
K

T

T

F

V

E

R

V

F

G

T

E

E

Y

K

-

S

-
x
R

-

K

-

G

P
|
P

N

G

V

I

E

D

T

W

V

L

H

F

F

F

P

P

K

E

S

Q

C
|
C

L
x
R

H

H

C
|
C

E

V

D

E

P
|
P

C
|
C

-

K

-

G

-

Q

V

A

P

D

V

V

C

D

P

L

T

E

G

G

A

A

S

V

Y

V

K

K

R

D

K

E

E

T

D

T

G

G

I

A

V
|
V

L

L

-

F

V

T

D

E

Y

L

D

T

K

A

C

K

I

V

G

D

C

G

K

E

Y

S

C

V

S

R

W

S

A

A

C
|
C

P

P

Y

Y

G

D

A
x
I

R
x
P

E

R

I

I

D

D

E

P

Q

V

Q

T

K

K

V

R

M

L

K

S

K
|
K

C
|
C

T
x
D

L
x
M

C
|
C

V

N

D

D

R

R

I

V

Y

Q

D

N

T

G

T

L

L

L

R

-

E

-

D

-

R

-

K

-

P

P

A

A

C
|
C

V

V

L

K

A

T

C
|
C

P
|
P

T
|
T

S

G

A
x
T

R
x
M

L

N

F

F

G

G

D

D

binding formamide: R59 (vs. gap), P62 (= P63)
binding iron/sulfur cluster: F4 (≠ L6), C11 (= C13), T12 (≠ V14), A13 (≠ G15), C14 (= C16), R15 (≠ S17), C17 (= C19), C21 (= C23), K25 (vs. gap), K50 (≠ Q55), C73 (= C74), R74 (≠ L75), C76 (= C77), P79 (= P80), P80 (= P81), C81 (= C82), V102 (= V100), C120 (= C117), I124 (≠ A121), P125 (≠ R122), K136 (= K133), C137 (= C134), D138 (≠ T135), M139 (≠ L136), C140 (= C137), C152 (= C155), C156 (= C159), P157 (= P160), T158 (= T161), T160 (≠ A163), M161 (≠ R164)

8bqgB W-formate dehydrogenase from desulfovibrio vulgaris - soaking with formate 1 min (see paper)
30% identity, 67% coverage: 6:168/243 of query aligns to 4:165/214 of 8bqgB

query
sites
8bqgB

L
x
F

V

F

I

V

D

D

L

L

N

S

V

R

C
|
C

V
x
T

G
x
A

C
|
C

S
x
R

A

G

C
|
C

V

Q

T

I

S

A

C
|
C

K

K

E

Q

W

W

-
x
K

N

N

T

L

S

P

S

A

E

E

G

E

G

T

K

R

G

N

M

T

V

G

D

S

K

H

N

-

P

-

Y

-

G

-

K

Q

D

N

P

P

T

P

G

D

T

L

F

S

F

Y

N

V

R

T

V

L

Q
x
K

T

T

F

V

E

R

V

F

G

T

E

E

Y

K

-

S

-

R

-

K

-

G

P

P

N

G

V

I

E

D

T

W

V

L

H

F

F

F

P

P

K

E

S

Q

C
|
C

L
x
R

H

H

C
|
C

E

V

D

E

P

P

P
|
P

C
|
C

-

K

-

G

-

Q

V

A

P

D

V

V

C

D

P

L

T

E

G

G

A

A

S

V

Y

V

K

K

R

D

K

E

E

T

D

T

G

G

I

A

V
|
V

L

L

-

F

V

T

D

E

Y

L

D

T

K

A

C

K

I

V

G

D

C

G

K

E

Y

S

C

V

S

R

W

S

A

A

C
|
C

P

P

Y

Y

G

D

A
x
I

R
x
P

E

R

I

I

D

D

E

P

Q

V

Q

T

K

K

V

R

M

L

K

S

K
|
K

C
|
C

T

D

L
x
M

C
|
C

V

N

D

D

R

R

I

V

Y

Q

D

N

T

G

T

L

L

L

R

-

E

-

D

-

R

-

K

-

P

P

A

A

C
|
C

V

V

L

K

A

T

C
|
C

P
|
P

T
|
T

S

G

A
x
T

R
x
M

L

N

F

F

G

G

D

D

binding iron/sulfur cluster: F4 (≠ L6), C11 (= C13), T12 (≠ V14), A13 (≠ G15), C14 (= C16), R15 (≠ S17), C17 (= C19), C21 (= C23), K25 (vs. gap), K50 (≠ Q55), C73 (= C74), R74 (≠ L75), C76 (= C77), P80 (= P81), C81 (= C82), V102 (= V100), C120 (= C117), I124 (≠ A121), P125 (≠ R122), K136 (= K133), C137 (= C134), M139 (≠ L136), C140 (= C137), C152 (= C155), C156 (= C159), P157 (= P160), T158 (= T161), T160 (≠ A163), M161 (≠ R164)

Query Sequence

>WP_028488974.1 NCBI__GCF_000621325.1:WP_028488974.1
MTQLALVIDLNVCVGCSACVTSCKEWNTSSEGGKGMVDKNPYGKDPTGTFFNRVQTFEVG
EYPNVETVHFPKSCLHCEDPPCVPVCPTGASYKRKEDGIVLVDYDKCIGCKYCSWACPYG
AREIDEQQKVMKKCTLCVDRIYDTTLREDRRKPACVLACPTSARLFGDVHDPASEVSIAI
NERGGYQLMPEWGTRPANHYLPRHKVKSQVTEESLNRIDNPLKKEEQRAPASNDLPSLDD
FLF

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory