SitesBLAST

4eaaA X-ray crystal structure of the h141n mutant of perosamine n- acetyltransferase from caulobacter crescentus in complex with coa and gdp-perosamine (see paper)
41% identity, 91% coverage: 14:202/207 of query aligns to 16:206/210 of 4eaaA

query
sites
4eaaA

H
|
H

G

A

K

K

V

V

A

I

G

E

A

S

L

L

I

R

S

A

A

C

G

G

Y

E

T

T

V

V

C

A

G

A

F

I

F
x
V

D
|
D

D
x
A

D

D

V

P

V

T

L

-

H

-

G

-

R

R

K

A

F

V

F

L

G

G

E

V

P

P

V

V

L

V

G

G

G

D

Q
x
D

E

L

D

A

F

L

A

P

V

M

L

L

E

R

A

E

-

Q

-

G

-

L

P

S

V

R

A

L

V

F

M

V

G

A

I
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I

G
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G

N

D

G

N

R

R

I

L

R

R

R

Q

M

K

I

L

M

G

E

R

R

K

-

A

-

R

-

D

-

H

-

G

F

F

S

S

L

L

V

V

Q

-

W

-

L

-

S

N

V

A

I

I

H

H

R

P

T

S

A

A

W

V

V

V

D

S

P

P

A

S

V

V

T

R

V

L

G

G

G

E

G

G

T

V

V

A

I

V

F

M

A

A

G

G

A

V

V

A

V

I

Q

N

P

A

D

D

S

S

R

W

I

I

G

G

K

D

H

L

C

A

I

I

N

N

T

T

G

G

A

A

T

V

V

V

D

D

H

N

D

D

C

C

V

R

V

L

G

G

D

A

Y

A

A

C

H

H

I

L

C

G

P
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P

G

A

V

S

N

A

L

L

A

A

G

G

N

G

V

V

T

S

V

V

G

G

A

E

G

R

A

A

W
x
F

V

L

G

G

I
x
V

G

G

S

A

Q

R

V

V

I

I

Q

P

G

G

V

V

T

T

I

I

G

G

A

A

H

D

A

T

V

I

V

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G

G

A
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A

G

G

A

G

T

V

V

V

T

V

R

R

D

D

V

L

P

P

E

D

G

S

V

V

T

L

V

A

V
x
I

G

G

T

V

P

P

A

A

K

K

binding coenzyme a: P150 (= P146), F165 (≠ W161), V168 (≠ I164), A186 (= A182), I201 (≠ V197)
binding GDP-perosamine: H16 (= H14), V35 (≠ F33), D36 (= D34), A37 (≠ D35), D52 (≠ Q53), I70 (= I68), G71 (= G69)

Sites not aligning to the query:

4ea9A X-ray structure of gdp-perosamine n-acetyltransferase in complex with transition state analog at 0.9 angstrom resolution (see paper)
41% identity, 91% coverage: 14:202/207 of query aligns to 16:204/207 of 4ea9A

query
sites
4ea9A

H
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H

G

A

K

K

V

V

A

I

G

E

A

S

L

L

I

R

S

A

A

C

G

G

Y

E

T

T

V

V

C

A

G

A

F

I

F
x
V

D
|
D

D
x
A

D

D

V

-

L

-

H

-

G

-

R

P

K

A

F

V

F

L

G

G

E

V

P

P

V

V

L

V

G

G

G

D

Q
x
D

E

L

D

A

F

L

A

P

V

M

L

L

E

R

A

E

-

Q

-

G

-

L

P

S

V

R

A

L

V

F

M

V

G

A

I
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I

G
|
G

N

D

G

N

R

R

I

L

R

R

R

Q

M

K

I

L

M

G

E

R

R

K

-

A

-

R

-

D

-

H

-

G

F

F

S

S

L

L

V

V

Q

-

W

-

L

-

S

N

V

A

I

I

H

H

R

P

T

S

A

A

W

V

V

V

D

S

P

P

A

S

V

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T

R

V

L

G

G

G

E

G

G

T

V

V

A

I

V

F

M

A

A

G

G

A

V

V

A

V

I

Q

N

P

A

D

D

S

S

R

W

I

I

G

G

K

D

H

L

C

A

I

I

N

N

T

T

G

G

A

A

T

V

V

V

D

D

H

H

D

D

C

C

V

R

V

L

G

G

D

A

Y

A

A

C

H
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H

I

L

C

G

P
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P

G

A

V

S

N

A

L

L

A

A

G

G

N

G

V

V

T

S

V

V

G

G

A

E

G

R

A

A

W
x
F

V

L

G
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G

I
x
V

G

G

S

A

Q

R

V

V

I

I

Q

P

G

G

V

V

T

T

I

I

G

G

A

A

H

D

A

T

V

I

V

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G

G

A
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A

G

G

A

G

T

V

V

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T

V

R

R

D

D

V

L

P

P

E

D

G

S

V

V

T

L

V

A

V
x
I

G

G

T

V

P

P

A

A

K

K

binding GDP-N-acetylperosamine-coenzyme A: H16 (= H14), V35 (≠ F33), D36 (= D34), A37 (≠ D35), D50 (≠ Q53), I68 (= I68), G69 (= G69), H145 (= H143), P148 (= P146), F163 (≠ W161), G165 (= G163), V166 (≠ I164), A184 (= A182), I199 (≠ V197)

Sites not aligning to the query:

binding GDP-N-acetylperosamine-coenzyme A: 14, 15, 206

4ea8A X-ray crystal structure of perb from caulobacter crescentus in complex with coenzyme a and gdp-n-acetylperosamine at 1 angstrom resolution (see paper)
41% identity, 91% coverage: 14:202/207 of query aligns to 16:204/207 of 4ea8A

query
sites
4ea8A

H
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H

G

A

K

K

V

V

A

I

G

E

A

S

L

L

I

R

S

A

A

C

G

G

Y

E

T

T

V

V

C

A

G

A

F

I

F
x
V

D
|
D

D
x
A

D

D

V

-

L

-

H

-

G

-

R

P

K

A

F

V

F

L

G

G

E

V

P

P

V

V

L

V

G

G

G

D

Q
x
D

E

L

D

A

F

L

A

P

V

M

L

L

E

R

A

E

-

Q

-

G

-

L

P

S

V

R

A

L

V

F

M

V

G

A

I
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I

G
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G

N

D

G

N

R

R

I

L

R

R

R

Q

M

K

I

L

M

G

E

R

R

K

-

A

-

R

-

D

-

H

-

G

F

F

S

S

L

L

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V

Q

-

W

-

L

-

S

N

V

A

I

I

H

H

R

P

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S

A

A

W

V

V

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D

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P

A

S

V

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L

G

G

G

E

G

G

T

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V

A

I

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F

M

A

A

G

G

A

V

V

A

V

I

Q

N

P

A

D

D

S

S

R

W

I

I

G

G

K

D

H

L

C

A

I

I

N

N

T

T

G

G

A

A

T

V

V

V

D

D

H

H

D

D

C

C

V

R

V

L

G

G

D

A

Y

A

A

C

H
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H

I

L

C

G

P

P

G

A

V

S

N

A

L

L

A

A

G

G

N

G

V

V

T

S

V

V

G

G

A

E

G

R

A

A

W
x
F

V

L

G
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G

I
x
V

G

G

S

A

Q

R

V

V

I

I

Q

P

G

G

V

V

T

T

I

I

G

G

A

A

H

D

A

T

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I

V

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G

G

A
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A

G

G

A

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T

V

V

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R

R

D

D

V

L

P

P

E

D

G

S

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V

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A

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I

G

G

T

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P

P

A

A

K

K

binding coenzyme a: H145 (= H143), F163 (≠ W161), G165 (= G163), V166 (≠ I164), A184 (= A182)
binding GDP-N-acetylperosamine: H16 (= H14), V35 (≠ F33), D36 (= D34), A37 (≠ D35), D50 (≠ Q53), I68 (= I68), G69 (= G69)

Sites not aligning to the query:

4m99A Acetyltransferase domain of pglb from neisseria gonorrhoeae fa1090 in complex with acetyl coenzyme a (see paper)
38% identity, 97% coverage: 3:203/207 of query aligns to 2:205/206 of 4m99A

query
sites
4m99A

K

N

N

R

S

K

V

L

Y

A

I

V

F

I

G

G

A

A

S

G

G

G

H

H

G

G

K

K

V

V

A

A

G

E

A

L

L

A

I

A

S

A

A

L

G

G

-

T

Y

Y

T

G

V

E

C

I

G

V

F

F

F

L

D

D

D

R

V

T

-

Q

-

G

V

S

L

V

H

N

G

G

R

F

K

P

F

V

F

I

G

G

E

T

P

T

V

L

L

L

G

-

Q

L

E

E

D

N

F

S

A

L

V

S

L

P

E

E

A

Q

P

F

V

D

A

I

V

T

M

V

G

A

I

V

G

G

N

N

G

N

R

R

I

I

R

R

M

Q

I

I

M

T

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E

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N

F

A

S

A

L

A

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L

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Q

K

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H

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A

A

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P

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M

A

A

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K

A

A

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Q

P

A

D

G

S

S

R

V

I

L

G

K

K

D

H

G

C

V

I

I

I

V

N

N

T

T

G

A

A

A

T

T

V

V

D
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D

H

H

D

D

C

C

V

L

G

D

D

A

Y

F

A

V

H

H

I

I

C

S

P
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P

G

G

V

A

N

H

L

L

A

S

G
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G

N

N

V

T

T

R

V

I

G

G

A

E

G

E

A

S

W

R

V

I

G
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G

I
x
T

G

G

S

A

Q

C

V

S

I
x
R

Q
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Q

G

Q

V

T

T

T

I

V

G

G

A

S

H

G

A

V

V

T

V

A

G
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G

A
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A

G

G

A

A

T

V

V

I

T
x
V

R

C

D

D

V

I

P

P

E

D

G

G

V

M

T

T

V

V

V
x
A

G

G

T
x
N

P

P

A

A

K

K

P

P

binding acetyl coenzyme *a: D135 (= D133), P148 (= P146), G154 (= G152), G165 (= G163), T166 (≠ I164), R171 (≠ I169), Q172 (= Q170), G183 (= G181), A184 (= A182), V189 (≠ T187), A199 (≠ V197), N201 (≠ T199)

3bsyA Pgld from campylobacter jejuni, nctc 11168, in complex with acetyl coenzyme a (see paper)
33% identity, 97% coverage: 2:202/207 of query aligns to 1:191/193 of 3bsyA

query
sites
3bsyA

R

R

K

T

N

E

S

K

V

I

Y

Y

I

I

F

Y

G

G

A

A

S

S

G

G

H

H

G

G

K

L

V

V

V

C

A

E

G

D

A

V

L

A

I

K

S

N

A

M

G

G

Y

Y

T

K

V

E

C

C

G

I

F

F

F

L

D

D

D

-

V

-

L

F

H

K

G

G

R

M

K

K

F

F

F

-

G

-

E

E

P

S

V

T

L

L

G

P

G

K

Q

Y

E

D

D

F

F

F

A

-

V

-

L

-

E

-

A

-

P

-

V

-

A

-

V

-

M

I

G

A

I

I

G

G

N

N

G

N

R

E

I

I

R

R

R

K

M

K

I

I

M

Y

E

Q

R

K

F

I

S

S

L

E

-

N

-

G

V

F

Q

K

W

I

L

V

S

N

V

L

I

I

H

H

R

K

T

S

A

A

W

L

V

I

D

S

P

P

A

S

V

A

T

I

V

V

-

E

G

N

G

A

G

G

T

I

V

L

I

I

F

M

A

P

G

Y

A

V

V

V

V

I

Q

N

P

A

D

K

S

A

R

K

I

I

G

E

K

K

H

G

C

V

I

I

I

L

N

N

T

T

G

S

A

S

T

V

V

I

D

E

H

H

D

E

C

C

V

V

V

I

G

G

D

E

Y

F

A

S

H
|
H

I

V

C
x
S

P
x
V

G

G

V

A

N

K

L

C

A
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A

G

G

N

N

V

V

T

K

V

I

G

G

A

K

G

N

A

C

W
x
F

V

L

G
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G

I
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I

G

N

S

S

Q

C

V

V

I
x
L

Q

P

G

N

V

L

T

S

I

L

G

A

A

D

H

D

A

S

V

I

V

L

G
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G

A
x
G

G

G

A

A

T

T

V

L

T
x
V

R

K

D

N

V

Q

P

D

E

E

G

K

V

G

T

V

V

F

V
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V

G

G

T

V

P
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P

A

A

K

K

binding acetyl coenzyme *a: H132 (= H143), S134 (≠ C145), V135 (≠ P146), A140 (= A151), F150 (≠ W161), G152 (= G163), I153 (= I164), L158 (≠ I169), G170 (= G181), G171 (≠ A182), V176 (≠ T187), V186 (= V197), P189 (= P200)

3bssA Pgld from campylobacter jejuni, nctc 11168, with native substrate (see paper)
33% identity, 97% coverage: 2:202/207 of query aligns to 2:192/194 of 3bssA

query
sites
3bssA

R

R

K

T

N

E

S

K

V

I

Y

Y

I

I

F

Y

G

G

A

A

S
|
S

G

G

H
|
H

G

G

K

L

V

V

V

C

A

E

G

D

A

V

L

A

I

K

S

N

A

M

G

G

Y

Y

T

K

V

E

C

C

G

I

F

F

F

L

D
|
D

D

-

V

-

L
x
F

H

K

G

G

R

M

K

K

F

F

F

-

G

-

E

E

P

S

V

T

L

L

G

P

G

K

Q

Y

E

D

D

F

F

F

A

-

V

-

L

-

E

-

A

-

P

-

V

-

A

-

V

-

M

I

G

A

I
|
I

G
|
G

N

N

G

N

R

E

I
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I

R

R

R

K

M

K

I

I

M

Y

E

Q

R

K

F

I

S

S

L

E

-

N

-

G

V

F

Q

K

W

I

L

V

S

N

V

L

I

I

H

H

R

K

T

S

A

A

W

L

V

I

D

S

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P

A

S

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A

T

I

V

V

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E

G

N

G

A

G

G

T

I

V

L

I

I

F

M

A

P

G

Y

A

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V

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V

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N

P

A

D

K

S

A

R

K

I

I

G

E

K

K

H

G

C

V

I

I

I

L

N

N

T

T

G

S

A

S

T

V

V

I

D

E

H

H

D

E

C

C

V

V

V

I

G

G

D

E

Y

F

A

S

H

H

I

V

C

S

P

V

G

G

V

A

N

K

L

C

A

A

G

G

N

N

V

V

T

K

V

I

G

G

A

K

G

N

A

C

W

F

V

L

G

G

I

I

G

N

S

S

Q

C

V

V

I

L

Q

P

G

N

V

L

T

S

I

L

G

A

A

D

H

D

A

S

V

I

V

L

G

G

A

G

G

G

A

A

T

T

V

L

T

V

R

K

D

N

V

Q

P

D

E

E

G

K

V

G

T

V

V

F

V

V

G

G

T

V

P

P

A

A

K

K

binding UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose: S12 (= S12), H14 (= H14), D34 (= D34), D35 (= D35), F36 (≠ L39), I54 (= I68), G55 (= G69), I59 (= I73)

2vheA Pgld-coa complex: an acetyl transferase from campylobacter jejuni (see paper)
33% identity, 97% coverage: 2:202/207 of query aligns to 2:192/194 of 2vheA

query
sites
2vheA

R

R

K

T

N

E

S

K

V

I

Y

Y

I

I

F

Y

G

G

A

A

S

S

G

G

H

H

G

G

K

L

V

V

V

C

A

E

G

D

A

V

L

A

I

K

S

N

A

M

G

G

Y

Y

T

K

V

E

C

C

G

I

F

F

F

L

D

D

D

-

V

-

L

F

H

K

G

G

R

M

K

K

F

F

F

-

G

-

E

E

P

S

V

T

L

L

G

P

G

K

Q

Y

E

D

D

F

F

F

A

-

V

-

L

-

E

-

A

-

P

-

V

-

A

-

V

-

M

I

G

A

I

I

G

G

N

N

G

N

R

E

I

I

R

R

R

K

M

K

I

I

M

Y

E

Q

R

K

F

I

S

S

L

E

-

N

-

G

V

F

Q

K

W

I

L

V

S

N

V

L

I

I

H

H

R

K

T

S

A

A

W

L

V

I

D

S

P

P

A

S

V

A

T

I

V

V

-

E

G

N

G

A

G

G

T

I

V

L

I

I

F

M

A

P

G

Y

A

V

V

V

V

I

Q

N

P

A

D

K

S

A

R

K

I

I

G

E

K

K

H

G

C

V

I

I

I

L

N

N

T

T

G

S

A

S

T

V

V

I

D

E

H

H

D

E

C

C

V

V

V

I

G

G

D

E

Y

F

A

S

H

H

I

V

C
x
S

P
x
V

G

G

V

A

N

K

L

C

A

A

G

G

N

N

V

V

T

K

V

I

G

G

A

K

G

N

A

C

W
x
F

V

L

G
|
G

I
|
I

G

N

S

S

Q

C

V

V

I

L

Q

P

G

N

V

L

T

S

I

L

G

A

A

D

H

D

A

S

V

I

V

L

G
|
G

A
x
G

G

G

A

A

T

T

V

L

T

V

R

K

D

N

V

Q

P

D

E

E

G

K

V

G

T

V

V

F

V
|
V

G

G

T

V

P

P

A

A

K

K

binding coenzyme a: S135 (≠ C145), V136 (≠ P146), F151 (≠ W161), G153 (= G163), I154 (= I164), G171 (= G181), G172 (≠ A182), V187 (= V197)

Sites not aligning to the query:

binding coenzyme a: 194

Q0P9D1 UDP-N-acetylbacillosamine N-acetyltransferase; Protein glycosylation D; UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase; EC 2.3.1.203 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see 2 papers)
33% identity, 97% coverage: 2:202/207 of query aligns to 3:193/195 of Q0P9D1

query
sites
Q0P9D1

R

R

K

T

N

E

S

K

V

I

Y

Y

I

I

F

Y

G

G

A

A

S

S

G

G

H
|
H

G

G

K

L

V

V

V

C

A

E

G

D

A

V

L

A

I

K

S

N

A

M

G

G

Y

Y

T

K

V

E

C

C

G

I

F

F

F

L

D

D

D

-

V

-

L

F

H

K

G

G

R

M

K

K

F

F

F

-

G

-

E

E

P

S

V

T

L

L

G

P

G

K

Q

Y

E

D

D

F

F

F

A

-

V

-

L

-

E

-

A

-

P

-

V

-

A

-

V

-

M

I

G

A

I

I

G

G

N

N

G

N

R

E

I

I

R

R

R

K

M

K

I

I

M

Y

E

Q

R

K

F

I

S

S

L

E

-

N

-

G

V

F

Q

K

W

I

L

V

S

N

V

L

I

I

H

H

R

K

T

S

A

A

W

L

V

I

D

S

P

P

A

S

V

A

T

I

V

V

-

E

G

N

G

A

G

G

T

I

V

L

I

I

F

M

A

P

G

Y

A

V

V

V

V

I

Q

N

P

A

D

K

S

A

R

K

I

I

G

E

K

K

H

G

C

V

I

I

I

L

N
|
N

T

T

G

S

A

S

T

V

V

I

D
x
E

H
|
H

D

E

C

C

V

V

V

I

G

G

D

E

Y

F

A

S

H
|
H

I

V

C

S

P

V

G

G

V

A

N

K

L

C

A

A

G

G

N

N

V

V

T

K

V

I

G

G

A

K

G

N

A

C

W

F

V

L

G

G

I
|
I

G

N

S

S

Q

C

V

V

I

L

Q

P

G

N

V

L

T

S

I

L

G

A

A

D

H

D

A

S

V

I

V

L

G

G

A
x
G

G

G

A

A

T

T

V

L

T

V

R

K

D

N

V

Q

P

D

E

E

G

K

V

G

T

V

V

F

V

V

G

G

T

V

P

P

A

A

K

K

H15 (= H14) mutation to A: Induces a higher KM and approximate 3-fold decrease in the turnover number.
N118 (= N127) mutation to A: Reduction in catalytic activity.
E124 (≠ D133) mutation to A: Reduction in catalytic activity.
H125 (= H134) active site, Proton acceptor; mutation to A: Strong reduction in catalytic activity.
H134 (= H143) binding acetyl-CoA; mutation to A: Slight reduction in catalytic activity.
I155 (= I164) binding acetyl-CoA
G173 (≠ A182) binding acetyl-CoA

5t2yA Crystal structure of c. Jejuni pgld in complex with 5-methyl-4- (methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid (see paper)
32% identity, 97% coverage: 2:202/207 of query aligns to 2:190/192 of 5t2yA

query
sites
5t2yA

R

R

K

T

N

E

S

K

V

I

Y

Y

I

I

F

Y

G

G

A

A

S

S

G

G

H

H

G

G

K

L

V

V

V

C

A

E

G

D

A

V

L

A

I

K

S

N

A

M

G

G

Y

Y

T

K

V

E

C

C

G

I

F

F

F

L

D

D

D

F

V

M

V

-

L

-

H

-

G

-

R

-

K

K

F

F

F

-

G

-

E

E

P

S

V

T

L

L

G

P

G

K

Q

Y

E

D

D

F

F

F

A

-

V

-

L

-

E

-

A

-

P

-

V

-

A

-

V

-

M

I

G

A

I

I

G

G

N

N

G

N

R

E

I

I

R

R

R

K

M

K

I

I

M

Y

E

Q

R

K

F

I

S

S

L

E

-

N

-

G

V

F

Q

K

W

I

L

V

S

N

V

L

I

I

H

H

R

K

T

S

A

A

W

L

V

I

D

S

P

P

A

S

V

A

T

I

V

V

-

E

G

N

G

A

G

G

T

I

V

L

I

I

F

M

A

P

G

Y

A

V

V

V

V

I

Q

N

P

A

D

K

S

A

R

K

I

I

G

E

K

K

H

G

C

V

I

I

I

L

N

N

T

T

G

S

A

S

T

V

V

I

D

E

H

H

D

E

C

C

V

V

V

I

G

G

D

E

Y

F

A

S

H

H

I

V

C
x
S

P

V

G

G

V

A

N

K

L

C

A

A

G

G

N

N

V

V

T

K

V

I

G

G

A

K

G

N

A

C

W
x
F

V

L

G
|
G

I
|
I

G

N

S

S

Q

C

V

V

I

L

Q

P

G

N

V

L

T

S

I

L

G

A

A

D

H

D

A

S

V

I

V

L

G

G

A
x
G

G

G

A

A

T

T

V

L

T

V

R

K

D

N

V

Q

P

D

E

E

G

K

V

G

T

V

V

F

V
|
V

G

G

T

V

P

P

A

A

K

K

binding 5-methyl-4-(methylamino)-2-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxylic acid: S133 (≠ C145), F149 (≠ W161), G151 (= G163), I152 (= I164), G170 (≠ A182), V185 (= V197)

5tyhA Pgld from campylobacter jejuni nctc 11168 in complex with 5-(2- furanyl)-1h-pyrazole-3-carboxylic acid (see paper)
29% identity, 97% coverage: 2:202/207 of query aligns to 2:183/185 of 5tyhA

query
sites
5tyhA

R

R

K

T

N

E

S

K

V

I

Y

Y

I

I

F

Y

G

G

A

-

S

-

G

-

H

H

G

G

K

L

V

V

V

C

A

E

G

D

A

V

L

A

I

K

S

N

A

M

G

G

Y

Y

T

K

V

E

C

C

G

I

F

F

F

L

D

D

D

F

D

E

V

S

V

T

L

L

H

P

G

K

R

Y

K

D

F

F

G

-

E

-

P

-

V

-

L

-

G

-

Q

-

E

-

D

-

F

-

A

-

V

-

L

-

E

-

A

-

P

-

V

-

A

-

V

-

M

I

G

A

I

I

G

G

N

N

G

N

R

E

I

I

R

R

R

K

M

K

I

I

M

Y

E

Q

R

K

F

I

S

S

L

E

-

N

-

G

V

F

Q

K

W

I

L

V

S

N

V

L

I

I

H

H

R

K

T

S

A

A

W

L

V
x
I

D
x
S

P

P

A

S

V

A

T

I

V

V

-

E

G

N

G

A

G

G

T

I

V

L

I

I

F

M

A

P

G

Y

A

V

V

V

V

I

Q
x
N

P

A

D

K

S

A

R

K

I

I

G

E

K

K

H

G

C

V

I

I

I

L

N
|
N

T

T

G

S

A

S

T

V

V

I

D

E

H

H

D

E

C

C

V

V

V

I

G

G

D

E

Y

F

A

S

H

H

I

V

C
x
S

P
x
V

G

G

V

A

N

K

L

C

A

A

G

G

N

N

V

V

T

K

V

I

G

G

A

K

G

N

A

C

W
x
F

V

L

G
|
G

I
|
I

G

N

S

S

Q

C

V

V

I

L

Q

P

G

N

V

L

T

S

I

L

G

A

A

D

H

D

A

S

V

I

V

L

G

G

A
x
G

G

G

A

A

T

T

V

L

T

V

R

K

D

N

V

Q

P

D

E

E

G

K

V

G

T

V

V

F

V

V

G

G

T

V

P

P

A

A

K

K

binding 3-(furan-2-yl)-1H-pyrazole-5-carboxylic acid: I75 (≠ V96), S76 (≠ D97), N96 (≠ Q115), N108 (= N127), S126 (≠ C145), V127 (≠ P146), F142 (≠ W161), G144 (= G163), I145 (= I164), G163 (≠ A182)

7txsA X-ray structure of the viob n-aetyltransferase from acinetobacter baumannii in the presence of a reaction intermediate (see paper)
32% identity, 96% coverage: 4:202/207 of query aligns to 2:203/209 of 7txsA

query
sites
7txsA

N

K

S

E

V

L

Y

I

I

I

F

V

G

G

A

A

S
x
G

G
|
G

H
|
H

G

G

K

N

V

E

V

I

A

S

G

W

A

L

L

A

I

K

S

R

A

C

G

G

Y

R

T

V

V

V

C

R

G

G

F

F

F

L

D
|
D

D
x
N

D
x
T

V

V

V

E

L
x
K

H

Q

G

G

R

T

K

F

F

I

F

R

G

D

E

I

P

P

V

V

L

L

G

G

G

T

Q

L

E

D

D

E

F

C

A

S

V

K

L

F

E

T

A

D

P

C

V

D

A

F

V

V

M

I

G

A

I
|
I

G
|
G

N

S

G

P

R

R

I

A

R

R

R

K

M
x
K

I
|
I

M

I

E

E

R

H

F

F

-

F

-

P

-

E

S

G

L

E

V

F

Q

T

W

F

L

A

S

T

V

L

I

I

H

D

R

P

T

T

A

A

W

T

V

I

D

G

P

E

A

N

V

I

T

H

V

I

G

E

G

G

T

T

V

M

I

I

F

C

A

A

G

G

A

G

V

I

V

L

Q

T

P

V

D

D

S

V

R

K

I

L

G

G

K

K

H

H

C

C

I

I

I

V

N

N

T

T

G

N

A

A

T

V

V

L

D

S

H

H

D

G

C

V

V

I

V

L

G

G

D

D

Y

Y

A

V

H

T

I

V

C

A

P
|
P

G

N

V

A

N

S

L

I

A

S

G

G

N

D

V

V

T

S

V

L

G

G

A

N

G

I

A

V

W

E

V

I

G
|
G

I
x
A

G

N

S

A

Q

T

V

I

I

R

Q

E

G

K

V

V

T

S

I

V

G

Q

A

D

H

G

A

A

V
x
M

V

V

G
|
G

A
x
M

G

G

A

S

T

V

V

V

T

I

R

R

D

N

V

I

P

L

E

S

G

N

V

Q

T

V

V

V

V
|
V

G

G

T

N

P

P

A

A

K

K

binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-4-({3-[(2-{[(1S)-1-{[(2R,3S,4S,5R,6R)-4,5-dihydroxy-6-{[(R)-hydroxy{[(R)-hydroxy{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)oxolan-2-yl]methoxy}phosphoryl]oxy}phosphoryl]oxy}-2-methyloxan-3-yl]amino}ethyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate (non-preferred name): G10 (≠ S12), G11 (= G13), H12 (= H14), D32 (= D34), N33 (≠ D35), T34 (≠ D36), K37 (≠ L39), I66 (= I68), G67 (= G69), K74 (≠ M76), I75 (= I77), P147 (= P146), G164 (= G163), A165 (≠ I164), M180 (≠ V179), G182 (= G181), M183 (≠ A182), V198 (= V197)

Sites not aligning to the query:

binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-4-({3-[(2-{[(1S)-1-{[(2R,3S,4S,5R,6R)-4,5-dihydroxy-6-{[(R)-hydroxy{[(R)-hydroxy{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)oxolan-2-yl]methoxy}phosphoryl]oxy}phosphoryl]oxy}-2-methyloxan-3-yl]amino}ethyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate (non-preferred name): 205

7txqA X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in the present of tdp and acetyl-coenzymea (see paper)
32% identity, 96% coverage: 4:202/207 of query aligns to 2:203/209 of 7txqA

query
sites
7txqA

N

K

S

E

V

L

Y

I

I

I

F

V

G

G

A

A

S
x
G

G
|
G

H
|
H

G

G

K

N

V

E

V

I

A

S

G

W

A

L

L

A

I

K

S

R

A

C

G

G

Y

R

T

V

V

V

C

R

G

G

F

F

F

L

D
|
D

D
x
N

D
x
T

V

V

V

E

L
x
K

H

Q

G

G

R

T

K

F

F

I

F

R

G

D

E

I

P

P

V

V

L

L

G

G

G

T

Q

L

E

D

D

E

F

C

A

S

V

K

L

F

E

T

A

D

P

C

V

D

A

F

V

V

M

I

G

A

I
|
I

G
|
G

N

S

G

P

R

R

I

A

R

R

R

K

M

K

I

I

M

I

E

E

R

H

F

F

-

F

-

P

-

E

S

G

L

E

V

F

Q

T

W

F

L

A

S

T

V

L

I

I

H

D

R

P

T

T

A

A

W

T

V

I

D

G

P

E

A

N

V

I

T

H

V

I

G

E

G

G

T

T

V

M

I

I

F

C

A

A

G

G

A

G

V

I

V

L

Q

T

P

V

D

D

S

V

R

K

I

L

G

G

K

K

H

H

C

C

I

I

I

V

N

N

T

T

G

N

A

A

T

V

V

L

D

S

H

H

D

G

C

V

V

I

V

L

G

G

D

D

Y

Y

A

V

H

T

I

V

C

A

P
|
P

G

N

V

A

N

S

L

I

A

S

G

G

N

D

V

V

T

S

V

L

G

G

A

N

G

I

A

V

W

E

V

I

G
|
G

I
x
A

G

N

S

A

Q

T

V

I

I

R

Q

E

G

K

V

V

T

S

I

V

G

Q

A

D

H

G

A

A

V

M

V

V

G
|
G

A
x
M

G

G

A

S

T

V

V

V

T

I

R

R

D

N

V

I

P

L

E

S

G

N

V

Q

T

V

V

V

V
|
V

G

G

T

N

P

P

A

A

K

K

binding acetyl coenzyme *a: P147 (= P146), G164 (= G163), A165 (≠ I164), G182 (= G181), M183 (≠ A182), V198 (= V197)
binding thymidine-5'-diphosphate: G10 (≠ S12), G11 (= G13), H12 (= H14), D32 (= D34), N33 (≠ D35), T34 (≠ D36), K37 (≠ L39), I66 (= I68), G67 (= G69)

Sites not aligning to the query:

binding acetyl coenzyme *a: 205

7txpA X-ray structure of the viob n-acetyltransferase from acinetobacter baumannii in complex with tdp-4-amino-4,6-dideoxy-d-glucose (see paper)
32% identity, 96% coverage: 4:202/207 of query aligns to 2:203/209 of 7txpA

query
sites
7txpA

N

K

S

E

V

L

Y

I

I

I

F

V

G

G

A

A

S
x
G

G
|
G

H
|
H

G

G

K

N

V

E

V

I

A

S

G

W

A

L

L

A

I

K

S

R

A

C

G

G

Y

R

T

V

V

V

C

R

G

G

F

F

F

L

D
|
D

D
x
N

D
x
T

V

V

V

E

L
x
K

H

Q

G

G

R

T

K

F

F

I

F

R

G

D

E

I

P

P

V

V

L

L

G

G

G

T

Q

L

E

D

D

E

F

C

A

S

V

K

L

F

E

T

A

D

P

C

V

D

A

F

V

V

M

I

G

A

I
|
I

G
|
G

N

S

G

P

R

R

I

A

R

R

R

K

M

K

I
|
I

M

I

E

E

R

H

F

F

-

F

-

P

-

E

S

G

L

E

V

F

Q

T

W

F

L

A

S

T

V

L

I

I

H

D

R

P

T

T

A

A

W

T

V

I

D

G

P

E

A

N

V

I

T

H

V

I

G

E

G

G

T

T

V

M

I

I

F

C

A

A

G

G

A

G

V

I

V

L

Q

T

P

V

D

D

S

V

R

K

I

L

G

G

K

K

H

H

C

C

I

I

I

V

N

N

T

T

G

N

A

A

T

V

V

L

D

S

H

H

D

G

C

V

V

I

V

L

G

G

D

D

Y

Y

A

V

H

T

I

V

C

A

P

P

G

N

V

A

N

S

L

I

A

S

G

G

N

D

V

V

T

S

V

L

G

G

A

N

G

I

A

V

W

E

V

I

G

G

I

A

G

N

S

A

Q

T

V

I

I

R

Q

E

G

K

V

V

T

S

I

V

G

Q

A

D

H

G

A

A

V

M

V

V

G

G

A

M

G

G

A

S

T

V

V

V

T

I

R

R

D

N

V

I

P

L

E

S

G

N

V

Q

T

V

V

V

G

G

T

N

P

P

A

A

K

K

binding dTDP-4-amino-4,6-dideoxyglucose: G10 (≠ S12), G11 (= G13), H12 (= H14), D32 (= D34), N33 (≠ D35), T34 (≠ D36), K37 (≠ L39), I66 (= I68), G67 (= G69), I75 (= I77)

7l82AAA Putative acetyl transferase protein (see paper)
31% identity, 67% coverage: 65:202/207 of query aligns to 70:214/216 of 7l82AAA

query
sites
7l82AAA

V

L

M

I

G

A

I
|
I

G
x
A

N

N

G

S

R

S

I

I

R

R

R

Q

M

K

I

I

M

A

E

D

R

K

F

L

S

V

L

K

-

D

-

G

V

I

Q

S

W

L

L

W

S

T

V

V

I

Q

H

G

R

M

T

T

A

T

W

L

V

I

D

M

P

D

A

E

V

V

T

S

V

I

G

D

G

A

G

G

T

A

V

A

I

L

F

S

A

P

G

F

A

V

V

T

V

I

Q

A

P

A

D

N

S

V

R

T

I

I

G

G

K

K

H

C

C

F

I

H

I

A

N

N

T

L

G

Y

A

S

T

Y

V

V

D

E

H

H

D

D

C

C

V

I

G

G

D

D

Y

Y

A

V

H

T

I

F

C

A

P

P

G

R

V

V

N

S

L

C

A

N

G

G

N

N

V

I

T

H

V

I

G

H

A

D

G

H

A

A

W
x
Y

V

I

G

G

I
x
T

G

G

S

A

Q

V

V

I

I

K

Q

Q

G

G

-

T

-

P

-

D

-

K

-

P

V

L

T

I

I

I

G

G

A

K

H

G

A

A

V

I

V

V

G
|
G

A
x
M

G

G

A

A

T

V

V

V

T

T

R

K

D

E

V

V

P

P

E

A

G

G

V

A

T

V

V

V

V
x
I

G

G

T

N

P

P

A

A

K

R

binding [(2~{R},3~{R},4~{S},5~{S},6~{R})-3-acetamido-5-[[(1~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanyl-ethyl]amino]-6-methyl-4-oxidanyl-oxan-2-yl] [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: I73 (= I68), A74 (≠ G69), Y168 (≠ W161), T171 (≠ I164), G193 (= G181), M194 (≠ A182), I209 (≠ V197)

Sites not aligning to the query:

binding [(2~{R},3~{R},4~{S},5~{S},6~{R})-3-acetamido-5-[[(1~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanyl-ethyl]amino]-6-methyl-4-oxidanyl-oxan-2-yl] [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: 10, 12, 39, 40

7l81AAA Putative acetyl transferase protein (see paper)
31% identity, 67% coverage: 65:202/207 of query aligns to 70:214/216 of 7l81AAA

query
sites
7l81AAA

V

L

M

I

G

A

I
|
I

G
x
A

N

N

G

S

R

S

I

I

R

R

R

Q

M

K

I

I

M

A

E

D

R

K

F

L

S

V

L

K

-

D

-

G

V

I

Q

S

W

L

L

W

S

T

V

V

I

Q

H

G

R

M

T

T

A

T

W

L

V

I

D

M

P

D

A

E

V

V

T

S

V

I

G

D

G

A

G

G

T

A

V

A

I

L

F

S

A

P

G

F

A

V

V

T

V

I

Q

A

P

A

D

N

S

V

R

T

I

I

G

G

K

K

H

C

C

F

I

H

I

A

N

N

T

L

G

Y

A

S

T

Y

V

V

D

E

H

H

D

D

C

C

V

I

G

G

D

D

Y

Y

A

V

H

T

I

F

C
x
A

P

P

G

R

V

V

N

S

L

C

A

N

G

G

N

N

V

I

T

H

V

I

G

H

A

D

G

H

A

A

W
x
Y

V

I

G

G

I
x
T

G

G

S

A

Q

V

V

I

I

K

Q

Q

G

G

-

T

-

P

-

D

-

K

-

P

V

L

T

I

I

I

G

G

A

K

H

G

A

A

V

I

V

V

G
|
G

A
x
M

G

G

A

A

T

V

V

V

T

T

R

K

D

E

V

V

P

P

E

A

G

G

V

A

T

V

V

V

V
x
I

G

G

T

N

P

P

A

A

K

R

binding coenzyme a: A152 (≠ C145), Y168 (≠ W161), T171 (≠ I164), G193 (= G181), M194 (≠ A182), I209 (≠ V197)
binding UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose: I73 (= I68), A74 (≠ G69)

Sites not aligning to the query:

binding UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose: 10, 12, 39, 40

7l7zAAA Putative acetyl transferase protein (see paper)
31% identity, 67% coverage: 65:202/207 of query aligns to 70:214/216 of 7l7zAAA

query
sites
7l7zAAA

V

L

M

I

G

A

I
|
I

G
x
A

N

N

G

S

R

S

I

I

R

R

R

Q

M

K

I

I

M

A

E

D

R

K

F

L

S

V

L

K

-

D

-

G

V

I

Q

S

W

L

L

W

S

T

V

V

I

Q

H

G

R

M

T

T

A

T

W

L

V

I

D

M

P

D

A

E

V

V

T

S

V

I

G

D

G

A

G

G

T

A

V

A

I

L

F

S

A

P

G

F

A

V

V

T

V

I

Q

A

P

A

D

N

S

V

R

T

I

I

G

G

K

K

H

C

C

F

I

H

I

A

N

N

T

L

G

Y

A

S

T

Y

V

V

D

E

H

H

D

D

C

C

V

I

G

G

D

D

Y

Y

A

V

H

T

I

F

C

A

P

P

G

R

V

V

N

S

L

C

A

N

G

G

N

N

V

I

T

H

V

I

G

H

A

D

G

H

A

A

W
x
Y

V

I

G

G

I
x
T

G

G

S

A

Q

V

V

I

I

K

Q

Q

G

G

-

T

-

P

-

D

-

K

-

P

V

L

T

I

I

I

G

G

A

K

H

G

A

A

V

I

V

V

G
|
G

A
x
M

G

G

A

A

T

V

V

V

T

T

R

K

D

E

V

V

P

P

E

A

G

G

V

A

T

V

V

V

V
x
I

G

G

T

N

P

P

A

A

K

R

binding coenzyme a: Y168 (≠ W161), T171 (≠ I164), G193 (= G181), M194 (≠ A182), I209 (≠ V197)
binding UDP-di-N-acetyl-alpha-bacillosamine: I73 (= I68), A74 (≠ G69)

Sites not aligning to the query:

binding UDP-di-N-acetyl-alpha-bacillosamine: 10, 12, 39, 40

7l7yAAA Putative acetyl transferase protein (see paper)
31% identity, 67% coverage: 65:202/207 of query aligns to 70:214/217 of 7l7yAAA

query
sites
7l7yAAA

V

L

M

I

G

A

I
|
I

G
x
A

N

N

G

S

R

S

I

I

R

R

R

Q

M

K

I

I

M

A

E

D

R

K

F

L

S

V

L

K

-

D

-

G

V

I

Q

S

W

L

L

W

S

T

V

V

I

Q

H

G

R

M

T

T

A

T

W

L

V

I

D

M

P

D

A

E

V

V

T

S

V

I

G

D

G

A

G

G

T

A

V

A

I

L

F

S

A

P

G

F

A

V

V

T

V

I

Q

A

P

A

D

N

S

V

R

T

I

I

G

G

K

K

H

C

C

F

I

H

I

A

N

N

T

L

G

Y

A

S

T

Y

V

V

D

E

H

H

D

D

C

C

V

I

G

G

D

D

Y

Y

A

V

H

T

I

F

C

A

P

P

G

R

V

V

N

S

L

C

A

N

G

G

N

N

V

I

T

H

V

I

G

H

A

D

G

H

A

A

W
x
Y

V

I

G
|
G

I
x
T

G

G

S

A

Q

V

V

I

I

K

Q

Q

G

G

-

T

-

P

-

D

-

K

-

P

V

L

T

I

I

I

G

G

A

K

H

G

A

A

V

I

V

V

G
|
G

A
x
M

G

G

A

A

T

V

V

V

T

T

R

K

D

E

V

V

P

P

E

A

G

G

V

A

T

V

V

V

V
x
I

G

G

T

N

P

P

A

A

K

R

binding acetyl coenzyme *a: Y168 (≠ W161), G170 (= G163), T171 (≠ I164), G193 (= G181), M194 (≠ A182), I209 (≠ V197)
binding uridine-5'-diphosphate: I73 (= I68), A74 (≠ G69)

Sites not aligning to the query:

binding uridine-5'-diphosphate: 10, 12, 39, 40

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
29% identity, 55% coverage: 89:202/207 of query aligns to 1:138/290 of 4mzuB

query
sites
4mzuB

V

M

I

I

H

H

R

K

T

L

A

A

W

D

V

V

D

Q

P

-

A

S

V

Q

T

N

V

I

G

G

G

D

G

N

T

T

V

K

I

V

F
x
W

A
x
Q

G

F

A

C

V

V

V

I

Q

L

P

A

D

G

S

A

R

V

I

I

G

G

K

R

H

N

C

C

I

N

I

I

N
x
C

T
x
A

G

N

A

S

T

L

V

I

D

E

H

N

D

D

C

V

V

V

V

I

G

G

D

D

Y

N

A

V

-

T

-

I

-

K

-

S

-
x
G

-

V

-

Q

-

I

-

W

-

D

-

G

-

I

H

H

I

I

C

Q

P

D

G

D

V

V

N
x
F

L

I

A

G

G

P

N
|
N

V

V

T

T

-

F

-
x
T

-
x
N

-
x
D

-
x
K

-

Q

-
x
P

-

R

-

S

-

L

-

K

-

T

-

I

V

V

G

K

A

K

G

G

A

A

W

S

V

I

G
|
G

I
x
A

G

N

S

S

Q

T

V

I

I

L

Q

P

G

G

V

I

T

L

I

I

G

G

A

E

H

N

A

A

V

M

V

V

G
|
G

A
|
A

G

G

A

A

T

V

V

I

T
|
T

R
x
K

D

N

V

V

P

P

E

D

G

N

V

A

T

I

V

V

V
x
I

G

G

T

N

P

P

A

G

K
x
R

binding coenzyme a: F72 (≠ N149), T80 (vs. gap), N81 (vs. gap), D82 (vs. gap), K83 (vs. gap), P85 (vs. gap), G99 (= G163), A100 (≠ I164), G117 (= G181), A118 (= A182), T123 (= T187), K124 (≠ R188), I133 (≠ V197), R138 (≠ K202)
binding magnesium ion: G58 (vs. gap), N76 (= N153)
binding thymine: W20 (≠ F109), Q21 (≠ A110), C38 (≠ N127), A39 (≠ T128)

Sites not aligning to the query:

binding coenzyme a: 199
binding thymidine-5'-diphosphate: 171, 176, 189, 191, 202, 203, 270

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
29% identity, 55% coverage: 89:202/207 of query aligns to 1:139/294 of 4mzuF

query
sites
4mzuF

V

M

I

I

H

H

R

K

T

L

A

A

W

D

V

V

D

Q

P

-

A

S

V

Q

T

N

V

I

G

G

G

D

G

N

T

T

V

K

I

V

F
x
W

A
x
Q

G

F

A

C

V

V

V

I

Q

L

P

A

D

G

S

A

R

V

I

I

G

G

K

R

H

N

C

C

I

N

I

I

N
x
C

T

A

G

N

A

S

T

L

V

I

D

E

H

N

D

D

C

V

V

V

V

I

G

G

D

D

Y

N

A

V

-

T

-

I

-

K

-

S

-

G

-

V

-

Q

-

I

-

W

-

D

-

G

-

I

H

H

I

I

C

Q

P

D

G

D

V

V

N

F

L

I

A

G

G

P

N

N

V

V

T

T

-

F

-

T

-
x
N

-
x
D

-
x
K

-

Q

-

P

-

R

-

S

-

K

-

I

-

K

-

T

-

I

V

V

G

K

A

K

G

G

A

A

W

S

V

I

G
|
G

I
x
A

G

N

S

S

Q

T

V

I

I
x
L

Q

P

G

G

V

I

T

L

I

I

G

G

A

E

H

N

A

A

V

M

V

V

G
|
G

A
|
A

G

G

A

A

T

V

V

I

T
|
T

R
x
K

D

N

V

V

P

P

E

D

G

N

V

A

T

I

V

V

V
x
I

G

G

T
x
N

P

P

A

G

K
x
R

binding coenzyme a: N81 (vs. gap), D82 (vs. gap), K83 (vs. gap), G100 (= G163), A101 (≠ I164), L106 (≠ I169), G118 (= G181), A119 (= A182), T124 (= T187), K125 (≠ R188), I134 (≠ V197), N136 (≠ T199), R139 (≠ K202)
binding thymine: W20 (≠ F109), Q21 (≠ A110), C38 (≠ N127)

Sites not aligning to the query:

binding thymidine-5'-diphosphate: 189, 203, 205, 270

Query Sequence

>WP_028585071.1 NCBI__GCF_000429965.1:WP_028585071.1
MRKNSVYIFGASGHGKVVAGALISAGYTVCGFFDDDVVLHGRKFFGEPVLGGQEDFAVLE
APVAVMGIGNGRIRRMIMERFSLVQWLSVIHRTAWVDPAVTVGGGTVIFAGAVVQPDSRI
GKHCIINTGATVDHDCVVGDYAHICPGVNLAGNVTVGAGAWVGIGSQVIQGVTIGAHAVV
GAGATVTRDVPEGVTVVGTPAKPNRTE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory