SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_029933655.1 NCBI__GCF_000711195.1:WP_029933655.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

6j2lA Crystal structure of bi-functional enzyme (see paper)
49% identity, 63% coverage: 31:124/149 of query aligns to 14:107/200 of 6j2lA

query
sites
6j2lA
A
 
T
D
 
D
G
 
G
L
 
L
M
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
Q
 
H
H
 
A
D
 
V
T
 
S
G
 
G
E
 
E
V
 
V
L
 
L
M
 
M
L
 
L
A
 
G
Y
 
Y
M
 
M
N
 
N
L
 
P
A
 
E
A
 
A
L
 
L
E
 
D
E
 
K
T
 
T
L
 
I
Q
 
E
T
 
S
G
 
G
R
 
K
V
 
V
C
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
Q
 
Q
N
 
R
Y
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
A
 
T
S
 
S
G
 
G
Q
 
N
I
 
F
Q
 
L
T
 
N
L
 
V
K
 
V
E
 
S
A
 
I
R
 
A
L
 
P
D
|
D
C
 
C
D
|
D
G
 
N
D
|
D
T
 
T
L
 
L
L
 
L
L
 
V
L
 
L
V
 
A
D
 
N
Q
 
P
T
 
I
G
 
G
P
 
P
A
 
T
C
|
C
H
 
H
S
 
K
G
 
G
R
 
T
A
 
S
N
 
S
C
|
C
F
 
F
Y
 
G
N
 
N
A
 
T

Sites not aligning to the query:

6j2lB Crystal structure of bi-functional enzyme (see paper)
46% identity, 63% coverage: 31:124/149 of query aligns to 13:100/185 of 6j2lB

query
sites
6j2lB
A
 
T
D
 
D
G
 
G
L
 
L
M
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
Q
 
H
H
 
A
D
 
V
T
 
S
G
 
G
E
 
E
V
 
V
L
 
L
M
 
M
L
 
L
A
 
G
Y
 
Y
M
 
M
N
 
N
L
 
P
A
 
E
A
 
A
L
 
L
E
 
D
E
 
K
T
 
T
L
 
I
Q
 
E
T
 
S
G
 
G
R
 
K
V
 
V
C
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
Q
 
Q
N
 
R
Y
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
A
 
T
S
 
S
G
 
G
Q
 
N
I
 
F
Q
 
L
T
 
N
L
 
V
K
 
V
E
 
S
A
 
I
R
 
A
L
 
P
D
|
D
C
 
C
D
|
D
G
 
N
D
|
D
T
 
T
L
 
L
L
 
L
L
 
V
L
 
L
V
 
A
D
 
N
Q
 
P
T
 
I
G
 
G
P
 
P
A
 
-
C
 
-
H
 
-
S
 
-
G
 
-
R
 
-
A
 
S
N
 
S
C
 
C
F
 
F
Y
 
G
N
 
N
A
 
T

Sites not aligning to the query:

7bgmA Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
39% identity, 68% coverage: 27:127/149 of query aligns to 11:111/213 of 7bgmA

query
sites
7bgmA
L
 
V
K
 
K
F
 
W
D
 
D
A
 
N
D
 
K
G
 
G
L
 
L
M
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
Q
 
N
H
 
V
D
 
D
T
 
T
G
 
G
E
 
A
V
 
I
L
 
L
M
 
M
L
 
Q
A
 
G
Y
 
F
M
 
A
N
 
N
L
 
R
A
 
E
A
 
A
L
 
V
E
 
A
E
 
T
T
 
T
L
 
I
Q
 
S
T
 
S
G
 
R
R
 
K
V
 
A
C
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
Q
 
S
N
 
S
Y
 
L
W
 
W
R
 
T
K
 
K
G
 
G
E
 
E
A
 
T
S
 
S
G
 
N
Q
 
N
I
 
F
Q
 
I
T
 
N
L
 
V
K
 
H
E
 
D
A
 
V
R
 
F
L
 
L
D
|
D
C
 
C
D
|
D
G
 
R
D
|
D
T
 
S
L
 
I
L
 
I
L
 
Y
L
 
L
V
 
G
D
 
K
Q
 
P
T
 
D
G
 
G
P
 
P
A
 
T
C
|
C
H
 
H
S
 
T
G
 
G
R
 
A
A
 
E
N
 
T
C
|
C
F
 
Y
Y
 
Y
N
 
T
A
 
P
I
 
V
K
 
F
D
 
D

Sites not aligning to the query:

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
39% identity, 68% coverage: 27:127/149 of query aligns to 9:109/204 of 7bgnA

query
sites
7bgnA
L
 
V
K
 
K
F
 
W
D
 
D
A
 
N
D
 
K
G
 
G
L
 
L
M
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
Q
 
N
H
 
V
D
 
D
T
 
T
G
 
G
E
 
A
V
 
I
L
 
L
M
 
M
L
 
Q
A
 
G
Y
 
F
M
 
A
N
 
N
L
 
R
A
 
E
A
 
A
L
 
V
E
 
A
E
 
T
T
 
T
L
 
I
Q
 
S
T
 
S
G
 
R
R
 
K
V
 
A
C
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
Q
 
S
N
 
S
Y
 
L
W
|
W
R
 
T
K
|
K
G
|
G
E
 
E
A
x
T
S
|
S
G
 
N
Q
 
N
I
 
F
Q
 
I
T
 
N
L
 
V
K
 
H
E
 
D
A
 
V
R
 
F
L
 
L
D
|
D
C
 
C
D
|
D
G
 
R
D
|
D
T
 
S
L
 
I
L
 
I
L
 
Y
L
 
L
V
 
G
D
 
K
Q
 
P
T
 
D
G
 
G
P
 
P
A
x
T
C
|
C
H
|
H
S
 
T
G
 
G
R
 
A
A
 
E
N
 
T
C
|
C
F
 
Y
Y
 
Y
N
 
T
A
 
P
I
 
V
K
 
F
D
 
D

Sites not aligning to the query:

Query Sequence

>WP_029933655.1 NCBI__GCF_000711195.1:WP_029933655.1
MSELNFLSLEHAKKGDQFDWAQLKTHLKFDADGLMPAIAQQHDTGEVLMLAYMNLAALEE
TLQTGRVCYWSRSRQNYWRKGEASGQIQTLKEARLDCDGDTLLLLVDQTGPACHSGRANC
FYNAIKDDKIEILTDPIIDPAELYKHHSH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory