SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_029935507.1 NCBI__GCF_000711195.1:WP_029935507.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5e25A Crystal structure of branched-chain aminotransferase from thermophilic archaea geoglobus acetivorans complexed with alpha-ketoglutarate (see paper)
36% identity, 95% coverage: 5:278/288 of query aligns to 4:279/290 of 5e25A

query
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5e25A

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active site: F33 (≠ Y34), G35 (≠ V36), K151 (= K149), E184 (= E182), L207 (= L206)
binding 2-oxoglutaric acid: Y88 (≠ F89), K151 (= K149), T247 (≠ S246), A248 (≠ T247)
binding pyridoxal-5'-phosphate: R52 (= R53), K151 (= K149), Y155 (≠ L153), E184 (= E182), G187 (≠ A185), D188 (≠ S186), L207 (= L206), G209 (= G208), I210 (= I209), T211 (= T210), G246 (≠ S245), T247 (≠ S246)

3lqsA Complex structure of d-amino acid aminotransferase and 4-amino-4,5- dihydro-thiophenecarboxylic acid (adta) (see paper)
37% identity, 91% coverage: 17:279/288 of query aligns to 14:274/280 of 3lqsA

query
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3lqsA

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active site: Y31 (= Y34), V33 (= V36), K145 (= K149), E177 (= E182), L201 (= L206)
binding 4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]thiophene-2-carboxylic acid: V33 (= V36), R50 (= R53), E177 (= E182), S180 (≠ A185), S181 (= S186), N182 (= N187), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ S246), T242 (= T247)

3daaA Crystallographic structure of d-amino acid aminotransferase inactivated by pyridoxyl-d-alanine (see paper)
37% identity, 91% coverage: 17:279/288 of query aligns to 14:274/277 of 3daaA

query
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3daaA

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active site: Y31 (= Y34), V33 (= V36), K145 (= K149), E177 (= E182), L201 (= L206)
binding n-(5'-phosphopyridoxyl)-d-alanine: Y31 (= Y34), R50 (= R53), K145 (= K149), E177 (= E182), S180 (≠ A185), S181 (= S186), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ S246)

2daaA Crystallographic structure of d-amino acid aminotransferase inactivated by d-cycloserine
37% identity, 91% coverage: 17:279/288 of query aligns to 14:274/277 of 2daaA

query
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2daaA

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active site: Y31 (= Y34), V33 (= V36), K145 (= K149), E177 (= E182), L201 (= L206)
binding d-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-n,o-cycloserylamide: Y31 (= Y34), V33 (= V36), R50 (= R53), R98 (= R102), H100 (= H104), K145 (= K149), E177 (= E182), S180 (≠ A185), S181 (= S186), N182 (= N187), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), T241 (≠ S246)

1daaA Crystallographic structure of d-amino acid aminotransferase complexed with pyridoxal-5'-phosphate (see paper)
37% identity, 91% coverage: 17:279/288 of query aligns to 14:274/277 of 1daaA

query
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1daaA

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T

R

R

G

G

V

T

Q

S

I

-

P

P

R

R

D

A

H

H

-

Q

M

F

P

P

A

E

A

N

D

T

L

V

T

K

P

P

T

V

V

I

Y

I

A

G

Y

Y

T

T

-

K

-

E

N

N

P

P

L

-

K

R

P

P

V

L

A

E

D

N

H

-

I

-

L

L

Q

E

H

K

G

G

I

V

K

K

V

A

I

T

S

F

L

V

E

E

D

D

I

I

R

R

W

W

L

L

R

R

C

C

D

D

I

I

K
|
K

A

S

L

L

T

N

L

L

P

G

N

A

V

V

M

L

A

A

K

K

L

Q

Q

E

A

A

Q

H

A

E

A

K

G

G

V

C

D

Y

D

E

V

A

I

I

L

L

V

H

R

R

A

-

D

N

G

N

S

T

V

V

S

T

E
|
E

G

G

S

S

A
x
S

S
|
S

N

N

L

V

F

F

M

G

V

I

K

K

D

D

Q

G

T

I

L

L

I

Y

T

T

P

H

P

P

N

A

S

N

H

N

K

M

I

I

L
|
L

P

K

G
|
G

I
|
I

T
|
T

R

R

L

D

V

V

I

V

E

I

K

A

L

C

A

A

R

N

R

E

H

I

H

N

I

M

D

P

L

V

I

K

E

E

R

I

D

P

I

F

Q

T

D

H

E

E

L

A

N

L

S

K

A

M

D

D

E

E

L

L

W

F

L

V

T

T

S
|
S

S
x
T

T

T

K

S

E

E

A

I

L

T

P

P

I

V

T

I

Q

E

L

I

N

D

G

G

Q

K

A

L

V

I

G

R

S

D

G

G

K

K

P

V

G

G

S

E

V

W

W

T

Q

R

T

K

L

L

R

Q

Q

K

H

Q

Y

F

Q

E

A

T

active site: Y31 (= Y34), V33 (= V36), K145 (= K149), E177 (= E182), L201 (= L206)
binding pyridoxal-5'-phosphate: R50 (= R53), K145 (= K149), E177 (= E182), S180 (≠ A185), S181 (= S186), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ S246)

P19938 D-alanine aminotransferase; D-amino acid aminotransferase; D-amino acid transaminase; DAAT; D-aspartate aminotransferase; EC 2.6.1.21 from Bacillus sp. (strain YM-1) (see 5 papers)
37% identity, 91% coverage: 17:279/288 of query aligns to 15:275/283 of P19938

query
sites
P19938

E

E

A

V

R

K

V

I

S

D

P

K

M

E

D

D

R

R

G

G

F

Y

L

Q

F

F

G

G

D

D

G

G

V

V

Y
|
Y

E

E

V

V

I

V

P

K

V

V

Y

Y

Q

N

R

G

Q

E

V

M

F

F

E

T

W

V

A

N

A

E

H

H

L

I

A

D

R
|
R

L

L

K

Y

Y

A

S

S

L

A

K

E

A

K

T

I

S

R

I

I

N

T

N

I

P

P

L

Y

S

T

D

K

E

D

A

K

W

F

L

H

D

Q

M

L

I

L

N

H

Q

E

L

L

I

V

K

E

R

K

H

N

D

E

W

L

A

N

D

T

Q

G

F

H

I

I

Y

Y

L

F

Q

Q

V

V

S

T

R

R

G

G

V

T

Q

S

I

-

P

P

R
|
R

D

A

H
|
H

-

Q

M

F

P

P

A

E

A

N

D

T

L

V

T

K

P

P

T

V

V

I

Y

I

A

G

Y

Y

T

T

-

K

-

E

N

N

P

P

L

-

K

R

P

P

V

L

A

E

D

N

H

-

I

-

L

L

Q

E

H

K

G

G

I

V

K

K

V

A

I

T

S

F

L

V

E

E

D

D

I

I

R

R

W

W

L

L

R

R

C

C

D

D

I

I

K
|
K

A

S

L

L

T

N

L

L

P

G

N

A

V

V

M

L

A

A

K

K

L

Q

Q

E

A

A

Q

H

A

E

A

K

G

G

V

C

D

Y

D

E

V

A

I

I

L

L

V

H

R

R

A

-

D

N

G

N

S

T

V

V

S

T

E
|
E

G

G

S

S

A

S

S

S

N

N

L

V

F

F

M

G

V

I

K

K

D

D

Q

G

T

I

L

L

I

Y

T

T

P

H

P

P

N

A

S

N

H

N

K

M

I

I

L
|
L

P

K

G

G

I

I

T

T

R

R

L

D

V

V

I

V

E

I

K

A

L

C

A

A

R

N

R

E

H

I

H

N

I

M

D

P

L

V

I

K

E

E

R

I

D

P

I

F

Q

T

D

H

E

E

L

A

N

L

S

K

A

M

D

D

E

E

L

L

W

F

L

V

T

T

S

S

S

T

T

T

K

S

E

E

A

I

L

T

P

P

I

V

T

I

Q

E

L

I

N

D

G

G

Q

K

A

L

V

I

G

R

S

D

G

G

K

K

P

V

G

G

S

E

V

W

W

T

Q

R

T

K

L

L

R

Q

Q

K

H

Q

Y

F

Q

E

A

T

Y32 (= Y34) binding substrate
R51 (= R53) binding pyridoxal 5'-phosphate
R99 (= R102) binding substrate
H101 (= H104) binding substrate
K146 (= K149) active site, Proton acceptor; modified: N6-(pyridoxal phosphate)lysine
E178 (= E182) binding pyridoxal 5'-phosphate; mutation to K: Loss of transaminase activity and small gain in racemase activity.
L202 (= L206) mutation to A: Inactivates enzyme.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

5mr0D Thermophilic archaeal branched-chain amino acid transaminases from geoglobus acetivorans and archaeoglobus fulgidus: biochemical and structural characterisation (see paper)
35% identity, 95% coverage: 6:278/288 of query aligns to 4:278/290 of 5mr0D

query
sites
5mr0D

V

V

Y

Y

L

M

D

D

G

G

E

E

F

F

M

V

P

P

M

E

N

N

E

E

A

A

R

K

V

V

S

S

P

I

M

F

D

D

R

H

G

G

F

F

L

L

F

Y

G

G

D

D

G

G

V

V

Y
x
F

E

E

V
x
G

I

I

P

R

V

A

Y

Y

Q

N

R

G

Q

R

V

V

F

F

E

R

W

L

A

K

A

E

H

H

L

I

A

D

R
|
R

L

L

K

Y

Y

D

S

S

L

A

K

K

A

A

T

I

S

D

I

L

N

E

N

I

P

P

L

I

S

T

D

K

E

E

A

E

W

F

L

M

D

E

M

I

I

I

N

L

Q

E

L

T

I

L

K

R

R

K

H

N

D

N

W

L

A

R

D

D

Q

A

F

Y

I

I

Y

R

L

P

Q

I

V

V

S

T

R

R

G

G

V

I

-

G

Q

D

I

L

P
x
G

R
x
L

D

D

H

-

M

-

P

P

A

R

A

K

D

C

L

Q

T

N

P

P

T

S

V

I

Y

I

A

V

Y

I

T

T

N

K

P

P

L

W

K

G

P

K

V

L

A

Y

D

G

H

D

I

L

L

Y

Q

E

H

K

G

G

I

L

K

T

V

A

I

I

S

T

L

V

E

A

D

V

I

R

R

R

-

N

-

S

-

F

-

D

W

A

L

L

R

P

C

P

D

N

I

I

K
|
K

A

S

L

L

T

N

L
x
Y

L

L

P

N

N

N

V

I

M

L

A

A

K

K

L

I

Q

E

A

A

Q

N

A

A

A

K

G

G

V

G

D

D

D

E

V

A

I

I

L

F

V

L

R

D

A

R

D

N

G

G

S

Y

V

V

S

S

E
|
E

G

G

S

S

A
x
G

S
x
D

N

N

L

I

F

F

M

V

V

V

K

K

D

N

Q

G

T

A

L

I

I

T

T

T

P

P

N

T

S

I

H

N

K

N

I

-

L
|
L

P

R

G

G

I
|
I

T
|
T

R

R

L

E

V

A

I

V

E

I

K

E

L

I

A

I

R

N

R

R

H

L

H

G

I

I

D

P

L

F

I

K

E

E

R

T

D

N

I

I

Q

G

Q

L

D

Y

E

D

L

L

N

Y

S

T

A

A

D

D

E

E

L

V

W

F

L

V

T

T

S
x
G

S
x
T

T

A

K

A

E

E

A

I

L

A

P

P

I

I

T

V

Q

V

L

I

N

D

G

G

Q

R

A

K

V

I

G

G

S

D

G

G

K

K

P

P

G

G

S

E

V

I

W

T

Q

R

T

K

L

L

R

M

Q

E

H

E

Y

F

Q

S

active site: F32 (≠ Y34), G34 (≠ V36), K150 (= K149), E183 (= E182), L206 (= L206)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: R51 (= R53), G100 (≠ P101), L101 (≠ R102), K150 (= K149), Y154 (≠ L153), E183 (= E182), G186 (≠ A185), D187 (≠ S186), L206 (= L206), I209 (= I209), T210 (= T210), G245 (≠ S245), T246 (≠ S246)

1a0gB L201a mutant of d-amino acid aminotransferase complexed with pyridoxamine-5'-phosphate (see paper)
36% identity, 91% coverage: 17:279/288 of query aligns to 14:274/282 of 1a0gB

query
sites
1a0gB

E

E

A

V

R

K

V

I

S

D

P

K

M

E

D

D

R

R

G

G

F

Y

L

Q

F

F

G

G

D

D

G

G

V

V

Y
|
Y

E

E

V
|
V

I

V

P

K

V

V

Y

Y

Q

N

R

G

Q

E

V

M

F

F

E

T

W

V

A

N

A

E

H

H

L

I

A

D

R
|
R

L

L

K

Y

Y

A

S

S

L

A

K

E

A

K

T

I

S

R

I

I

N

T

N

I

P

P

L

Y

S

T

D

K

E

D

A

K

W

F

L

H

D

Q

M

L

I

L

N

H

Q

E

L

L

I

V

K

E

R

K

H

N

D

E

W

L

A

N

D

T

Q

G

F

H

I

I

Y

Y

L

F

Q

Q

V

V

S

T

R

R

G

G

V

T

Q

S

I

-

P

P

R

R

D

A

H

H

-

Q

M

F

P

P

A

E

A

N

D

T

L

V

T

K

P

P

T

V

V

I

Y

I

A

G

Y

Y

T

T

-

K

-

E

N

N

P

P

L

-

K

R

P

P

V

L

A

E

D

N

H

-

I

-

L

L

Q

E

H

K

G

G

I

V

K

K

V

A

I

T

S

F

L

V

E

E

D

D

I

I

R

R

W

W

L

L

R

R

C

C

D

D

I

I

K
|
K

A

S

L

L

T

N

L

L

P

G

N

A

V

V

M

L

A

A

K

K

L

Q

Q

E

A

A

Q

H

A

E

A

K

G

G

V

C

D

Y

D

E

V

A

I

I

L

L

V

H

R

R

A

-

D

N

G

N

S

T

V

V

S

T

E
|
E

G

G

S

S

A
x
S

S
|
S

N

N

L

V

F

F

M

G

V

I

K

K

D

D

Q

G

T

I

L

L

I

Y

T

T

P

H

P

P

N

A

S

N

H

N

K

M

I

I

L
x
A

P

K

G
|
G

I
|
I

T
|
T

R

R

L

D

V

V

I

V

E

I

K

A

L

C

A

A

R

N

R

E

H

I

H

N

I

M

D

P

L

V

I

K

E

E

R

I

D

P

I

F

Q

T

D

H

E

E

L

A

N

L

S

K

A

M

D

D

E

E

L

L

W

F

L

V

T

T

S
|
S

S
x
T

T

T

K

S

E

E

A

I

L

T

P

P

I

V

T

I

Q

E

L

I

N

D

G

G

Q

K

A

L

V

I

G

R

S

D

G

G

K

K

P

V

G

G

S

E

V

W

W

T

Q

R

T

K

L

L

R

Q

Q

K

H

Q

Y

F

Q

E

A

T

active site: Y31 (= Y34), V33 (= V36), K145 (= K149), E177 (= E182), A201 (≠ L206)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R50 (= R53), K145 (= K149), E177 (= E182), S180 (≠ A185), S181 (= S186), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ S246)

7p3tB Transaminase of gamma-proteobacterium (see paper)
34% identity, 96% coverage: 5:281/288 of query aligns to 5:283/299 of 7p3tB

query
sites
7p3tB

I

I

V

I

Y

Y

L

I

D

N

G

G

E

D

F

Y

M

L

P

P

M

L

N

S

E

Q

A

A

R

R

V

V

S

S

P

P

M

V

D

D

R

Q

G

G

F

F

L

L

F

L

G

G

D

D

G

G

V

V

Y

F

E

D

V

V

I

V

P

S

V

A

Y

W

Q

K

R

G

Q

N

V

I

F

F

E

K

W

L

A

D

A

A

H

H

L

L

A

D

R
|
R

L

F

K

F

Y

D

S

S

L

I

K

Q

A

A

T

A

S

R

I

L

N

N

N

H

P

D

L

M

S

S

D

R

E

D

A

A

W

W

L

K

D

E

M

A

I

I

N

I

Q

E

L

T

I

T

K

R

R

R

H

N

D

G

W

L

A

D

D

D

Q

A

F

S

I

I

Y

R

L

F

Q

I

V

V

S

T

R

R

G

G

-

E

-

P

-

K

-

G

-

V

V

V

Q

A

I

D

P

P

R

R

D

-

H

-

M

-

P

-

A

-

D

D

L

F

T

K

P

P

T

T

V

C

Y

I

A

V

Y

W

T

V

N

A

P

P

L

Y

K

I

P

F

V

L

A

A

D

D

-

E

H

E

I

K

L

R

Q

R

H

N

G

G

I

I

K

R

V

L

I

M

S

-

L

I

E

S

D

A

I

T

R

R

W

G

L

F

R

P

C

A

D

D

I

T

-

L

-

D

-

P

-

R

-

Y

K
|
K

A

C

L

L

T

D

L
x
R

L

L

P

H

N

S

V

Q

M

L

A

I

K

R

L

L

Q

E

A

A

Q

L

A

E

A

A

G

G

V

Y

D

D

V

A

I

L

L

W

V

L

R

D

A

H

D

S

G

G

S

H

V

V

S

S

E
|
E

G
x
S

S
x
A

A
|
A

S
|
S

N

N

L

L

F

F

M

I

V

V

K

K

D

N

Q

G

T

V

L

L

I

Y

T

T

P

P

P

-

N

-

S

S

H

A

K

G

I

I

L

L

P

R

G
|
G

I
|
I

T
|
T

R

R

L

D

V

T

I

I

E

L

K

E

L

L

A

A

R

T

R

E

H

L

H

D

I

I

D

P

L

W

I

K

E

E

R

R

D

Q

I

L

Q

S

Q

A

D

F

E

D

L

V

N

Y

S

I

A

A

D

D

E

E

L

V

W

F

L

T

T

C

S

S

S
x
T

T

A

K

G

E

G

A

A

L

L

P

P

I

V

T

R

Q

E

L

V

N

A

G

G

Q

R

A

T

V

I

G

R

S

G

G

T

K

T

P

P

G

G

S

P

V

I

W

T

Q

Q

T

A

L

I

R

D

Q

N

H

A

Y

Y

Q

W

A

A

Y

M

K

R

binding pyridoxal-5'-phosphate: R53 (= R53), K153 (= K149), R157 (≠ L153), E186 (= E182), S187 (≠ G183), A188 (≠ S184), A189 (= A185), S190 (= S186), G210 (= G208), I211 (= I209), T212 (= T210), T248 (≠ S246)

8onjA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense point mutant r88l (see paper)
28% identity, 95% coverage: 5:277/288 of query aligns to 5:268/277 of 8onjA

query
sites
8onjA

I

L

V

C

Y

Y

L

I

D

D

G

G

E

K

F

F

M

L

P

P

M

L

N

E

E

E

A

A

R

K

V

L

S

P

P

V

M

T

D

D

R

L

G

I

F

I

L

Q

F

R

G

G

D

V

G

G

V

V

Y

F

E

E

V

T

I

I

P

S

V

T

Y

H

Q

S

R

R

Q

R

V

P

F

L

E

M

W

L

A

T

A

P

H

H

L

L

A

K

R
|
R

L

L

K

E

Y

G

S

S

L

A

K

T

A

A

T

S

S

S

I

I

N

V

N

M

P

P

L

A

S

T

D

L

E

D

A

E

W

M

L

A

D

R

M

I

I

I

N

R

Q

E

L

G

I

I

K

K

R

K

H

M

D

G

W

-

A

C

D

E

Q

T

F

M

I

V

Y

L

L

P

Q

Y

V

I

S

T

R

G

G

G

V

D

Q

S

I

F

P

G

R

K

D

D

H

H

M

L

P

F

A

S

D

S

L

R

T

Y

P

F

T

V

V

I

Y

F

A

E

Y

E

T

I

N

R

P

K

L

P

K

D

P

P

V

I

A

-

D

-

H

-

I

L

L

Y

Q

E

H

K

G

G

I

V

K

A

V

L

I

H

S

P

L

I

E

N

D

A

I

E

R
|
R

W

Y

L

L

R

P

C

-

D

S

I

T

K
|
K

A

S

L

I

T

N

L

Y

L

M

P

L

N

S

V

F

M

T

A

G

K

Q

L

R

Q

D

A

S

Q

K

A

G

A

A

G

-

V

-

D

-

D

Y

V

E

I

I

L

L

V

Y

R

C

A

P

D

E

G

G

S

E

V

I

S

V

E
|
E

G

G

S

S

A
x
H

S
|
S

N

T

L

F

F

F

M

L

V

I

K

K

D

N

Q

G

T

H

L

L

I

I

T

T

P

A

P

P

N

T

S

S

H

-

K

R

I

A

L
|
L

P

S

G

G

I
x
T

T
|
T

R

R

L

Q

V

I

I

V

E

L

K

E

L

L

A

A

R

R

H

G

H

N

I

I

D

Q

L

V

I

E

E

E

R

R

D

C

I

P

Q

L

D

T

E

E

L

L

N

P

S

E

A

A

D

E

E

E

L

A

W

F

L

I

T

T

S
x
G

S
x
T

T

V

K

K

E

E

A

L

L

L

P

P

I

V

T

V

Q

R

L

I

N

G

G

D

Q

Q

A

I

V

I

G

G

S

N

G

G

K

V

P

P

G

G

S

K

V

L

W

T

Q

K

T

H

L

L

R

H

Q

Q

H

V

Y

Y

binding pyridoxal-5'-phosphate: R53 (= R53), R138 (= R142), K144 (= K149), E174 (= E182), H177 (≠ A185), S178 (= S186), L197 (= L206), T200 (≠ I209), T201 (= T210), G236 (≠ S245), T237 (≠ S246)

8aieB Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense complexed with d-cycloserine
28% identity, 95% coverage: 5:277/288 of query aligns to 3:266/275 of 8aieB

query
sites
8aieB

I

L

V

C

Y

Y

L

I

D

D

G

G

E

K

F

F

M

L

P

P

M

L

N

E

E

E

A

A

R

K

V

L

S

P

P

V

M

T

D

D

R

L

G

I

F

I

L

Q

F

R

G

G

D

V

G

G

V

V

Y

F

E

E

V
x
T

I

I

P

S

V

T

Y

H

Q

S

R

R

Q

R

V

P

F

L

E

M

W

L

A

T

A

P

H

H

L

L

A

K

R
|
R

L

L

K

E

Y

G

S

S

L

A

K

T

A

A

T

S

S

S

I

I

N

V

N

M

P

P

L

A

S

T

D

L

E

D

A

E

W

M

L

A

D

R

M

I

I

I

N

R

Q

E

L

G

I

I

K

K

R

K

H

M

D

G

W

-

A

C

D

E

Q

T

F

M

I

V

Y

R

L

P

Q

Y

V

I

S

T

R

G

G

G

V

D

Q

S

I

F

P

G

R

K

D

D

H

H

M

L

P

F

A

S

D

S

L

R

T

Y

P

F

T

V

V

I

Y

F

A

E

Y

E

T

I

N

R

P

K

L

P

K

D

P

P

V

I

A

-

D

-

H

-

I

L

L

Y

Q

E

H

K

G

G

I

V

K

A

V

L

I

H

S

P

L

I

E

N

D

A

I

E

R

R

W

Y

L

L

R

P

C

-

D

S

I

T

K
|
K

A

S

L

I

T

N

L
x
Y

L

M

P

L

N

S

V

F

M

T

A

G

K

Q

L

R

Q

D

A

S

Q

K

A

G

A

A

G

-

V

-

D

-

D

Y

V

E

I

I

L

L

V

Y

R

C

A

P

D

E

G

G

S

E

V

I

S

V

E
|
E

G

G

S
|
S

A
x
H

S
|
S

N

T

L

F

F

F

M

L

V

I

K

K

D

N

Q

G

T

H

L

L

I

I

T

T

P

A

P

P

N

T

S

S

H

-

K

R

I

A

L
|
L

P

S

G

G

I
x
T

T
|
T

R

R

L

Q

V

I

I

V

E

L

K

E

L

L

A

A

R

R

H

G

H

N

I

I

D

Q

L

V

I

E

E

E

R

R

D

C

I

P

Q

L

D

T

E

E

L

L

N

P

S

E

A

A

D

E

E

E

L

A

W

F

L

I

T

T

S
x
G

S
x
T

T
x
V

K
|
K

E

E

A

L

L

L

P

P

I

V

T

V

Q

R

L

I

N

G

G

D

Q

Q

A

I

V

I

G

G

S

N

G

G

K

V

P

P

G

G

S

K

V

L

W

T

Q

K

T

H

L

L

R

H

Q

Q

H

V

Y

Y

binding 3-azanyloxy-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]propanoic acid: T34 (≠ V36), R51 (= R53), K142 (= K149), Y146 (≠ L153), E172 (= E182), H175 (≠ A185), S176 (= S186), T198 (≠ I209), T199 (= T210), G234 (≠ S245), T235 (≠ S246), V236 (≠ T247), K237 (= K248)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R51 (= R53), Y146 (≠ L153), E172 (= E182), S174 (= S184), H175 (≠ A185), S176 (= S186), L195 (= L206), T198 (≠ I209), T199 (= T210), G234 (≠ S245), T235 (≠ S246)

8aykA Crystal structure of d-amino acid aminotrensferase from aminobacterium colombiense complexed with d-glutamate (see paper)
28% identity, 95% coverage: 5:277/288 of query aligns to 4:267/276 of 8aykA

query
sites
8aykA

I

L

V

C

Y

Y

L

I

D

D

G

G

E

K

F

F

M

L

P

P

M

L

N

E

E

E

A

A

R

K

V

L

S

P

P

V

M

T

D

D

R

L

G

I

F

I

L

Q

F

R

G

G

D

V

G

G

V

V

Y

F

E

E

V
x
T

I

I

P

S

V

T

Y

H

Q

S

R

R

Q

R

V

P

F

L

E

M

W

L

A

T

A

P

H

H

L

L

A

K

R
|
R

L

L

K

E

Y

G

S

S

L

A

K

T

A

A

T

S

S

S

I

I

N

V

N

M

P

P

L

A

S

T

D

L

E

D

A

E

W

M

L

A

D

R

M

I

I

I

N

R

Q

E

L

G

I

I

K

K

R

K

H

M

D

G

W

-

A

C

D

E

Q

T

F

M

I

V

Y

R

L

P

Q

Y

V

I

S

T

R

G

G

G

V

D

Q

S

I

F

P

G

R

K

D

D

H

H

M

L

P

F

A

S

D

S

L

R

T

Y

P

F

T

V

V

I

Y

F

A

E

Y

E

T

I

N

R

P

K

L

P

K

D

P

P

V

I

A

-

D

-

H

-

I

L

L

Y

Q

E

H

K

G

G

I

V

K

A

V

L

I

H

S

P

L

I

E

N

D

A

I

E

R
|
R

W

Y

L

L

R

P

C

-

D

S

I

T

K
|
K

A

S

L

I

T

N

L

Y

L

M

P

L

N

S

V

F

M

T

A

G

K

Q

L

R

Q

D

A

S

Q

K

A

G

A

A

G

-

V

-

D

-

D

Y

V

E

I

I

L

L

V

Y

R

C

A

P

D

E

G

G

S

E

V

I

S

V

E
|
E

G

G

S
|
S

A
x
H

S
|
S

N

T

L

F

F

F

M

L

V

I

K

K

D

N

Q

G

T

H

L

L

I

I

T

T

P

A

P

P

N

T

S

S

H

-

K

R

I

A

L
|
L

P

S

G
|
G

I
x
T

T
|
T

R

R

L

Q

V

I

I

V

E

L

K

E

L

L

A

A

R

R

H

G

H

N

I

I

D

Q

L

V

I

E

E

E

R

R

D

C

I

P

Q

L

D

T

E

E

L

L

N

P

S

E

A

A

D

E

E

E

L

A

W

F

L

I

T

T

S
x
G

S
x
T

T
x
V

K
|
K

E

E

A

L

L

L

P

P

I

V

T

V

Q

R

L

I

N

G

G

D

Q

Q

A

I

V

I

G

G

S

N

G

G

K

V

P

P

G

G

S

K

V

L

W

T

Q

K

T

H

L

L

R

H

Q

Q

H

V

Y

Y

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R52 (= R53), R137 (= R142), K143 (= K149), E173 (= E182), S175 (= S184), H176 (≠ A185), S177 (= S186), L196 (= L206), T199 (≠ I209), T200 (= T210), G235 (≠ S245), T236 (≠ S246)
binding (~{Z})-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]pent-2-enedioic acid: T35 (≠ V36), R52 (= R53), R137 (= R142), K143 (= K149), E173 (= E182), H176 (≠ A185), S177 (= S186), L196 (= L206), G198 (= G208), T199 (≠ I209), T200 (= T210), G235 (≠ S245), T236 (≠ S246), V237 (≠ T247), K238 (= K248)

8ayjA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiens complexed with 3-aminooxypropionic acid (see paper)
28% identity, 95% coverage: 5:277/288 of query aligns to 4:267/276 of 8ayjA

query
sites
8ayjA

I

L

V

C

Y

Y

L

I

D

D

G

G

E

K

F

F

M

L

P

P

M

L

N

E

E

E

A

A

R

K

V

L

S

P

P

V

M

T

D

D

R

L

G

I

F

I

L

Q

F

R

G

G

D

V

G

G

V

V

Y

F

E

E

V
x
T

I

I

P

S

V

T

Y

H

Q

S

R

R

Q

R

V

P

F

L

E

M

W

L

A

T

A

P

H

H

L

L

A

K

R
|
R

L

L

K

E

Y

G

S

S

L

A

K

T

A

A

T

S

S

S

I

I

N

V

N

M

P

P

L

A

S

T

D

L

E

D

A

E

W

M

L

A

D

R

M

I

I

I

N

R

Q

E

L

G

I

I

K

K

R

K

H

M

D

G

W

-

A

C

D

E

Q

T

F
x
M

I

V

Y
x
R

L

P

Q

Y

V

I

S

T

R

G

G

G

V

D

Q

S

I

F

P

G

R

K

D

D

H

H

M

L

P

F

A

S

D

S

L

R

T

Y

P

F

T

V

V

I

Y

F

A

E

Y

E

T

I

N

R

P

K

L

P

K

D

P

P

V

I

A

-

D

-

H

-

I

L

L

Y

Q

E

H

K

G

G

I

V

K

A

V

L

I

H

S

P

L

I

E

N

D

A

I

E

R
|
R

W

Y

L

L

R

P

C

-

D

S

I

T

K
|
K

A

S

L

I

T

N

L
x
Y

L

M

P

L

N

S

V

F

M

T

A

G

K

Q

L

R

Q

D

A

S

Q

K

A

G

A

A

G

-

V

-

D

-

D

Y

V

E

I

I

L

L

V

Y

R

C

A

P

D

E

G

G

S

E

V

I

S

V

E
|
E

G

G

S
|
S

A
x
H

S
|
S

N

T

L

F

F

F

M

L

V

I

K

K

D

N

Q

G

T

H

L

L

I

I

T

T

P

A

P

P

N

T

S

S

H

-

K

R

I

A

L
|
L

P

S

G
|
G

I
x
T

T
|
T

R

R

L

Q

V

I

I

V

E

L

K

E

L

L

A

A

R

R

H

G

H

N

I

I

D

Q

L

V

I

E

E

E

R

R

D

C

I

P

Q

L

D

T

E

E

L

L

N

P

S

E

A

A

D

E

E

E

L

A

W

F

L

I

T

T

S
x
G

S
x
T

T
x
V

K
|
K

E

E

A

L

L

L

P

P

I

V

T

V

Q

R

L

I

N

G

G

D

Q

Q

A

I

V

I

G

G

S

N

G

G

K

V

P

P

G

G

S

K

V

L

W

T

Q

K

T

H

L

L

R

H

Q

Q

H

V

Y

Y

binding 3-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxypropanoic acid: T35 (≠ V36), T35 (≠ V36), R52 (= R53), M87 (≠ F89), R89 (≠ Y91), R137 (= R142), K143 (= K149), Y147 (≠ L153), Y147 (≠ L153), E173 (= E182), H176 (≠ A185), H176 (≠ A185), S177 (= S186), L196 (= L206), G198 (= G208), T199 (≠ I209), T200 (= T210), G235 (≠ S245), T236 (≠ S246), T236 (≠ S246), V237 (≠ T247), K238 (= K248)
binding pyridoxal-5'-phosphate: R52 (= R53), R137 (= R142), Y147 (≠ L153), E173 (= E182), S175 (= S184), H176 (≠ A185), S177 (= S186), L196 (= L206), G198 (= G208), T199 (≠ I209), T200 (= T210), T236 (≠ S246)

8aieA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense complexed with d-cycloserine
28% identity, 95% coverage: 5:277/288 of query aligns to 4:267/276 of 8aieA

query
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binding [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate: T35 (≠ V36), R52 (= R53), K143 (= K149), Y147 (≠ L153), S175 (= S184), H176 (≠ A185), S177 (= S186), T199 (≠ I209), T200 (= T210), G235 (≠ S245), T236 (≠ S246), V237 (≠ T247), K238 (= K248)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R52 (= R53), R137 (= R142), K143 (= K149), Y147 (≠ L153), E173 (= E182), S177 (= S186), L196 (= L206), G198 (= G208), T199 (≠ I209), T200 (= T210), G235 (≠ S245), T236 (≠ S246)

6fteB Crystal structure of an (r)-selective amine transaminase from exophiala xenobiotica
27% identity, 95% coverage: 5:279/288 of query aligns to 29:307/321 of 6fteB

query
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active site: Y58 (= Y34), K179 (= K149), E212 (= E182), L234 (= L206)
binding pyridoxal-5'-phosphate: R77 (= R53), K179 (= K149), E212 (= E182), F216 (≠ S186), N217 (= N187), L234 (= L206), G236 (= G208), V237 (≠ I209), T238 (= T210), T274 (≠ S246)

8ivpB Crystal structure of mv in complex with llp and fru from mycobacterium vanbaalenii
27% identity, 97% coverage: 5:283/288 of query aligns to 30:312/322 of 8ivpB

query
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