SitesBLAST
Comparing WP_028951255.1 NCBI__GCF_000619805.1:WP_028951255.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
53% identity, 100% coverage: 2:246/246 of query aligns to 1:242/244 of P0AEK2
- GASR 12:15 (≠ GSTR 13:16) binding NADP(+)
- T37 (= T42) binding NADP(+)
- NV 59:60 (≠ DL 64:65) binding NADP(+)
- N86 (= N90) binding NADP(+)
- Y151 (= Y155) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YATTK 155:159) binding NADP(+)
- A154 (≠ T158) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K159) mutation to A: Defect in the affinity for NADPH.
- I184 (= I188) binding NADP(+)
- E233 (= E237) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
53% identity, 99% coverage: 3:246/246 of query aligns to 1:241/243 of 1q7bA
- active site: G15 (= G17), E101 (≠ D106), S137 (= S142), Q147 (= Q152), Y150 (= Y155), K154 (= K159)
- binding calcium ion: E232 (= E237), T233 (= T238)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G13), S13 (≠ T15), R14 (= R16), T36 (= T42), N58 (≠ D64), V59 (≠ L65), N85 (= N90), A86 (= A91), G87 (= G92), I88 (= I93), S137 (= S142), Y150 (= Y155), K154 (= K159), P180 (= P185), G181 (= G186), I183 (= I188)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
52% identity, 98% coverage: 7:246/246 of query aligns to 5:245/246 of 3osuA
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
52% identity, 99% coverage: 3:246/246 of query aligns to 1:241/243 of 1q7cA
- active site: G15 (= G17), S137 (= S142), Q147 (= Q152), F150 (≠ Y155), K154 (= K159)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G13), S13 (≠ T15), R14 (= R16), A35 (≠ S41), T36 (= T42), L57 (= L63), N58 (≠ D64), V59 (≠ L65), G87 (= G92), I88 (= I93)
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
52% identity, 100% coverage: 2:246/246 of query aligns to 1:242/244 of P0A2C9
- M125 (= M129) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (= A227) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (= S228) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
52% identity, 100% coverage: 2:246/246 of query aligns to 4:245/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), S17 (≠ T15), R18 (= R16), I20 (= I18), T40 (= T42), N62 (≠ D64), V63 (≠ L65), N89 (= N90), A90 (= A91), I92 (= I93), V139 (≠ I140), S141 (= S142), Y154 (= Y155), K158 (= K159), P184 (= P185), G185 (= G186), I187 (= I188), T189 (= T190), M191 (= M192)
1edoA The x-ray structure of beta-keto acyl carrier protein reductase from brassica napus complexed with NADP+ (see paper)
54% identity, 96% coverage: 9:245/246 of query aligns to 4:242/244 of 1edoA
- active site: G12 (= G17), S138 (= S142), Y151 (= Y155), K155 (= K159)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G13), S10 (≠ T15), R11 (= R16), I13 (= I18), N31 (≠ T36), Y32 (vs. gap), A33 (≠ G37), R34 (= R38), S35 (≠ E39), D59 (≠ N62), V60 (≠ L63), N86 (= N90), A87 (= A91), S138 (= S142), Y151 (= Y155), K155 (= K159), P181 (= P185), G182 (= G186), I184 (= I188), S186 (≠ T190), M188 (= M192)
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
51% identity, 100% coverage: 2:246/246 of query aligns to 1:242/244 of 6t77A
- active site: G16 (= G17), S138 (= S142), Y151 (= Y155)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), S14 (≠ T15), R15 (= R16), T37 (= T42), L58 (= L63), N59 (≠ D64), V60 (≠ L65), A87 (= A91), G88 (= G92), I89 (= I93)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
52% identity, 98% coverage: 7:246/246 of query aligns to 2:238/239 of 3sj7A
- active site: G12 (= G17), S138 (= S142), Q148 (= Q152), Y151 (= Y155), K155 (= K159)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G13), S10 (≠ T15), R11 (= R16), I13 (= I18), N31 (≠ T36), Y32 (vs. gap), A33 (vs. gap), G34 (vs. gap), S35 (≠ G37), A58 (= A58), N59 (= N62), V60 (≠ L63), N86 (= N90), A87 (= A91), T109 (= T113), S138 (= S142), Y151 (= Y155), K155 (= K159), P181 (= P185), G182 (= G186)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
50% identity, 99% coverage: 2:245/246 of query aligns to 1:245/247 of 4jroC
- active site: G16 (= G17), S142 (= S142), Q152 (= Q152), Y155 (= Y155), K159 (= K159)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), S14 (≠ T15), R15 (= R16), G16 (= G17), I17 (= I18), N35 (≠ T36), Y36 (vs. gap), N37 (vs. gap), G38 (= G37), S39 (≠ R38), N63 (= N62), V64 (≠ L63), N90 (= N90), A91 (= A91), I93 (= I93), I113 (≠ T113), S142 (= S142), Y155 (= Y155), K159 (= K159), P185 (= P185), I188 (= I188), T190 (= T190)
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution (see paper)
51% identity, 100% coverage: 2:246/246 of query aligns to 8:252/254 of 4ag3A
- active site: G23 (= G17), S148 (= S142), Y161 (= Y155), K165 (= K159)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G13), S21 (≠ T15), R22 (= R16), G23 (= G17), I24 (= I18), T44 (≠ R38), L68 (= L63), D69 (= D64), V70 (≠ L65), N96 (= N90), A97 (= A91), I146 (= I140), S148 (= S142), Y161 (= Y155), K165 (= K159), P191 (= P185), G192 (= G186), F193 (= F187), I194 (= I188), T196 (= T190), M198 (= M192), T199 (= T193)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
51% identity, 100% coverage: 2:246/246 of query aligns to 4:241/243 of 4i08A
- active site: G19 (= G17), N113 (= N114), S141 (= S142), Q151 (= Q152), Y154 (= Y155), K158 (= K159)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G13), S17 (≠ T15), R18 (= R16), I20 (= I18), T40 (= T42), N62 (≠ D64), V63 (≠ L65), N89 (= N90), A90 (= A91), G140 (≠ S141), S141 (= S142), Y154 (= Y155), K158 (= K159), P184 (= P185), G185 (= G186), T189 (= T190)
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
51% identity, 99% coverage: 3:246/246 of query aligns to 1:241/243 of 7emgB
P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
54% identity, 96% coverage: 10:245/246 of query aligns to 10:244/247 of P73574
- A14 (≠ S14) mutation to G: 4.2-fold increase in activity on acetoacetyl-CoA.
- P151 (≠ I150) mutation to F: 2.7-fold increase in activity on acetoacetyl-CoA.; mutation to V: 5.7-fold increase in activity on acetoacetyl-CoA.
- K160 (= K159) mutation to A: Almost no activity on acetoacetyl-CoA.
- F188 (= F187) mutation to Y: 3.3-fold increase in activity on acetoacetyl-CoA.
- N198 (≠ P197) mutation to R: 3.5-fold increase in activity on acetoacetyl-CoA.
4bo4C Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
50% identity, 100% coverage: 2:246/246 of query aligns to 14:253/255 of 4bo4C
4bnzA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-methyl-n-phenylindole- 3-carboxamide at 2.5a resolution (see paper)
49% identity, 100% coverage: 2:246/246 of query aligns to 3:239/241 of 4bnzA
4dmmB 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
49% identity, 99% coverage: 2:245/246 of query aligns to 1:237/240 of 4dmmB
- active site: G16 (= G17), S142 (= S142), Q152 (= Q152), Y155 (= Y155), K159 (= K159)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G13), S14 (≠ T15), R15 (= R16), G16 (= G17), I17 (= I18), A37 (≠ R38), S38 (≠ E39), S39 (≠ R40), A62 (≠ L63), D63 (= D64), V64 (≠ L65), N90 (= N90), A91 (= A91), L113 (≠ T113), I140 (= I140), S142 (= S142), Y155 (= Y155), K159 (= K159), P185 (= P185), G186 (= G186), I188 (= I188), T190 (= T190), M192 (= M192)
4bnyA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8a resolution (see paper)
49% identity, 100% coverage: 2:246/246 of query aligns to 2:237/239 of 4bnyA
4bnxA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 6-(4-(2-chloroanilino)- 1h-quinazolin-2-ylidene)cyclohexa-2, 4-dien-1-one at 2.3a resolution (see paper)
49% identity, 100% coverage: 2:246/246 of query aligns to 3:238/239 of 4bnxA
- active site: G18 (= G17), S134 (= S142), Y147 (= Y155), K151 (= K159)
- binding 6-[4-(2-chloroanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one: V103 (≠ I111), N104 (= N112), L107 (≠ I115), A149 (≠ T157), G153 (= G161), G156 (= G164), F157 (= F165)
4bnuA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2-phenyl-4-(1,2,4- triazol-4-yl)quinazoline at 2.0a resolution (see paper)
48% identity, 100% coverage: 2:246/246 of query aligns to 3:237/239 of 4bnuA
- active site: G18 (= G17), S133 (= S142), Y146 (= Y155), K150 (= K159)
- binding 2-phenyl-4-(1,2,4-triazol-4-yl)quinazoline: W98 (= W107), V102 (≠ I111), L106 (≠ I115), A148 (≠ T157), G152 (= G161), G155 (= G164)
Query Sequence
>WP_028951255.1 NCBI__GCF_000619805.1:WP_028951255.1
MLNFKDKNVLITGSTRGIGKAIALSFAKYGANVIITGRERSTAEILAKNIENEFGVKAFG
INLDLSGDIENSFKEIVDWSGGKIDILVNNAGITKDTLFIRMKQEDWDSVINTNITGTFK
ITQAVAKLMIKQRYGRIINISSIIGFIGNIGQVNYATTKAGLIGFTKSLAKELASRNITV
NAVAPGFIETDMTANLPADIVENYLNQIPLGRFGKPEDVANVVLFLASDMASYITGETIH
VNGGMF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory