SitesBLAST
Comparing WP_028950476.1 NCBI__GCF_000619805.1:WP_028950476.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6zhkA Crystal structure of adenosylmethionine-8-amino-7-oxononanoate aminotransferase from methanocaldococcus jannaschii dsm 2661
52% identity, 99% coverage: 2:450/453 of query aligns to 1:436/438 of 6zhkA
3du4A Crystal structure of 7-keto-8-aminopelargonic acid bound 7,8- diaminopelargonic acid synthase in bacillus subtilis (see paper)
49% identity, 99% coverage: 3:450/453 of query aligns to 2:443/448 of 3du4A
- active site: F17 (= F18), Y146 (= Y148), E217 (= E224), D251 (= D258), A254 (= A261), K280 (= K287), A417 (≠ V424)
- binding 7-keto-8-aminopelargonic acid: L82 (= L84), Y146 (= Y148), G315 (= G322), S317 (≠ T324), R410 (= R417)
- binding pyridoxal-5'-phosphate: S112 (≠ D114), G113 (= G115), A114 (≠ S116), Y146 (= Y148), H147 (= H149), E217 (= E224), D251 (= D258), V253 (= V260), A254 (= A261), K280 (= K287), H316 (= H323), S317 (≠ T324)
P53555 L-Lysine--8-amino-7-oxononanoate transaminase; 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; 7,8-diaminononanoate synthase; DANS; Diaminopelargonic acid synthase; L-Lysine--8-amino-7-oxononanoate aminotransferase; EC 2.6.1.105 from Bacillus subtilis (strain 168) (see paper)
49% identity, 99% coverage: 3:450/453 of query aligns to 2:443/448 of P53555
- GA 113:114 (≠ GS 115:116) binding pyridoxal 5'-phosphate
- Y146 (= Y148) binding substrate
- K280 (= K287) modified: N6-(pyridoxal phosphate)lysine
- G315 (= G322) binding substrate
- HS 316:317 (≠ HT 323:324) binding pyridoxal 5'-phosphate
- R410 (= R417) binding substrate
6wnnA Bacillus subtilis bioa in complex with amino donor l-lys
46% identity, 98% coverage: 5:450/453 of query aligns to 1:415/420 of 6wnnA
- active site: F14 (= F18), Y143 (= Y148), D223 (= D258), K252 (= K287)
- binding (2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid: F14 (= F18), W51 (= W56), S109 (≠ D114), G110 (= G115), A111 (≠ S116), Y143 (= Y148), H144 (= H149), D223 (= D258), V225 (= V260), K252 (= K287), R382 (= R417)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: H288 (= H323), S289 (≠ T324)
3dodA Crystal structure of plp bound 7,8-diaminopelargonic acid synthase in bacillus subtilis (see paper)
45% identity, 99% coverage: 4:450/453 of query aligns to 1:412/417 of 3dodA
- active site: F15 (= F18), E186 (= E224), D220 (= D258), A223 (= A261), K249 (= K287), A386 (≠ V424)
- binding pyridoxal-5'-phosphate: W52 (= W56), S110 (≠ D114), G111 (= G115), A112 (≠ S116), D220 (= D258), V222 (= V260), K249 (= K287), H285 (= H323), S286 (≠ T324)
6erkA Crystal structure of diaminopelargonic acid aminotransferase from psychrobacter cryohalolentis (see paper)
36% identity, 96% coverage: 9:443/453 of query aligns to 9:409/420 of 6erkA
6io1B Crystal structure of a novel thermostable (s)-enantioselective omega- transaminase from thermomicrobium roseum (see paper)
36% identity, 98% coverage: 5:450/453 of query aligns to 7:446/448 of 6io1B
- active site: L20 (≠ F18), Y151 (= Y148), D257 (= D258), K286 (= K287)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (≠ D114), G118 (= G115), A119 (≠ S116), N122 (≠ M119), Y151 (= Y148), H152 (= H149), D257 (= D258), V259 (= V260), I260 (≠ A261), K286 (= K287)
5lhaA Amine transaminase crystal structure from an uncultivated pseudomonas species in the pmp-bound form
35% identity, 98% coverage: 11:452/453 of query aligns to 7:447/447 of 5lhaA
- active site: Y146 (= Y148), D253 (= D258), K282 (= K287), T319 (= T324)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G113 (= G115), S114 (= S116), Y146 (= Y148), H147 (= H149), G148 (= G150), E220 (= E224), D253 (= D258), K282 (= K287), Y318 (≠ H323), T319 (= T324)
5lh9D Amine transaminase crystal structure from an uncultivated pseudomonas species in the plp-bound (internal aldimine) form
35% identity, 98% coverage: 11:452/453 of query aligns to 9:449/449 of 5lh9D
- active site: Y148 (= Y148), D255 (= D258), K284 (= K287), T321 (= T324)
- binding pyridoxal-5'-phosphate: G115 (= G115), S116 (= S116), Y148 (= Y148), H149 (= H149), G150 (= G150), E222 (= E224), D255 (= D258), V257 (= V260), K284 (= K287)
6s54A Transaminase from pseudomonas fluorescens (see paper)
33% identity, 98% coverage: 3:448/453 of query aligns to 1:449/453 of 6s54A
- active site: M20 (≠ F18), Y152 (= Y148), D258 (= D258), K287 (= K287)
- binding pyridoxal-5'-phosphate: G119 (= G115), S120 (= S116), Y152 (= Y148), H153 (= H149), G154 (= G150), E225 (= E224), D258 (= D258), V260 (= V260), I261 (≠ A261), K287 (= K287)
6gwiB The crystal structure of halomonas elongata amino-transferase (see paper)
33% identity, 99% coverage: 1:450/453 of query aligns to 1:445/450 of 6gwiB
- active site: F18 (= F18), Y149 (= Y148), D255 (= D258), K284 (= K287)
- binding pyridoxal-5'-phosphate: S115 (≠ D114), G116 (= G115), S117 (= S116), Y149 (= Y148), H150 (= H149), G151 (= G150), E222 (= E224), D255 (= D258), V257 (= V260), I258 (≠ A261), K284 (= K287)
6fyqA The crystal structure of a new transaminase from the marine bacterium virgibacillus (see paper)
35% identity, 98% coverage: 5:450/453 of query aligns to 2:438/443 of 6fyqA
- active site: F15 (= F18), Y147 (= Y148), D243 (= D258), K272 (= K287)
- binding pyridoxal-5'-phosphate: G114 (= G115), S115 (= S116), Y147 (= Y148), H148 (= H149), G149 (= G150), E210 (= E224), D243 (= D258), V245 (= V260), I246 (≠ A261), K272 (= K287)
6ed7A Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor mac13772
34% identity, 98% coverage: 3:447/453 of query aligns to 2:421/429 of 6ed7A
- active site: Y17 (≠ F18), Y144 (= Y148), D245 (= D258), K274 (= K287)
- binding 2-[(2-nitrophenyl)sulfanyl]acetohydrazide: Y17 (≠ F18), W52 (≠ L55), W52 (≠ L55), Y144 (= Y148), D147 (= D151), A217 (= A230), K274 (= K287), R391 (= R417), F393 (≠ L419), F393 (≠ L419)
- binding pyridoxal-5'-phosphate: G112 (= G115), S113 (= S116), Y144 (= Y148), H145 (= H149), D245 (= D258), I247 (≠ V260), K274 (= K287)
P12995 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; 7,8-diaminononanoate synthase; DANS; Diaminopelargonic acid synthase; EC 2.6.1.62 from Escherichia coli (strain K12) (see 4 papers)
34% identity, 99% coverage: 1:447/453 of query aligns to 1:421/429 of P12995
- Y17 (≠ F18) mutation to F: Severely reduces the aminotransferase activity.
- W52 (≠ L55) binding substrate
- GS 112:113 (= GS 115:116) binding pyridoxal 5'-phosphate
- Y144 (= Y148) mutation to F: Severely reduces the aminotransferase activity.
- D147 (= D151) mutation to N: Loss of aminotransferase activity.
- D245 (= D258) binding pyridoxal 5'-phosphate
- R253 (= R266) mutation to A: Has only a small effect on the rate of reaction with DAPA.; mutation to K: Increases aminotransferase activity toward SAM.; mutation to M: Loss of aminotransferase activity.; mutation to Q: Increases aminotransferase activity toward SAM.
- K274 (= K287) binding substrate; modified: N6-(pyridoxal phosphate)lysine
- G307 (= G322) binding substrate
- PT 308:309 (≠ HT 323:324) binding pyridoxal 5'-phosphate
- R391 (= R417) binding substrate; mutation to A: Reduces aminotransferase activity.
1dtyA Crystal structure of adenosylmethionine-8-amino-7-oxonanoate aminotransferase with pyridoxal phosphate cofactor.
34% identity, 99% coverage: 1:447/453 of query aligns to 1:421/429 of 1dtyA
- active site: Y17 (≠ F18), Y144 (= Y148), E211 (= E224), D245 (= D258), A248 (= A261), K274 (= K287), Y398 (≠ V424)
- binding pyridoxal-5'-phosphate: G112 (= G115), S113 (= S116), Y144 (= Y148), H145 (= H149), D245 (= D258), I247 (≠ V260), K274 (= K287)
1mlzA Crystal structure of 7,8-diaminopelargonic acid synthase in complex with the trans-isomer of amiclenomycin. (see paper)
34% identity, 99% coverage: 1:447/453 of query aligns to 1:420/427 of 1mlzA
- active site: Y17 (≠ F18), Y144 (= Y148), E210 (= E224), D244 (= D258), A247 (= A261), K273 (= K287), Y397 (≠ V424)
- binding pyridoxal-5'-phosphate: G112 (= G115), S113 (= S116), Y144 (= Y148), H145 (= H149), D244 (= D258), I246 (≠ V260), K273 (= K287), P307 (≠ H323), T308 (= T324)
- binding trans-amiclenomycin: W52 (≠ L55), W53 (= W56), Y144 (= Y148), K273 (= K287), R390 (= R417), F392 (≠ L419)
1mlyA Crystal structure of 7,8-diaminopelargonic acid synthase in complex with the cis isomer of amiclenomycin (see paper)
34% identity, 99% coverage: 1:447/453 of query aligns to 1:420/427 of 1mlyA
- active site: Y17 (≠ F18), Y144 (= Y148), E210 (= E224), D244 (= D258), A247 (= A261), K273 (= K287), Y397 (≠ V424)
- binding cis-amiclenomycin: W52 (≠ L55), W53 (= W56), K273 (= K287), R390 (= R417), F392 (≠ L419)
- binding pyridoxal-5'-phosphate: G112 (= G115), S113 (= S116), Y144 (= Y148), H145 (= H149), D244 (= D258), I246 (≠ V260), K273 (= K287), P307 (≠ H323), T308 (= T324)
6g4dB Crystal structure of the omega transaminase from pseudomonas jessenii in complex with plp (see paper)
32% identity, 98% coverage: 4:447/453 of query aligns to 1:442/453 of 6g4dB
- active site: Y15 (≠ F18), Y146 (= Y148), D253 (= D258), K282 (= K287)
- binding pyridoxal-5'-phosphate: S112 (≠ D114), G113 (= G115), S114 (= S116), Y146 (= Y148), H147 (= H149), E220 (= E224), D253 (= D258), V255 (= V260), I256 (≠ A261), K282 (= K287)
6g4fA Crystal structure of the omega transaminase from pseudomonas jessenii in complex with pmp (see paper)
32% identity, 98% coverage: 4:447/453 of query aligns to 1:442/451 of 6g4fA
- active site: Y15 (≠ F18), Y146 (= Y148), D253 (= D258), K282 (= K287)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: S112 (≠ D114), G113 (= G115), S114 (= S116), Y146 (= Y148), H147 (= H149), E220 (= E224), D253 (= D258), V255 (= V260), I256 (≠ A261), K282 (= K287)
6g4eA Crystal structure of the omega transaminase from pseudomonas jessenii in complex with plp and 6-aminohexanoate (6-aca) (see paper)
32% identity, 98% coverage: 4:447/453 of query aligns to 1:442/451 of 6g4eA
- active site: Y15 (≠ F18), Y146 (= Y148), D253 (= D258), K282 (= K287)
- binding 6-aminohexanoic acid: K282 (= K287), R412 (= R417), M414 (≠ L419)
- binding pyridoxal-5'-phosphate: S112 (≠ D114), G113 (= G115), S114 (= S116), Y146 (= Y148), H147 (= H149), E220 (= E224), D253 (= D258), V255 (= V260), I256 (≠ A261), K282 (= K287)
Query Sequence
>WP_028950476.1 NCBI__GCF_000619805.1:WP_028950476.1
MENNDLIKWDKEHFWHPFTQMKVYREEENVIVERGEGNYIYDIFGNKYLDGVASLWCNVH
GHNHPKLNKAICDQVSKISHFTTLGASNVPAIILAKKLVEITPKSLNKVFYSEDGSEAME
IAIKIAYHYWHNKGYKEKTKFITLSQAYHGDTIGSVSVGGINIFHEKYKPLLFDVYKLPS
PYLKAVEIAGREKALEYETTKKLIEEVEEFVFEHHQTIAGFVLEASVQGAAGILPFPKGY
LKEVERICREYNVLMIVDEVATGFGRTGEMFACIKENVNPDIMALGKGITGGYLPLAATL
TTDEIFEAFLGDFGEAKHFYHGHTYTGNPVACNVALANIDLFEEEKTLENVRKNIDILEK
RLPEFLQLNHVIDVRNYGLMAGVELIKDKKTKQPYPYGDRTGFKVAKAMLKRGIWVRPLG
DVMVIMPPLSIKEDELNYFLNSLKESIIEVCGD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory