SitesBLAST
Comparing WP_028585450.1 NCBI__GCF_000429965.1:WP_028585450.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4yi7A Anthranilate bound at active site of anthranilate phosphoribosyl transferase from acinetobacter (anprt; trpd)
41% identity, 98% coverage: 2:338/344 of query aligns to 4:325/331 of 4yi7A
1zxyA Anthranilate phosphoribosyltransferase from sulfolobus solfataricus in complex with prpp and magnesium (see paper)
35% identity, 98% coverage: 2:337/344 of query aligns to 3:328/344 of 1zxyA
- binding magnesium ion: D223 (= D229), E224 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: A78 (≠ S75), G79 (= G84), D83 (= D88), T87 (≠ S92), N89 (= N94), S91 (= S96), T92 (= T97), K106 (= K112), S118 (= S124), D223 (= D229), E224 (= E230)
2gvqD Anthranilate phosphoribosyl-transferase (trpd) from s. Solfataricus in complex with anthranilate (see paper)
35% identity, 98% coverage: 2:337/344 of query aligns to 3:328/345 of 2gvqD
P50384 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 2 papers)
35% identity, 98% coverage: 2:337/344 of query aligns to 3:328/345 of P50384
- T87 (≠ S92) binding 5-phospho-alpha-D-ribose 1-diphosphate
- K106 (= K112) mutation to Q: Affinity for phosphoribosylpyrophosphate is similar to that of the wild-type enzyme and catalytic efficiency dedreases only 10-fold.
- H107 (= H113) mutation to A: Limited effect on either affinity for anthranilate and catalytic efficiency. 300-fold decrease of the affinity for anthranilate, whereas catalytic efficiency remains nearly unchanged; when associated with A-178.
- S118 (= S124) binding 5-phospho-alpha-D-ribose 1-diphosphate
- H154 (= H160) mutation to A: Limited effect on either affinity for anthranilate and catalytic efficiency.
- R164 (= R170) mutation to A: Strong decrease of the affinity for anthranilate, although only a moderate 7-fold decrease in catalytic efficiency.
- D223 (= D229) mutation to N: Affinity for phosphoribosylpyrophosphate is similar to that of the wild-type enzyme and catalytic efficiency is unchanged.
- E224 (= E230) mutation to Q: Affinity for phosphoribosylpyrophosphate is similar to that of the wild-type enzyme and catalytic efficiency is unchanged.
5nofA Anthranilate phosphoribosyltransferase from thermococcus kodakaraensis (see paper)
36% identity, 98% coverage: 6:341/344 of query aligns to 4:325/325 of 5nofA
1kgzB Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora (current name, pectobacterium carotovorum) (see paper)
35% identity, 97% coverage: 6:337/344 of query aligns to 6:329/330 of 1kgzB
- binding manganese (ii) ion: S92 (= S96), D222 (= D229), E223 (= E230), E223 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V79 (= V83), G82 (= G86), G83 (= G87), N90 (= N94), I91 (≠ V95), S92 (= S96), T93 (= T97), K108 (= K112), S118 (= S124)
1gxbA Anthranilate phosphoribosyltransferase in complex with pyrophosphate and magnesium (see paper)
33% identity, 98% coverage: 2:337/344 of query aligns to 3:324/339 of 1gxbA
5c1rA Stereoisomer of prpp bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyl (anprt; trpd)
41% identity, 97% coverage: 9:341/344 of query aligns to 10:343/343 of 5c1rA
- active site: V82 (= V83)
- binding 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose: V82 (= V83), G83 (= G84), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), R115 (= R116), A117 (≠ V118), S118 (= S119), S119 (= S120)
- binding magnesium ion: D87 (= D88), V89 (≠ S90), S95 (= S96), E228 (= E230)
3r88B Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs145) (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 10:343/344 of 3r88B
- active site: V82 (= V83)
- binding 2-amino-4,5-dimethoxybenzoic acid: N114 (= N115), A155 (= A156), P156 (= P157), H159 (= H160), Y162 (≠ M163), R163 (≠ K164), A166 (≠ I167)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V82 (= V83), G83 (= G84), G85 (= G86), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), N114 (= N115), A117 (≠ V118), S118 (= S119), S119 (= S120)
4n93A Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 11:345/346 of 4n93A
- active site: V83 (= V83)
- binding 2-amino-6-methylbenzoic acid: V83 (= V83), G84 (= G84), T85 (= T85), H113 (= H113), N115 (= N115), N115 (= N115), A156 (= A156), P157 (= P157), H160 (= H160), Y163 (≠ M163), A167 (≠ I167), R170 (= R170), G183 (= G183), P184 (= P184)
- binding magnesium ion: S96 (= S96), D228 (= D229), E229 (= E230), E229 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G84), G86 (= G86), G87 (= G87), N94 (= N94), S96 (= S96), T97 (= T97), K112 (= K112), A117 (= A117), A118 (≠ V118), S120 (= S120), G123 (= G123)
P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
41% identity, 97% coverage: 9:341/344 of query aligns to 34:369/370 of P9WFX5
- G107 (= G84) binding 5-phospho-alpha-D-ribose 1-diphosphate
- T115 (≠ S92) binding 5-phospho-alpha-D-ribose 1-diphosphate
- G147 (≠ S124) binding 5-phospho-alpha-D-ribose 1-diphosphate
4n5vA Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 12:346/347 of 4n5vA
- active site: V84 (= V83)
- binding 2-amino-4-fluorobenzoic acid: V84 (= V83), G85 (= G84), H114 (= H113), G115 (= G114), N116 (= N115), A157 (= A156), A157 (= A156), P158 (= P157), H161 (= H160), Y164 (≠ M163), R165 (≠ K164), A168 (≠ I167), R171 (= R170), G184 (= G183)
- binding magnesium ion: S97 (= S96), D229 (= D229), E230 (= E230), E230 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G85 (= G84), G87 (= G86), G88 (= G87), N95 (= N94), S97 (= S96), T98 (= T97), K113 (= K112), A119 (≠ V118), S120 (= S119), S121 (= S120), G124 (= G123)
5c2lA Magnesium soaked into the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
41% identity, 97% coverage: 9:341/344 of query aligns to 12:347/349 of 5c2lA
4owoA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 6-fluoroanthranilate, prpp and magnesium (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 12:347/348 of 4owoA
- active site: V84 (= V83)
- binding 2-azanyl-6-fluoranyl-benzoic acid: V84 (= V83), G85 (= G84), T86 (= T85), H114 (= H113), N116 (= N115), N116 (= N115), A157 (= A156), P158 (= P157), H161 (= H160), Y164 (≠ M163), A168 (≠ I167), R171 (= R170), G184 (= G183)
- binding magnesium ion: S97 (= S96), D229 (= D229), E230 (= E230), E230 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V84 (= V83), G85 (= G84), G87 (= G86), G88 (= G87), N95 (= N94), S97 (= S96), T98 (= T97), K113 (= K112), A118 (= A117), A119 (≠ V118), S120 (= S119), S121 (= S120), G124 (= G123)
4owuA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 5-methylanthranilate, prpp and magnesium (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 11:346/347 of 4owuA
- active site: V83 (= V83)
- binding 2-azanyl-5-methyl-benzoic acid: N115 (= N115), P157 (= P157), Y163 (≠ M163), R164 (≠ K164), A167 (≠ I167)
- binding magnesium ion: S96 (= S96), D228 (= D229), E229 (= E230), E229 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G84), G86 (= G86), G87 (= G87), N94 (= N94), S96 (= S96), T97 (= T97), K112 (= K112), A118 (≠ V118), S120 (= S120), G123 (= G123)
4owqA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-methylanthranilate, prpp and magnesium (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 11:346/347 of 4owqA
- active site: V83 (= V83)
- binding 2-azanyl-3-methyl-benzoic acid: P157 (= P157), H160 (= H160), Y163 (≠ M163), A167 (≠ I167), R171 (= R171)
- binding magnesium ion: S96 (= S96), D228 (= D229), E229 (= E230), E229 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V83 (= V83), G84 (= G84), G86 (= G86), G87 (= G87), N94 (= N94), S96 (= S96), T97 (= T97), K112 (= K112), A117 (= A117), A118 (≠ V118), S120 (= S120), G123 (= G123)
4zokA Methylsulfonyl-containing inhibitor bound in the substrate capture site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
41% identity, 97% coverage: 9:341/344 of query aligns to 10:342/342 of 4zokA
- active site: V82 (= V83)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfonyl)phenyl]amino}benzoic acid: P156 (= P157), R163 (≠ K164), A166 (≠ I167), A167 (≠ Q168)
- binding magnesium ion: S95 (= S96), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A116 (= A117), A117 (≠ V118), S119 (= S120), G122 (= G123)
4zofA Lobenzarit-like inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
41% identity, 97% coverage: 9:341/344 of query aligns to 10:342/342 of 4zofA
- active site: V82 (= V83)
- binding 2-[(2-carboxy-5-nitrophenyl)amino]-3-methylbenzoic acid: G113 (= G114), N114 (= N115), A155 (= A156), H159 (= H160), Y162 (≠ M163), R169 (= R170), G182 (= G183)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G85 (= G86), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A116 (= A117), A117 (≠ V118), S119 (= S120), G122 (= G123)
4owmA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-fluoroanthranilate, prpp and magnesium (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 10:345/346 of 4owmA
- active site: V82 (= V83)
- binding 2-azanyl-3-fluoranyl-benzoic acid: P156 (= P157), H159 (= H160), Y162 (≠ M163), R163 (≠ K164), A166 (≠ I167), R170 (= R171)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G84), G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123)
4gkmA Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (anprt; trpd) (see paper)
41% identity, 97% coverage: 9:341/344 of query aligns to 10:345/346 of 4gkmA
- active site: V82 (= V83)
- binding 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid: N114 (= N115), A155 (= A156), P156 (= P157), Y162 (≠ M163), R163 (≠ K164), A166 (≠ I167), R169 (= R170), R170 (= R171)
- binding magnesium ion: S95 (= S96), D227 (= D229), E228 (= E230), E228 (= E230)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G87), N93 (= N94), S95 (= S96), T96 (= T97), K111 (= K112), A117 (≠ V118), S118 (= S119), S119 (= S120), G122 (= G123)
Query Sequence
>WP_028585450.1 NCBI__GCF_000429965.1:WP_028585450.1
MIRKAISMLIEQSDLSEAQMIEVMEQIMGGDATPAQIGSFITALRMKGETIDEIVGAVKV
MRAKATFVDTGVDTSTGLLMDIVGTGGDGSGSFNVSTTTSFVVAGAGIPVAKHGNRAVSS
SCGSADVLEALGVDLTMAPSEVGRCVQTIGIGFLFAPMLHGAMKYAIQPRREIGIRTIFN
VLGPLTNPAGANVQLTGVFARELTTVLAEVLVRLGMKRTLVVWGEGNLDELTIGGTSYIA
DGHDGQVSSSTVTPEEVGLQRAGMEAIRGGRTPEESAEMVRSVLRGTPGARLDMVLLNGG
AALLAADKVADLRQGVAMAREIVASGAALEKLDQLVAFCNQQQS
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory