SitesBLAST
Comparing WP_029132936.1 NCBI__GCF_000428045.1:WP_029132936.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
8c0zE Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
50% identity, 99% coverage: 1:415/419 of query aligns to 1:417/424 of 8c0zE
6pfzA Structure of a NAD-dependent persulfide reductase from a. Fulgidus (see paper)
29% identity, 93% coverage: 1:388/419 of query aligns to 1:416/541 of 6pfzA
- active site: V37 (≠ P37), C42 (≠ M42)
- binding calcium ion: D306 (≠ P296), T332 (≠ M322)
- binding coenzyme a: K14 (≠ T14), R18 (≠ T18), R21 (≠ K21), S38 (≠ A38), G40 (≠ S40), C42 (≠ M42), K76 (vs. gap), R313 (= R303)
- binding flavin-adenine dinucleotide: G7 (= G7), A11 (= A11), E32 (≠ G32), A33 (≠ D33), R41 (= R41), C42 (≠ M42), A86 (vs. gap), A115 (= A104), T116 (= T105), G117 (= G106), L136 (≠ C125), G286 (= G275), D287 (= D276), P303 (≠ A293), F304 (≠ I294), G305 (≠ Q295)
Sites not aligning to the query:
3cgeA Pyridine nucleotide complexes with bacillus anthracis coenzyme a- disulfide reductase: a structural analysis of dual NAD(p)h specificity (see paper)
28% identity, 79% coverage: 1:330/419 of query aligns to 1:335/444 of 3cgeA
- active site: A10 (≠ P10), Y37 (≠ P37), Q41 (≠ R41), C42 (≠ M42), N304 (≠ A299)
- binding coenzyme a: M17 (≠ E17), R21 (≠ K21), S38 (≠ A38), C42 (≠ M42), R61 (≠ H61), N304 (≠ A299), R308 (= R303)
- binding flavin-adenine dinucleotide: I6 (= I6), D9 (≠ G9), A10 (≠ P10), A11 (= A11), L31 (≠ I31), E32 (≠ G32), K33 (≠ D33), Q41 (≠ R41), C42 (≠ M42), V80 (= V78), T112 (= T105), G113 (= G106), G281 (= G275), D282 (= D276), I299 (≠ V297), G300 (vs. gap), A303 (= A298)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I156 (≠ M147), G157 (= G148), A160 (≠ F151), I161 (= I152), E164 (≠ I155), E180 (= E171), R181 (≠ M172), N182 (≠ G173), T187 (≠ R179), V242 (≠ A238), G243 (= G239), P298 (= P296), I299 (≠ V297)
Sites not aligning to the query:
3cgdA Pyridine nucleotide complexes with bacillus anthracis coenzyme a- disulfide reductase: a structural analysis of dual NAD(p)h specificity (see paper)
28% identity, 79% coverage: 1:330/419 of query aligns to 1:335/444 of 3cgdA
- active site: A10 (≠ P10), Y37 (≠ P37), Q41 (≠ R41), C42 (≠ M42), N304 (≠ A299)
- binding coenzyme a: M17 (≠ E17), Q18 (≠ T18), R21 (≠ K21), S38 (≠ A38), Y39 (= Y39), C42 (≠ M42), R61 (≠ H61), N304 (≠ A299), R308 (= R303)
- binding flavin-adenine dinucleotide: I6 (= I6), G7 (= G7), D9 (≠ G9), A10 (≠ P10), A11 (= A11), L31 (≠ I31), E32 (≠ G32), K33 (≠ D33), Q41 (≠ R41), C42 (≠ M42), V80 (= V78), A111 (= A104), T112 (= T105), G281 (= G275), D282 (= D276), I299 (≠ V297), G300 (vs. gap), A303 (= A298)
- binding nicotinamide-adenine-dinucleotide: I156 (≠ M147), G157 (= G148), G159 (= G150), A160 (≠ F151), I161 (= I152), E164 (≠ I155), E180 (= E171), R181 (≠ M172), V242 (≠ A238), G243 (= G239), P298 (= P296), I299 (≠ V297)
Sites not aligning to the query:
3cgbA Pyridine nucleotide complexes with bacillus anthracis coenzyme a- disulfide reductase: a structural analysis of dual NAD(p)h specificity (see paper)
28% identity, 79% coverage: 1:330/419 of query aligns to 1:335/444 of 3cgbA
- active site: A10 (≠ P10), Y37 (≠ P37), Q41 (≠ R41), C42 (≠ M42), N304 (≠ A299)
- binding coenzyme a: D9 (≠ G9), A10 (≠ P10), M17 (≠ E17), R21 (≠ K21), S38 (≠ A38), Y39 (= Y39), C42 (≠ M42), R61 (≠ H61), N304 (≠ A299), R308 (= R303)
- binding flavin-adenine dinucleotide: I6 (= I6), G7 (= G7), D9 (≠ G9), A10 (≠ P10), A11 (= A11), E32 (≠ G32), K33 (≠ D33), Q41 (≠ R41), C42 (≠ M42), V80 (= V78), T112 (= T105), L132 (≠ C125), I161 (= I152), G281 (= G275), D282 (= D276), I299 (≠ V297), G300 (vs. gap), A303 (= A298)
Sites not aligning to the query:
3nt6A Structure of the shewanella loihica pv-4 nadh-dependent persulfide reductase c43s/c531s double mutant (see paper)
28% identity, 73% coverage: 25:330/419 of query aligns to 26:356/565 of 3nt6A
- active site: V38 (≠ P37), N42 (≠ R41), S43 (≠ M42), N325 (≠ A299)
- binding coenzyme a: S39 (≠ A38), N42 (≠ R41), S43 (≠ M42), A321 (≠ Q295), N325 (≠ A299), R329 (= R303)
- binding flavin-adenine dinucleotide: E33 (≠ G32), R34 (≠ D33), N42 (≠ R41), S43 (≠ M42), E80 (≠ R77), V81 (= V78), S112 (≠ A104), P113 (≠ T105), G114 (= G106), L133 (≠ C125), R134 (≠ W126), F161 (= F151), G302 (= G275), D303 (= D276), P319 (≠ A293), L320 (≠ I294), A321 (≠ Q295)
Sites not aligning to the query:
- active site: 11, 471, 472
- binding coenzyme a: 11, 18, 19, 22, 459, 462, 463, 466, 534, 535
- binding flavin-adenine dinucleotide: 7, 8, 10, 11, 12
6rvhA Nadh-dependent coenzyme a disulfide reductase soaked with menadione (see paper)
28% identity, 75% coverage: 21:336/419 of query aligns to 23:340/443 of 6rvhA
- active site: V39 (≠ P37), C44 (≠ M42), E53 (≠ K51), E58 (≠ G56), Y159 (≠ F151), E163 (≠ I155)
- binding coenzyme a: R23 (≠ K21), S40 (≠ A38), Y41 (= Y39), C44 (≠ M42), R63 (≠ H61), N303 (≠ A299), R307 (= R303)
- binding flavin-adenine dinucleotide: E34 (≠ G32), K35 (≠ D33), A43 (≠ R41), C44 (≠ M42), V81 (= V78), T113 (= T105), G114 (= G106), R134 (≠ W126), Y159 (≠ F151), G280 (= G275), D281 (= D276), P297 (≠ A293), L298 (≠ I294), G299 (≠ Q295)
Sites not aligning to the query:
- active site: 425, 430
- binding coenzyme a: 20, 359, 431, 437, 441, 442
- binding flavin-adenine dinucleotide: 8, 11, 12, 13, 424, 425
- binding menadione: 364, 365, 430, 431
6rvbA Nadh-dependent coenzyme a disulfide reductase soaked with nadh (see paper)
28% identity, 75% coverage: 21:336/419 of query aligns to 23:340/443 of 6rvbA
- active site: V39 (≠ P37), C44 (≠ M42), E53 (≠ K51), E58 (≠ G56), Y159 (≠ F151), E163 (≠ I155)
- binding coenzyme a: R23 (≠ K21), S40 (≠ A38), Y41 (= Y39), C44 (≠ M42), R63 (≠ H61), N303 (≠ A299), R307 (= R303)
- binding flavin-adenine dinucleotide: Y33 (≠ I31), E34 (≠ G32), K35 (≠ D33), S36 (≠ E34), A43 (≠ R41), C44 (≠ M42), E80 (≠ R77), V81 (= V78), T113 (= T105), G114 (= G106), L133 (≠ C125), R134 (≠ W126), I160 (= I152), G280 (= G275), D281 (= D276), L298 (≠ I294), G299 (≠ Q295)
- binding nicotinamide-adenine-dinucleotide: G156 (= G148), G158 (= G150), Y159 (≠ F151), I160 (= I152), E179 (= E171), A180 (≠ M172), A240 (= A237), T241 (≠ A238), G242 (= G239), P297 (≠ A293), I328 (≠ V324), F329 (≠ L325)
Sites not aligning to the query:
- active site: 425, 430
- binding coenzyme a: 15, 20, 359, 437, 441, 442
- binding flavin-adenine dinucleotide: 8, 11, 12, 13, 424, 425
6ruzA Nadh-dependent coenzyme a disulfide reductase (see paper)
28% identity, 75% coverage: 21:336/419 of query aligns to 23:340/443 of 6ruzA
- active site: V39 (≠ P37), C44 (≠ M42), E53 (≠ K51), E58 (≠ G56), Y159 (≠ F151), E163 (≠ I155)
- binding coenzyme a: R23 (≠ K21), S40 (≠ A38), Y41 (= Y39), C44 (≠ M42), R63 (≠ H61), N303 (≠ A299), R307 (= R303)
- binding flavin-adenine dinucleotide: Y33 (≠ I31), E34 (≠ G32), K35 (≠ D33), A43 (≠ R41), C44 (≠ M42), E80 (≠ R77), V81 (= V78), T113 (= T105), G114 (= G106), A115 (≠ S107), L133 (≠ C125), R134 (≠ W126), Y159 (≠ F151), G280 (= G275), D281 (= D276), P297 (≠ A293), L298 (≠ I294), G299 (≠ Q295)
Sites not aligning to the query:
- active site: 425, 430
- binding coenzyme a: 15, 19, 20, 359, 441, 442
- binding flavin-adenine dinucleotide: 8, 11, 12, 13, 424, 425
5er0A Water-forming nadh oxidase from lactobacillus brevis (lbnox) (see paper)
25% identity, 77% coverage: 1:321/419 of query aligns to 2:324/450 of 5er0A
- active site: H11 (≠ P10), I38 (≠ P37), L41 (≠ S40), S42 (≠ R41), C43 (≠ M42), Q75 (= Q73), T102 (≠ A95), A277 (= A273), A282 (≠ C278), A283 (≠ G280), V302 (≠ A299)
- binding flavin-adenine dinucleotide: G8 (= G7), T10 (≠ G9), H11 (≠ P10), A12 (= A11), E33 (≠ G32), R34 (≠ D33), S42 (≠ R41), C43 (≠ M42), N79 (≠ R77), V80 (= V78), S112 (≠ T105), G113 (= G106), K133 (≠ W126), Y158 (≠ F151), I159 (= I152), N246 (≠ A243), G279 (= G275), D280 (= D276), P296 (≠ A293), L297 (≠ I294), A298 (≠ Q295)
Sites not aligning to the query:
5vn0A Water-forming nadh oxidase from lactobacillus brevis (lbnox) bound to nadh. (see paper)
25% identity, 77% coverage: 1:321/419 of query aligns to 2:324/449 of 5vn0A
- active site: H11 (≠ P10), I38 (≠ P37), L41 (≠ S40), S42 (≠ R41), C43 (≠ M42), Q75 (= Q73), T102 (≠ A95), A277 (= A273), A282 (≠ C278), A283 (≠ G280), V302 (≠ A299)
- binding flavin-adenine dinucleotide: G8 (= G7), T10 (≠ G9), H11 (≠ P10), A12 (= A11), E33 (≠ G32), R34 (≠ D33), N35 (≠ E34), S42 (≠ R41), C43 (≠ M42), N79 (≠ R77), V80 (= V78), T111 (≠ A104), S112 (≠ T105), G113 (= G106), K133 (≠ W126), G279 (= G275), D280 (= D276), L297 (≠ I294), A298 (≠ Q295)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G157 (= G150), Y158 (≠ F151), I159 (= I152), E162 (≠ I155), D178 (≠ E171), A179 (≠ M172), K186 (≠ R179), Y187 (≠ M180), I241 (≠ A238), G242 (= G239), F243 (≠ V240), P296 (≠ A293), L297 (≠ I294)
Sites not aligning to the query:
3fg2P Crystal structure of ferredoxin reductase for the cyp199a2 system from rhodopseudomonas palustris (see paper)
27% identity, 75% coverage: 4:318/419 of query aligns to 5:316/404 of 3fg2P
- binding flavin-adenine dinucleotide: G8 (= G7), G10 (= G9), H11 (≠ P10), A12 (= A11), D34 (= D33), E35 (= E34), R42 (= R41), P43 (≠ M42), S46 (≠ P45), K47 (≠ Y46), R78 (= R77), M79 (≠ V78), T106 (= T105), R127 (≠ W126), I153 (= I152), D275 (= D276), S292 (≠ A293), V293 (≠ I294)
Sites not aligning to the query:
5vohA Crystal structure of engineered water-forming NADPH oxidase (tpnox) bound to NADPH. The g159a, d177a, a178r, m179s, p184r mutant of lbnox. (see paper)
24% identity, 77% coverage: 1:321/419 of query aligns to 1:323/448 of 5vohA
- active site: H10 (≠ P10), I37 (≠ P37), L40 (≠ S40), S41 (≠ R41), C42 (≠ M42), Q74 (= Q73), T101 (≠ A95), A276 (= A273), A281 (≠ C278), A282 (≠ G280), V301 (≠ A299)
- binding flavin-adenine dinucleotide: G7 (= G7), T9 (≠ G9), H10 (≠ P10), A11 (= A11), E32 (≠ G32), R33 (≠ D33), N34 (≠ E34), S41 (≠ R41), C42 (≠ M42), N78 (≠ R77), V79 (= V78), T110 (≠ A104), S111 (≠ T105), G112 (= G106), K132 (≠ W126), I158 (= I152), F242 (≠ V240), N245 (≠ A243), G278 (= G275), D279 (= D276), P295 (≠ A293), L296 (≠ I294), A297 (≠ Q295), A300 (= A298)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: A155 (= A149), G156 (= G150), Y157 (≠ F151), I158 (= I152), R178 (≠ M172), S179 (≠ G173), R184 (≠ P178), K185 (≠ R179), Y186 (≠ M180), I240 (≠ A238), F242 (≠ V240), P295 (≠ A293), L296 (≠ I294)
Sites not aligning to the query:
2cduA The crystal structure of water-forming NAD(p)h oxidase from lactobacillus sanfranciscensis (see paper)
23% identity, 80% coverage: 1:336/419 of query aligns to 1:341/451 of 2cduA
- active site: H10 (≠ P10), I37 (≠ P37), S41 (≠ R41), C42 (≠ M42), V304 (≠ A299)
- binding adenosine-5'-diphosphate: G158 (= G150), I160 (= I152), D179 (≠ E171), G180 (≠ M172), H181 (≠ G173), Y188 (≠ M180), K213 (≠ R205), V214 (= V206), I243 (≠ A238), G244 (= G239)
- binding flavin-adenine dinucleotide: G7 (= G7), T9 (≠ G9), H10 (≠ P10), A11 (= A11), E32 (≠ G32), M33 (≠ D33), S41 (≠ R41), C42 (≠ M42), V81 (= V78), T112 (≠ A104), T113 (= T105), G114 (= G106), K134 (≠ W126), I160 (= I152), G281 (= G275), D282 (= D276), P298 (≠ A293), L299 (≠ I294), A300 (≠ Q295)
Sites not aligning to the query:
6tukB Crystal structure of fdr9 (see paper)
32% identity, 66% coverage: 2:278/419 of query aligns to 3:262/393 of 6tukB
- binding flavin-adenine dinucleotide: V7 (≠ I6), G8 (= G7), G9 (≠ A8), G10 (= G9), A12 (= A11), A34 (≠ D33), E35 (= E34), R42 (= R41), P43 (≠ M42), K47 (≠ L48), A75 (≠ R77), A76 (≠ V78), T102 (= T105), G103 (= G106), V118 (≠ C125), R119 (≠ W126), G259 (= G275), D260 (= D276)
Sites not aligning to the query:
P16640 Putidaredoxin reductase CamA; Pdr; Putidaredoxin--NAD(+) reductase; EC 1.18.1.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 2 papers)
28% identity, 74% coverage: 4:313/419 of query aligns to 8:320/422 of P16640
- A15 (= A11) binding FAD
- D37 (= D33) binding FAD
- K50 (≠ P45) binding FAD
- V83 (= V78) binding FAD
- R134 (≠ W126) binding FAD
- D284 (= D276) binding FAD
- V302 (≠ I294) binding FAD
1q1wA Crystal structure of putidaredoxin reductase from pseudomonas putida (see paper)
28% identity, 74% coverage: 4:313/419 of query aligns to 7:319/422 of 1q1wA
- active site: L13 (≠ P10), L44 (≠ S40), P45 (≠ R41), L305 (≠ A299)
- binding flavin-adenine dinucleotide: G10 (= G7), G12 (= G9), L13 (≠ P10), A14 (= A11), G35 (= G32), D36 (= D33), L44 (≠ S40), P45 (≠ R41), K49 (≠ P45), V82 (= V78), A108 (= A104), T109 (= T105), G110 (= G106), R133 (≠ W126), I159 (= I152), D283 (= D276), S300 (≠ A293), V301 (≠ I294)
Sites not aligning to the query:
P37061 NADH oxidase; NOXase; EC 1.6.3.4 from Enterococcus faecalis (strain ATCC 700802 / V583) (see paper)
28% identity, 66% coverage: 1:278/419 of query aligns to 1:283/446 of P37061
- C42 (≠ M42) active site, Redox-active
8a56B Coenzyme a-persulfide reductase (coapr) from enterococcus faecalis (see paper)
26% identity, 80% coverage: 2:336/419 of query aligns to 2:338/539 of 8a56B
- binding flavin-adenine dinucleotide: I6 (= I6), G7 (= G7), V9 (≠ G9), G11 (≠ A11), E32 (≠ G32), K33 (≠ D33), C42 (≠ M42), V80 (= V78), S109 (≠ A104), P110 (≠ T105), G111 (= G106), I159 (= I152), G278 (= G275), D279 (= D276), S295 (≠ A293), L296 (≠ I294), A297 (≠ Q295)
- binding 3'-phosphate-adenosine-5'-diphosphate: T17 (≠ E17), R18 (≠ T18), R21 (≠ K21), F70 (vs. gap), R305 (= R303)
Sites not aligning to the query:
3lxdA Crystal structure of ferredoxin reductase arr from novosphingobium aromaticivorans (see paper)
28% identity, 80% coverage: 19:355/419 of query aligns to 22:361/409 of 3lxdA
- active site: R44 (= R41), P45 (≠ M42), N302 (≠ A299)
- binding flavin-adenine dinucleotide: R36 (≠ D33), E37 (= E34), R44 (= R41), P45 (≠ M42), S48 (≠ P45), K49 (≠ Y46), E81 (≠ R77), V82 (= V78), T109 (= T105), I157 (= I152), G278 (= G275), D279 (= D276), S297 (≠ P296), V298 (= V297), F325 (≠ M320), W326 (≠ A321)
Sites not aligning to the query:
Query Sequence
>WP_029132936.1 NCBI__GCF_000428045.1:WP_029132936.1
MQYVVIGAGPAGVTAAETIRKQDPSGEVILIGDEPEPAYSRMAIPYYLADKIPEQGTYLR
HDPKHLDSLGVRQLKQRVTRVDSAARQLQLAGGGALGFDRLLLATGSDPVKPPIDGLDQP
GVHHCWTLEDARNIVKYAQPGSHVVLMGAGFIGCIIMEALAERGVDLTVVEMGDRMVPRM
MDQESGNLIKQWCIDKGVTVHTSTRVTGVKANASGAARITLSCDPVGTLEADLVVVAAGV
KPAVDYLRDSGIELAQGVVVNEYMESSVPGIYAAGDTCEGIDWGSDGQHAVHAIQPVAAE
TGRIAALNMCGEVTPYPGSMAMNVLDTLGLVSVSYGQWMGVPGGDEVHRLDSDEYRYIKL
QFNGDRLIGAITLGRTEHVGVLRGLIQSRTRLGKWKQHLMEDPTRIMEAYLGATQLTQG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory