SitesBLAST
Comparing WP_028951259.1 NCBI__GCF_000619805.1:WP_028951259.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2j6hA E. Coli glucosamine-6-p synthase in complex with glucose-6p and 5-oxo- l-norleucine (see paper)
48% identity, 100% coverage: 2:604/604 of query aligns to 1:608/608 of 2j6hA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W76), N98 (= N102), G99 (= G103), Y248 (≠ F250), E481 (= E476), K485 (= K480), E488 (= E483), H504 (= H499), K603 (= K599)
- binding glucose-6-phosphate: T302 (= T297), S347 (= S342), Q348 (= Q343), S349 (= S344), T352 (= T347), V399 (= V393), S401 (≠ A395), E488 (= E483)
- binding 5-oxo-l-norleucine: C1 (= C2), R73 (= R75), W74 (= W76), T76 (= T78), H86 (= H88), N98 (= N102), G99 (= G103), D123 (= D127)
4amvA E.Coli glucosamine-6p synthase in complex with fructose-6p (see paper)
48% identity, 100% coverage: 2:604/604 of query aligns to 1:608/608 of 4amvA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W76), N98 (= N102), G99 (= G103), Y248 (≠ F250), E481 (= E476), K485 (= K480), E488 (= E483), H504 (= H499), K603 (= K599)
- binding fructose -6-phosphate: G301 (= G296), T302 (= T297), S303 (= S298), S347 (= S342), Q348 (= Q343), S349 (= S344), T352 (= T347), S401 (≠ A395), K485 (= K480), E488 (= E483)
1jxaA Glucosamine 6-phosphate synthase with glucose 6-phosphate (see paper)
48% identity, 100% coverage: 2:604/604 of query aligns to 1:608/608 of 1jxaA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W76), N98 (= N102), G99 (= G103), Y248 (≠ F250), E481 (= E476), K485 (= K480), E488 (= E483), H504 (= H499), K603 (= K599)
- binding glucose-6-phosphate: T302 (= T297), S303 (= S298), S347 (= S342), Q348 (= Q343), S349 (= S344), T352 (= T347), S401 (≠ A395), K485 (= K480), E488 (= E483)
6svmA Crystal structure of human gfat-1 in complex with glucose-6-phosphate, l-glu, and udp-galnac (see paper)
39% identity, 100% coverage: 2:604/604 of query aligns to 1:660/660 of 6svmA
- active site: L7 (≠ V8), R32 (= R27), W95 (= W76), N122 (= N102), G123 (= G103), E533 (= E476), K537 (= K480), E540 (= E483), H556 (= H499), K655 (= K599)
- binding glucose-6-phosphate: C353 (= C295), T355 (= T297), S356 (= S298), S400 (= S342), Q401 (= Q343), S402 (= S344), T405 (= T347), S453 (≠ A395), K537 (= K480), E540 (= E483)
- binding glutamic acid: C1 (= C2), R94 (= R75), W95 (= W76), T97 (= T78), H107 (= H88), G123 (= G103), D147 (= D127)
- binding magnesium ion: S434 (= S376), R435 (= R377), T437 (≠ S379)
- binding uridine-diphosphate-n-acetylgalactosamine: Q289 (≠ N239), R322 (≠ F272), G334 (vs. gap), G424 (≠ S366), T426 (≠ V368), S434 (= S376), T437 (≠ S379), C439 (≠ F381), G440 (≠ V382), V441 (≠ I383), H442 (≠ Y384)
6r4eA Crystal structure of human gfat-1 in complex with glucose-6-phosphate and l-glu (see paper)
39% identity, 100% coverage: 2:604/604 of query aligns to 1:663/663 of 6r4eA
- active site: L7 (≠ V8), R32 (= R27), W95 (= W76), N122 (= N102), G123 (= G103), E536 (= E476), K540 (= K480), E543 (= E483), H559 (= H499), K658 (= K599)
- binding glucose-6-phosphate: T358 (= T297), S359 (= S298), S403 (= S342), Q404 (= Q343), S405 (= S344), T408 (= T347), S456 (≠ A395), K540 (= K480), E543 (= E483)
- binding glutamic acid: C1 (= C2), R94 (= R75), W95 (= W76), T97 (= T78), G123 (= G103), D147 (= D127)
6r4gA Crystal structure of human gfat-1 in complex with udp-glcnac (see paper)
39% identity, 99% coverage: 2:597/604 of query aligns to 1:652/652 of 6r4gA
- active site: L7 (≠ V8), R32 (= R27), W95 (= W76), N122 (= N102), G123 (= G103), E532 (= E476), K536 (= K480), E539 (= E483), H555 (= H499)
- binding glucose-6-phosphate: G353 (= G296), T354 (= T297), S355 (= S298), S399 (= S342), Q400 (= Q343), S401 (= S344), T404 (= T347), S452 (≠ A395), E539 (= E483)
- binding magnesium ion: S433 (= S376), R434 (= R377), T436 (≠ S379)
- binding uridine-diphosphate-n-acetylglucosamine: Q288 (≠ N239), R321 (≠ F272), G333 (vs. gap), G423 (≠ S366), T425 (≠ V368), S433 (= S376), T436 (≠ S379), C438 (≠ F381), G439 (≠ V382), V440 (≠ I383), H441 (≠ Y384)
Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1; EC 2.6.1.16 from Homo sapiens (Human) (see paper)
37% identity, 100% coverage: 1:604/604 of query aligns to 1:699/699 of Q06210
- TS 394:395 (= TS 297:298) binding substrate
- SQS 439:441 (= SQS 342:344) binding substrate
- T444 (= T347) binding substrate
- H595 (= H499) binding substrate
1mosA Isomerase domain of glucosamine 6-phosphate synthase complexed with 2- amino-2-deoxyglucitol 6-phosphate (see paper)
49% identity, 60% coverage: 244:604/604 of query aligns to 1:367/367 of 1mosA
- active site: E240 (= E476), K244 (= K480), E247 (= E483), H263 (= H499), K362 (= K599)
- binding 2-deoxy-2-amino glucitol-6-phosphate: T61 (= T297), S62 (= S298), S106 (= S342), Q107 (= Q343), S108 (= S344), T111 (= T347), K244 (= K480), E247 (= E483)
1morA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucose 6-phosphate (see paper)
49% identity, 60% coverage: 245:604/604 of query aligns to 1:366/366 of 1morA
- active site: E239 (= E476), K243 (= K480), E246 (= E483), H262 (= H499), K361 (= K599)
- binding 6-O-phosphono-alpha-D-glucopyranose: T60 (= T297), S105 (= S342), Q106 (= Q343), S107 (= S344), T110 (= T347), V157 (= V393), A360 (= A598), K361 (= K599)
1moqA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucosamine 6-phosphate (see paper)
49% identity, 60% coverage: 245:604/604 of query aligns to 1:366/366 of 1moqA
- active site: E239 (= E476), K243 (= K480), E246 (= E483), H262 (= H499), K361 (= K599)
- binding 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose: T60 (= T297), S61 (= S298), S105 (= S342), Q106 (= Q343), S107 (= S344), T110 (= T347), V157 (= V393), A360 (= A598), K361 (= K599)
7dnrA Crystal structure of zn-bound sis domain of glucosamine-6-p synthase from e. Coli
48% identity, 58% coverage: 245:595/604 of query aligns to 1:357/357 of 7dnrA
2zj4A Isomerase domain of human glucose:fructose-6-phosphate amidotransferase (see paper)
42% identity, 59% coverage: 247:604/604 of query aligns to 2:365/365 of 2zj4A
- active site: E238 (= E476), K242 (= K480), E245 (= E483), H261 (= H499), K360 (= K599)
- binding 2-deoxy-2-amino glucitol-6-phosphate: T60 (= T297), S61 (= S298), S105 (= S342), Q106 (= Q343), S107 (= S344), T110 (= T347), V156 (= V393), A157 (= A394), K242 (= K480), E245 (= E483)
2zj3A Isomerase domain of human glucose:fructose-6-phosphate amidotransferase (see paper)
42% identity, 59% coverage: 247:604/604 of query aligns to 2:365/365 of 2zj3A
- active site: E238 (= E476), K242 (= K480), E245 (= E483), H261 (= H499), K360 (= K599)
- binding 6-O-phosphono-alpha-D-glucopyranose: T60 (= T297), S61 (= S298), S105 (= S342), Q106 (= Q343), S107 (= S344), T110 (= T347), V156 (= V393), A359 (= A598), K360 (= K599)
2v4mA The isomerase domain of human glutamine-fructose-6-phosphate transaminase 1 (gfpt1) in complex with fructose 6-phosphate
41% identity, 57% coverage: 247:592/604 of query aligns to 1:352/352 of 2v4mA
- active site: E237 (= E476), K241 (= K480), E244 (= E483), H260 (= H499)
- binding fructose -6-phosphate: T59 (= T297), S60 (= S298), S104 (= S342), Q105 (= Q343), S106 (= S344), T109 (= T347), A156 (= A394), S157 (≠ A395), K241 (= K480), E244 (= E483)
P14742 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; GFAT; D-fructose-6-phosphate amidotransferase; Hexosephosphate aminotransferase; EC 2.6.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
38% identity, 71% coverage: 177:604/604 of query aligns to 281:717/717 of P14742
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 active site, For GATase activity
2pocB The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans (see paper)
38% identity, 57% coverage: 250:592/604 of query aligns to 2:352/352 of 2pocB
- active site: E236 (= E476), K240 (= K480), E243 (= E483), H259 (= H499)
- binding 6-O-phosphono-beta-D-glucopyranose: C55 (= C295), T57 (= T297), S58 (= S298), S102 (= S342), Q103 (= Q343), S104 (= S344), T107 (= T347), E243 (= E483)
- binding uridine-diphosphate-n-acetylglucosamine: R24 (≠ F272), G36 (vs. gap), G126 (≠ S366), V128 (= V368), S136 (= S376), T139 (≠ S379), C141 (≠ F381), G142 (≠ V382), V143 (≠ I383), H144 (≠ Y384)
1xfgA Glutaminase domain of glucosamine 6-phosphate synthase complexed with l-glu hydroxamate (see paper)
47% identity, 39% coverage: 2:239/604 of query aligns to 1:237/238 of 1xfgA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W76), N98 (= N102), G99 (= G103)
- binding glutamine hydroxamate: C1 (= C2), R73 (= R75), W74 (= W76), T76 (= T78), H86 (= H88), N98 (= N102), G99 (= G103), D123 (= D127)
1xffA Glutaminase domain of glucosamine 6-phosphate synthase complexed with glutamate (see paper)
47% identity, 39% coverage: 2:239/604 of query aligns to 1:237/238 of 1xffA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W76), N98 (= N102), G99 (= G103)
- binding glutamic acid: C1 (= C2), R73 (= R75), W74 (= W76), T76 (= T78), H86 (= H88), N98 (= N102), G99 (= G103), D123 (= D127)
2putA The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans (see paper)
36% identity, 57% coverage: 250:592/604 of query aligns to 2:339/339 of 2putA
- active site: E236 (= E476), K240 (= K480), E243 (= E483)
- binding fructose -6-phosphate: C55 (= C295), T57 (= T297), S102 (= S342), Q103 (= Q343), S104 (= S344), T107 (= T347), A154 (= A394), S155 (≠ A395), K240 (= K480)
- binding uridine-diphosphate-n-acetylglucosamine: R24 (≠ F272), G36 (vs. gap), G126 (≠ S366), V128 (= V368), S136 (= S376), T139 (≠ S379), C141 (≠ F381), G142 (≠ V382), V143 (≠ I383), H144 (≠ Y384)
2puvA The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans (see paper)
36% identity, 57% coverage: 248:592/604 of query aligns to 1:338/338 of 2puvA
- active site: E237 (= E476), K241 (= K480), E244 (= E483)
- binding 5-amino-5-deoxy-1-o-phosphono-d-mannitol: C56 (= C295), T58 (= T297), S103 (= S342), Q104 (= Q343), S105 (= S344), T108 (= T347), A155 (= A394), E244 (= E483)
- binding uridine-diphosphate-n-acetylglucosamine: R25 (≠ F272), G37 (vs. gap), G127 (≠ S366), V129 (= V368), S137 (= S376), T140 (≠ S379), C142 (≠ F381), G143 (≠ V382), V144 (≠ I383), H145 (≠ Y384)
Query Sequence
>WP_028951259.1 NCBI__GCF_000619805.1:WP_028951259.1
MCGIVGYVGYRKAVPVLLHGLQRLEYRGYDSAGIAVLDEKAKKIIVEKQVGKIKDLQEHI
WGKEINGNIGIAHTRWATHGPPSIENAHPHTSKSETFAVVHNGIIENYAKLKEELIKKGY
HFKSQTDTEVIAHLLEEYYEKDLLTTVLKVAKMIEGAYAIGVISTLEPDKIVALRKGSPL
IIGIGKGENFIASDIPAILEYTKTFITLDDEEIAVITKDKVEVYDINGNKIEKKPFTVNW
DLASAEKGGFKHFMLKEIYEQPKTITDTISGFFSDLDNPVYKEIKNIENIVIIACGTSYH
AGLVGKFWIEKFVKVPTIVDYASEFRYRDFPINEKTLIIAISQSGETADTRFSAIDARKK
GAKVLSIVNVVGSSLSRESDFVIYTYCGPEIGVAATKTFTAQLITLLLFSLKAGLERGNL
TQEEFEKYHNDVIHLPHLINEVLKQDKVIEEISYKYHNVKDFLFLGRGLNYPIALEGALK
LKEISYIHAEGYPAGEMKHGPIALIDENLPVVCMVPKDSLYEKMISNIQEVKARKGIVIS
ISDSQDSHLLSPSDSIIKIPSVENENLYPIISVVPLQLLAYHIATILGKDVDQPRNLAKT
VTVE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory