SitesBLAST
Comparing WP_028999235.1 NCBI__GCF_000430725.1:WP_028999235.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 95% coverage: 23:584/590 of query aligns to 8:574/596 of 1t9cA
- active site: Y29 (= Y44), G31 (= G46), G32 (= G47), A33 (≠ S48), I34 (≠ V49), E55 (= E70), T78 (= T93), F117 (= F132), Q118 (= Q133), E119 (= E134), K167 (= K182), R227 (≠ A241), M263 (= M277), V290 (= V304), V406 (= V414), L431 (= L439), G432 (= G440), M434 (= M442), D459 (≠ E467), N486 (= N494), E488 (≠ Y496), Q489 (≠ L497), M491 (= M499), V492 (= V500), W495 (= W503), L517 (= L526), G522 (= G531), L523 (≠ H532), K556 (≠ P566)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G47), V107 (= V122), P108 (= P123), F117 (= F132), K167 (= K182), D288 (= D302), R289 (= R303), W495 (= W503)
- binding flavin-adenine dinucleotide: R157 (= R172), G216 (= G231), A217 (≠ G232), G218 (= G233), N221 (vs. gap), T243 (= T257), L244 (= L258), Q245 (≠ M259), L261 (= L275), M263 (= M277), H264 (= H278), G283 (= G297), A284 (= A298), R285 (= R299), D287 (= D301), R289 (= R303), V290 (= V304), E316 (≠ D322), V317 (≠ I323), N321 (≠ S327), G334 (= G340), D335 (= D341), A336 (≠ V342), M411 (= M419), G429 (= G437), G430 (= G438)
- binding magnesium ion: D459 (≠ E467), N486 (= N494), E488 (≠ Y496)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
44% identity, 95% coverage: 23:584/590 of query aligns to 10:577/599 of 1n0hA
- active site: Y31 (= Y44), G33 (= G46), G34 (= G47), A35 (≠ S48), I36 (≠ V49), E57 (= E70), T80 (= T93), F119 (= F132), Q120 (= Q133), E121 (= E134), K169 (= K182), R230 (≠ A241), M266 (= M277), V293 (= V304), V409 (= V414), L434 (= L439), G435 (= G440), M437 (= M442), D462 (≠ E467), N489 (= N494), E491 (≠ Y496), Q492 (≠ L497), M494 (= M499), V495 (= V500), W498 (= W503), L520 (= L526), G525 (= G531), L526 (≠ H532), K559 (≠ P566)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V414), G410 (= G415), Q411 (= Q416), H412 (= H417), G435 (= G440), M437 (= M442), G461 (= G466), D462 (≠ E467), A463 (≠ G468), S464 (= S469), M467 (= M472), N489 (= N494), E491 (≠ Y496), Q492 (≠ L497), G493 (= G498), V495 (= V500)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G47), A35 (≠ S48), V109 (= V122), P110 (= P123), F119 (= F132), K169 (= K182), M266 (= M277), D291 (= D302), R292 (= R303), V495 (= V500), W498 (= W503)
- binding flavin-adenine dinucleotide: R159 (= R172), G219 (= G231), A220 (≠ G232), G221 (= G233), N224 (vs. gap), T246 (= T257), L247 (= L258), Q248 (≠ M259), L264 (= L275), G265 (= G276), M266 (= M277), H267 (= H278), G286 (= G297), A287 (= A298), R288 (= R299), D290 (= D301), R292 (= R303), V293 (= V304), E319 (≠ D322), V320 (≠ I323), N324 (≠ S327), G337 (= G340), D338 (= D341), A339 (≠ V342), M414 (= M419), G432 (= G437), G433 (= G438)
- binding magnesium ion: D462 (≠ E467), N489 (= N494), E491 (≠ Y496)
- binding thiamine diphosphate: Y31 (= Y44), E57 (= E70), P83 (= P96)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 95% coverage: 23:584/590 of query aligns to 8:574/596 of 1t9dA
- active site: Y29 (= Y44), G31 (= G46), G32 (= G47), A33 (≠ S48), I34 (≠ V49), E55 (= E70), T78 (= T93), F117 (= F132), Q118 (= Q133), E119 (= E134), K167 (= K182), R227 (≠ A241), M263 (= M277), V290 (= V304), V406 (= V414), L431 (= L439), G432 (= G440), M434 (= M442), D459 (≠ E467), N486 (= N494), E488 (≠ Y496), Q489 (≠ L497), M491 (= M499), V492 (= V500), W495 (= W503), L517 (= L526), G522 (= G531), L523 (≠ H532), K556 (≠ P566)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G47), A33 (≠ S48), V107 (= V122), P108 (= P123), F117 (= F132), K167 (= K182), M263 (= M277), D288 (= D302), R289 (= R303), W495 (= W503)
- binding flavin-adenine dinucleotide: R157 (= R172), G216 (= G231), A217 (≠ G232), G218 (= G233), N221 (vs. gap), T243 (= T257), L244 (= L258), Q245 (≠ M259), M260 (= M274), L261 (= L275), H264 (= H278), G283 (= G297), A284 (= A298), R285 (= R299), D287 (= D301), R289 (= R303), V290 (= V304), E316 (≠ D322), V317 (≠ I323), N321 (≠ S327), G334 (= G340), D335 (= D341), A336 (≠ V342), Q410 (= Q418), M411 (= M419), G429 (= G437), G430 (= G438)
- binding magnesium ion: D459 (≠ E467), N486 (= N494), E488 (≠ Y496)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E70), P81 (= P96), Q118 (= Q133), G432 (= G440), M434 (= M442), M464 (= M472)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
44% identity, 97% coverage: 12:584/590 of query aligns to 79:665/687 of P07342
- R241 (= R172) binding FAD
- 355:376 (vs. 278:299, 50% identical) binding FAD
- 407:426 (vs. 322:341, 35% identical) binding FAD
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 95% coverage: 23:584/590 of query aligns to 9:575/597 of 1t9aA
- active site: Y30 (= Y44), G32 (= G46), G33 (= G47), A34 (≠ S48), I35 (≠ V49), E56 (= E70), T79 (= T93), F118 (= F132), Q119 (= Q133), E120 (= E134), K168 (= K182), R228 (≠ A241), M264 (= M277), V291 (= V304), V407 (= V414), L432 (= L439), G433 (= G440), M435 (= M442), D460 (≠ E467), N487 (= N494), E489 (≠ Y496), Q490 (≠ L497), M492 (= M499), V493 (= V500), W496 (= W503), L518 (= L526), G523 (= G531), L524 (≠ H532), K557 (≠ P566)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G47), V108 (= V122), P109 (= P123), F118 (= F132), K168 (= K182), M264 (= M277), D289 (= D302), R290 (= R303), M492 (= M499), V493 (= V500), W496 (= W503)
- binding flavin-adenine dinucleotide: R158 (= R172), G217 (= G231), A218 (≠ G232), G219 (= G233), N222 (vs. gap), T244 (= T257), L245 (= L258), Q246 (≠ M259), L262 (= L275), M264 (= M277), H265 (= H278), G284 (= G297), A285 (= A298), R286 (= R299), D288 (= D301), R290 (= R303), V291 (= V304), E317 (≠ D322), V318 (≠ I323), N322 (≠ S327), G335 (= G340), D336 (= D341), A337 (≠ V342), Q411 (= Q418), M412 (= M419), G430 (= G437), G431 (= G438)
- binding magnesium ion: D460 (≠ E467), N487 (= N494), E489 (≠ Y496)
- binding propyl trihydrogen diphosphate: V407 (= V414), G408 (= G415), Q409 (= Q416), H410 (= H417), M435 (= M442), G459 (= G466), D460 (≠ E467), A461 (≠ G468), S462 (= S469), N487 (= N494), E489 (≠ Y496), Q490 (≠ L497), G491 (= G498), M492 (= M499)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G440), M435 (= M442), M465 (= M472)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
44% identity, 95% coverage: 23:584/590 of query aligns to 8:569/591 of 5wkcA
- active site: Y29 (= Y44), G31 (= G46), G32 (= G47), A33 (≠ S48), I34 (≠ V49), E55 (= E70), T78 (= T93), F117 (= F132), Q118 (= Q133), E119 (= E134), K167 (= K182), R222 (≠ A241), M258 (= M277), V285 (= V304), V401 (= V414), L426 (= L439), G427 (= G440), M429 (= M442), D454 (≠ E467), N481 (= N494), E483 (≠ Y496), Q484 (≠ L497), M486 (= M499), V487 (= V500), W490 (= W503), L512 (= L526), G517 (= G531), L518 (≠ H532), K551 (≠ P566)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V414), G402 (= G415), Q403 (= Q416), H404 (= H417), G427 (= G440), M429 (= M442), G453 (= G466), D454 (≠ E467), A455 (≠ G468), S456 (= S469), M459 (= M472), N481 (= N494), E483 (≠ Y496), Q484 (≠ L497), G485 (= G498), M486 (= M499), V487 (= V500)
- binding ethaneperoxoic acid: G32 (= G47), Q118 (= Q133)
- binding flavin-adenine dinucleotide: R157 (= R172), G211 (= G231), A212 (≠ G232), G213 (= G233), N216 (vs. gap), T238 (= T257), L239 (= L258), Q240 (≠ M259), L256 (= L275), M258 (= M277), G278 (= G297), A279 (= A298), R280 (= R299), R284 (= R303), V285 (= V304), E311 (≠ D322), V312 (≠ I323), N316 (≠ S327), D330 (= D341), A331 (≠ V342), M406 (= M419), G424 (= G437)
- binding magnesium ion: D454 (≠ E467), N481 (= N494), E483 (≠ Y496)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G47), A33 (≠ S48), V107 (= V122), F117 (= F132), K167 (= K182), M258 (= M277), R284 (= R303), M486 (= M499), W490 (= W503)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P45), E55 (= E70)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
45% identity, 95% coverage: 23:584/590 of query aligns to 8:561/583 of 1t9bA
- active site: Y29 (= Y44), G31 (= G46), G32 (= G47), A33 (≠ S48), I34 (≠ V49), E55 (= E70), T78 (= T93), F117 (= F132), Q118 (= Q133), E119 (= E134), K167 (= K182), R214 (≠ A241), M250 (= M277), V277 (= V304), V393 (= V414), L418 (= L439), G419 (= G440), M421 (= M442), D446 (≠ E467), N473 (= N494), E475 (≠ Y496), Q476 (≠ L497), M478 (= M499), V479 (= V500), W482 (= W503), L504 (= L526), G509 (= G531), L510 (≠ H532), K543 (≠ P566)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V122), P108 (= P123), F117 (= F132), D275 (= D302), R276 (= R303), M478 (= M499), W482 (= W503)
- binding flavin-adenine dinucleotide: R157 (= R172), G203 (= G231), A204 (≠ G232), G205 (= G233), N208 (vs. gap), T230 (= T257), L231 (= L258), Q232 (≠ M259), M247 (= M274), L248 (= L275), M250 (= M277), H251 (= H278), G270 (= G297), A271 (= A298), R272 (= R299), D274 (= D301), R276 (= R303), V277 (= V304), E303 (≠ D322), V304 (≠ I323), N308 (≠ S327), D322 (= D341), A323 (≠ V342), Q397 (= Q418), M398 (= M419), G416 (= G437), G417 (= G438)
- binding magnesium ion: D446 (≠ E467), N473 (= N494), E475 (≠ Y496)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
44% identity, 95% coverage: 23:584/590 of query aligns to 8:573/595 of 1t9bB
- active site: Y29 (= Y44), G31 (= G46), G32 (= G47), A33 (≠ S48), I34 (≠ V49), E55 (= E70), T78 (= T93), F117 (= F132), Q118 (= Q133), E119 (= E134), K167 (= K182), R226 (≠ A241), M262 (= M277), V289 (= V304), V405 (= V414), L430 (= L439), G431 (= G440), M433 (= M442), D458 (≠ E467), N485 (= N494), E487 (≠ Y496), Q488 (≠ L497), M490 (= M499), V491 (= V500), W494 (= W503), L516 (= L526), G521 (= G531), L522 (≠ H532), K555 (≠ P566)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V122), P108 (= P123), D287 (= D302), R288 (= R303), M490 (= M499), W494 (= W503)
- binding flavin-adenine dinucleotide: R157 (= R172), G215 (= G231), A216 (≠ G232), G217 (= G233), N220 (vs. gap), T242 (= T257), L243 (= L258), Q244 (≠ M259), M259 (= M274), L260 (= L275), M262 (= M277), H263 (= H278), G282 (= G297), A283 (= A298), R284 (= R299), D286 (= D301), R288 (= R303), V289 (= V304), E315 (≠ D322), V316 (≠ I323), N320 (≠ S327), G333 (= G340), D334 (= D341), A335 (≠ V342), Q409 (= Q418), M410 (= M419), G428 (= G437), G429 (= G438)
- binding magnesium ion: D458 (≠ E467), N485 (= N494), E487 (≠ Y496)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
45% identity, 95% coverage: 23:584/590 of query aligns to 7:560/582 of 1t9dB
- active site: Y28 (= Y44), G30 (= G46), G31 (= G47), A32 (≠ S48), I33 (≠ V49), E54 (= E70), T77 (= T93), F116 (= F132), Q117 (= Q133), E118 (= E134), K166 (= K182), R213 (≠ A241), M249 (= M277), V276 (= V304), V392 (= V414), L417 (= L439), G418 (= G440), M420 (= M442), D445 (≠ E467), N472 (= N494), E474 (≠ Y496), Q475 (≠ L497), M477 (= M499), V478 (= V500), W481 (= W503), L503 (= L526), G508 (= G531), L509 (≠ H532), K542 (≠ P566)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G47), A32 (≠ S48), V106 (= V122), P107 (= P123), F116 (= F132), K166 (= K182), M249 (= M277), D274 (= D302), R275 (= R303), W481 (= W503)
- binding flavin-adenine dinucleotide: R156 (= R172), G202 (= G231), A203 (≠ G232), G204 (= G233), N207 (vs. gap), T229 (= T257), L230 (= L258), Q231 (≠ M259), L247 (= L275), M249 (= M277), H250 (= H278), G269 (= G297), A270 (= A298), R271 (= R299), D273 (= D301), R275 (= R303), V276 (= V304), E302 (≠ D322), V303 (≠ I323), N307 (≠ S327), G320 (= G340), D321 (= D341), A322 (≠ V342), Q396 (= Q418), M397 (= M419), G415 (= G437), G416 (= G438)
- binding magnesium ion: D445 (≠ E467), N472 (= N494), E474 (≠ Y496)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E70), P80 (= P96), G418 (= G440), M420 (= M442), M450 (= M472)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
44% identity, 95% coverage: 23:584/590 of query aligns to 12:585/607 of 6u9dB
- active site: Y33 (= Y44), G35 (= G46), G36 (= G47), A37 (≠ S48), I38 (≠ V49), E59 (= E70), T82 (= T93), F121 (= F132), Q122 (= Q133), E123 (= E134), K171 (= K182), M274 (= M277), V301 (= V304), V417 (= V414), G443 (= G440), M445 (= M442), D470 (≠ E467), N497 (= N494), E499 (≠ Y496), Q500 (≠ L497), M502 (= M499), V503 (= V500), W506 (= W503)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G47), V111 (= V122), P112 (= P123), F121 (= F132), K171 (= K182), D299 (= D302), R300 (= R303), M502 (= M499), W506 (= W503)
- binding flavin-adenine dinucleotide: R161 (= R172), A228 (≠ G232), G229 (= G233), N232 (vs. gap), T254 (= T257), L255 (= L258), Q256 (≠ M259), L272 (= L275), M274 (= M277), G294 (= G297), R296 (= R299), D298 (= D301), R300 (= R303), V301 (= V304), E327 (≠ D322), V328 (≠ I323), N332 (≠ S327), D346 (= D341), A347 (≠ V342), M422 (= M419), G440 (= G437), G441 (= G438)
- binding magnesium ion: D470 (≠ E467), N497 (= N494)
- binding thiamine diphosphate: E59 (= E70), P85 (= P96), V417 (= V414), G418 (= G415), Q419 (= Q416), H420 (= H417), G443 (= G440), M445 (= M442), A471 (≠ G468), S472 (= S469), N497 (= N494), E499 (≠ Y496), Q500 (≠ L497), G501 (= G498), M502 (= M499), V503 (= V500)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 14:580/601 of 6deqA
- active site: Y35 (= Y44), G37 (= G46), G38 (= G47), A39 (≠ S48), I40 (≠ V49), E61 (= E70), T84 (= T93), F123 (= F132), Q124 (= Q133), E125 (= E134), K173 (= K182), K232 (≠ E242), M268 (= M277), V295 (= V304), V411 (= V414), L436 (= L439), G437 (= G440), M439 (= M442), D464 (≠ E467), N491 (= N494), E493 (≠ Y496), Q494 (≠ L497), M496 (= M499), V497 (= V500), W500 (= W503), L522 (= L526), N527 (≠ G531), V528 (≠ H532)
- binding flavin-adenine dinucleotide: R163 (= R172), G221 (= G231), A222 (≠ G232), G223 (= G233), N226 (≠ L236), T248 (= T257), L249 (= L258), Q250 (≠ M259), L266 (= L275), G288 (= G297), A289 (= A298), R290 (= R299), D292 (= D301), R294 (= R303), V295 (= V304), E321 (≠ D322), I322 (= I323), D340 (= D341), V341 (= V342), M416 (= M419), G434 (= G437)
- binding magnesium ion: D464 (≠ E467), N491 (= N494), E493 (≠ Y496)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M277), R294 (= R303), M496 (= M499), V497 (= V500), W500 (= W503), A571 (= A576)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V414), G412 (= G415), Q413 (= Q416), H414 (= H417), M439 (= M442), G463 (= G466), D464 (≠ E467), A465 (≠ G468), S466 (= S469), N491 (= N494), E493 (≠ Y496), Q494 (≠ L497), G495 (= G498), M496 (= M499), V497 (= V500)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 12:576/597 of 6demA
- active site: Y33 (= Y44), G35 (= G46), G36 (= G47), A37 (≠ S48), I38 (≠ V49), E59 (= E70), T82 (= T93), F121 (= F132), Q122 (= Q133), E123 (= E134), K171 (= K182), K228 (≠ E242), M264 (= M277), V291 (= V304), V407 (= V414), L432 (= L439), G433 (= G440), M435 (= M442), D460 (≠ E467), N487 (= N494), E489 (≠ Y496), Q490 (≠ L497), M492 (= M499), V493 (= V500), W496 (= W503), L518 (= L526), N523 (≠ G531), V524 (≠ H532)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M277), D289 (= D302), R290 (= R303), M492 (= M499), W496 (= W503), A567 (= A576)
- binding flavin-adenine dinucleotide: R161 (= R172), G217 (= G231), A218 (≠ G232), G219 (= G233), N222 (≠ L236), T244 (= T257), L245 (= L258), Q246 (≠ M259), L262 (= L275), G284 (= G297), A285 (= A298), R286 (= R299), D288 (= D301), R290 (= R303), V291 (= V304), E317 (≠ D322), I318 (= I323), N322 (≠ S327), D336 (= D341), V337 (= V342), M412 (= M419), G430 (= G437)
- binding magnesium ion: D460 (≠ E467), N487 (= N494), E489 (≠ Y496)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V414), G408 (= G415), Q409 (= Q416), H410 (= H417), M435 (= M442), G459 (= G466), D460 (≠ E467), A461 (≠ G468), S462 (= S469), M465 (= M472), N487 (= N494), E489 (≠ Y496), Q490 (≠ L497), G491 (= G498), M492 (= M499), V493 (= V500)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 12:576/597 of 6delA
- active site: Y33 (= Y44), G35 (= G46), G36 (= G47), A37 (≠ S48), I38 (≠ V49), E59 (= E70), T82 (= T93), F121 (= F132), Q122 (= Q133), E123 (= E134), K171 (= K182), K228 (≠ E242), M264 (= M277), V291 (= V304), V407 (= V414), L432 (= L439), G433 (= G440), M435 (= M442), D460 (≠ E467), N487 (= N494), E489 (≠ Y496), Q490 (≠ L497), M492 (= M499), V493 (= V500), W496 (= W503), L518 (= L526), N523 (≠ G531), V524 (≠ H532)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D302), R290 (= R303), W496 (= W503)
- binding flavin-adenine dinucleotide: R161 (= R172), G217 (= G231), A218 (≠ G232), G219 (= G233), N222 (≠ L236), T244 (= T257), L245 (= L258), Q246 (≠ M259), L262 (= L275), G284 (= G297), A285 (= A298), R286 (= R299), D288 (= D301), R290 (= R303), V291 (= V304), E317 (≠ D322), I318 (= I323), N322 (≠ S327), D336 (= D341), V337 (= V342), M412 (= M419), G430 (= G437)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V414), G408 (= G415), Q409 (= Q416), H410 (= H417), G433 (= G440), M435 (= M442), G459 (= G466), D460 (≠ E467), A461 (≠ G468), S462 (= S469), M465 (= M472), N487 (= N494), E489 (≠ Y496), Q490 (≠ L497), G491 (= G498), M492 (= M499), V493 (= V500)
- binding magnesium ion: D460 (≠ E467), N487 (= N494), E489 (≠ Y496)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V414), G408 (= G415), Q409 (= Q416), H410 (= H417), G433 (= G440), M435 (= M442), G459 (= G466), D460 (≠ E467), A461 (≠ G468), S462 (= S469), M465 (= M472), N487 (= N494), E489 (≠ Y496), Q490 (≠ L497), G491 (= G498), M492 (= M499), V493 (= V500)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 12:577/598 of 6desA
- active site: Y33 (= Y44), G35 (= G46), G36 (= G47), A37 (≠ S48), I38 (≠ V49), E59 (= E70), T82 (= T93), F121 (= F132), Q122 (= Q133), E123 (= E134), K171 (= K182), K229 (≠ E242), M265 (= M277), V292 (= V304), V408 (= V414), L433 (= L439), G434 (= G440), M436 (= M442), D461 (≠ E467), N488 (= N494), E490 (≠ Y496), Q491 (≠ L497), M493 (= M499), V494 (= V500), W497 (= W503), L519 (= L526), N524 (≠ G531), V525 (≠ H532)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M277), D290 (= D302), R291 (= R303), W497 (= W503)
- binding flavin-adenine dinucleotide: R161 (= R172), G218 (= G231), A219 (≠ G232), G220 (= G233), N223 (≠ L236), T245 (= T257), L246 (= L258), Q247 (≠ M259), L263 (= L275), G285 (= G297), A286 (= A298), R287 (= R299), D289 (= D301), R291 (= R303), V292 (= V304), E318 (≠ D322), I319 (= I323), N323 (≠ S327), D337 (= D341), V338 (= V342), Q412 (= Q418), M413 (= M419), G431 (= G437)
- binding magnesium ion: D461 (≠ E467), N488 (= N494), E490 (≠ Y496)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V414), G409 (= G415), Q410 (= Q416), H411 (= H417), G434 (= G440), M436 (= M442), G460 (= G466), D461 (≠ E467), A462 (≠ G468), S463 (= S469), N488 (= N494), E490 (≠ Y496), Q491 (≠ L497), G492 (= G498), M493 (= M499), V494 (= V500)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 12:577/598 of 6depA
- active site: Y33 (= Y44), G35 (= G46), G36 (= G47), A37 (≠ S48), I38 (≠ V49), E59 (= E70), T82 (= T93), F121 (= F132), Q122 (= Q133), E123 (= E134), K171 (= K182), K229 (≠ E242), M265 (= M277), V292 (= V304), V408 (= V414), L433 (= L439), G434 (= G440), M436 (= M442), D461 (≠ E467), N488 (= N494), E490 (≠ Y496), Q491 (≠ L497), M493 (= M499), V494 (= V500), W497 (= W503), L519 (= L526), N524 (≠ G531), V525 (≠ H532)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D302), R291 (= R303), M493 (= M499), W497 (= W503)
- binding flavin-adenine dinucleotide: R161 (= R172), G218 (= G231), A219 (≠ G232), G220 (= G233), N223 (≠ L236), T245 (= T257), L246 (= L258), Q247 (≠ M259), L263 (= L275), G264 (= G276), G285 (= G297), A286 (= A298), R287 (= R299), D289 (= D301), R291 (= R303), V292 (= V304), E318 (≠ D322), I319 (= I323), N323 (≠ S327), D337 (= D341), V338 (= V342), M413 (= M419), G431 (= G437)
- binding magnesium ion: D461 (≠ E467), N488 (= N494), E490 (≠ Y496)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V414), G409 (= G415), Q410 (= Q416), H411 (= H417), G434 (= G440), M436 (= M442), G460 (= G466), D461 (≠ E467), A462 (≠ G468), S463 (= S469), M466 (= M472), N488 (= N494), E490 (≠ Y496), Q491 (≠ L497), G492 (= G498), M493 (= M499), V494 (= V500)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V414), G409 (= G415), Q410 (= Q416), H411 (= H417), G434 (= G440), M436 (= M442), G460 (= G466), D461 (≠ E467), A462 (≠ G468), S463 (= S469), M466 (= M472), N488 (= N494), E490 (≠ Y496), Q491 (≠ L497), G492 (= G498), M493 (= M499), V494 (= V500)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 14:579/600 of 6derA
- active site: Y35 (= Y44), G37 (= G46), G38 (= G47), A39 (≠ S48), I40 (≠ V49), E61 (= E70), T84 (= T93), F123 (= F132), Q124 (= Q133), E125 (= E134), K173 (= K182), K231 (≠ E242), M267 (= M277), V294 (= V304), V410 (= V414), L435 (= L439), G436 (= G440), M438 (= M442), D463 (≠ E467), N490 (= N494), E492 (≠ Y496), Q493 (≠ L497), M495 (= M499), V496 (= V500), W499 (= W503), L521 (= L526), N526 (≠ G531), V527 (≠ H532)
- binding flavin-adenine dinucleotide: R163 (= R172), G220 (= G231), A221 (≠ G232), G222 (= G233), N225 (≠ L236), T247 (= T257), L248 (= L258), Q249 (≠ M259), L265 (= L275), H268 (= H278), G287 (= G297), A288 (= A298), R289 (= R299), D291 (= D301), R293 (= R303), V294 (= V304), E320 (≠ D322), I321 (= I323), N325 (≠ S327), G338 (= G340), D339 (= D341), V340 (= V342), Q414 (= Q418), M415 (= M419), G433 (= G437)
- binding Metosulam: R293 (= R303), M495 (= M499), W499 (= W503), A570 (= A576)
- binding magnesium ion: D463 (≠ E467), N490 (= N494), E492 (≠ Y496)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V414), G411 (= G415), Q412 (= Q416), H413 (= H417), G436 (= G440), M438 (= M442), G462 (= G466), D463 (≠ E467), A464 (≠ G468), S465 (= S469), N490 (= N494), E492 (≠ Y496), Q493 (≠ L497), G494 (= G498), M495 (= M499), V496 (= V500)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V414), G411 (= G415), Q412 (= Q416), H413 (= H417), G436 (= G440), M438 (= M442), G462 (= G466), D463 (≠ E467), A464 (≠ G468), S465 (= S469), M468 (= M472), N490 (= N494), E492 (≠ Y496), Q493 (≠ L497), G494 (= G498), V496 (= V500)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 14:578/599 of 6denA
- active site: Y35 (= Y44), G37 (= G46), G38 (= G47), A39 (≠ S48), I40 (≠ V49), E61 (= E70), T84 (= T93), F123 (= F132), Q124 (= Q133), E125 (= E134), K173 (= K182), K230 (≠ E242), M266 (= M277), V293 (= V304), V409 (= V414), L434 (= L439), G435 (= G440), M437 (= M442), D462 (≠ E467), N489 (= N494), E491 (≠ Y496), Q492 (≠ L497), M494 (= M499), V495 (= V500), W498 (= W503), L520 (= L526), N525 (≠ G531), V526 (≠ H532)
- binding flavin-adenine dinucleotide: R163 (= R172), G219 (= G231), A220 (≠ G232), G221 (= G233), N224 (≠ L236), T246 (= T257), L247 (= L258), Q248 (≠ M259), L264 (= L275), G286 (= G297), A287 (= A298), R288 (= R299), D290 (= D301), R292 (= R303), V293 (= V304), E319 (≠ D322), I320 (= I323), N324 (≠ S327), D338 (= D341), V339 (= V342), M414 (= M419), G432 (= G437)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M277), D291 (= D302), R292 (= R303), W498 (= W503)
- binding magnesium ion: D462 (≠ E467), N489 (= N494), E491 (≠ Y496)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V414), G410 (= G415), Q411 (= Q416), H412 (= H417), G435 (= G440), M437 (= M442), G461 (= G466), D462 (≠ E467), A463 (≠ G468), S464 (= S469), N489 (= N494), E491 (≠ Y496), Q492 (≠ L497), G493 (= G498), M494 (= M499), V495 (= V500)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
43% identity, 95% coverage: 23:585/590 of query aligns to 10:572/593 of 6deoA
- active site: Y31 (= Y44), G33 (= G46), G34 (= G47), A35 (≠ S48), I36 (≠ V49), E57 (= E70), T80 (= T93), F119 (= F132), Q120 (= Q133), E121 (= E134), K169 (= K182), K224 (≠ E242), M260 (= M277), V287 (= V304), V403 (= V414), L428 (= L439), G429 (= G440), M431 (= M442), D456 (≠ E467), N483 (= N494), E485 (≠ Y496), Q486 (≠ L497), M488 (= M499), V489 (= V500), W492 (= W503), L514 (= L526), N519 (≠ G531), V520 (≠ H532)
- binding flavin-adenine dinucleotide: R159 (= R172), G213 (= G231), A214 (≠ G232), G215 (= G233), N218 (≠ L236), T240 (= T257), L241 (= L258), Q242 (≠ M259), L258 (= L275), G280 (= G297), A281 (= A298), R282 (= R299), D284 (= D301), R286 (= R303), V287 (= V304), E313 (≠ D322), I314 (= I323), N318 (≠ S327), D332 (= D341), V333 (= V342), M408 (= M419), G426 (= G437)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M277), D285 (= D302), R286 (= R303), M488 (= M499), W492 (= W503)
- binding magnesium ion: D456 (≠ E467), N483 (= N494), E485 (≠ Y496)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V414), G404 (= G415), Q405 (= Q416), H406 (= H417), G429 (= G440), M431 (= M442), G455 (= G466), D456 (≠ E467), A457 (≠ G468), S458 (= S469), M461 (= M472), N483 (= N494), E485 (≠ Y496), Q486 (≠ L497), G487 (= G498), M488 (= M499), V489 (= V500)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
42% identity, 96% coverage: 18:584/590 of query aligns to 7:576/583 of 5k3sA
- active site: Y33 (= Y44), G35 (= G46), G36 (= G47), A37 (≠ S48), S38 (≠ V49), E59 (= E70), T82 (= T93), F121 (= F132), Q122 (= Q133), E123 (= E134), K171 (= K182), M266 (= M277), V293 (= V304), V400 (= V414), G426 (= G440), M428 (= M442), D453 (≠ E467), N480 (= N494), H482 (≠ Y496), L483 (= L497), M485 (= M499), V486 (= V500), W489 (= W503), H558 (≠ P566)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R303), M485 (= M499), W489 (= W503), G569 (= G577)
- binding flavin-adenine dinucleotide: R161 (= R172), G222 (= G231), G223 (= G232), G224 (= G233), T246 (= T257), L247 (= L258), M248 (= M259), L264 (= L275), M266 (= M277), G286 (= G297), R288 (= R299), D290 (= D301), V293 (= V304), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), M405 (= M419), G423 (= G437)
- binding magnesium ion: D453 (≠ E467), N480 (= N494), H482 (≠ Y496)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V414), G401 (= G415), Q402 (= Q416), H403 (= H417), G426 (= G440), M428 (= M442), D453 (≠ E467), G454 (= G468), S455 (= S469), N480 (= N494), H482 (≠ Y496), L483 (= L497), G484 (= G498), M485 (= M499), V486 (= V500)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
42% identity, 96% coverage: 18:584/590 of query aligns to 92:661/670 of P17597
- A122 (≠ S48) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L50) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E70) binding thiamine diphosphate
- S186 (= S112) binding FAD
- P197 (= P123) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ A125) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q133) binding thiamine diphosphate
- K220 (= K146) binding (R)-imazaquin
- R246 (= R172) binding (R)-imazaquin; binding FAD
- K256 (= K182) binding chlorimuron-ethyl
- G308 (= G232) binding FAD
- TL 331:332 (= TL 257:258) binding FAD
- C340 (≠ A266) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 275:278) binding FAD
- GVRFD 371:375 (≠ GARFD 297:301) binding FAD
- DR 376:377 (= DR 302:303) binding chlorimuron-ethyl
- DI 395:396 (= DI 322:323) binding FAD
- DV 414:415 (= DV 341:342) binding FAD
- QH 487:488 (= QH 416:417) binding thiamine diphosphate
- GG 508:509 (= GG 437:438) binding FAD
- GAM 511:513 (≠ GTM 440:442) binding thiamine diphosphate
- D538 (≠ E467) binding Mg(2+)
- DGS 538:540 (≠ EGS 467:469) binding thiamine diphosphate
- N565 (= N494) binding Mg(2+)
- NQHLGM 565:570 (≠ NRYLGM 494:499) binding thiamine diphosphate
- H567 (≠ Y496) binding Mg(2+)
- W574 (= W503) binding chlorimuron-ethyl; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ A576) binding chlorimuron-ethyl; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
Query Sequence
>WP_028999235.1 NCBI__GCF_000430725.1:WP_028999235.1
MDMSAAEVKGALRAQPQSPSAELNGSEILVRSLQAEGVKYLWGYPGGSVLYIYDALYKQD
SIQHVLVRHEQAAVHAADGYARATGEVGVALVTSGPGVTNAVTGIATAYMDSIPMVIITG
QVPTAAIGLDAFQECDTVGITRPIVKHNFLVKDVRELALTLKKAFHIARTGRPGPVVVDI
PKDVSLKTAPFSYPDKVEMRSYNPVRKGHGGQIRKAVQLLLQAKRPYIYSGGGVVLANAA
AELRELADLLGYPCTNTLMGLGAIPASDPKFLGMLGMHGTYEANMTMQHCDVLLAVGARF
DDRVIGNPAHFASVERKIVHVDIDPSSISKRVKVDIPIVGDVKEVLQELIAQIREAQQRP
DQQAMAHWWSQVNGWRQRECLAYKNSSEVIKPQYVVQKLAELTRGRDTYITSDVGQHQMF
AAQFYGFEEPRRWINSGGLGTMGVGLPYAMGIKLAKPESDVFCITGEGSIQMCIQELSTC
QQYKTPVKVISLNNRYLGMVRQWQELDYEGRYSHSYMDALPDFVKLAEAYGHVGLKIERP
ADVEPALREAIRLTDRTVFLDIRTDPTENVWPMVKAGKGISEMLLGSEDL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory