SitesBLAST
Comparing WP_034412295.1 NCBI__GCF_000482785.1:WP_034412295.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
67% identity, 98% coverage: 6:265/265 of query aligns to 1:255/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (= T18), S14 (= S19), G15 (= G20), I16 (= I21), G35 (= G40), F36 (= F41), L60 (≠ I69), N86 (= N95), G88 (= G97), I89 (= I98), A137 (= A146), Y151 (= Y160), K155 (= K164), P181 (= P190), G182 (= G191), V184 (= V193), T186 (= T195)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
68% identity, 98% coverage: 7:265/265 of query aligns to 2:260/260 of 2ztlA
- active site: G15 (= G20), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (= K164), L200 (≠ R205)
- binding (3s)-3-hydroxybutanoic acid: Q94 (= Q99), S142 (= S147), H144 (= H149), K152 (= K157), Y155 (= Y160), Q196 (= Q201)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), G15 (= G20), I16 (= I21), F36 (= F41), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (= G97), L113 (≠ I118), Y155 (= Y160), K159 (= K164), P185 (= P190), W187 (= W192), V188 (= V193), T190 (= T195), V193 (= V198)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
68% identity, 98% coverage: 7:265/265 of query aligns to 2:260/260 of 1wmbA
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
66% identity, 98% coverage: 6:265/265 of query aligns to 1:255/255 of 2q2qD
- active site: G15 (= G20), S138 (= S147), Y151 (= Y160), K155 (= K164), R196 (= R205)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (= T18), S14 (= S19), G15 (= G20), I16 (= I21), F36 (= F41), D59 (= D68), L60 (≠ I69), N86 (= N95), G88 (= G97), L109 (≠ I118), I136 (= I145), S138 (= S147), Y151 (= Y160), K155 (= K164), P181 (= P190), G182 (= G191), W183 (= W192), V184 (= V193), T186 (= T195), L188 (= L197), V189 (= V198)
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
64% identity, 98% coverage: 7:265/265 of query aligns to 2:260/260 of 5b4tA
- active site: G15 (= G20), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (= K164), I200 (≠ R205)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q99), S142 (= S147), H144 (= H149), K152 (= K157), Y155 (= Y160), W187 (= W192), Q196 (= Q201)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (= T18), G15 (= G20), I16 (= I21), F36 (= F41), D63 (= D68), L64 (≠ I69), N90 (= N95), G92 (= G97), L113 (≠ I118), I140 (= I145), Y155 (= Y160), K159 (= K164), P185 (= P190), G186 (= G191), W187 (= W192), V188 (= V193), T190 (= T195), L192 (= L197), V193 (= V198)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
64% identity, 98% coverage: 7:265/265 of query aligns to 2:260/260 of 3w8dA
- active site: G15 (= G20), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (= K164), I200 (≠ R205)
- binding methylmalonic acid: Q94 (= Q99), S142 (= S147), H144 (= H149), K152 (= K157), Y155 (= Y160), W187 (= W192), Q196 (= Q201), W257 (= W262)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (= T18), S14 (= S19), G15 (= G20), I16 (= I21), F36 (= F41), A62 (= A67), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (= G97), L113 (≠ I118), S142 (= S147), Y155 (= Y160), K159 (= K164), P185 (= P190), G186 (= G191), W187 (= W192), V188 (= V193), T190 (= T195), L192 (= L197), V193 (= V198)
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
64% identity, 98% coverage: 7:265/265 of query aligns to 2:260/260 of 3vdrA
- active site: G15 (= G20), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (= K164), I200 (≠ R205)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q99), H144 (= H149), K152 (= K157), Y155 (= Y160), W187 (= W192), Q196 (= Q201), W257 (= W262)
- binding acetoacetic acid: Q94 (= Q99), H144 (= H149), K152 (= K157), Y155 (= Y160), W187 (= W192), Q196 (= Q201), W257 (= W262)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (= T18), I16 (= I21), F36 (= F41), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (= G97), L113 (≠ I118), K159 (= K164), G186 (= G191), V188 (= V193), T190 (= T195), L192 (= L197), V193 (= V198)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G16), T13 (= T18), I16 (= I21), F36 (= F41), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (= G97), L113 (≠ I118), S142 (= S147), Y155 (= Y160), K159 (= K164), G186 (= G191), V188 (= V193), T190 (= T195), L192 (= L197), V193 (= V198)
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
64% identity, 98% coverage: 7:265/265 of query aligns to 2:260/260 of 3vdqA
- active site: G15 (= G20), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (= K164), I200 (≠ R205)
- binding acetate ion: Q94 (= Q99), H144 (= H149), K152 (= K157), W187 (= W192), L192 (= L197), Q196 (= Q201)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), S14 (= S19), I16 (= I21), F36 (= F41), D63 (= D68), L64 (≠ I69), N90 (= N95), A91 (= A96), G92 (= G97), L113 (≠ I118), I140 (= I145), S142 (= S147), Y155 (= Y160), K159 (= K164), P185 (= P190), G186 (= G191), W187 (= W192), V188 (= V193), T190 (= T195), L192 (= L197), V193 (= V198)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
64% identity, 98% coverage: 7:265/265 of query aligns to 2:236/236 of 1x1tA
- active site: G15 (= G20), N114 (= N119), S142 (= S147), Y155 (= Y160), K159 (= K164)
- binding cacodylate ion: S142 (= S147), H144 (= H149), Y155 (= Y160), W187 (= W192), W233 (= W262)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (= T18), S14 (= S19), G15 (= G20), I16 (= I21), G35 (= G40), F36 (= F41), D63 (= D68), L64 (≠ I69), N90 (= N95), G92 (= G97), L113 (≠ I118), S142 (= S147), Y155 (= Y160), K159 (= K164), P185 (= P190), W187 (= W192), V188 (= V193), T190 (≠ D219)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
42% identity, 98% coverage: 7:265/265 of query aligns to 5:261/261 of 6zzsD
- active site: G18 (= G20), S143 (= S147), Y156 (= Y160)
- binding nicotinamide-adenine-dinucleotide: G14 (= G16), S17 (= S19), I19 (= I21), D38 (≠ A49), M39 (≠ L50), D64 (≠ E74), V65 (= V75), N91 (= N95), A92 (= A96), G93 (= G97), M141 (≠ I145), A142 (= A146), S143 (= S147), Y156 (= Y160), K160 (= K164), P186 (= P190), G187 (= G191), V189 (= V193), T191 (= T195), L193 (= L197)
- binding 3-oxidanylidenepentanoic acid: Q95 (= Q99), S143 (= S147), N145 (≠ H149), K153 (= K157), Y156 (= Y160), Q197 (= Q201)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
42% identity, 98% coverage: 7:265/265 of query aligns to 4:260/260 of 6zzqA
- active site: G17 (= G20), S142 (= S147), Y155 (= Y160)
- binding acetoacetic acid: Q94 (= Q99), S142 (= S147), K152 (= K157), Y155 (= Y160), Q196 (= Q201)
- binding nicotinamide-adenine-dinucleotide: G13 (= G16), S16 (= S19), G17 (= G20), I18 (= I21), D37 (≠ A49), M38 (≠ L50), D63 (≠ E74), V64 (= V75), N90 (= N95), A91 (= A96), G92 (= G97), M140 (≠ I145), A141 (= A146), S142 (= S147), Y155 (= Y160), K159 (= K164), Y187 (≠ W192), V188 (= V193), T190 (= T195)
9febA Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae in complex with NADP
41% identity, 97% coverage: 6:261/265 of query aligns to 5:256/261 of 9febA
9fe6B Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae
41% identity, 97% coverage: 6:261/265 of query aligns to 5:256/261 of 9fe6B
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
37% identity, 97% coverage: 7:264/265 of query aligns to 3:247/248 of 6ixmC
- active site: G16 (= G20), S142 (= S147), Y155 (= Y160), K159 (= K164)
- binding nicotinamide-adenine-dinucleotide: G12 (= G16), S15 (= S19), G16 (= G20), I17 (= I21), D36 (≠ G40), I37 (≠ F41), A61 (= A67), D62 (= D68), T63 (≠ I69), N89 (= N95), A90 (= A96), M140 (≠ I145), S142 (= S147), Y155 (= Y160), K159 (= K164), P185 (= P190), A186 (≠ G191), Y187 (≠ W192), I188 (≠ V193), L192 (= L197)
8y83A Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
38% identity, 97% coverage: 7:264/265 of query aligns to 4:248/249 of 8y83A
- binding nicotinamide-adenine-dinucleotide: G13 (= G16), S16 (= S19), G17 (= G20), I18 (= I21), D37 (≠ G40), I38 (≠ F41), A62 (= A67), D63 (= D68), S64 (≠ I69), N90 (= N95), M141 (≠ I145), Y156 (= Y160), K160 (= K164), P186 (= P190), G187 (= G191), Y188 (≠ W192), I189 (≠ V193), L193 (= L197)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
38% identity, 97% coverage: 6:263/265 of query aligns to 2:246/247 of 4jroC
- active site: G16 (= G20), S142 (= S147), Q152 (≠ K157), Y155 (= Y160), K159 (= K164)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ T18), R15 (≠ S19), G16 (= G20), I17 (= I21), N35 (= N39), Y36 (≠ G40), N37 (≠ F41), G38 (= G42), S39 (≠ D43), N63 (≠ D68), V64 (≠ I69), N90 (= N95), A91 (= A96), I93 (= I98), I113 (= I118), S142 (= S147), Y155 (= Y160), K159 (= K164), P185 (= P190), I188 (≠ V193), T190 (= T195)
6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate (see paper)
38% identity, 98% coverage: 3:262/265 of query aligns to 4:262/265 of 6zzpA
- binding nicotinamide-adenine-dinucleotide: G17 (= G16), S20 (= S19), G21 (= G20), I22 (= I21), D41 (≠ A49), I42 (≠ L50), M66 (vs. gap), D67 (= D68), V68 (≠ I69), N94 (= N95), A95 (= A96), G96 (= G97), M145 (≠ I145), S147 (= S147), Y160 (= Y160), K164 (= K164), P190 (= P190), F192 (≠ W192), V193 (= V193), T195 (= T195), L197 (= L197), V198 (= V198)
- binding 3-oxidanylidenepentanoic acid: Q98 (= Q99), S147 (= S147), H149 (= H149), K157 (= K157), Y160 (= Y160), F192 (≠ W192), Q201 (= Q201)
6zzoC Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
38% identity, 98% coverage: 3:262/265 of query aligns to 4:262/265 of 6zzoC
- binding acetoacetic acid: Q98 (= Q99), H149 (= H149), K157 (= K157), F192 (≠ W192), Q201 (= Q201)
- binding nicotinamide-adenine-dinucleotide: G17 (= G16), S20 (= S19), G21 (= G20), I22 (= I21), D41 (≠ A49), I42 (≠ L50), M66 (vs. gap), D67 (= D68), V68 (≠ I69), N94 (= N95), A95 (= A96), G96 (= G97), M145 (≠ I145), Y160 (= Y160), K164 (= K164), P190 (= P190), F192 (≠ W192), V193 (= V193), T195 (= T195), L197 (= L197), V198 (= V198)
5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
36% identity, 98% coverage: 6:265/265 of query aligns to 4:255/255 of 5itvA
- active site: G18 (= G20), S141 (= S147), Y154 (= Y160), K158 (= K164)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G16), S17 (= S19), G18 (= G20), I19 (= I21), D38 (≠ G40), I39 (≠ F41), T61 (≠ A67), I63 (= I69), N89 (= N95), G91 (= G97), T139 (≠ I145), S141 (= S147), Y154 (= Y160), K158 (= K164), P184 (= P190), G185 (= G191), I186 (≠ W192), I187 (≠ V193)
3sjuA Hedamycin polyketide ketoreductase bound to NADPH (see paper)
39% identity, 95% coverage: 10:261/265 of query aligns to 1:251/255 of 3sjuA
- active site: G11 (= G20), S138 (= S147), Y151 (= Y160), K155 (= K164), Y196 (≠ R205)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G7 (= G16), S10 (= S19), A31 (≠ F41), R32 (≠ G42), D33 (= D43), C56 (≠ A67), D57 (= D68), V58 (≠ I69), S84 (≠ N95), A85 (= A96), G86 (= G97), I136 (= I145), Y151 (= Y160), K155 (= K164), P181 (= P190), G182 (= G191), Y183 (≠ W192), V184 (= V193), T186 (= T195), M188 (≠ L197)
Query Sequence
>WP_034412295.1 NCBI__GCF_000482785.1:WP_034412295.1
MALNTSLKGKVALVTGSTSGIGLGIAHCLAAEGADLVLNGFGDAAAIEALRKETAEKYGV
RVEYSGADISKPAEVAAMVKFAQDTLGSLDILVNNAGIQYVAPVEEFPDEKWDAIIAINL
SSNFHAIKAALPAMKAKNWGRIINIASAHGLVASAQKSAYVTAKHGVVGLTKVVALENAQ
TGITCNAICPGWVLTPLVQKQIDARAANEGKTIEQAKRDLLGEKQPSLEFVTPEQLGGLA
VFLCSDAAAQIRGVAYNVDGGWVAQ
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory